manuscript revision

pni-lab · Jul 7, 2022 · feea6e0 · feea6e0
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diff --git a/empirical/analysis_abide.ipynb b/empirical/analysis_abide.ipynb
diff --git a/empirical/analysis_hcp.ipynb b/empirical/analysis_hcp.ipynb
diff --git a/empirical/fig/raw/emp_hcp_age_raw_partial.dot.pdf b/empirical/fig/raw/emp_hcp_age_raw_partial.dot.pdf
diff --git a/empirical/fig/raw/emp_hcp_iq_quanttrf_hist.pdf b/empirical/fig/raw/emp_hcp_iq_quanttrf_hist.pdf
diff --git a/empirical/supplement/.ipynb_checkpoints/external_validation-checkpoint.ipynb b/empirical/supplement/.ipynb_checkpoints/external_validation-checkpoint.ipynb
diff --git a/empirical/supplement/causal_forest.ipynb b/empirical/supplement/causal_forest.ipynb
diff --git a/empirical/supplement/check_assumptions.ipynb b/empirical/supplement/check_assumptions.ipynb
diff --git a/empirical/supplement/check_assumptions_abide.ipynb b/empirical/supplement/check_assumptions_abide.ipynb
diff --git a/empirical/supplement/external_validation.ipynb b/empirical/supplement/external_validation.ipynb
diff --git a/fig/fig_abide.png b/fig/fig_abide.png
diff --git a/fig/fig_abide.svg b/fig/fig_abide.svg
diff --git a/fig/fig_hcp.png b/fig/fig_hcp.png
diff --git a/fig/fig_hcp.svg b/fig/fig_hcp.svg
diff --git a/fig/raw/assumptions_hcp_agecomb_c.pdf b/fig/raw/assumptions_hcp_agecomb_c.pdf
diff --git a/fig/raw/assumptions_hcp_agecomb_y.pdf b/fig/raw/assumptions_hcp_agecomb_y.pdf
diff --git a/fig/raw/assumptions_hcp_agereg_c.pdf b/fig/raw/assumptions_hcp_agereg_c.pdf
diff --git a/fig/raw/assumptions_hcp_agereg_y.pdf b/fig/raw/assumptions_hcp_agereg_y.pdf
diff --git a/fig/raw/assumptions_hcp_raw_c.pdf b/fig/raw/assumptions_hcp_raw_c.pdf
diff --git a/fig/raw/assumptions_hcp_raw_y.pdf b/fig/raw/assumptions_hcp_raw_y.pdf
diff --git a/fig/raw/emp_abide_motion_comb_full.dot b/fig/raw/emp_abide_motion_comb_full.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label=0.005]
+	c -- yhat [label=0.002]
 	c -- y [label=0.028]
-	y -- yhat [label="0.066 (p<0.0001*)" style=dashed]
+	y -- yhat [label="0.111 (p<0.0001*)" style=dashed]
 }
diff --git a/fig/raw/emp_abide_motion_comb_full.dot.pdf b/fig/raw/emp_abide_motion_comb_full.dot.pdf
diff --git a/fig/raw/emp_abide_motion_comb_full.tex b/fig/raw/emp_abide_motion_comb_full.tex
@@ -31,9 +31,9 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,47.5bp) node {0.028};
   \draw [] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (212.26bp,8.242bp) and (308.45bp,13.31bp)  .. (yhat);
-  \draw (158.0bp,18.5bp) node {0.005};
+  \draw (158.0bp,18.5bp) node {0.002};
   \draw [dashed] (y) ..controls (226.87bp,42.252bp) and (312.06bp,28.76bp)  .. (yhat);
-  \draw (269.5bp,52.5bp) node {0.066 (p<0.0001*)};
+  \draw (269.5bp,52.5bp) node {0.111 (p<0.0001*)};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_abide_motion_comb_partial.dot b/fig/raw/emp_abide_motion_comb_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.005 (p=0.18)" style=dashed]
+	c -- yhat [label="0.002 (p=0.58)" style=dashed]
 	c -- y [label=0.028]
-	y -- yhat [label=0.066]
+	y -- yhat [label=0.111]
 }
diff --git a/fig/raw/emp_abide_motion_comb_partial.dot.pdf b/fig/raw/emp_abide_motion_comb_partial.dot.pdf
diff --git a/fig/raw/emp_abide_motion_comb_partial.tex b/fig/raw/emp_abide_motion_comb_partial.tex
@@ -31,9 +31,9 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,43.5bp) node {0.028};
   \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (179.42bp,9.3567bp) and (191.58bp,9.3567bp)  .. (240.0bp,11.0bp) .. controls (266.33bp,11.894bp) and (296.39bp,14.069bp)  .. (yhat);
-  \draw (185.5bp,18.5bp) node {0.005 (p=0.18)};
+  \draw (185.5bp,18.5bp) node {0.002 (p=0.58)};
   \draw [] (y) ..controls (240.52bp,40.92bp) and (288.78bp,30.126bp)  .. (yhat);
-  \draw (278.5bp,43.5bp) node {0.066};
+  \draw (278.5bp,43.5bp) node {0.111};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_abide_motion_comb_rocplot.pdf b/fig/raw/emp_abide_motion_comb_rocplot.pdf
diff --git a/fig/raw/emp_abide_motion_comb_stripplot.pdf b/fig/raw/emp_abide_motion_comb_stripplot.pdf
diff --git a/fig/raw/emp_abide_motion_hist.pdf b/fig/raw/emp_abide_motion_hist.pdf
diff --git a/fig/raw/emp_abide_motion_quanttrf_hist.pdf b/fig/raw/emp_abide_motion_quanttrf_hist.pdf
diff --git a/fig/raw/emp_abide_motion_raw_full.dot.pdf b/fig/raw/emp_abide_motion_raw_full.dot.pdf
diff --git a/fig/raw/emp_abide_motion_raw_partial.dot.pdf b/fig/raw/emp_abide_motion_raw_partial.dot.pdf
diff --git a/fig/raw/emp_abide_motion_raw_stripplot.pdf b/fig/raw/emp_abide_motion_raw_stripplot.pdf
diff --git a/fig/raw/emp_abide_motion_reg_full.dot b/fig/raw/emp_abide_motion_reg_full.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label=0.062]
+	c -- yhat [label=0.002]
 	c -- y [label=0.028]
-	y -- yhat [label="0.031 (p=0.001*)" style=dashed]
+	y -- yhat [label="0.098 (p<0.0001*)" style=dashed]
 }
diff --git a/fig/raw/emp_abide_motion_reg_full.dot.pdf b/fig/raw/emp_abide_motion_reg_full.dot.pdf
diff --git a/fig/raw/emp_abide_motion_reg_full.tex b/fig/raw/emp_abide_motion_reg_full.tex
@@ -25,15 +25,15 @@
 %%
 \node (c) at (27.0bp,18.0bp) [draw,ellipse] {c};
   \node (y) at (158.0bp,53.0bp) [draw,ellipse] {y};
-  \node (yhat) at (372.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
+  \node (yhat) at (381.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
   \draw [] (c) ..controls (75.327bp,30.841bp) and (109.82bp,40.199bp)  .. (y);
   \definecolor{strokecol}{rgb}{0.0,0.0,0.0};
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,47.5bp) node {0.028};
-  \draw [] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (208.9bp,8.3558bp) and (301.06bp,13.31bp)  .. (yhat);
-  \draw (158.0bp,18.5bp) node {0.062};
-  \draw [dashed] (y) ..controls (225.43bp,42.033bp) and (304.96bp,28.903bp)  .. (yhat);
-  \draw (265.0bp,52.5bp) node {0.031 (p=0.001*)};
+  \draw [] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (212.26bp,8.242bp) and (308.45bp,13.31bp)  .. (yhat);
+  \draw (158.0bp,18.5bp) node {0.002};
+  \draw [dashed] (y) ..controls (226.87bp,42.252bp) and (312.06bp,28.76bp)  .. (yhat);
+  \draw (269.5bp,52.5bp) node {0.098 (p<0.0001*)};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_abide_motion_reg_partial.dot b/fig/raw/emp_abide_motion_reg_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.062 (p<0.0001*)" style=dashed]
+	c -- yhat [label="0.002 (p=0.51)" style=dashed]
 	c -- y [label=0.028]
-	y -- yhat [label=0.031]
+	y -- yhat [label=0.098]
 }
diff --git a/fig/raw/emp_abide_motion_reg_partial.dot.pdf b/fig/raw/emp_abide_motion_reg_partial.dot.pdf
diff --git a/fig/raw/emp_abide_motion_reg_partial.tex b/fig/raw/emp_abide_motion_reg_partial.tex
@@ -24,16 +24,16 @@
 \begin{tikzpicture}[>=latex',line join=bevel,]
 %%
 \node (c) at (27.0bp,18.0bp) [draw,ellipse] {c};
-  \node (y) at (197.5bp,53.0bp) [draw,ellipse] {y};
-  \node (yhat) at (368.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
-  \draw [] (c) ..controls (85.084bp,29.857bp) and (139.57bp,41.174bp)  .. (y);
+  \node (y) at (185.5bp,53.0bp) [draw,ellipse] {y};
+  \node (yhat) at (344.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
+  \draw [] (c) ..controls (82.016bp,30.08bp) and (130.28bp,40.874bp)  .. (y);
   \definecolor{strokecol}{rgb}{0.0,0.0,0.0};
   \pgfsetstrokecolor{strokecol}
-  \draw (92.5bp,42.5bp) node {0.028};
-  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (190.08bp,8.9948bp) and (204.92bp,8.9948bp)  .. (264.0bp,11.0bp) .. controls (290.33bp,11.894bp) and (320.39bp,14.069bp)  .. (yhat);
-  \draw (197.5bp,18.5bp) node {0.062 (p<0.0001*)};
-  \draw [] (y) ..controls (255.58bp,41.143bp) and (310.07bp,29.826bp)  .. (yhat);
-  \draw (302.5bp,42.5bp) node {0.031};
+  \draw (92.5bp,43.5bp) node {0.028};
+  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (179.42bp,9.3567bp) and (191.58bp,9.3567bp)  .. (240.0bp,11.0bp) .. controls (266.33bp,11.894bp) and (296.39bp,14.069bp)  .. (yhat);
+  \draw (185.5bp,18.5bp) node {0.002 (p=0.51)};
+  \draw [] (y) ..controls (240.52bp,40.92bp) and (288.78bp,30.126bp)  .. (yhat);
+  \draw (278.5bp,43.5bp) node {0.098};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_abide_motion_reg_rocplot.pdf b/fig/raw/emp_abide_motion_reg_rocplot.pdf
diff --git a/fig/raw/emp_abide_motion_reg_stripplot.pdf b/fig/raw/emp_abide_motion_reg_stripplot.pdf
diff --git a/fig/raw/emp_abide_raw_rocplot.pdf b/fig/raw/emp_abide_raw_rocplot.pdf
diff --git a/fig/raw/emp_abide_site_comb_full.dot.pdf b/fig/raw/emp_abide_site_comb_full.dot.pdf
diff --git a/fig/raw/emp_abide_site_comb_partial.dot.pdf b/fig/raw/emp_abide_site_comb_partial.dot.pdf
diff --git a/fig/raw/emp_abide_site_comb_rocplot.pdf b/fig/raw/emp_abide_site_comb_rocplot.pdf
diff --git a/fig/raw/emp_abide_site_comb_striplot.pdf b/fig/raw/emp_abide_site_comb_striplot.pdf
diff --git a/fig/raw/emp_abide_site_raw_full.dot.pdf b/fig/raw/emp_abide_site_raw_full.dot.pdf
diff --git a/fig/raw/emp_abide_site_raw_partial.dot.pdf b/fig/raw/emp_abide_site_raw_partial.dot.pdf
diff --git a/fig/raw/emp_abide_site_raw_striplot.pdf b/fig/raw/emp_abide_site_raw_striplot.pdf
diff --git a/fig/raw/emp_abide_site_reg_full.dot b/fig/raw/emp_abide_site_reg_full.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label=0.052]
+	c -- yhat [label=0.004]
 	c -- y [label=0.019]
-	y -- yhat [label="0.161 (p<0.0001*)" style=dashed]
+	y -- yhat [label="0.179 (p<0.0001*)" style=dashed]
 }
diff --git a/fig/raw/emp_abide_site_reg_full.dot.pdf b/fig/raw/emp_abide_site_reg_full.dot.pdf
diff --git a/fig/raw/emp_abide_site_reg_full.tex b/fig/raw/emp_abide_site_reg_full.tex
@@ -31,9 +31,9 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,47.5bp) node {0.019};
   \draw [] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (212.26bp,8.242bp) and (308.45bp,13.31bp)  .. (yhat);
-  \draw (158.0bp,18.5bp) node {0.052};
+  \draw (158.0bp,18.5bp) node {0.004};
   \draw [dashed] (y) ..controls (226.87bp,42.252bp) and (312.06bp,28.76bp)  .. (yhat);
-  \draw (269.5bp,52.5bp) node {0.161 (p<0.0001*)};
+  \draw (269.5bp,52.5bp) node {0.179 (p<0.0001*)};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_abide_site_reg_partial.dot b/fig/raw/emp_abide_site_reg_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.052 (p=0.003*)" style=dashed]
+	c -- yhat [label="0.004 (p=1.0)" style=dashed]
 	c -- y [label=0.019]
-	y -- yhat [label=0.161]
+	y -- yhat [label=0.179]
 }
diff --git a/fig/raw/emp_abide_site_reg_partial.dot.pdf b/fig/raw/emp_abide_site_reg_partial.dot.pdf
diff --git a/fig/raw/emp_abide_site_reg_partial.tex b/fig/raw/emp_abide_site_reg_partial.tex
@@ -24,16 +24,16 @@
 \begin{tikzpicture}[>=latex',line join=bevel,]
 %%
 \node (c) at (27.0bp,18.0bp) [draw,ellipse] {c};
-  \node (y) at (193.0bp,53.0bp) [draw,ellipse] {y};
-  \node (yhat) at (359.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
-  \draw [] (c) ..controls (83.822bp,29.913bp) and (136.23bp,41.098bp)  .. (y);
+  \node (y) at (181.0bp,53.0bp) [draw,ellipse] {y};
+  \node (yhat) at (335.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
+  \draw [] (c) ..controls (81.025bp,30.21bp) and (126.99bp,40.794bp)  .. (y);
   \definecolor{strokecol}{rgb}{0.0,0.0,0.0};
   \pgfsetstrokecolor{strokecol}
-  \draw (92.5bp,42.5bp) node {0.019};
-  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (186.08bp,9.1305bp) and (199.92bp,9.1305bp)  .. (255.0bp,11.0bp) .. controls (281.33bp,11.894bp) and (311.39bp,14.069bp)  .. (yhat);
-  \draw (193.0bp,18.5bp) node {0.052 (p=0.003*)};
-  \draw [] (y) ..controls (249.82bp,41.087bp) and (302.23bp,29.902bp)  .. (yhat);
-  \draw (293.5bp,42.5bp) node {0.161};
+  \draw (92.5bp,43.5bp) node {0.019};
+  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (175.42bp,9.4924bp) and (186.58bp,9.4924bp)  .. (231.0bp,11.0bp) .. controls (257.33bp,11.894bp) and (287.39bp,14.069bp)  .. (yhat);
+  \draw (181.0bp,18.5bp) node {0.004 (p=1.0)};
+  \draw [] (y) ..controls (235.03bp,40.79bp) and (280.99bp,30.206bp)  .. (yhat);
+  \draw (269.5bp,43.5bp) node {0.179};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_abide_site_reg_rocplot.pdf b/fig/raw/emp_abide_site_reg_rocplot.pdf
diff --git a/fig/raw/emp_abide_site_reg_striplot.pdf b/fig/raw/emp_abide_site_reg_striplot.pdf
diff --git a/fig/raw/emp_hcp_acq_comb_full.dot.pdf b/fig/raw/emp_hcp_acq_comb_full.dot.pdf
diff --git a/fig/raw/emp_hcp_acq_comb_partial.dot b/fig/raw/emp_hcp_acq_comb_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.013 (p=0.65)" style=dashed]
+	c -- yhat [label="0.013 (p=0.66)" style=dashed]
 	c -- y [label=0.032]
 	y -- yhat [label=0.122]
 }
diff --git a/fig/raw/emp_hcp_acq_comb_partial.dot.pdf b/fig/raw/emp_hcp_acq_comb_partial.dot.pdf
diff --git a/fig/raw/emp_hcp_acq_comb_partial.tex b/fig/raw/emp_hcp_acq_comb_partial.tex
@@ -31,7 +31,7 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,43.5bp) node {0.032};
   \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (179.42bp,9.3567bp) and (191.58bp,9.3567bp)  .. (240.0bp,11.0bp) .. controls (266.33bp,11.894bp) and (296.39bp,14.069bp)  .. (yhat);
-  \draw (185.5bp,18.5bp) node {0.013 (p=0.65)};
+  \draw (185.5bp,18.5bp) node {0.013 (p=0.66)};
   \draw [] (y) ..controls (240.52bp,40.92bp) and (288.78bp,30.126bp)  .. (yhat);
   \draw (278.5bp,43.5bp) node {0.122};
 %

diff --git a/fig/raw/emp_hcp_acq_comb_regplot.pdf b/fig/raw/emp_hcp_acq_comb_regplot.pdf
diff --git a/fig/raw/emp_hcp_acq_raw_full.dot.pdf b/fig/raw/emp_hcp_acq_raw_full.dot.pdf
diff --git a/fig/raw/emp_hcp_acq_raw_partial.dot.pdf b/fig/raw/emp_hcp_acq_raw_partial.dot.pdf
diff --git a/fig/raw/emp_hcp_acq_raw_regplot.pdf b/fig/raw/emp_hcp_acq_raw_regplot.pdf
diff --git a/fig/raw/emp_hcp_acq_reg_full.dot b/fig/raw/emp_hcp_acq_reg_full.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label=0.011]
+	c -- yhat [label=0.0]
 	c -- y [label=0.032]
-	y -- yhat [label="0.105 (p<0.0001*)" style=dashed]
+	y -- yhat [label="0.114 (p<0.0001*)" style=dashed]
 }
diff --git a/fig/raw/emp_hcp_acq_reg_full.dot.pdf b/fig/raw/emp_hcp_acq_reg_full.dot.pdf
diff --git a/fig/raw/emp_hcp_acq_reg_full.tex b/fig/raw/emp_hcp_acq_reg_full.tex
@@ -31,9 +31,9 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,47.5bp) node {0.032};
   \draw [] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (212.26bp,8.242bp) and (308.45bp,13.31bp)  .. (yhat);
-  \draw (158.0bp,18.5bp) node {0.011};
+  \draw (158.0bp,18.5bp) node {0.0};
   \draw [dashed] (y) ..controls (226.87bp,42.252bp) and (312.06bp,28.76bp)  .. (yhat);
-  \draw (269.5bp,52.5bp) node {0.105 (p<0.0001*)};
+  \draw (269.5bp,52.5bp) node {0.114 (p<0.0001*)};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_hcp_acq_reg_partial.dot b/fig/raw/emp_hcp_acq_reg_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.011 (p=0.73)" style=dashed]
+	c -- yhat [label="0.0 (p=1.0)" style=dashed]
 	c -- y [label=0.032]
-	y -- yhat [label=0.105]
+	y -- yhat [label=0.114]
 }
diff --git a/fig/raw/emp_hcp_acq_reg_partial.dot.pdf b/fig/raw/emp_hcp_acq_reg_partial.dot.pdf
diff --git a/fig/raw/emp_hcp_acq_reg_partial.tex b/fig/raw/emp_hcp_acq_reg_partial.tex
@@ -24,16 +24,16 @@
 \begin{tikzpicture}[>=latex',line join=bevel,]
 %%
 \node (c) at (27.0bp,18.0bp) [draw,ellipse] {c};
-  \node (y) at (185.5bp,53.0bp) [draw,ellipse] {y};
-  \node (yhat) at (344.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
-  \draw [] (c) ..controls (82.016bp,30.08bp) and (130.28bp,40.874bp)  .. (y);
+  \node (y) at (172.0bp,53.0bp) [draw,ellipse] {y};
+  \node (yhat) at (317.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
+  \draw [] (c) ..controls (78.775bp,30.427bp) and (120.01bp,40.519bp)  .. (y);
   \definecolor{strokecol}{rgb}{0.0,0.0,0.0};
   \pgfsetstrokecolor{strokecol}
-  \draw (92.5bp,43.5bp) node {0.032};
-  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (179.42bp,9.3567bp) and (191.58bp,9.3567bp)  .. (240.0bp,11.0bp) .. controls (266.33bp,11.894bp) and (296.39bp,14.069bp)  .. (yhat);
-  \draw (185.5bp,18.5bp) node {0.011 (p=0.73)};
-  \draw [] (y) ..controls (240.52bp,40.92bp) and (288.78bp,30.126bp)  .. (yhat);
-  \draw (278.5bp,43.5bp) node {0.105};
+  \draw (92.5bp,45.5bp) node {0.032};
+  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (167.42bp,9.7637bp) and (176.58bp,9.7637bp)  .. (213.0bp,11.0bp) .. controls (239.33bp,11.894bp) and (269.39bp,14.069bp)  .. (yhat);
+  \draw (172.0bp,18.5bp) node {0.0 (p=1.0)};
+  \draw [] (y) ..controls (223.78bp,40.573bp) and (265.01bp,30.481bp)  .. (yhat);
+  \draw (251.5bp,45.5bp) node {0.114};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_hcp_acq_reg_regplot.pdf b/fig/raw/emp_hcp_acq_reg_regplot.pdf
diff --git a/fig/raw/emp_hcp_age_comb_full.dot.pdf b/fig/raw/emp_hcp_age_comb_full.dot.pdf
diff --git a/fig/raw/emp_hcp_age_comb_partial.dot b/fig/raw/emp_hcp_age_comb_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.005 (p=0.16)" style=dashed]
+	c -- yhat [label="0.005 (p=0.15)" style=dashed]
 	c -- y [label=0.011]
 	y -- yhat [label=0.121]
 }
diff --git a/fig/raw/emp_hcp_age_comb_partial.dot.pdf b/fig/raw/emp_hcp_age_comb_partial.dot.pdf
diff --git a/fig/raw/emp_hcp_age_comb_partial.tex b/fig/raw/emp_hcp_age_comb_partial.tex
@@ -31,7 +31,7 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,43.5bp) node {0.011};
   \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (179.42bp,9.3567bp) and (191.58bp,9.3567bp)  .. (240.0bp,11.0bp) .. controls (266.33bp,11.894bp) and (296.39bp,14.069bp)  .. (yhat);
-  \draw (185.5bp,18.5bp) node {0.005 (p=0.16)};
+  \draw (185.5bp,18.5bp) node {0.005 (p=0.15)};
   \draw [] (y) ..controls (240.52bp,40.92bp) and (288.78bp,30.126bp)  .. (yhat);
   \draw (278.5bp,43.5bp) node {0.121};
 %

diff --git a/fig/raw/emp_hcp_age_comb_regplot.pdf b/fig/raw/emp_hcp_age_comb_regplot.pdf
diff --git a/fig/raw/emp_hcp_age_raw_full.dot.pdf b/fig/raw/emp_hcp_age_raw_full.dot.pdf
diff --git a/fig/raw/emp_hcp_age_raw_partial.dot.pdf b/fig/raw/emp_hcp_age_raw_partial.dot.pdf
diff --git a/fig/raw/emp_hcp_age_raw_regplot.pdf b/fig/raw/emp_hcp_age_raw_regplot.pdf
diff --git a/fig/raw/emp_hcp_age_reg_full.dot b/fig/raw/emp_hcp_age_reg_full.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label=0.004]
+	c -- yhat [label=0.0]
 	c -- y [label=0.011]
-	y -- yhat [label="0.114 (p<0.0001*)" style=dashed]
+	y -- yhat [label="0.118 (p<0.0001*)" style=dashed]
 }
diff --git a/fig/raw/emp_hcp_age_reg_full.dot.pdf b/fig/raw/emp_hcp_age_reg_full.dot.pdf
diff --git a/fig/raw/emp_hcp_age_reg_full.tex b/fig/raw/emp_hcp_age_reg_full.tex
@@ -31,9 +31,9 @@
   \pgfsetstrokecolor{strokecol}
   \draw (92.5bp,47.5bp) node {0.011};
   \draw [] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (212.26bp,8.242bp) and (308.45bp,13.31bp)  .. (yhat);
-  \draw (158.0bp,18.5bp) node {0.004};
+  \draw (158.0bp,18.5bp) node {0.0};
   \draw [dashed] (y) ..controls (226.87bp,42.252bp) and (312.06bp,28.76bp)  .. (yhat);
-  \draw (269.5bp,52.5bp) node {0.114 (p<0.0001*)};
+  \draw (269.5bp,52.5bp) node {0.118 (p<0.0001*)};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_hcp_age_reg_partial.dot b/fig/raw/emp_hcp_age_reg_partial.dot
@@ -3,7 +3,7 @@ graph {
 	c [label=c]
 	y [label=y]
 	yhat [label=<y&#770;>]
-	c -- yhat [label="0.004 (p=0.2)" style=dashed]
+	c -- yhat [label="0.0 (p=0.95)" style=dashed]
 	c -- y [label=0.011]
-	y -- yhat [label=0.114]
+	y -- yhat [label=0.118]
 }
diff --git a/fig/raw/emp_hcp_age_reg_partial.dot.pdf b/fig/raw/emp_hcp_age_reg_partial.dot.pdf
diff --git a/fig/raw/emp_hcp_age_reg_partial.tex b/fig/raw/emp_hcp_age_reg_partial.tex
@@ -24,16 +24,16 @@
 \begin{tikzpicture}[>=latex',line join=bevel,]
 %%
 \node (c) at (27.0bp,18.0bp) [draw,ellipse] {c};
-  \node (y) at (181.0bp,53.0bp) [draw,ellipse] {y};
-  \node (yhat) at (335.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
-  \draw [] (c) ..controls (81.025bp,30.21bp) and (126.99bp,40.794bp)  .. (y);
+  \node (y) at (176.5bp,53.0bp) [draw,ellipse] {y};
+  \node (yhat) at (326.0bp,18.0bp) [draw,ellipse] {<<y\&\#770;>>};
+  \draw [] (c) ..controls (79.916bp,30.319bp) and (123.47bp,40.654bp)  .. (y);
   \definecolor{strokecol}{rgb}{0.0,0.0,0.0};
   \pgfsetstrokecolor{strokecol}
-  \draw (92.5bp,43.5bp) node {0.011};
-  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (175.42bp,9.4924bp) and (186.58bp,9.4924bp)  .. (231.0bp,11.0bp) .. controls (257.33bp,11.894bp) and (287.39bp,14.069bp)  .. (yhat);
-  \draw (181.0bp,18.5bp) node {0.004 (p=0.2)};
-  \draw [] (y) ..controls (235.03bp,40.79bp) and (280.99bp,30.206bp)  .. (yhat);
-  \draw (269.5bp,43.5bp) node {0.114};
+  \draw (92.5bp,44.5bp) node {0.011};
+  \draw [dashed] (c) ..controls (74.615bp,14.069bp) and (104.67bp,11.894bp)  .. (131.0bp,11.0bp) .. controls (171.42bp,9.628bp) and (181.58bp,9.628bp)  .. (222.0bp,11.0bp) .. controls (248.33bp,11.894bp) and (278.39bp,14.069bp)  .. (yhat);
+  \draw (176.5bp,18.5bp) node {0.0 (p=0.95)};
+  \draw [] (y) ..controls (229.42bp,40.681bp) and (272.97bp,30.346bp)  .. (yhat);
+  \draw (260.5bp,44.5bp) node {0.118};
 %
 \end{tikzpicture}
 % End of code

diff --git a/fig/raw/emp_hcp_age_reg_regplot.pdf b/fig/raw/emp_hcp_age_reg_regplot.pdf
diff --git a/fig/raw/emp_hcp_iq_nonnorm_hist.pdf b/fig/raw/emp_hcp_iq_nonnorm_hist.pdf
diff --git a/fig/raw/emp_hcp_iq_quanttrf_hist.pdf b/fig/raw/emp_hcp_iq_quanttrf_hist.pdf
diff --git a/fig/raw/example_jointplot_non-norm_dist.pdf b/fig/raw/example_jointplot_non-norm_dist.pdf
diff --git a/fig/raw/example_jointplot_non-normal_linear_cyhat.pdf b/fig/raw/example_jointplot_non-normal_linear_cyhat.pdf
diff --git a/fig/raw/example_jointplot_non-normal_linear_yc.pdf b/fig/raw/example_jointplot_non-normal_linear_yc.pdf
diff --git a/fig/raw/example_jointplot_non-normal_linear_yyhat.pdf b/fig/raw/example_jointplot_non-normal_linear_yyhat.pdf
diff --git a/fig/raw/example_jointplot_normal_linear_cyhat.pdf b/fig/raw/example_jointplot_normal_linear_cyhat.pdf
diff --git a/fig/raw/example_jointplot_normal_linear_yc.pdf b/fig/raw/example_jointplot_normal_linear_yc.pdf
diff --git a/fig/raw/example_jointplot_normal_linear_yyhat.pdf b/fig/raw/example_jointplot_normal_linear_yyhat.pdf
diff --git a/fig/raw/example_jointplot_normal_sigmoid_cyhat.pdf b/fig/raw/example_jointplot_normal_sigmoid_cyhat.pdf
diff --git a/fig/raw/example_jointplot_normal_sigmoid_yc.pdf b/fig/raw/example_jointplot_normal_sigmoid_yc.pdf
diff --git a/fig/raw/example_jointplot_normal_sigmoid_yyhat.pdf b/fig/raw/example_jointplot_normal_sigmoid_yyhat.pdf
diff --git a/fig/raw/power_comparison_yc=0.33.pdf b/fig/raw/power_comparison_yc=0.33.pdf
diff --git a/fig/raw/power_comparison_yc=0.66.pdf b/fig/raw/power_comparison_yc=0.66.pdf
diff --git a/fig/raw/power_comparison_yc=1.0.pdf b/fig/raw/power_comparison_yc=1.0.pdf
diff --git a/fig/raw/sim_dist1.pdf b/fig/raw/sim_dist1.pdf
diff --git a/fig/raw/sim_dist2.pdf b/fig/raw/sim_dist2.pdf
diff --git a/fig/raw/sim_dist3.pdf b/fig/raw/sim_dist3.pdf
diff --git a/fig/raw/sim_dist4.pdf b/fig/raw/sim_dist4.pdf
diff --git a/fig/raw/sim_dist5.pdf b/fig/raw/sim_dist5.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d01e2_lin_cpt_gam.pdf b/fig/raw/sim_h0_ccc_partial_d01e2_lin_cpt_gam.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d01e2_lin_pc_cpt_lin.pdf b/fig/raw/sim_h0_ccc_partial_d01e2_lin_pc_cpt_lin.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d01e2_lin_pc_pearson.pdf b/fig/raw/sim_h0_ccc_partial_d01e2_lin_pc_pearson.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d01e2_lin_pc_spearman.pdf b/fig/raw/sim_h0_ccc_partial_d01e2_lin_pc_spearman.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_lin_cpt_gam.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_lin_cpt_gam.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_lin_pc_cpt_lin.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_lin_pc_cpt_lin.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_lin_pc_pearson.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_lin_pc_pearson.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_lin_pc_spearman.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_lin_pc_spearman.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_sig_cpt_gam.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_sig_cpt_gam.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_sig_pc_cpt_lin.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_sig_pc_cpt_lin.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_sig_pc_pearson.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_sig_pc_pearson.pdf
diff --git a/fig/raw/sim_h0_ccc_partial_d10e0_sig_pc_spearman.pdf b/fig/raw/sim_h0_ccc_partial_d10e0_sig_pc_spearman.pdf
diff --git a/fig/raw/sim_h0_norm_violated_lin.pdf b/fig/raw/sim_h0_norm_violated_lin.pdf
diff --git a/fig/raw/sim_h0_norm_violated_sig.pdf b/fig/raw/sim_h0_norm_violated_sig.pdf
diff --git a/fig/raw/sim_h1_bbb_full_d1e0_linear_cpt_gam.pdf b/fig/raw/sim_h1_bbb_full_d1e0_linear_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_bbb_full_d1e0_sigmoid_cpt_gam.pdf b/fig/raw/sim_h1_bbb_full_d1e0_sigmoid_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_bbb_partial_d10e0_lin_cpt_gam.pdf b/fig/raw/sim_h1_bbb_partial_d10e0_lin_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_bbb_partial_d10e0_sig_cpt_gam.pdf b/fig/raw/sim_h1_bbb_partial_d10e0_sig_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_ccc_full_d1e0_linear_cpt_gam.pdf b/fig/raw/sim_h1_ccc_full_d1e0_linear_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_ccc_full_d1e0_sigmoid_cpt_gam.pdf b/fig/raw/sim_h1_ccc_full_d1e0_sigmoid_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_ccc_partial_d10e0_lin_cpt_gam.pdf b/fig/raw/sim_h1_ccc_partial_d10e0_lin_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_ccc_partial_d10e0_sig_cpt_gam.pdf b/fig/raw/sim_h1_ccc_partial_d10e0_sig_cpt_gam.pdf
diff --git a/fig/raw/sim_h1_norm_violated_lin.pdf b/fig/raw/sim_h1_norm_violated_lin.pdf
diff --git a/fig/raw/sim_h1_norm_violated_sig.pdf b/fig/raw/sim_h1_norm_violated_sig.pdf
diff --git a/fig/supplement/Page 1.png b/fig/supplement/Page 1.png
diff --git a/fig/supplement/external_validation.png b/fig/supplement/external_validation.png