Acyl-CoA desaturase activity edits. Fixes #29820

[sjm41]

No description provided.

[github-actions]

Here's a diff of how these changes impact the classified ontology:

Ontology comparison

Left

• Ontology IRI: http://purl.obolibrary.org/obo/go.owl
• Version IRI: http://purl.obolibrary.org/obo/go/releases/2025-02-28/go.owl
• Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/../../reasoned-master.owl/reasoned.owl

Right

• Ontology IRI: http://purl.obolibrary.org/obo/go.owl
• Version IRI: http://purl.obolibrary.org/obo/go/releases/2025-02-28/go.owl
• Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/../../reasoned-pr.owl/reasoned.owl

Ontology imports

Ontology annotations

9,12-cis-hexadecadienoic acid delta 15 desaturase activity http://purl.obolibrary.org/obo/GO_0102988

Removed

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity label "9,12-cis-hexadecadienoic acid delta 15 desaturase activity"

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity SubClassOf has participant some dioxygen

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity SubClassOf oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity SubClassOf has participant some water

Added

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity has_exact_synonym "9,12-cis-hexadecadienoic acid delta 15 desaturase activity"

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity label "acyl-CoA 15-desaturase activity"

• 9,12-cis-hexadecadienoic acid delta 15 desaturase activity SubClassOf acyl-CoA desaturase activity

acyl-CoA delta11-(Z)-desaturase activity http://purl.obolibrary.org/obo/GO_0017105

Removed

• acyl-CoA delta11-(Z)-desaturase activity label "acyl-CoA delta11-(Z)-desaturase activity"

Added

• acyl-CoA delta11-(Z)-desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

• acyl-CoA delta11-(Z)-desaturase activity has_exact_synonym "acyl-CoA delta11-(Z)-desaturase activity"

• acyl-CoA delta11-(Z)-desaturase activity label "acyl-CoA 11-(Z)-desaturase activity"

acyl-CoA delta5-desaturase activity http://purl.obolibrary.org/obo/GO_0062076

Removed

• acyl-CoA delta5-desaturase activity has_exact_synonym "acyl-CoA (8-3)-desaturase"

• acyl-CoA delta5-desaturase activity label "acyl-CoA delta5-desaturase activity"

Added

• acyl-CoA delta5-desaturase activity label "acyl-CoA (8-3)-desaturase activity"

• acyl-CoA delta5-desaturase activity has_exact_synonym "acyl-CoA delta5-desaturase activity"

• acyl-CoA delta5-desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

acyl-CoA desaturase activity http://purl.obolibrary.org/obo/GO_0016215

Removed

• acyl-CoA desaturase activity database_cross_reference "RHEA:25416"

• acyl-CoA desaturase activity definition "Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O."

  • database_cross_reference "RHEA:25416"

Added

• acyl-CoA desaturase activity definition "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O."

  • database_cross_reference "GOC:curators"

• acyl-CoA desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

delta12-fatty-acid desaturase activity http://purl.obolibrary.org/obo/GO_0102985

Removed

• delta12-fatty-acid desaturase activity label "delta12-fatty-acid desaturase activity"

• delta12-fatty-acid desaturase activity definition "Catalysis of the reaction: (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Also converts (9Z)-octadecenoyl-CoA into (9Z,12Z)-octadecadienoyl-CoA. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9."

  • database_cross_reference "EC:1.14.19.6"

• delta12-fatty-acid desaturase activity SubClassOf oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Added

• delta12-fatty-acid desaturase activity label "acyl-CoA (9+3)-desaturase activity"

• delta12-fatty-acid desaturase activity definition "Catalysis of the introduction of a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. Specific reactions include: (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; and (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."

  • database_cross_reference "EC:1.14.19.6"

• delta12-fatty-acid desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

• delta12-fatty-acid desaturase activity has_exact_synonym "delta12-fatty-acid desaturase activity"

• delta12-fatty-acid desaturase activity SubClassOf acyl-CoA desaturase activity

linoleoyl-CoA desaturase activity http://purl.obolibrary.org/obo/GO_0016213

Removed

• linoleoyl-CoA desaturase activity definition "Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)."

  • database_cross_reference "PMID:12713571"

  • database_cross_reference "PMID:7212717"

  • database_cross_reference "EC:1.14.19.3"

• linoleoyl-CoA desaturase activity label "linoleoyl-CoA desaturase activity"

Added

• linoleoyl-CoA desaturase activity has_exact_synonym "linoleoyl-CoA desaturase activity"

• linoleoyl-CoA desaturase activity definition "Catalysis of the introduction of a cis double bond at carbon 6 of acyl-CoAs, introducing a new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. Specific reactions include: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; and (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."

  • database_cross_reference "PMID:12713571"

  • database_cross_reference "PMID:7212717"

  • database_cross_reference "EC:1.14.19.3"

• linoleoyl-CoA desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

• linoleoyl-CoA desaturase activity label "acyl-CoA 6-desaturase activity"

palmitoyl-CoA 9-desaturase activity http://purl.obolibrary.org/obo/GO_0032896

Removed

• palmitoyl-CoA 9-desaturase activity definition "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O."

  • database_cross_reference "PMID:16443825"

  • database_cross_reference "GOC:kmv"

Added

• palmitoyl-CoA 9-desaturase activity database_cross_reference "RHEA:36931"

  • source "skos:exactMatch"

• palmitoyl-CoA 9-desaturase activity definition "Catalysis of the reaction: hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."

  • database_cross_reference "RHEA:36931"

  • database_cross_reference "PMID:16443825"

• palmitoyl-CoA 9-desaturase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29820"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)