Skip to content

Commit

Permalink
Hyperlink DOIs to preferred resolver
Browse files Browse the repository at this point in the history
  • Loading branch information
katrinleinweber committed Jan 8, 2020
1 parent 1ce7004 commit 3f616b7
Show file tree
Hide file tree
Showing 2 changed files with 3 additions and 3 deletions.
2 changes: 1 addition & 1 deletion deps/AMICI/ThirdParty/sundials/README.md
Original file line number Diff line number Diff line change
Expand Up @@ -114,7 +114,7 @@ reporting work done with SUNDIALS:
* Alan C. Hindmarsh, Peter N. Brown, Keith E. Grant, Steven L. Lee, Radu
Serban, Dan E. Shumaker, and Carol S. Woodward. 2005. SUNDIALS: Suite of
nonlinear and differential/algebraic equation solvers. ACM Trans. Math. Softw.
31, 3 (September 2005), 363-396. DOI=http://dx.doi.org/10.1145/1089014.1089020
31, 3 (September 2005), 363-396. DOI=https://doi.org/10.1145/1089014.1089020

## License ##
SUNDIALS is released under the BSD 3-clause license. See the [LICENSE](./LICENSE)
Expand Down
4 changes: 2 additions & 2 deletions deps/AMICI/documentation/amici_refs.bib
Original file line number Diff line number Diff line change
Expand Up @@ -300,7 +300,7 @@ @article{LoosMoe2018
Title = {A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability},
Volume = {6},
Year = {2018},
Bdsk-Url-1 = {http://dx.doi.org/10.1016/j.cels.2018.04.008}}
Bdsk-Url-1 = {https://doi.org/10.1016/j.cels.2018.04.008}}

@article{MaierLoo2017,
Author = {Maier, C. and Loos, C. and Hasenauer, J.},
Expand Down Expand Up @@ -457,7 +457,7 @@ @Article{SchmiesterSch2019
year = {2019},
month = {07},
issn = {1367-4803},
abstract = {{Mechanistic models of biochemical reaction networks facilitate the quantitative understanding of biological processes and the integration of heterogeneous datasets. However, some biological processes require the consideration of comprehensive reaction networks and therefore large-scale models. Parameter estimation for such models poses great challenges, in particular when the data are on a relative scale.Here, we propose a novel hierarchical approach combining (i) the efficient analytic evaluation of optimal scaling, offset, and error model parameters with (ii) the scalable evaluation of objective function gradients using adjoint sensitivity analysis. We evaluate the properties of the methods by parameterizing a pan-cancer ordinary differential equation model (\\>1000 state variables, \\>4000 parameters) using relative protein, phospho-protein and viability measurements. The hierarchical formulation improves optimizer performance considerably. Furthermore, we show that this approach allows estimating error model parameters with negligible computational overhead when no experimental estimates are available, providing an unbiased way to weight heterogeneous data. Overall, our hierarchical formulation is applicable to a wide range of models, and allows for the efficient parameterization of large-scale models based on heterogeneous relative measurements.Supplementary information are available at Bioinformatics online. Supplementary code and data are available online at http://doi.org/10.5281/zenodo.3254429 and http://doi.org/10.5281/zenodo.3254441.}},
abstract = {{Mechanistic models of biochemical reaction networks facilitate the quantitative understanding of biological processes and the integration of heterogeneous datasets. However, some biological processes require the consideration of comprehensive reaction networks and therefore large-scale models. Parameter estimation for such models poses great challenges, in particular when the data are on a relative scale.Here, we propose a novel hierarchical approach combining (i) the efficient analytic evaluation of optimal scaling, offset, and error model parameters with (ii) the scalable evaluation of objective function gradients using adjoint sensitivity analysis. We evaluate the properties of the methods by parameterizing a pan-cancer ordinary differential equation model (\\>1000 state variables, \\>4000 parameters) using relative protein, phospho-protein and viability measurements. The hierarchical formulation improves optimizer performance considerably. Furthermore, we show that this approach allows estimating error model parameters with negligible computational overhead when no experimental estimates are available, providing an unbiased way to weight heterogeneous data. Overall, our hierarchical formulation is applicable to a wide range of models, and allows for the efficient parameterization of large-scale models based on heterogeneous relative measurements.Supplementary information are available at Bioinformatics online. Supplementary code and data are available online at https://doi.org/10.5281/zenodo.3254429 and https://doi.org/10.5281/zenodo.3254441.}},
doi = {10.1093/bioinformatics/btz581},
eprint = {http://oup.prod.sis.lan/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btz581/29004243/btz581.pdf},
url = {https://doi.org/10.1093/bioinformatics/btz581},
Expand Down

0 comments on commit 3f616b7

Please sign in to comment.