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Add Bican Flow Diagram #2

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66 changes: 66 additions & 0 deletions bican_flow_diagram/bican_flow_diagram.md
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# Purpose
The purpose of this diagram is to show how data and materials flow across the BICAN ecosystem.

# Definitions
| Node Name | Definition |
|----------------|------------------------------------------------------|
| NBB | Neuro Bio Bank |
| IMS | [Information Management Services](https://www.imsweb.com) |
| BICAN Investigator | TODO |
| Specimen Portal | The [Specimen Portal](https://brain-specimenportal.org) focuses on tissue management from donors to brain slabs and annotated brain samples.|
| SeqLib Portal | The [Sequence Library (SeqLib) Portal](https://brain-specimenportal.org) manages the workflow starting from tissue, all the way downstream to track data deposition to assay-dependent data-modality-specific archives.|
| SeqCores | TODO |
| NeMO | The [Neuroscience Multi-omic Archive (NeMO Archive)](https://nemoarchive.org) is a data repository specifically focused on the storage and dissemination of omic data generated from the BRAIN Initiative, SCORCH consortium and other brain research projects.|
| Terra Alignment | TODO |
| Data Catalog, BICAN Dashboard | A searchable [data catalog](https://knowledge.brain-map.org/data) listing all public BICCN and BICAN generated data about cell types.|
| Knowledge Base, BICAN Cell Atlas | The Brain Cell Knowledge Base ingests and standardizes comprehensive cell type information from BICAN's development of a multimodal, multi-species brain cell atlas and disseminate that atlas as an open and interactive community resource for advancing knowledge of the brain.|

# Sequence Diagram
```mermaid
sequenceDiagram
participant NBB
participant IMS
participant BICAN Investigator
participant Specimen Portal
participant SeqLib Portal
participant SeqCores
participant NeMO
participant Terra Alignment
participant DataCatalog as Data Catalog, BICAN Dashboard
participant KnowledgeBase as Knowledge Base, BICAN Cell Atlas

BICAN Investigator ->> Specimen Portal: 1. Tissue Request

Specimen Portal ->> IMS: 2. Request Forward
IMS ->> NBB: 2. Request Forward

IMS ->> Specimen Portal: 3. Status Update
NBB ->> IMS: 3. Status Update
NBB ->> Specimen Portal: 3. Update ROI Drawing
NBB ->> BICAN Investigator: 3. Tissue Shipment

BICAN Investigator ->> Specimen Portal: 4. Tissue QC Free text & Structured
BICAN Investigator ->> SeqLib Portal: 4.Library & Pool Generation

BICAN Investigator ->> SeqCores: 5. Library Shipment
SeqLib Portal ->> SeqCores: 5. SeqCore Dashboard Update & Notification
SeqLib Portal ->> NeMO: 5. NeMO Dashboard Update & Notification

SeqCores ->> NeMO: 6. Fastq File Deposition
SeqCores ->> SeqLib Portal: 6. Run QC Metric

NeMO ->> SeqLib Portal: 7. QC Metric Update

Terra Alignment ->> NeMO: 8. Investigator validation


Specimen Portal -->> SeqLib Portal: Information Flow
Specimen Portal -->> DataCatalog: Information Flow
Specimen Portal -->> KnowledgeBase: Information Flow
SeqLib Portal -->> KnowledgeBase: Information Flow
SeqLib Portal -->> NeMO: Information Flow
NeMO -->> KnowledgeBase: Information Flow
NeMO -->> DataCatalog: Information Flow
BICAN Investigator -->> DataCatalog: Information Flow
DataCatalog -->> NeMO: Information Flow
```