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Package: heemod | ||
Title: Models for Health Economic Evaluation | ||
Version: 0.7.0 | ||
Version: 0.7.1 | ||
Authors@R: c( | ||
person("Antoine", "Filipovic-Pierucci", email = "[email protected]", role = c("aut", "cre")), | ||
person("Kevin", "Zarca", email = "[email protected]", role = "aut"), | ||
|
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--- | ||
title: "Results with more than 2 Strategies" | ||
date: "`r Sys.Date()`" | ||
output: | ||
rmarkdown::html_vignette: | ||
toc: true | ||
vignette: > | ||
%\VignetteIndexEntry{Results with more than 2 Strategies} | ||
%\VignetteEngine{knitr::rmarkdown} | ||
\usepackage[utf8]{inputenc} | ||
--- | ||
|
||
```{r, echo=FALSE, include=FALSE} | ||
library(heemod) | ||
library(ggplot2) | ||
``` | ||
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We define some strategies. | ||
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```{r} | ||
sA <- define_state( | ||
cost = 1, | ||
ut = 1 | ||
) | ||
sA2 <- define_state( | ||
cost = c1, | ||
ut = 1 | ||
) | ||
sAmax <- define_state( | ||
cost = c1+.5, | ||
ut = 1.01 | ||
) | ||
sAmaxx <- define_state( | ||
cost = c1 + 1, | ||
ut = 1.01 | ||
) | ||
sAmaxx2 <- define_state( | ||
cost = c1 + .6, | ||
ut = 1.05 | ||
) | ||
sB <- define_state( | ||
cost = 0, | ||
ut = 0 | ||
) | ||
sX <- define_state( | ||
cost = .9, | ||
ut = 1.1 | ||
) | ||
param <- define_parameters( | ||
rrII = .8, | ||
rrIII = .7, | ||
c1 = 1 | ||
) | ||
mI <- define_transition( | ||
C, .5, | ||
0, 1 | ||
) | ||
mII <- define_transition( | ||
C, .5 * rrII, | ||
0, 1 | ||
) | ||
mIII <- define_transition( | ||
C, .5 * rrIII, | ||
0, 1 | ||
) | ||
sI <- define_strategy( | ||
sA, sB, | ||
transition = mI | ||
) | ||
sII <- define_strategy( | ||
sA2, sB, | ||
transition = mII | ||
) | ||
sIII <- define_strategy( | ||
sAmaxx, sB, | ||
transition = mII | ||
) | ||
sIV <- define_strategy( | ||
sAmax, sB, | ||
transition = mIII | ||
) | ||
sV <- define_strategy( | ||
sX, sB, | ||
transition = mI | ||
) | ||
sVI <- define_strategy( | ||
sAmaxx2, sB, | ||
transition = mII | ||
) | ||
res <- run_model( | ||
A=sI, C=sII, D=sIII, F=sIV, B=sV, E=sVI, | ||
parameters = param, | ||
cycles = 10, | ||
cost = cost, effect = ut | ||
) | ||
``` | ||
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||
We can look at the CE plot to understand what is going on: | ||
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```{r} | ||
plot(res, type = "ce") + | ||
geom_hline(yintercept = 0, linetype = "dashed") + | ||
geom_vline(xintercept = 0, linetype = "dashed") | ||
``` | ||
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The efficiency frontier is B, C, F. A is dominated by B, D by F, and E is under extended domination by C and F. By default the plot is centered on B, the strategy at the root at the efficiency frontier. This can be changed with the `central_strategy` argument (this is just an aesthetic change). | ||
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```{r} | ||
plot(run_model( | ||
A=sI, C=sII, D=sIII, F=sIV, B=sV, E=sVI, | ||
parameters = param, | ||
cycles = 10, | ||
cost = cost, effect = ut, | ||
central_strategy = "A" | ||
), type = "ce") + | ||
geom_hline(yintercept = 0, linetype = "dashed") + | ||
geom_vline(xintercept = 0, linetype = "dashed") | ||
``` | ||
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We can look at the summary statistics: | ||
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```{r} | ||
res | ||
``` | ||
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The *Values* section reports total absolute values. The *Differences* section reports incremental differences. We can see that D, E and F all take C as a reference. We can alos see there is no incremental differences represented for A. | ||
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Let us try a PSA: | ||
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```{r} | ||
dpsa <- define_psa( | ||
rrII ~ lognormal(.8, .1), | ||
rrIII ~ lognormal(.7, .1), | ||
c1 ~ normal(1, .1) | ||
) | ||
use_cluster(4) | ||
psa <- run_psa(res, dpsa, 1e3) | ||
close_cluster() | ||
``` | ||
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Classic CE plot (the central model depends on the `central_strategy` defined in `run_model()`): | ||
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```{r} | ||
plot(psa) + | ||
geom_hline(yintercept = 0, linetype = "dashed") + | ||
geom_vline(xintercept = 0, linetype = "dashed") | ||
``` | ||
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And PSA: | ||
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```{r} | ||
plot(psa, type = "ac", max_wtp = 200) | ||
``` | ||
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|
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