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Upgraded to hetio-ind commit to
dhimmel/integrate@f72d32c. Gene-disease
associations were renamed to variations. Functions are now called associations.

Abbreviated Illumina for facet title.

Entrez gene download in `network-degrees.ipynb` no longer needed.
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dhimmel committed Sep 1, 2015
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2 changes: 1 addition & 1 deletion README.md
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Expand Up @@ -47,5 +47,5 @@ This analysis can be reproduced by running the Jupyter notebooks in the followin
1. [`network-degrees.ipynb`](network-degrees.ipynb) to extract gene degrees from [hetio-ind](https://github.com/dhimmel/integrate), a hetnet that includes many gene metaedges.
2. [`SNP-to-Gene.ipynb`](SNP-to-Gene.ipynb) to download data and perform processing for SNP chips.
3. [`exac.ipynb`](exac.ipynb) to process the [ExAC](http://exac.broadinstitute.org/) sequencing variants.
4. [`combine-SNPs-with-degrees.ipynb`](combine-SNPs-with-degrees.ipynb) to combine SNPs per Gene measurements from all platforms and hetnet degrees.
4. [`combine-SNPs-and-degrees.ipynb`](combine-SNPs-and-degrees.ipynb) to combine SNPs per Gene measurements from all platforms and hetnet degrees.
5. [`visualization.ipynb`](visualization.ipynb) to create visualizations. This is an [R notebook](https://github.com/IRkernel/IRkernel).
68 changes: 29 additions & 39 deletions combine-SNPs-with-degrees.ipynb → combine-SNPs-and-degrees.ipynb

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34 changes: 17 additions & 17 deletions download/network-summary.tsv
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metaedge abbreviation inverted edges source_nodes target_nodes unbiased
gene - binding - compound GbC 1 2502 572 554 0
gene - participation - pathway GpPW 0 79101 9511 1615 0
gene - downregulation - compound GdC 1 20312 923 748 20312
gene - variation - disease GvD 1 1284 926 91 1284
gene - expression - anatomy GeA 0 987862 18041 194 914193
gene - downregulation - disease GdD 1 674 664 3 674
gene - participation - biological process GpBP 0 534004 14533 11014 0
gene < knockdown downregulation < gene G<kdG 1 140942 957 4207 140942
gene - upregulation - compound GuC 1 17261 953 729 17261
gene < knockdown upregulation < gene G<kuG 1 78752 970 4068 78752
gene - participation - biological process GpBP 0 534004 14533 11014 0
gene - upregulation - anatomy GuA 0 97848 15929 36 97848
gene - interaction - gene GiG 0 297253 15211 15211 31575
gene - participation - molecular function GpMF 0 93857 12890 2826 0
gene > overexpression downregulation > gene God>G 0 14911 1660 830 14911
gene > knockdown downregulation > gene Gkd>G 0 140942 4207 957 140942
gene > overexpression upregulation > gene Gup>G 0 15292 1862 909 15292
gene - participation - cellular component GpCC 0 65377 10269 1332 0
gene > knockdown upregulation > gene Gku>G 0 78752 4068 970 78752
gene - evolution - gene GeG 0 123382 12453 12453 123382
gene - target - compound GtC 1 4603 1133 1182 0
gene < knockdown downregulation < gene G<kdG 1 140942 957 4207 140942
gene > overexpression upregulation > gene Gup>G 0 15292 1862 909 15292
gene - function - disease GfD 1 10193 3701 103 0
gene < overexpression downregulation < gene G<odG 1 14911 830 1660 14911
gene - participation - molecular function GpMF 0 93857 12890 2826 0
gene > knockdown downregulation > gene Gkd>G 0 140942 4207 957 140942
gene - upregulation - anatomy GuA 0 97848 15929 36 97848
gene - regulation - perturbation GrPB 0 366502 18245 3395 0
gene < overexpression upregulation < gene G<upG 1 15292 909 1862 15292
gene - upregulation - disease GuD 1 910 870 3 910
gene < overexpression upregulation < gene G<upG 1 15292 909 1862 15292
gene - binding - compound GbC 1 2502 572 554 0
gene - association - disease GaD 1 11824 5067 134 0
gene > knockdown upregulation > gene Gku>G 0 78752 4068 970 78752
gene - interaction - gene GiG 0 297253 15211 15211 31575
gene - downregulation - anatomy GdA 0 102240 15097 36 102240
gene - expression - anatomy GeA 0 987862 18041 194 914193
gene - participation - pathway GpPW 0 79101 9511 1615 0
gene - evolution - gene GeG 0 123382 12453 12453 123382
gene - downregulation - disease GdD 1 674 664 3 674
gene - downregulation - compound GdC 1 20312 923 748 20312
gene - association - disease GaD 1 1284 926 91 1284
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824 changes: 409 additions & 415 deletions figure/adj-degree-v-snps.svg
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11,606 changes: 5,799 additions & 5,807 deletions figure/degree-v-snps-all.svg
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937 changes: 468 additions & 469 deletions figure/degree-v-snps.svg
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