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Add unvalidated tests for early_zero_weight()
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library(dplyr) | ||
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test_that("early_zero_weight() with unstratified data", { | ||
# Example 1: Unstratified | ||
set.seed(123) | ||
input <- sim_pw_surv(n = 200) | ||
input <- cut_data_by_event(input, 125) | ||
input <- counting_process(input, arm = "experimental") | ||
output <- early_zero_weight(input, early_period = 2) | ||
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observed <- output$weight | ||
expected <- rep(c(0, 1), c(15L, 110L)) | ||
expect_equal(observed, expected) | ||
}) | ||
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test_that("early_zero_weight() with stratified data", { | ||
# Example 2: Stratified | ||
n <- 500 | ||
# Two strata | ||
stratum <- c("Biomarker-positive", "Biomarker-negative") | ||
prevelance_ratio <- c(0.6, 0.4) | ||
# Enrollment rate | ||
enroll_rate <- gsDesign2::define_enroll_rate( | ||
stratum = rep(stratum, each = 2), | ||
duration = c(2, 10, 2, 10), | ||
rate = c(c(1, 4) * prevelance_ratio[1], c(1, 4) * prevelance_ratio[2]) | ||
) | ||
enroll_rate$rate <- enroll_rate$rate * n / sum(enroll_rate$duration * enroll_rate$rate) | ||
# Failure rate | ||
med_pos <- 10 # Median of the biomarker positive population | ||
med_neg <- 8 # Median of the biomarker negative population | ||
hr_pos <- c(1, 0.7) # Hazard ratio of the biomarker positive population | ||
hr_neg <- c(1, 0.8) # Hazard ratio of the biomarker negative population | ||
fail_rate <- gsDesign2::define_fail_rate( | ||
stratum = rep(stratum, each = 2), | ||
duration = c(3, 1000, 4, 1000), | ||
fail_rate = c(log(2) / c(med_pos, med_pos, med_neg, med_neg)), | ||
hr = c(hr_pos, hr_neg), | ||
dropout_rate = 0.01 | ||
) | ||
# Simulate data | ||
temp <- simfix2simpwsurv(fail_rate) # Convert the failure rate | ||
set.seed(2023) | ||
input <- sim_pw_surv( | ||
n = n, # Sample size | ||
# Stratified design with prevalence ratio of 6:4 | ||
stratum = data.frame(stratum = stratum, p = prevelance_ratio), | ||
# Randomization ratio | ||
block = c("control", "control", "experimental", "experimental"), | ||
enroll_rate = enroll_rate, # Enrollment rate | ||
fail_rate = temp$fail_rate, # Failure rate | ||
dropout_rate = temp$dropout_rate # Dropout rate | ||
) | ||
input <- cut_data_by_event(input, 125) | ||
input <- counting_process(input, arm = "experimental") | ||
output <- early_zero_weight(input, early_period = 2, fail_rate = fail_rate) | ||
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observed <- output$weight | ||
expected <- rep(c(0, 0.8, 0, 0.7), c(43L, 20L, 29L, 33L)) | ||
expect_equal(observed, expected) | ||
}) | ||
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