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Merge pull request #2205 from geneontology/pgaudet-patch-103
Update gorule-0000061.md
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| GAF2.2 files require a gene product to term (gp2term) relation in Column 4. Allowed gp2term relations: | ||
| * For `GO:0003674 "molecular function"` and subclass descendants: | ||
| * If the annotation is to the root term `"molecular function"`, then the gp2term relation should `RO:0002327 "enables"`; else, it is repaired to `RO:0002327 "enables"`. | ||
| * If the annotation is to is a subclass descendant of `"molecular function"`, then the allowed gp2term relations are `RO:0002327 "enables"` and `RO_0002326 "contributes_to"`; else, it is updated to `RO:0002327 "enables"`. | ||
| * For `GO:0003674 "molecular_function"` and subclass descendants: | ||
| * If the annotation is to the root term `"molecular_function"`, then the gp2term relation should `RO:0002327 "enables"`; else, it is repaired to `RO:0002327 "enables"`. | ||
| * If the annotation is to is a subclass descendant of `"molecular_function"`, then the allowed gp2term relations are `RO:0002327 "enables"` and `RO_0002326 "contributes_to"`; else, it is updated to `RO:0002327 "enables"`. | ||
| * For `GO:0008150 "biological process"`: | ||
| * If the annotation is to the root term `"biological process"`, then the gp2term relation should be `RO:0002331 "involved_in"`. If the gp2term relation is different, it is repaired to `RO:0002331 "involved_in"`. | ||
| * If the annotation is to is a subclass descendant of `"biological process"` then the allowed gp2term relations are `RO:0002331 "involved_in"`, `RO:0002264 "acts upstream or within"`, `RO:0004032 "acts upstream of or within, positive effect"`, `RO:0004033 "acts upstream of or within, negative effect"`, `RO:0002263 "acts upstream of"`, `RO:0004034 "acts upstream of, positive effect"`, `RO:0004035 "acts upstream of, negative effect"`; else, the relation is repaired to `RO:0002264 "acts upstream of or within"`. | ||
| * If the annotation is to the root term `"biological_process"`, then the gp2term relation should be `RO:0002331 "involved_in"`. If the gp2term relation is different, it is repaired to `RO:0002331 "involved_in"`. | ||
| * If the annotation is to is a subclass descendant of `"biological_process"` then the allowed gp2term relations are `RO:0002331 "involved_in"`, `RO:0002264 "acts_upstream_or_within"`, `RO:0004032 "acts_upstream_of_or_within_positive_effect"`, `RO:0004033 "acts upstream of or within_negative_effect"`, `RO:0002263 "acts_upstream_of"`, `RO:0004034 "acts_upstream_of_positive_effect"`, `RO:0004035 "acts upstream of, negative effect"`; else, the relation is repaired to `RO:0002264 "acts upstream of or within"`. | ||
| * For `GO:0005575 "cellular component"` | ||
| * If the annotation is to the root term `"cellular_component"`, then the gp2term relation should be `RO:0002432 "is_active_in"`; else, it is repaired to `RO:0002432 "is_active_in"`. | ||
| * If the annotation is to `"GO:0032991 "protein-containing complex"` or a subclass descendant of, then the gp2term relation should be `"BFO:0000050 "part of"`; else, it is repaired to `"BFO:0000050 "part of"`. | ||
| * If the annotation is to `GO:0110165 "cellular anatomical entity"` or to `GO:0044423 "virion component"` or a descendant of either of these terms, then the allowed gp2term relations are `RO:0001025 "located in"` and `RO:0002432 "is_active_in"`, and `RO_0002325 "colocalizes_with"`; else it is repaired to `RO:0001025 "located in"`. | ||
| * If the annotation is to `"GO:0032991 "protein-containing complex"` or a subclass descendant of, then the gp2term relation should be `"BFO:0000050 "part_of"`; else, it is repaired to `"BFO:0000050 "part of"`. | ||
| * If the annotation is to `GO:0110165 "cellular anatomical entity"` or to `GO:0044423 "virion component"` or a descendant of either of these terms, then the allowed gp2term relations are `RO:0001025 "located_in"` and `RO:0002432 "is_active_in"`, and `RO_0002325 "colocalizes_with"`; else it is repaired to `RO:0001025 "located_in"`. | ||
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| * If an annotation has a negation (`NOT`), is is kept as a pipe-separated value with the gp2term relation. | ||
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| * Note that RO does not have underscores in the term labels, but the userscores are used in the GP2Term relations in GAF 2.2. | ||