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Acyl-CoA desaturase activity edits. Fixes #29820 #29825

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Acyl-CoA desaturase activity edits. Fixes #29820 #29825

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37 changes: 24 additions & 13 deletions src/ontology/go-edit.obo
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Expand Up @@ -120237,9 +120237,9 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i

[Term]
id: GO:0016213
name: linoleoyl-CoA desaturase activity
name: acyl-CoA 6-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)." [EC:1.14.19.3, PMID:12713571, PMID:7212717]
def: "Catalysis of the introduction of a cis double bond at carbon 6 of acyl-CoAs, introducing a new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. Specific reactions include: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; and (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [EC:1.14.19.3, PMID:12713571, PMID:7212717]
synonym: "delta(6)-acyl CoA desaturase activity" BROAD []
synonym: "delta(6)-desaturase activity" BROAD []
synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD []
Expand All @@ -120253,6 +120253,7 @@ synonym: "linoleate desaturase activity" RELATED []
synonym: "linoleic acid desaturase activity" RELATED []
synonym: "linoleic desaturase activity" RELATED []
synonym: "linoleoyl CoA desaturase activity" EXACT []
synonym: "linoleoyl-CoA desaturase activity" EXACT []
synonym: "linoleoyl-coenzyme A desaturase activity" EXACT []
synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD []
synonym: "long-chain fatty acid delta6-desaturase activity" RELATED [EC:1.14.19.3]
Expand All @@ -120262,17 +120263,18 @@ xref: RHEA:47140 {source="skos:narrowMatch"}
xref: RHEA:47144 {source="skos:narrowMatch"}
is_a: GO:0016215 ! acyl-CoA desaturase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21804" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI

[Term]
id: GO:0016215
name: acyl-CoA desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O." [RHEA:25416]
def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [GOC:curators]
synonym: "CoA desaturase activity" BROAD []
xref: RHEA:25416
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21108" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24103" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI

[Term]
id: GO:0016216
Expand Down Expand Up @@ -128144,12 +128146,13 @@ is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0017105
name: acyl-CoA delta11-(Z)-desaturase activity
name: acyl-CoA 11-(Z)-desaturase activity
namespace: molecular_function
alt_id: GO:0050601
def: "Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [PMID:15063718, PMID:15544945, RHEA:25852]
synonym: "acyl-CoA D11-desaturase activity" EXACT []
synonym: "acyl-CoA delta(11)-desaturase activity" EXACT []
synonym: "acyl-CoA delta11-(Z)-desaturase activity" EXACT []
synonym: "acyl-CoA delta11-desaturase activity" BROAD []
synonym: "delta(11) desaturase" BROAD [EC:1.14.19.5]
synonym: "delta(11)-fatty-acid desaturase" BROAD [EC:1.14.19.5]
Expand All @@ -128163,6 +128166,7 @@ xref: RHEA:25852
is_a: GO:0016215 ! acyl-CoA desaturase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22050" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24103" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI

[Term]
id: GO:0017106
Expand Down Expand Up @@ -187579,9 +187583,11 @@ intersection_of: positively_regulates GO:0015849 ! organic acid transport
id: GO:0032896
name: palmitoyl-CoA 9-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv, PMID:16443825]
def: "Catalysis of the reaction: hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [PMID:16443825, RHEA:36931]
synonym: "palmitoyl-CoA delta9-desaturase activity" EXACT []
xref: RHEA:36931 {source="skos:exactMatch"}
is_a: GO:0016215 ! acyl-CoA desaturase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI

[Term]
id: GO:0032897
Expand Down Expand Up @@ -364680,17 +364686,18 @@ creation_date: 2018-09-19T19:25:59Z

[Term]
id: GO:0062076
name: acyl-CoA delta5-desaturase activity
name: acyl-CoA (8-3)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA)." [PMID:10601301, PMID:10769175, RHEA:46424]
synonym: "acyl-CoA (8-3)-desaturase" EXACT []
synonym: "acyl-CoA D5-desaturase activity" EXACT []
synonym: "acyl-CoA delta(5)-desaturase activity" EXACT []
synonym: "acyl-CoA delta5-desaturase activity" EXACT []
xref: EC:1.14.19.44
xref: RHEA:46420 {source="skos:narrowMatch"}
xref: RHEA:46424 {source="skos:narrowMatch"}
is_a: GO:0016215 ! acyl-CoA desaturase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24103" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI
created_by: dph
creation_date: 2018-09-24T15:33:59Z

Expand Down Expand Up @@ -438974,16 +438981,18 @@ is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group

[Term]
id: GO:0102985
name: delta12-fatty-acid desaturase activity
name: acyl-CoA (9+3)-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Also converts (9Z)-octadecenoyl-CoA into (9Z,12Z)-octadecadienoyl-CoA. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9." [EC:1.14.19.6]
def: "Catalysis of the introduction of a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. Specific reactions include: (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; and (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." [EC:1.14.19.6]
synonym: "delta12-fatty-acid desaturase activity" EXACT []
xref: EC:1.14.19.6 {source="skos:exactMatch"}
xref: MetaCyc:RXN-9601 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-9616 {source="skos:narrowMatch"}
xref: RHEA:25856 {source="skos:narrowMatch"}
xref: RHEA:45096 {source="skos:narrowMatch"}
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0016215 ! acyl-CoA desaturase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28526" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI

[Term]
id: GO:0102986
Expand Down Expand Up @@ -439012,14 +439021,16 @@ replaced_by: GO:0102985

[Term]
id: GO:0102988
name: 9,12-cis-hexadecadienoic acid delta 15 desaturase activity
name: acyl-CoA 15-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor = 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.13]
synonym: "9,12-cis-hexadecadienoic acid delta 15 desaturase activity" EXACT []
xref: EC:1.14.19.13 {source="skos:exactMatch"}
xref: MetaCyc:RXN-9617
xref: RHEA:46232
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0016215 ! acyl-CoA desaturase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29820" xsd:anyURI

[Term]
id: GO:0102989
Expand Down
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