diff --git a/sbml/WP111.sbml b/sbml/WP111.sbml index 4ec976e..ae9e8ab 100644 --- a/sbml/WP111.sbml +++ b/sbml/WP111.sbml @@ -1,5 +1,5 @@ - + @@ -14,22 +14,20 @@ Source: Wikipedia ([[wikipedia:Electron_transport_chain]]) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP111 CPTAC Assay Portal] [ARROW:a0b32] Curved connections are not supported. +[CATALYSIS:a4aef] Interaction is not connected +[CATALYSIS:ad726] Interaction is not connected [ARROW:b0e4a] Curved connections are not supported. [ARROW:b17ae] Curved connections are not supported. -[-:-] Unknown gpml interaction type: mim-translocation -[-:-] Unknown gpml interaction type: mim-translocation [ARROW:b92fd] Curved connections are not supported. -[-:-] Unknown gpml interaction type: mim-translocation [ARROW:c4d38] Curved connections are not supported. [ARROW:cdee2] Curved connections are not supported. -[-:-] Unknown gpml interaction type: mim-translocation +[CATALYSIS:cfb2a] Interaction is not connected [ARROW:da1d5] Curved connections are not supported. [ARROW:dbdc8] Curved connections are not supported. [ARROW:e0a8b] Curved connections are not supported. -[-:-] Unknown gpml interaction type: mim-translocation [ARROW:f713d] Curved connections are not supported. [ARROW:fa8bc] Curved connections are not supported. -[-:-] Unknown gpml interaction type: mim-translocation +[CATALYSIS:feb3f] Interaction is not connected [ARROW:id86f308da] Curved connections are not supported. [LINE:iddb4b9fa] Curved connections are not supported. [LINE:iddb4b9fa] Interaction is not connected @@ -58,9 +56,9 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -112,14 +110,6 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - @@ -139,96 +129,76 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + + + + + + + + + - + - + - + @@ -239,116 +209,167 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + + + + - + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + + + + + + + + + - + - + - + - + - + + + + + + + + + + + + + + + + + @@ -370,452 +391,526 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - - - + + + - - + + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - - - - + + + + - - + + - + - + - - - + + + - - + + - - - + + + + + + + + + + + + + + - + - + - + - + - + - - - + + + - - + + - + - + - - - - - - - - - - - - + + + - - + + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - - - + + + - - + + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + - - - - - - + + + + + + - - + + - - - + + + - - + + - + - + - - - + + + - - + + - + - + - + - + - + - - - - - - + + + + + + - - + + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - - - + + + - - + + @@ -825,378 +920,313 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - - - - - - - - @@ -1205,143 +1235,130 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - + - + - + - - - - - - + + + + + + - + - + - + - + - + - - - - - - - - - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + @@ -1350,14 +1367,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -1381,63 +1398,51 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - + + - + - - - - + + + + - - + + - + - - - - + - - - - + + + + - + - + - + - - - - + @@ -1449,211 +1454,211 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - - - - + + + + - + - + + + + - + + + + - - - - + + + + - - - - + - - + + - + - - - - + + + + - - - - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + + + + - + - - - - + + + + - + - + - + - + - - - - + + + + - + + + + - + - + - - - - + + + + - - - - + - + - - - - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + @@ -1716,872 +1721,882 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - - - - + - - - - - - - - - - - - - + - - + + - + - + - + - - + + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - - + + - + - + - - - - - - - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - - - - - - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + + + + + + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + + + + + + + - + - + + + + + + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + + + + + + + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + + + + + + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + + + + + + + - + - - + + - + - - + + + + + + - + - - + + @@ -2624,105 +2639,71 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + @@ -2732,7 +2713,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -2746,7 +2727,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -2756,7 +2737,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -2766,211 +2747,249 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - - - - - + + - - - - - - - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + @@ -2980,7 +2999,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -2990,7 +3009,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3000,7 +3019,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3012,161 +3031,113 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - - - - - - - - - - - + - - + + - - - - - - - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - + @@ -3174,7 +3145,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3184,7 +3155,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3194,7 +3165,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3208,69 +3179,63 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + @@ -3280,33 +3245,81 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + + - + - + + + + + + + + + + + + + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -3316,39 +3329,87 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + - + - + - + - - + + - + - + - + - + + + + + + + @@ -3358,99 +3419,105 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - + - + - + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + @@ -3460,129 +3527,111 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - - - - - - - - - - - - + - + - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - + @@ -3592,40 +3641,28 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - - - - + - + - + - + - - - - - - - + - - + + @@ -3634,52 +3671,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - + - - + + - + - + - + - + - + - - + + - + - - + + @@ -3688,250 +3707,226 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - + - + - + - + - + - + - + - - + + - + - + - + - + - - - - - - - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - - - - - - - + - + - + - + - + - + - - - - - - - + - + - + - - + + - + - + - + - - + + - + - - + + @@ -3940,195 +3935,177 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - + - + - + - - + + - + - + - + - + - - - - - - - - - - - - - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -4136,16 +4113,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + @@ -4154,424 +4131,467 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -4580,26 +4600,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + @@ -4608,178 +4628,161 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + + + - + - + - + - + - + - + - + - + - + - + @@ -4788,1180 +4791,1168 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - + + + + + @@ -5989,7 +5980,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -5998,29 +5989,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -6029,29 +6020,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -6062,7 +6053,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6070,19 +6061,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6093,7 +6084,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6101,19 +6092,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6122,29 +6113,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -6155,7 +6146,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6163,19 +6154,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6186,7 +6177,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6194,19 +6185,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6217,7 +6208,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6225,19 +6216,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6248,7 +6239,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6256,19 +6247,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6279,7 +6270,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6287,19 +6278,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6310,7 +6301,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6318,19 +6309,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6339,29 +6330,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -6372,7 +6363,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6380,19 +6371,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6403,7 +6394,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6411,19 +6402,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6434,7 +6425,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6442,19 +6433,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6465,7 +6456,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6473,19 +6464,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6496,7 +6487,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6504,19 +6495,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6527,7 +6518,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6535,19 +6526,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6558,7 +6549,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6566,19 +6557,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6589,7 +6580,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6597,19 +6588,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6620,7 +6611,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6628,19 +6619,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6651,7 +6642,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6659,14 +6650,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -6692,17 +6683,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -6713,7 +6704,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6721,19 +6712,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6744,7 +6735,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6752,19 +6743,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6773,29 +6764,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -6806,7 +6797,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6814,19 +6805,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6837,7 +6828,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6845,19 +6836,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6868,7 +6859,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6876,19 +6867,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6897,29 +6888,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -6930,7 +6921,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6938,19 +6929,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6961,7 +6952,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6969,19 +6960,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6992,7 +6983,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7000,19 +6991,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7023,7 +7014,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7031,19 +7022,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7052,29 +7043,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -7085,7 +7076,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7093,19 +7084,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7116,7 +7107,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7124,19 +7115,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7147,7 +7138,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7155,19 +7146,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7176,29 +7167,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -7209,7 +7200,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7217,19 +7208,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7240,7 +7231,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7248,19 +7239,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7271,7 +7262,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7279,19 +7270,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7302,7 +7293,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7310,19 +7301,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7333,7 +7324,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7341,19 +7332,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7364,7 +7355,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7372,19 +7363,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7395,7 +7386,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7403,19 +7394,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7426,7 +7417,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7434,19 +7425,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7457,7 +7448,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7465,19 +7456,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7488,7 +7479,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7496,19 +7487,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7519,7 +7510,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7527,19 +7518,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7550,7 +7541,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7558,19 +7549,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7581,7 +7572,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7589,19 +7580,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7612,7 +7603,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7620,19 +7611,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7643,7 +7634,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7651,19 +7642,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7674,7 +7665,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + @@ -7682,19 +7683,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7705,7 +7706,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7713,19 +7714,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7734,29 +7735,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -7767,7 +7768,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7775,19 +7776,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7796,29 +7797,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -7829,7 +7830,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7837,19 +7838,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7860,7 +7861,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7868,19 +7869,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7891,7 +7892,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7899,19 +7900,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7922,7 +7923,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7930,19 +7931,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7951,29 +7952,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -7984,7 +7985,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7992,19 +7993,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8015,7 +8016,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8023,19 +8024,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8044,29 +8045,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8077,7 +8078,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8085,19 +8086,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8108,7 +8109,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8116,19 +8117,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8139,7 +8140,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8147,19 +8148,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8170,7 +8171,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8178,19 +8179,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8199,29 +8200,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8232,7 +8233,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8240,19 +8241,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8263,7 +8264,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8271,19 +8272,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8294,7 +8295,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8302,19 +8303,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8325,7 +8326,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8333,19 +8334,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8356,7 +8357,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8364,19 +8365,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8387,7 +8388,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8395,19 +8396,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8418,7 +8419,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8426,19 +8427,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8447,29 +8448,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -8480,7 +8481,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8488,19 +8489,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8511,7 +8512,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8519,19 +8520,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8540,29 +8541,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -8573,7 +8574,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8581,19 +8582,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8604,7 +8605,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8612,19 +8613,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8635,7 +8636,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8643,19 +8644,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8666,7 +8667,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8674,19 +8675,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8697,7 +8698,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8705,19 +8706,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8726,29 +8727,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -8759,7 +8760,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8767,19 +8768,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8790,7 +8791,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8798,19 +8799,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8821,7 +8822,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8829,19 +8830,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8852,7 +8853,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8860,19 +8861,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8883,7 +8884,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8891,19 +8892,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8914,7 +8915,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8922,19 +8923,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8945,7 +8946,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8953,19 +8954,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8976,17 +8977,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + @@ -8994,19 +8985,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9017,7 +9008,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9025,19 +9016,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9048,7 +9039,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9056,19 +9047,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9079,7 +9070,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9087,19 +9078,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9110,7 +9101,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9118,19 +9109,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9141,7 +9132,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9149,19 +9140,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9172,7 +9163,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9180,19 +9171,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9203,7 +9194,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9211,19 +9202,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9234,7 +9225,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9242,19 +9233,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9265,7 +9256,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9273,19 +9264,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9296,7 +9287,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9304,19 +9295,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9327,7 +9318,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9335,19 +9326,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9358,7 +9349,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9366,19 +9357,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9389,7 +9380,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9397,19 +9388,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9420,7 +9411,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9428,19 +9419,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9449,29 +9440,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9482,7 +9473,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9490,19 +9481,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9513,7 +9504,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9521,19 +9512,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9544,7 +9535,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9552,19 +9543,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9575,7 +9566,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9583,19 +9574,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9606,7 +9597,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9614,19 +9605,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9637,7 +9628,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9645,19 +9636,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9666,29 +9657,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9699,7 +9690,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9707,19 +9698,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9728,29 +9719,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9761,7 +9752,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9769,19 +9760,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9792,7 +9783,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9800,19 +9791,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9821,29 +9812,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9854,7 +9845,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9862,19 +9853,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9885,7 +9876,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9893,19 +9884,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9916,7 +9907,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9924,19 +9915,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9947,7 +9938,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9955,19 +9946,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9978,7 +9969,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9986,19 +9977,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10009,7 +10000,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10017,21 +10008,52 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + + + + + +

+ + + + + + + + + + + + + + + + - + + + + + + - +

@@ -10039,16 +10061,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + @@ -10065,13 +10087,13 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10079,23 +10101,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - + - - - - +

@@ -10103,20 +10121,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - @@ -10132,17 +10147,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - - - - +

@@ -10150,19 +10162,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -10170,19 +10182,23 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + - +

@@ -10190,22 +10206,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -10213,20 +10226,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + - + - +

@@ -10234,19 +10246,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -10254,22 +10266,23 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + - + - +

@@ -10277,22 +10290,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10300,19 +10313,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + - + - +

@@ -10320,21 +10334,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - + - - - @@ -10350,10 +10360,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -10370,10 +10380,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + diff --git a/sbml/WP111.svg b/sbml/WP111.svg index 5b87360..63b4473 100644 --- a/sbml/WP111.svg +++ b/sbml/WP111.svg @@ -1,13 +1,13 @@ -?cd7da??c4d30?c3e7ac4d30?Stalkad4b9?c3e7a??Complex 1F1 complexd7f68F0 complexcc4c1d719ed7f68Complex 4cc4c1COX6B1UQCRBATP5J2Cytochrome CSDHDATP5OUQCRFS1ND5ATP5JO2SDHCNDUFB1NDUFB3H+UQCRBNDUFA9NAD+H+UCP3e-ATP5ONDUFC1COX15SURF1SDHBCOX6CNDUFC1COX6B1COX6A1COX3NDUFS5COX7A1NDUFS7NDUFA4TCA cycleNDUFB1ATP5HNDUFA8ATP5BNDUFA7NDUFB3ATP5HUCP2Assembly PWcomplex 1SLC25A4COX15NDUFA3ATP5J2COX7CUQCRFS1ATP5BFADNADHNDUFS7ATP5DNDUFV2COX2SDHBNDUFB9SLC25A14Cytochrome CNDUFA6SLC25A27NDUFB8SDHASLC25A5SuccinateNDUFA10NDUFA5ATP8NDUFS6ATP5G2COX5BCOX6A1NDUFB8SLC25A4SLC25A5COX6A2UQCRC1ND4SLC25A14NDUFS1e-NDUFB7COX7A3COX2COX7A2LNDUFA7Assembly PWcomplex 1ATP6NDUFV1UCP2COX8ATCA cycleNDUFA1H+ND6NDUFB10ND4COX4I1NDUFS8COX5BNDUFS1ATP5INDUFS3SLC25A27COX8ASLC25A6DAP13SDHDND4LFADATP5G1ATP5A1NDUFB4UQCRUCRCNDUFS4ATP5A1SDHCUCP1NDUFB10COX11H+COX7CATPIF1O2SDHANDUFAB1COX17NDUFV2ATP5LUbiquinoneND3NDUFV3SURF1NDUFB6NDUFB5NDUFB7ATP5G1ATP5F1NDUFA5NDUFS2ATP6ND2H+UQCRHQP-CSLC25A6UQCRC1COX1UQCRHH2ONDUFC2COX7BATPIF1NDUFS6H+ATP5G3NDUFS4ATP5JCOX17CYTBATP5G2H+NDUFA2COX7A2ATP5G3ND6COX5AATP5SH+NDUFS8NDUFA4COX1COX6CNDUFS2H+NDUFA10ND4Le-ATP5F1NDUFB2H+UbiquinoneUCP3NDUFA6NDUFA2H+ND1UQCRC2SCO1CYTBNDUFAB1e-SuccinateNDUFA9ATP5C1NDUFV1NADHATP5SNDUFB4ND1COX7A3NDUFV3NDUFS5QP-CATPATP5Le-ATP8NDUFC2FADH2NAD+NDUFB6COX7A2LH+NDUFA8COX11NDUFB2ATPATP5ECOX3ND3COX7A2ND2ATP5IATP5DCOX4I1UQCRC2COX7A1NDUFA1UQCRNDUFS3COX6A2NDUFB9ATP5C1COX5ASCO1FADH2H+e-COX7BNDUFA3ATP5EUCRCND5DAP13NDUFA13Complex ICytochrome C oxidaseComplex IVComplex V ATP synthase MatrixAssemblyATP synthasecomplexComplex IIIComplex V ATP synthase Uncoupling proteinNADH-ubiquinone oxidoreductaseComplex IVBinds ATP synthase betaCytochrome C oxidaseAdenine nucleotide translocatorUbiquinol-cytochrome C reductaseComplex IIntermembrane spaceAssemblyMatrixC subunitSuccinate-ubiquinone oxidoreductaseBinds ATP synthase betaIntermembrane spaceNADH-ubiquinone oxidoreductaseUncoupling proteinComplex II - + @@ -13,6 +13,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + @@ -22,77 +27,60 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - + - - - - - - - - - - + - + - + + + + + + + + + + - - - - - - - - - - - - - - - - - - + @@ -108,297 +96,232 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - - + + - + - + - + - + - + - - - - - - - - - - - - - - - - - + - + - + - + - + + + + + + + + + + + + + + + + + + - - - - + + + + - + - - - - - - - - - + - - - - + + + + - + - - - - - - - - - - - + + + - - + + - - + + - + - + - + - - - + + + + + + + + + + + + - - + + - + - + - - - + + + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - + + - - - - - - + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - + + - + - + - + - + - + - + - + - - - - + + + + @@ -406,51 +329,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - 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- - - - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - + - - - - - - - - - - - - - + - - + + - + - + - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -6286,106 +6237,100 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + @@ -6394,130 +6339,130 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + @@ -6526,118 +6471,148 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + + + - 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+ - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + @@ -7052,511 +7057,568 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - + @@ -7565,12 +7627,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -7579,17 +7641,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + @@ -7598,72 +7660,109 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + + + + + - + - + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + @@ -7672,12 +7771,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -7686,12 +7785,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -7700,17 +7799,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + @@ -7719,365 +7818,296 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - - + + - + - - - - - - + - + - + - + - - - - - + - + @@ -8086,74 +8116,49 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - - - - - - + + + + @@ -8181,7 +8186,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -8190,29 +8195,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8226,24 +8231,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -8252,29 +8257,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -8285,7 +8285,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8293,19 +8293,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8316,7 +8316,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8324,19 +8324,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8347,7 +8347,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8355,19 +8355,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8378,7 +8378,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8386,19 +8386,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8409,7 +8409,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8417,19 +8417,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8438,29 +8438,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8474,19 +8474,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - + - +

@@ -8497,7 +8502,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8505,19 +8510,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8526,11 +8531,6 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - @@ -8538,17 +8538,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -8559,7 +8559,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8567,19 +8567,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8588,29 +8588,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -8621,7 +8621,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8629,19 +8629,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8655,24 +8655,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -8681,24 +8681,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -8709,7 +8714,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8717,19 +8722,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8743,19 +8748,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - + - +

@@ -8766,7 +8776,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8776,17 +8786,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -8795,29 +8805,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8828,7 +8838,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8836,19 +8846,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8857,29 +8867,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -8888,29 +8898,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8921,7 +8931,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8931,17 +8941,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -8952,7 +8962,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8960,19 +8970,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8983,7 +8993,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8991,19 +9001,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9014,7 +9024,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9022,19 +9032,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9045,7 +9055,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9053,19 +9063,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9076,7 +9086,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9084,19 +9094,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9105,29 +9115,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9138,7 +9148,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9146,19 +9156,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9167,29 +9177,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9198,29 +9208,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9231,7 +9241,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9241,17 +9251,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9260,24 +9270,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -9286,29 +9301,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9319,7 +9334,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9329,17 +9344,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9350,7 +9365,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9360,17 +9375,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9381,7 +9396,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9391,17 +9406,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9412,7 +9427,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9422,17 +9437,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9443,7 +9458,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9451,19 +9466,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9474,7 +9489,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9482,19 +9497,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9505,7 +9520,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9513,19 +9528,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9536,7 +9551,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9544,19 +9559,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9567,7 +9582,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9575,19 +9590,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9598,7 +9613,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9608,17 +9623,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9627,29 +9642,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -9660,7 +9670,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9668,19 +9678,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9691,7 +9701,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9699,19 +9709,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9722,7 +9732,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9730,19 +9740,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9751,29 +9761,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9792,19 +9802,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9815,7 +9825,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9823,19 +9833,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9846,7 +9856,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9854,19 +9864,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9875,11 +9885,6 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - @@ -9887,17 +9892,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9908,7 +9913,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9916,19 +9921,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9942,24 +9947,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -9970,7 +9975,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9978,19 +9983,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10001,7 +10006,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10009,19 +10014,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10032,7 +10037,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10040,19 +10045,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10063,7 +10068,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10073,17 +10078,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10094,7 +10099,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10102,19 +10107,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10125,7 +10130,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10133,19 +10138,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10156,7 +10161,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10164,22 +10169,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

+ +

@@ -10187,7 +10194,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10195,19 +10202,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -10216,29 +10223,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -10247,29 +10254,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -10278,29 +10280,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10311,7 +10313,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10319,19 +10321,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10342,7 +10344,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10352,17 +10354,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10371,24 +10373,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -10399,7 +10406,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10407,19 +10414,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10428,6 +10435,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + @@ -10435,17 +10447,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10456,7 +10468,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10464,19 +10476,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10487,7 +10499,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10495,19 +10507,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10516,11 +10528,6 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - @@ -10528,17 +10535,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10547,29 +10554,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10580,7 +10587,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10590,17 +10597,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10609,6 +10616,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + @@ -10616,17 +10628,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10637,7 +10649,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10645,19 +10657,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10666,29 +10678,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -10699,7 +10711,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10707,19 +10719,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10730,7 +10742,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10740,17 +10752,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10761,7 +10773,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10769,19 +10781,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10792,7 +10804,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10800,19 +10812,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10823,7 +10835,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10831,19 +10843,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10852,29 +10864,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -10885,7 +10892,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10893,19 +10900,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10916,7 +10923,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10924,19 +10931,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10947,7 +10954,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10957,17 +10964,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10976,29 +10983,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11009,7 +11016,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11017,19 +11024,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11038,29 +11045,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -11069,6 +11071,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + @@ -11076,17 +11083,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -11095,29 +11102,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11128,7 +11135,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11136,19 +11143,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11159,7 +11166,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11167,19 +11174,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11190,7 +11197,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11198,19 +11205,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11221,7 +11228,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11229,19 +11236,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11252,7 +11259,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11260,19 +11267,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11283,7 +11290,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11291,19 +11298,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11317,24 +11324,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -11345,7 +11352,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11353,19 +11360,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11376,7 +11383,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11384,19 +11391,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11405,29 +11412,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11436,29 +11443,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11467,29 +11474,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - - + + - + - + - + - +

@@ -11500,7 +11507,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11508,19 +11515,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11529,29 +11536,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - + -

- -

+

@@ -11559,7 +11569,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11567,19 +11577,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11588,29 +11598,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11619,29 +11629,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11652,7 +11662,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11660,19 +11670,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11683,7 +11693,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11691,19 +11701,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11722,19 +11732,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11745,7 +11755,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11753,19 +11763,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11776,7 +11786,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11784,19 +11794,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11807,7 +11817,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11815,19 +11825,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11836,29 +11846,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11867,29 +11877,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -11898,31 +11908,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -11930,22 +11935,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -11953,22 +11955,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -11976,22 +11975,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11999,22 +11998,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -12022,22 +12021,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12045,22 +12044,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12068,22 +12067,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -12091,22 +12087,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12114,19 +12110,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -12134,22 +12133,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -12157,19 +12153,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -12177,19 +12176,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -12197,22 +12199,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -12220,22 +12219,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12243,22 +12242,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12266,22 +12265,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12289,22 +12288,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12312,22 +12311,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12335,22 +12334,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12358,22 +12357,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12381,22 +12380,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12404,22 +12403,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12427,22 +12426,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12450,22 +12449,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12473,22 +12472,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12496,22 +12495,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12519,22 +12518,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12542,22 +12541,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12565,22 +12564,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12588,22 +12587,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12611,22 +12610,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12634,22 +12633,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -12657,19 +12653,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -12677,22 +12676,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -12700,22 +12699,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12723,19 +12722,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -12743,22 +12742,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -12766,22 +12765,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12789,22 +12788,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12812,22 +12811,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12835,22 +12834,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12858,19 +12857,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -12887,16 +12886,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -12904,22 +12903,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -12927,22 +12923,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12950,19 +12946,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -12970,22 +12969,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12993,19 +12992,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -13013,19 +13015,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -13033,22 +13038,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13056,22 +13061,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13079,22 +13084,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -13102,22 +13104,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13125,22 +13127,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13148,19 +13150,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -13168,19 +13173,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -13188,22 +13196,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13211,22 +13219,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13234,20 +13242,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - diff --git a/sbml/WP143.svg b/sbml/WP143.svg index 82b1427..f998da6 100644 --- a/sbml/WP143.svg +++ b/sbml/WP143.svg @@ -8,406 +8,456 @@ />a9c06c1ebcadc6ad256ad00b7bf69aac0a1e6daaaa946b9ec0c3868b34cbc6581d7c72eeec7bf69ac6581d00b7c3868e6daaca83daa946d256aadc6ab9ec0ac0a1d7c72a9c06b34cbc1ebcca83d3-Oxododexanoyl-CoAtrans,cis-Lauro-2,6-dienoyl-CoAOctaoyl-CoAFatty Acid(S)-3-Hydroxydodexanonyl-CoACronoyl-CoATrans-Tetradex-2-enoyl-CoAGlutarateCronoyl-CoAOctaoyl-CoA3-Oxocanoyl-CoA(S)-Hydrocyhexanoyltrans,cis-Lauro-2,6-dienoyl-CoA4-cis-dexeboyl-CoATrans-Hexadecanoyl-CoA3-Oxododexanoyl-CoAFatty AcidDxotetradecanoyl-CoA3-Oxocanoyl-CoATrans-Hexadecanoyl-CoA4-cis-dexeboyl-CoALipases(S)-3-Hydroxydecanoyl-CoAACAT1HADHADecanoyl-CoAAcetyl-CoACPT1BHexanoyl-CoADCITCA cycleHADHBACSL6HADHSCACADMAcetyl-CoATriacylglycerolAcetyl-CoAAcetyl-CoACHKBHADHBCPT2ECHS1HADHAHADHBSLC25A20DECR1GPD2HADHSCPalmitoyl-CoADecanoyl-CoA3-Oxopalmitoyl-CoA3-Oxo-octanoyl-CoAGCDHAcetoacetyl-CoAAcetyl-CoAHADHAHADHAACADMGlycerolTrans-Oct-2-enoyl-CoAHADHSCLIPCHADHAHADHBDihydroxyacetone PhosphateACADMGK2Hexanoyl-CoA(S)-3-Hydroxytetradecanoyl-CoAACADVLPNPLA2ECHS1HADHBGlyceraldehyde-3-PhosphateHADHBACAS23-Oxo-octanoyl-CoAAcetyl-CoATrans-Hex-2-enoyl-CoAAcetyl-CoAHADHBACADS(S)-3-Hydroxyhexadecanoyl-CoAHADHAACAT1HADHAHADHBHADHAACADSLIPCHADHBTPI1HADHB2-trans-4-cis-decadienoyl-CoAACADLACSL1L-Glycerol-3-PhosphateDLDACADSHADHSCAcetyl-CoAGlyceraldehyde-3-PhosphateHADHACHKBACADL2-trans-dodecenoyl-CoAMyristoyl-CoATrans-Dec-2-enoyl-CoAAcetyl-CoAHADHBLIPEMyristoyl-CoA3-trans-decenoyl-CoATPI1Acetyl-CoACPT1ADCILIPEHADHAECHS1HADHBHADHAHADHBACADMACSL5Acyl-CoAECHS12-trans-4-cis-decadienoyl-CoA(S)-3-Hydroxybutanoyl-CoAACSL1HADHBACSL3ACSL6Butanoyl-CoATrans-Dec-2-enoyl-CoAECHS1CRATHADHBLIPFACADLGPD2Linoleoyl-CoA(S)-3-Hydroxyoctanoyl-CoAACADMCPT1A(S)-3-Hydroxyhexadecanoyl-CoAPalmitoyl-CoAHADHAAcetyl-CoAECHS1HADHSC(S)-3-Hydroxyoctanoyl-CoA2-trans-dodecenoyl-CoAAcetyl-CoALinoleoyl-CoADLDHADHAACADLL-Glycerol-3-PhosphateHADHACRATAcetyl-CoAACAS2GKLPLECHS1HADHA(S)-3-Hydroxydecanoyl-CoAHADHBACSL5HADHSCACSL3HADHBcis,cis-3,6-Dodecadienoyl-CoAHADHSCHADHA(S)-3-Hydroxybutanoyl-CoAGK2Trans-Hex-2-enoyl-CoA3-trans-decenoyl-CoALauroyl-CoADihydroxyacetone PhosphateTriacylglycerolAcetyl-CoADCIGlycerol3-Oxohexanoyl-CoAHADHAECHS1GKAcetyl-CoATrans-Oct-2-enoyl-CoAcis,cis-3,6-Dodecadienoyl-CoAHADHAHADHBDCIACSL4LIPFGCDHACADLHADHAHADHSCACADLGlutaryl-CoA3-Oxopalmitoyl-CoALauroyl-CoAECHS1Butanoyl-CoADECR1Acetyl-CoACPT1BAcyl-CoALPLHADHBHADHAPNPLA2ECHS1HADHBCPT2ACADVLACSL4ACADMACADSHADHAHADHSCSLC25A20Glutaryl-CoAAcetoacetyl-CoATCA cycleTCA cycle - + @@ -271,23 +271,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + - + - + - - + + + + + @@ -304,46 +307,43 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + + + + + + + - + - + - + - - - - - - - - - - + - + - + @@ -389,71 +389,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + @@ -469,19 +414,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - + + - - + + @@ -497,35 +434,35 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + - - + + - + - + - - + + - - + + - - + + @@ -541,62 +478,98 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + + + + + + + + + + + + + - + - + - + - + + + + + + + + + - + - + + + + + + + + + - - - - - - + + + + + + - + - + + + + + + + + + - + - + @@ -613,69 +586,94 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - - + + - + - + - - + + - - + + - - - + + + + + + + + + + + + + + + + + + + - - - - - - + + + + + + + - - + + - - - + + + - + - - + + - - + + - + + + + + + + + + @@ -692,34 +690,62 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + + + + - + + + + + + + + + + + + + - + - - + + - - + + - + + + + + + + + + - + - + @@ -736,55 +762,46 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + - - - - - - + + + + + + - - - + + - + - + - - - - - - - - - - + + @@ -800,18 +817,18 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - - + + + - - + + - + @@ -828,11 +845,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + + + + + + + + + @@ -848,97 +873,62 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - - - + + + - + - + - + - + - + - - + + - - - - - - + + + + + + - - + + - + - + - - - - - - - - - + @@ -955,10 +945,18 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + + + + @@ -975,126 +973,62 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - - - - - + + + - - + + - - + + - - - - - - + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - + - + - + - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - - + + @@ -1110,35 +1044,35 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - + - + - + - + - - + + @@ -1154,10 +1088,30 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + + + + + + + + + + + + + + + + + + + + + @@ -1174,59 +1128,63 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - - - + + + + + + - + - + - + - - - - - - - - - - - - - - - + + + - - + + - - + + + + + + + + + + + + + + + + + + @@ -1242,26 +1200,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - - - + + + + - + + + + + + + + + - + - + - + @@ -1278,27 +1244,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - + + + - - + + - - + + @@ -1314,63 +1272,43 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + - - + + - + - + - - - - - - - - - - - - - - - + + + - - + + - - + + - - - - - - - - - - + + - - + + @@ -1386,63 +1324,55 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + + + + + + + + + - + - + - - - - - - + + + + + + - + - + - - - - - - - - - + - - - - - - - - - - + + @@ -1458,11 +1388,27 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + + + + + + + + + + + + + + + + + @@ -1478,27 +1424,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - + + - - - + + + - - + + - - + + @@ -1514,11 +1452,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + @@ -1534,8 +1472,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -1557,80 +1495,72 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - - - + + + + - - - - - - - - - - + + - - + + - - + + - - - - - - - - - + - - - - - - + + + + + + - + - + - + - - + + + + + + + + + + @@ -1646,8 +1576,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + + + + + + + + + @@ -1669,8 +1607,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -1686,79 +1624,59 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - + - + - - - - - - + + + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + - - + + - - + + @@ -1774,15 +1692,15 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + @@ -1793,71 +1711,110 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - - - - - + + + + + + - - - + + - - + + - - - - - - + + + + + + - - + + - + + + + + + + + + - + - + + + + + + + + + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1874,27 +1831,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - + - + - - + + @@ -1910,19 +1859,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - + + + + + - - + + - - + + @@ -1938,126 +1887,147 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + + + + + + + + + - + - + - - - - - - + + + + + + - + - - - - - - - - - - + + - - - - - - + + + + + + - - + + - + + + + + + + + + - + - + + + + + + + + + + + + + + + + + + + + + - + - + - - - - - - - - - - - - - - + + + + + + + - - + + - + - + - - - + + + - - + + - - + + @@ -2073,42 +2043,54 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - - + + + + + + + + + + + + + + + - - + + - + - + - + - + - - + + - - + + - + @@ -2125,27 +2107,35 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - - + + + + + + + + + + @@ -2161,11 +2151,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + + + + + + + + + @@ -2181,11 +2179,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + @@ -2201,11 +2199,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + @@ -2221,46 +2219,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - - - - - - - - - - - - - - - - - - - - - - - + + + - - + + - + @@ -2277,51 +2255,43 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - - + + - - + + - - - - - - - - - - + + - + - + - - - + + + - + - - + + @@ -2337,27 +2307,31 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - + + - - - + + + + + + + + + + + + + + + - - + + - - + + @@ -2373,102 +2347,77 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - + + - + - + - + - + - - - - - - - - - + - + - - - - - - - - - - + + - - + + - + - + - - + + - - - - - - + + + + + + - - - + + - - + + - - + + - + @@ -2485,18 +2434,18 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -2513,110 +2462,110 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + - - + + - - + + - - + + - - + + - - + + - + - + - - + + - - - - - - - + + - - + + + + - - - + + + + + + - - + + - + - + - - + + - - - - - - + + + + + + - - + + - - - + + + - + - + @@ -2633,42 +2582,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - + - - - - - - - - - + @@ -2685,11 +2602,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + @@ -2705,31 +2622,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - + - - + + @@ -2745,37 +2642,61 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - + + + + + + + + + - - - - - - + + + + + + - + + + + + + + + + + + + + + + + + @@ -2795,23 +2716,55 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + - + - + + + + + + + + + - + - + + + + + + + + + + + + + + + + + @@ -2828,39 +2781,35 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - - - - - + + + - - + + - - + + - - + + - - + + + + + + + + + + @@ -2876,38 +2825,42 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - + - + - + @@ -2924,34 +2877,42 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - + + + - - + + - + + + + + + + + + - + - - + + - - - - + + + + @@ -2960,37 +2921,69 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + - - + + - - - - - - + + + + + + - - + + - - + + + + + + + + + + - + + + + + + + + + + + + + + + + + @@ -3011,7 +3004,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3028,43 +3021,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - + - + - - - - - - - - - - - - - - - - - - + + @@ -3080,10 +3049,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + + + + + + + + + + + + + + + + + @@ -3100,10 +3085,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -3120,26 +3105,18 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - + - - - - + + + + @@ -3148,11 +3125,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + @@ -3168,50 +3145,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - - - - - - - - - - - - - - - - - + - + - + - - + + - - - - + + + + @@ -3220,18 +3181,73 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + + + + + + + + + + + + - + - + @@ -3248,7 +3264,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3271,8 +3287,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -3288,75 +3304,39 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - + - + - - - + + + + + + + + + + + + + + + - - + + - + - - - - - - - - - - - - - - - - @@ -3372,33 +3352,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - + - - - - - - - - - - - - - - - - @@ -3419,31 +3383,51 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + + + + + - + - - - + + + - - + + - - + + - - + + - + @@ -3460,10 +3444,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -3480,101 +3464,117 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + - + - + - - + + - - - - + + + + - + - + - - + + + + + - - - - + + + + - - - - + - - - - + - - + + - - - - + + + + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -3583,52 +3583,52 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -3639,410 +3639,383 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - + - - - - - - - - - - - + + - + - + - - + + - - - - + + + + - + - + - - - - - - - - - - - + + - + - + - + - - + + - - - - + + + + - + - + - - - - - - - - - - - + + - + - + - - - - - - - - - - - + + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - - + + - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + + + + - + - - + + + + + + + + + + + - + - - - - + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - + + + + - + - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -4051,463 +4024,463 @@ Proteins on this pathway have targeted assays available via the [https://assays. - 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+ - - - - + + + + - + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + + + + - + - - - - - - - - - - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - + - - - - + - - - - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + + + + + + + + + + - - + + - - + + - - + + - - - - + + + + - + - - - - - - - + - + - - - - + + + + - + - + - + - - - - + + + + + + + + + + + + + + + + - + - - + + - - - - + + + + @@ -4858,34 +4840,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -4896,130 +4878,169 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + + + + + + + + + + - + - + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + @@ -5031,149 +5052,110 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - + - - - - - - - - - - - - - - - - + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + + + + + + + - + - + - - + + - - - - + + + + @@ -5182,169 +5164,169 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - + + + + - + - + - - + + - - - - + + + + - + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + + + + - + - + - - + + + + + + + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - - - - - - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -5358,14 +5340,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -5376,14 +5358,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -5394,32 +5376,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -5430,428 +5412,455 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - + - - - - + + + + + + + - + - - + + + + + + + + + + + - + - + - - + + + + + + + + + + + - + - - + + + + + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - - - + - - - - + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + + + + + + + + + + - + - - - - - - - + - - + + - - - - + + + + + + + + + + - + - + - + - - + + - - - - + + + + @@ -5860,114 +5869,90 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - + + + + - + - - - - + - - + + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - + + + + - + - + - + - + - + - + @@ -5979,188 +5964,221 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - + + - - + + - - + + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - - + + - + - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - - - - + - - + + - - - - + + + + - + - - + + - + - - - - + + + + + + + - + - + - - + + - - - - + + + + @@ -6171,14 +6189,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -6189,32 +6207,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -6223,379 +6241,370 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + - - - - + - - + + + + + - - - - - - + + + + + + - - - - + - - + + + + + - - - - + + + + - - - - + - + - - - - - - - - - - - + + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + + + + - + - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + + + + - - - - + + + + - - - - + - + @@ -6603,248 +6612,239 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + - - - - + + + + - - - - - - - - - - - - - - - - - - - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - - + + - + - - - - + + + + + + + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + + + + - + - + - - + + - - - - + + + + @@ -6855,50 +6855,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -6909,14 +6909,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -6927,215 +6927,215 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - - - - + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + + + + - + - + - - - - + + + + @@ -7144,16 +7144,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - - + + + + @@ -7300,1030 +7300,1012 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - - - - - - - + + - + - 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+ - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - - - - - - - + - - + + - + - - + + - + - + - + - - + + @@ -17344,136 +17296,148 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + @@ -17482,28 +17446,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - + - - + + - + - - + + - + - - + + @@ -17512,340 +17470,364 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + + + + + + + - + + + + + + + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + @@ -17854,178 +17836,184 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + @@ -18034,226 +18022,220 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -18262,28 +18244,28 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + - + - - + + @@ -18292,249 +18274,267 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -18546,373 +18546,409 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + - + - + - + + - - + - + - + - + - + - + - + - + - + + + + + + - + + + + - + - + - + - + - + @@ -18921,62 +18957,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -19018,7 +19018,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -19029,7 +19029,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -19039,51 +19039,65 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

+

EC 2.7.7.2 + +FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) + +

+ + + + + + + + + + + + + + + - - - - - - + - + - + - +
- + -

Prostaglandin F2a +

interferon, gamma

@@ -19093,17 +19107,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + @@ -19111,19 +19125,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -19134,27 +19148,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - + @@ -19162,22 +19156,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

scavenger receptor class B, member 1 +

high-density lipoprotein cholesterol + +Cholesterol transport

@@ -19187,12 +19183,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -19200,22 +19196,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

interferon, gamma +

very-low-density lipoprotein

@@ -19225,12 +19221,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + @@ -19238,22 +19239,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

interleukin 1, beta + +

@@ -19261,17 +19264,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + @@ -19279,24 +19277,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

EC 1.5.1.5 - -methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 +

serum amyloid A2

@@ -19306,17 +19302,17 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + - + - + @@ -19326,20 +19322,20 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + - +
- + -

5,10-Methylenetetrahydrofolate +

Prostaglandin E2

@@ -19349,17 +19345,17 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + - + - + @@ -19369,20 +19365,20 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + - +
- + -

8-Hydroxy-deoxyguanosine +

Nicotinamide adenine dinucleotide phosphate-Reduced

@@ -19392,12 +19388,7 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - - - - - - + @@ -19407,22 +19398,20 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + - +
- + -

Nicotinamide adenine dinucleotide phosphate-Reduced - -

+

@@ -19430,7 +19419,12 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + + + + + + @@ -19440,22 +19434,20 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 - + - + - + -

EC 3.4.21.7 - -Plasminogen +

5,10-Methenyltetrahydrofolic acid

@@ -19465,12 +19457,12 @@ Plasminogen - + - + @@ -19478,24 +19470,22 @@ Plasminogen - + - + - + - +
- + -

folate receptor 2 (fetal) - -

+

@@ -19503,12 +19493,7 @@ Plasminogen - - - - - - + @@ -19516,24 +19501,22 @@ Plasminogen - + - + - + - + - + -

Flavin adenine dinucleotide - -

+

@@ -19541,12 +19524,7 @@ Plasminogen - - - - - - + @@ -19556,20 +19534,22 @@ Plasminogen - + - + - + -

+

Nitric oxide + +

@@ -19577,12 +19557,17 @@ Plasminogen - + - + + + + + + @@ -19592,20 +19577,22 @@ Plasminogen - + - +
- + -

apolipoprotein B +

EC 1.11.1.9 + +Selenoprotein-glutathione peroxidase 2

@@ -19615,12 +19602,7 @@ Plasminogen - - - - - - + @@ -19628,22 +19610,24 @@ Plasminogen - + - + - + - +
- + -

+

ozone + +

@@ -19651,22 +19635,7 @@ Plasminogen - - - - - - - - - - - - - - - - + @@ -19676,22 +19645,20 @@ Plasminogen - + - +
- + -

EC 1.11.1.12 - -Selenoprotein-glutathione peroxidase 4 +

Hydrogen peroxide

@@ -19701,7 +19668,7 @@ Selenoprotein-glutathione peroxidase 4 - + @@ -19709,22 +19676,24 @@ Selenoprotein-glutathione peroxidase 4 - + - + - + - +
- + -

+

Nicotinamide adenine dinucleotide phosphate-Reduced + +

@@ -19732,12 +19701,7 @@ Selenoprotein-glutathione peroxidase 4 - - - - - - + @@ -19747,22 +19711,20 @@ Selenoprotein-glutathione peroxidase 4 - + - +
- + -

Peroxynitrite - -

+

@@ -19770,7 +19732,12 @@ Selenoprotein-glutathione peroxidase 4 - + + + + + + @@ -19780,22 +19747,20 @@ Selenoprotein-glutathione peroxidase 4 - + - + - + -

5-methyltetrahydrofolate - -Predominant food folate +

Tetrahydrofolic acid

@@ -19805,17 +19770,12 @@ Predominant food folate - - - - - - + @@ -19825,48 +19785,55 @@ Predominant food folate - + - +
- + -

+

apolipoprotein B + +

+ + + + + + + + + + - - - - - - + - + - + - +
- +

@@ -19877,7 +19844,17 @@ Predominant food folate - + + + + + + + + + + + @@ -19885,24 +19862,22 @@ Predominant food folate - + - + - + - + - + -

Adenosine diphosphate - -

+

@@ -19910,7 +19885,12 @@ Predominant food folate - + + + + + + @@ -19920,22 +19900,20 @@ Predominant food folate - + - + - + -

EC 6.3.3.2 - -5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) +

H4B

@@ -19945,12 +19923,12 @@ Predominant food folate - + - + @@ -19958,24 +19936,22 @@ Predominant food folate - + - + - + - +
- + -

Monocyte Chemotactic Protein 1 - -CCL2 +

Nitric oxide synthase

@@ -19985,12 +19961,12 @@ CCL2 - + - + @@ -19998,24 +19974,22 @@ CCL2 - + - + - + - +
- + -

low-density lipoprotein - -

+

@@ -20023,32 +19997,12 @@ CCL2 - - - - - - - - - - - - - - - - - - - - - + - + @@ -20058,22 +20012,20 @@ CCL2 - + - + - + -

Superoxide - -

+

@@ -20081,7 +20033,7 @@ CCL2 - + @@ -20089,62 +20041,30 @@ CCL2 - - - - - - - - - - - - - - - -

C-reactive protein, pentraxin-related - -

- -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + +
+ + + +

+ + + + + - + @@ -20152,22 +20072,24 @@ CCL2 - + - + - + - + - + -

+

Prostaglandin E1 + +

@@ -20175,12 +20097,12 @@ CCL2 - + - + @@ -20190,22 +20112,20 @@ CCL2 - + - +
- + -

EC 1.11.1.7 - -Myeloperoxidase +

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

@@ -20215,27 +20135,12 @@ Myeloperoxidase - - - - - - - - - - - - - - - - + - + @@ -20245,20 +20150,22 @@ Myeloperoxidase - + - +
- + -

+

8-Hydroxy-deoxyguanosine + +

@@ -20266,17 +20173,12 @@ Myeloperoxidase - - - - - - + - + @@ -20286,87 +20188,51 @@ Myeloperoxidase - + - +
- + -

tumor protein p53 - -

+

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + + + + + + - + - + -

EC 2.1.2.1 - -Serine hydroxymethyltransferase 1 (soluble) - -

+

@@ -20374,12 +20240,12 @@ Serine hydroxymethyltransferase 1 (soluble) - + - + @@ -20387,22 +20253,24 @@ Serine hydroxymethyltransferase 1 (soluble) - + - + - + - + - + -

+

interleukin 1, beta + +

@@ -20410,7 +20278,17 @@ Serine hydroxymethyltransferase 1 (soluble) - + + + + + + + + + + + @@ -20418,22 +20296,22 @@ Serine hydroxymethyltransferase 1 (soluble) - + - + - + - +
- + -

interferon, gamma +

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2

@@ -20443,17 +20321,7 @@ Serine hydroxymethyltransferase 1 (soluble) - - - - - - - - - - - + @@ -20461,24 +20329,22 @@ Serine hydroxymethyltransferase 1 (soluble) - + - + - + - +
- + -

EC 1.16.1.8 - -5-methyltetrahydrofolate-homocysteine methyltransferase reductase +

soluble intercellular adhesion molecule 1

@@ -20488,17 +20354,22 @@ Serine hydroxymethyltransferase 1 (soluble) - + - + - + + + + + + @@ -20508,17 +20379,17 @@ Serine hydroxymethyltransferase 1 (soluble) - + - +
- +

@@ -20527,34 +20398,44 @@ Serine hydroxymethyltransferase 1 (soluble) + + + + + + + + + + + + + + + - - - - - - + - + - + - + - + -

Triglyceride +

EC 1.15.1.1 -Triacylglycerol +superoxide dismutase 1, soluble

@@ -20564,12 +20445,7 @@ Triacylglycerol - - - - - - + @@ -20577,19 +20453,19 @@ Triacylglycerol - + - + - + - +
- +

@@ -20600,12 +20476,7 @@ Triacylglycerol - - - - - - + @@ -20613,22 +20484,22 @@ Triacylglycerol - + - + - + - + - + -

Nitrogen dioxide +

Hypochlorite

@@ -20638,7 +20509,7 @@ Triacylglycerol - + @@ -20648,20 +20519,20 @@ Triacylglycerol - + - +
- + -

very-low-density lipoprotein +

oxidized low-density lipoprotein

@@ -20671,17 +20542,27 @@ Triacylglycerol - + - + - + + + + + + + + + + + @@ -20691,20 +20572,22 @@ Triacylglycerol - + - +
- + -

Nitrotyrosinated apolipoprotein A-I +

EC 2.1.2.1 + +Serine hydroxymethyltransferase

@@ -20714,12 +20597,17 @@ Triacylglycerol - + - + + + + + + @@ -20729,20 +20617,20 @@ Triacylglycerol - + - +
- + -

high-density lipoprotein +

8-Hydroxy-deoxyguanosine

@@ -20752,17 +20640,12 @@ Triacylglycerol - - - - - - + - + @@ -20772,20 +20655,22 @@ Triacylglycerol - + - +
- + -

+

interferon, gamma + +

@@ -20793,12 +20678,12 @@ Triacylglycerol - + - + @@ -20806,24 +20691,22 @@ Triacylglycerol - + - + - + - +
- + -

interleukin 6 (interferon, beta 2) - -

+

@@ -20831,17 +20714,7 @@ Triacylglycerol - - - - - - - - - - - + @@ -20849,24 +20722,24 @@ Triacylglycerol - + - + - + - + - + -

EC 2.1.2.1 +

EC 1.11.1.7 -Serine hydroxymethyltransferase +Myeloperoxidase

@@ -20876,17 +20749,27 @@ Serine hydroxymethyltransferase - + - + - + + + + + + + + + + + @@ -20896,20 +20779,22 @@ Serine hydroxymethyltransferase - + - +
- + -

albumin +

very-low-density lipoprotein + +The VLDL is produced in the liver, contains one molecule of apoB100

@@ -20919,12 +20804,12 @@ Serine hydroxymethyltransferase - + - + @@ -20932,57 +20817,55 @@ Serine hydroxymethyltransferase - + - + - + - +
- + -

EC 1.11.1.9 - -Selenoprotein-glutathione peroxidase 1 - -

+

- - - - - - + - + - + + + + + + - + - + -

+

Glutathione disulfide + +

@@ -20990,17 +20873,7 @@ Selenoprotein-glutathione peroxidase 1 - - - - - - - - - - - + @@ -21010,22 +20883,20 @@ Selenoprotein-glutathione peroxidase 1 - + - +
- + -

Flavin Mononucleotide - -

+

@@ -21033,12 +20904,12 @@ Selenoprotein-glutathione peroxidase 1 - + - + @@ -21048,22 +20919,20 @@ Selenoprotein-glutathione peroxidase 1 - + - + - + -

very-low-density lipoprotein-triglyceride - -Triglyceride transport +

hemoglobin, alpha 1

@@ -21073,12 +20942,12 @@ Triglyceride transport - + - + @@ -21086,22 +20955,24 @@ Triglyceride transport - + - + - + - +
- + -

+

Nicotinamide adenine dinucleotide phosphate-Oxidized + +

@@ -21109,22 +20980,7 @@ Triglyceride transport - - - - - - - - - - - - - - - - + @@ -21134,17 +20990,17 @@ Triglyceride transport - + - +
- +

@@ -21155,12 +21011,7 @@ Triglyceride transport - - - - - - + @@ -21170,22 +21021,20 @@ Triglyceride transport - + - + - + -

Prostaglandin F2a - -

+

@@ -21193,17 +21042,12 @@ Triglyceride transport - - - - - - + - + @@ -21213,20 +21057,20 @@ Triglyceride transport - + - + - + -

nuclear factor NF-kappa-B p50 subunit +

albumin

@@ -21236,7 +21080,12 @@ Triglyceride transport - + + + + + + @@ -21244,19 +21093,19 @@ Triglyceride transport - + - + - + - +
- +

@@ -21265,34 +21114,34 @@ Triglyceride transport + + + + + - - - - - - + - + - + - + - + -

EC 4.4.1.1 +

EC 3.3.1.1 -cystathionase +Adenosylhomocysteinase

@@ -21302,12 +21151,12 @@ cystathionase - + - + @@ -21317,22 +21166,20 @@ cystathionase - + - +
- + -

Reduced cobalamin - -

+

@@ -21340,22 +21187,7 @@ cystathionase - - - - - - - - - - - - - - - - + @@ -21363,22 +21195,24 @@ cystathionase - + - + - + - + - + -

8-Hydroxy-deoxyguanosine +

Triglyceride + +Triacylglycerol

@@ -21388,12 +21222,12 @@ cystathionase - + - + @@ -21403,22 +21237,20 @@ cystathionase - + - +
- + -

EC 3.4.21.7 - -Plasminogen +

solute carrier family 19 (folate transporter), member 1

@@ -21428,12 +21260,12 @@ Plasminogen - + - + @@ -21441,24 +21273,22 @@ Plasminogen - + - + - + - +
- + -

EC 3.4.21.68 - -plasminogen activator, tissue +

Nicotinamide adenine dinucleotide phosphate-Oxidized

@@ -21468,12 +21298,7 @@ plasminogen activator, tissue - - - - - - + @@ -21481,24 +21306,22 @@ plasminogen activator, tissue - + - + - + - +
- + -

ATP-binding cassette, sub-family A (ABC1), member 1 - -

+

@@ -21506,17 +21329,7 @@ plasminogen activator, tissue - - - - - - - - - - - + @@ -21524,22 +21337,22 @@ plasminogen activator, tissue - + - + - + - + - + -

H4B +

http://en.wikipedia.org/wiki/Fibrin_degradation_product

@@ -21549,12 +21362,17 @@ plasminogen activator, tissue - + - + + + + + + @@ -21562,24 +21380,24 @@ plasminogen activator, tissue - + - + - + - +
- + -

EC 1.11.1.9 +

Monocyte Chemotactic Protein 1 -Selenoprotein-glutathione peroxidase 3 +CCL2

@@ -21589,7 +21407,12 @@ Selenoprotein-glutathione peroxidase 3 - + + + + + + @@ -21597,26 +21420,22 @@ Selenoprotein-glutathione peroxidase 3 - + - + - + - +
- + -

EC 1.11.1.7 - -Myeloperoxidase - -

+

@@ -21624,27 +21443,12 @@ Myeloperoxidase - - - - - - - - - - - - - - - - + - + @@ -21652,24 +21456,22 @@ Myeloperoxidase - + - + - + - + - + -

high-density lipoprotein - -

+

@@ -21677,12 +21479,7 @@ Myeloperoxidase - - - - - - + @@ -21697,20 +21494,22 @@ Myeloperoxidase - + - + - + -

oxidized low-density lipoprotein +

EC 1.5.1.3 + +Dihydrofolate reductase

@@ -21720,27 +21519,22 @@ Myeloperoxidase - - - - - - + - + - + - + @@ -21748,24 +21542,22 @@ Myeloperoxidase - + - + - + - +
- + -

EC 3.4.21.68 - -plasminogen activator, tissue +

folate receptor 2 (fetal)

@@ -21775,12 +21567,12 @@ plasminogen activator, tissue - + - + @@ -21788,22 +21580,26 @@ plasminogen activator, tissue - + - + - + - +
- + -

+

EC 3.4.21.7 + +Plasminogen + +

@@ -21811,7 +21607,12 @@ plasminogen activator, tissue - + + + + + + @@ -21819,22 +21620,24 @@ plasminogen activator, tissue - + - + - + - +
- + -

+

very-low-density lipoprotein + +

@@ -21842,12 +21645,17 @@ plasminogen activator, tissue - + - + + + + + + @@ -21857,22 +21665,20 @@ plasminogen activator, tissue - + - +
- + -

interleukin 4 - -

+

@@ -21880,12 +21686,7 @@ plasminogen activator, tissue - - - - - - + @@ -21893,24 +21694,22 @@ plasminogen activator, tissue - + - + - + - + - + -

oxidized cobalamin - -

+

@@ -21918,17 +21717,12 @@ plasminogen activator, tissue - - - - - - + - + @@ -21938,22 +21732,22 @@ plasminogen activator, tissue - + - + - + -

very-low-density lipoprotein +

EC 3.4.21.68 -The VLDL is produced in the liver, contains one molecule of apoB100 +plasminogen activator, tissue

@@ -21963,12 +21757,12 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + - + @@ -21976,24 +21770,22 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + - + - + - +
- + -

serum amyloid A4, constitutive - -

+

@@ -22001,17 +21793,17 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + - + - + @@ -22019,47 +21811,30 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - - - - - - + - + - - - - - -

Synthetic folate - -

- -
- - - - - - - - - - - - - - - - - - + + + + + + +
+ + + +

+ + + + + - + @@ -22069,22 +21844,20 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + - + - + -

nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 - -

+

@@ -22092,7 +21865,17 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + + + + + + + + + + + @@ -22100,24 +21883,22 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + - + - + - + - + -

interleukin 6 (interferon, beta 2) - -

+

@@ -22125,27 +21906,17 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - - - - - - - - - - - + - + - + @@ -22153,24 +21924,24 @@ The VLDL is produced in the liver, contains one molecule of apoB100 - + - + - + - + - + -

reactive nitrogen species +

EC 6.3.3.2 -http://en.wikipedia.org/wiki/Reactive_nitrogen_species +5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

@@ -22180,17 +21951,12 @@ http://en.wikipedia.org/wiki/Reactive_nitrogen_species - - - - - - + - + @@ -22198,24 +21964,22 @@ http://en.wikipedia.org/wiki/Reactive_nitrogen_species - + - + - + - +
- + -

alpha-1-antichymotrypsin - -serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 +

Flavin adenine dinucleotide

@@ -22225,17 +21989,12 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - - - - - - + - + @@ -22243,22 +22002,26 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

+

EC 3.4.21.21 + +coagulation factor VII (serum prothrombin conversion accelerator) + +

@@ -22266,12 +22029,17 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + + + + + + @@ -22279,22 +22047,24 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

+

folate receptor 3 (gamma) + +

@@ -22302,7 +22072,12 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + + + + + + @@ -22310,22 +22085,24 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

Nicotinamide adenine dinucleotide phosphate-Oxidized +

EC 4.2.1.22 + +cystathionine-beta-synthase

@@ -22335,7 +22112,17 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + + + + + + + + + + + @@ -22343,24 +22130,24 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

Glycated hemoglobin +

EC 3.4.21.68 -http://en.wikipedia.org/wiki/Glycated_hemoglobin +plasminogen activator, tissue

@@ -22370,12 +22157,12 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + @@ -22385,20 +22172,20 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - +
- + -

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 +

Insulin

@@ -22408,12 +22195,22 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + + + + + + + + + + + @@ -22423,20 +22220,24 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - +
- + -

+

EC 1.11.1.9 + +Selenoprotein-glutathione peroxidase 6 + +

@@ -22444,7 +22245,7 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + @@ -22452,19 +22253,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +
- +

@@ -22475,12 +22276,12 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + @@ -22488,22 +22289,24 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + - + -

colony stimulating factor 1 (macrophage) +

alpha-1-antichymotrypsin + +serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

@@ -22513,12 +22316,17 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + + + + + + @@ -22528,22 +22336,20 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - +
- + -

EC 1.15.1.1 - -superoxide dismutase 3, extracellular +

low-density lipoprotein

@@ -22553,7 +22359,32 @@ superoxide dismutase 3, extracellular - + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -22561,22 +22392,22 @@ superoxide dismutase 3, extracellular - + - + - + - +
- + -

Insulin +

Flavin adenine dinucleotide

@@ -22586,22 +22417,12 @@ superoxide dismutase 3, extracellular - - - - - - - - - - - + - + @@ -22609,22 +22430,24 @@ superoxide dismutase 3, extracellular - + - + - + - +
- + -

interleukin 1, beta +

EC 1.16.1.8 + +5-methyltetrahydrofolate-homocysteine methyltransferase reductase

@@ -22634,17 +22457,17 @@ superoxide dismutase 3, extracellular - + - + - + @@ -22654,17 +22477,17 @@ superoxide dismutase 3, extracellular - + - +
- +

@@ -22675,27 +22498,7 @@ superoxide dismutase 3, extracellular - - - - - - - - - - - - - - - - - - - - - + @@ -22703,22 +22506,22 @@ superoxide dismutase 3, extracellular - + - + - + - + - + -

Insulin receptor +

interferon, gamma

@@ -22728,17 +22531,12 @@ superoxide dismutase 3, extracellular - - - - - - + - + @@ -22748,20 +22546,20 @@ superoxide dismutase 3, extracellular - + - +
- + -

Hydrogen peroxide +

interleukin 4

@@ -22771,7 +22569,12 @@ superoxide dismutase 3, extracellular - + + + + + + @@ -22779,22 +22582,24 @@ superoxide dismutase 3, extracellular - + - + - + - +
- + -

hemoglobin, alpha 1 +

Glycated hemoglobin + +http://en.wikipedia.org/wiki/Glycated_hemoglobin

@@ -22804,12 +22609,12 @@ superoxide dismutase 3, extracellular - + - + @@ -22819,22 +22624,20 @@ superoxide dismutase 3, extracellular - + - +
- + -

interferon, gamma - -

+

@@ -22842,12 +22645,12 @@ superoxide dismutase 3, extracellular - + - + @@ -22855,24 +22658,22 @@ superoxide dismutase 3, extracellular - + - + - + - + - + -

EC 1.5.1.3 - -Dihydrofolate reductase +

interleukin 6 (interferon, beta 2)

@@ -22882,22 +22683,27 @@ Dihydrofolate reductase - + - + - + - + + + + + + @@ -22907,20 +22713,22 @@ Dihydrofolate reductase - + - +
- + -

folate receptor 3 (gamma) +

EC 1.11.1.9 + +Selenoprotein-glutathione peroxidase 3

@@ -22930,12 +22738,7 @@ Dihydrofolate reductase - - - - - - + @@ -22943,24 +22746,22 @@ Dihydrofolate reductase - + - + - + - +
- + -

apolipoprotein A-I - -

+

@@ -22968,12 +22769,12 @@ Dihydrofolate reductase - + - + @@ -22981,24 +22782,22 @@ Dihydrofolate reductase - + - + - + - + - + -

Flavin adenine dinucleotide - -

+

@@ -23006,12 +22805,12 @@ Dihydrofolate reductase - + - + @@ -23021,53 +22820,51 @@ Dihydrofolate reductase - + - + - + -

Adenosine triphosphate - -

+

- - - - - - + - + - + + + + + + - + - + -

Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). +

serum amyloid A3 pseudogene

@@ -23077,57 +22874,17 @@ Dihydrofolate reductase - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + @@ -23135,22 +22892,22 @@ Dihydrofolate reductase - + - + - + - +
- + -

Hypochlorite +

Adenosine diphosphate

@@ -23160,7 +22917,7 @@ Dihydrofolate reductase - + @@ -23170,22 +22927,20 @@ Dihydrofolate reductase - + - +
- + -

EC 3.3.1.1 - -Adenosylhomocysteinase +

Prostaglandin E1

@@ -23195,12 +22950,17 @@ Adenosylhomocysteinase - + - + + + + + + @@ -23208,24 +22968,22 @@ Adenosylhomocysteinase - + - + - + - +
- + -

Prostaglandin E2 - -

+

@@ -23233,17 +22991,7 @@ Adenosylhomocysteinase - - - - - - - - - - - + @@ -23253,17 +23001,17 @@ Adenosylhomocysteinase - + - + - +

@@ -23274,12 +23022,12 @@ Adenosylhomocysteinase - + - + @@ -23289,20 +23037,24 @@ Adenosylhomocysteinase - + - + - + -

+

high-density lipoprotein cholesterol + +Cholesterol transport + +

@@ -23310,17 +23062,12 @@ Adenosylhomocysteinase - - - - - - + - + @@ -23328,26 +23075,22 @@ Adenosylhomocysteinase - + - + - + - +
- + -

EC 2.7.7.2 - -FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - -

+

@@ -23355,17 +23098,22 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + - + + + + + + @@ -23373,22 +23121,24 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + - + - + - + -

10-formyltetrahydrofolate +

EC 3.4.21.7 + +Plasminogen

@@ -23398,12 +23148,12 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + @@ -23411,19 +23161,19 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + - + - +
- +

@@ -23434,7 +23184,12 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + + + + + + @@ -23444,20 +23199,20 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + - + -

Prostaglandin E1 +

EC 1.11.1.6

@@ -23467,17 +23222,17 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + - + @@ -23485,24 +23240,22 @@ FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) - + - + - + - +
- + -

EC 3.4.21.21 - -coagulation factor VII (serum prothrombin conversion accelerator) +

Prostaglandin F2a

@@ -23512,17 +23265,17 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + @@ -23530,22 +23283,24 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + - +
- + -

+

Insulin + +

@@ -23553,17 +23308,22 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + + + + + + @@ -23571,24 +23331,22 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + - +
- + -

interleukin 2 - -

+

@@ -23596,17 +23354,17 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + @@ -23614,22 +23372,22 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + - + - + -

Nicotinamide adenine dinucleotide phosphate-Oxidized +

Nitric oxide

@@ -23639,7 +23397,27 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + + + + + + + + + + + + + + + + + + + + + @@ -23649,22 +23427,22 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - +
- + -

EC 1.11.1.9 +

alpha-1-antichymotrypsin -Selenoprotein-glutathione peroxidase 3 +serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

@@ -23674,7 +23452,17 @@ Selenoprotein-glutathione peroxidase 3 - + + + + + + + + + + + @@ -23684,22 +23472,20 @@ Selenoprotein-glutathione peroxidase 3 - + - +
- + -

high-density lipoprotein cholesterol - -Cholesterol transport +

apolipoprotein B

@@ -23709,12 +23495,12 @@ Cholesterol transport - + - + @@ -23722,22 +23508,24 @@ Cholesterol transport - + - + - + - +
- + -

+

high-density lipoprotein + +

@@ -23745,7 +23533,17 @@ Cholesterol transport - + + + + + + + + + + + @@ -23753,26 +23551,22 @@ Cholesterol transport - + - + - + - +
- + -

EC 1.11.1.9 - -Selenoprotein-glutathione peroxidase 6 - -

+

@@ -23780,7 +23574,7 @@ Selenoprotein-glutathione peroxidase 6 - + @@ -23788,22 +23582,26 @@ Selenoprotein-glutathione peroxidase 6 - + - + - + - + - + -

+

EC 2.1.2.2 + +phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase + +

@@ -23811,7 +23609,17 @@ Selenoprotein-glutathione peroxidase 6 - + + + + + + + + + + + @@ -23819,22 +23627,24 @@ Selenoprotein-glutathione peroxidase 6 - + - + - + - +
- + -

+

5,10-Methylenetetrahydrofolate + +

@@ -23842,17 +23652,17 @@ Selenoprotein-glutathione peroxidase 6 - + - + - + @@ -23862,20 +23672,20 @@ Selenoprotein-glutathione peroxidase 6 - + - +
- + -

folate receptor 1 (adult) +

interleukin 4

@@ -23885,12 +23695,12 @@ Selenoprotein-glutathione peroxidase 6 - + - + @@ -23898,50 +23708,59 @@ Selenoprotein-glutathione peroxidase 6 - + - + - + - +
- + -

+

very-low-density lipoprotein-triglyceride + +Triglyceride transport + +

+ + + + + + + + + + - - - - - - + - + - + - +
- +

@@ -23952,22 +23771,27 @@ Selenoprotein-glutathione peroxidase 6 - + - + - + - + + + + + + @@ -23975,24 +23799,22 @@ Selenoprotein-glutathione peroxidase 6 - + - + - + - + - + -

EC 2.7.1.26 - -riboflavin kinase +

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

@@ -24002,12 +23824,12 @@ riboflavin kinase - + - + @@ -24017,22 +23839,20 @@ riboflavin kinase - + - +
- + -

5-methyltetrahydrofolate - -Predominant food folate +

serum amyloid A4, constitutive

@@ -24042,7 +23862,17 @@ Predominant food folate - + + + + + + + + + + + @@ -24050,22 +23880,24 @@ Predominant food folate - + - + - + - +
- + -

+

Superoxide + +

@@ -24073,47 +23905,7 @@ Predominant food folate - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + @@ -24123,20 +23915,24 @@ Predominant food folate - + - +
- + -

+

high-density lipoprotein + +ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles + +

@@ -24144,12 +23940,12 @@ Predominant food folate - + - + @@ -24159,20 +23955,20 @@ Predominant food folate - + - +
- + -

Prostaglandin E1 +

Vitamin B6

@@ -24182,12 +23978,22 @@ Predominant food folate - + - + + + + + + + + + + + @@ -24197,22 +24003,24 @@ Predominant food folate - + - +
- + -

EC 2.5.1.6 +

EC 1.5.1.20 -Methionine adenosyltransferase +5,10-methylenetetrahydrofolate reductase + +Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia

@@ -24222,12 +24030,17 @@ Methionine adenosyltransferase - + - + + + + + + @@ -24237,20 +24050,22 @@ Methionine adenosyltransferase - + - +
- + -

+

Prostaglandin E2 + +

@@ -24258,17 +24073,17 @@ Methionine adenosyltransferase - + - + - + @@ -24278,20 +24093,20 @@ Methionine adenosyltransferase - + - +
- + -

very-low-density lipoprotein +

formylglycinamide ribonucleotide

@@ -24301,17 +24116,17 @@ Methionine adenosyltransferase - + - + - + @@ -24321,20 +24136,20 @@ Methionine adenosyltransferase - + - +
- + -

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 +

Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).

@@ -24344,12 +24159,57 @@ Methionine adenosyltransferase - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -24357,22 +24217,24 @@ Methionine adenosyltransferase - + - + - + - +
- + -

interleukin 2 +

EC 2.1.2.1 + +Serine hydroxymethyltransferase 1 (soluble)

@@ -24382,17 +24244,45 @@ Methionine adenosyltransferase - + - + + + + + + + + + + + + + + + + + +
+ + + +

nuclear factor NF-kappa-B p50 subunit + +

+ +
+ + + - + @@ -24400,30 +24290,39 @@ Methionine adenosyltransferase - + - + - + - +
- + -

+

EC 2.5.1.6 + +Methionine adenosyltransferase + +

- + + + + + + - + @@ -24431,34 +24330,34 @@ Methionine adenosyltransferase - + - + - + - +
- +

EC 1.15.1.1 -superoxide dismutase 1, soluble +superoxide dismutase 2, mitochondrial

- + - + @@ -24466,42 +24365,44 @@ superoxide dismutase 1, soluble - + - + - + - +
- + -

formylglycinamide ribonucleotide +

EC 3.4.21.5 + +coagulation factor II (thrombin)

- + - + - + - + @@ -24509,42 +24410,52 @@ superoxide dismutase 1, soluble - + - + - + - +
- + -

serum amyloid A2 +

oxidized low-density lipoprotein

- + - + - + - + + + + + + + + + + + @@ -24552,19 +24463,19 @@ superoxide dismutase 1, soluble - + - + - + - +
- +

@@ -24572,10 +24483,10 @@ superoxide dismutase 1, soluble - + - + @@ -24583,44 +24494,44 @@ superoxide dismutase 1, soluble - + - + - + - + - + -

EC 3.4.21.5 +

EC 1.5.1.5 -coagulation factor II (thrombin) +methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1

- + - + - + - + @@ -24630,63 +24541,35 @@ coagulation factor II (thrombin) - + - +
- + -

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 +

5-Formyltetrahydrofolate

- + - + - - - - - - - - - - - - - - - - -
- - - -

Nitrous acid - -

- -
- - - - + @@ -24696,17 +24579,17 @@ coagulation factor II (thrombin) - + - +
- +

@@ -24717,7 +24600,7 @@ coagulation factor II (thrombin) - + @@ -24737,20 +24620,20 @@ coagulation factor II (thrombin) - + - + - + -

http://en.wikipedia.org/wiki/Fibrin_degradation_product +

Flavin Mononucleotide

@@ -24760,17 +24643,12 @@ coagulation factor II (thrombin) - - - - - - + - + @@ -24778,24 +24656,22 @@ coagulation factor II (thrombin) - + - + - + - +
- + -

Nitric oxide - -

+

@@ -24803,27 +24679,12 @@ coagulation factor II (thrombin) - - - - - - - - - - - - - - - - + - + @@ -24831,22 +24692,26 @@ coagulation factor II (thrombin) - + - + - + - + - + -

+

EC 1.11.1.9 + +Selenoprotein-glutathione peroxidase 3 + +

@@ -24854,17 +24719,7 @@ coagulation factor II (thrombin) - - - - - - - - - - - + @@ -24872,24 +24727,22 @@ coagulation factor II (thrombin) - + - + - + - +
- + -

EC 2.1.2.2 - -phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase +

apolipoprotein A-I

@@ -24899,17 +24752,12 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - - - - - - + - + @@ -24919,20 +24767,22 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - +
- + -

+

interleukin 2 + +

@@ -24940,17 +24790,17 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + @@ -24958,22 +24808,24 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + - +
- + -

+

high-density lipoprotein + +

@@ -24981,12 +24833,17 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + + + + + + @@ -24996,22 +24853,20 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - +
- + -

Reduced cobalamin - -

+

@@ -25019,22 +24874,17 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - - - - - - + - + - + @@ -25044,45 +24894,32 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + -

Vitamin B6 - -

- -
- - - - - - - - - - - - - - - - - - +

5-methyltetrahydrofolate + +Predominant food folate + +

+ +
+ + + - + @@ -25092,20 +24929,20 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + -

glycinamide ribonucleotide +

low-density lipoprotein

@@ -25115,17 +24952,32 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + + + + + + + + + + + + + + + + @@ -25135,17 +24987,17 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - +
- +

@@ -25154,34 +25006,32 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - - - - - - + - + - + + + + + + - + - + -

Nitric oxide - -

+

@@ -25189,17 +25039,47 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -25209,20 +25089,20 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + -

apolipoprotein B +

hemoglobin, beta

@@ -25232,12 +25112,12 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + @@ -25247,17 +25127,17 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - +
- +

@@ -25268,7 +25148,27 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + + + + + + + + + + + + + + + + + + + + + @@ -25278,20 +25178,24 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + -

soluble intercellular adhesion molecule 1 +

EC 2.1.1.13 + +5-methyltetrahydrofolate-homocysteine methyltransferase + +Also known as MS

@@ -25301,22 +25205,27 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - + - + - + + + + + + @@ -25326,20 +25235,22 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - +
- + -

+

(11R)-hydroxymethylenetetrahydrofolate + +

@@ -25347,7 +25258,7 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + @@ -25357,26 +25268,20 @@ phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetas - + - +
- + -

EC 1.5.1.20 - -5,10-methylenetetrahydrofolate reductase - -Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia - -

+

@@ -25384,17 +25289,17 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + - + @@ -25402,22 +25307,26 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + - + - + - + -

+

5-methyltetrahydrofolate + +Predominant food folate + +

@@ -25425,7 +25334,7 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + @@ -25433,6 +25342,11 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower + + + + +
@@ -25440,20 +25354,22 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + - + -

+

Reduced cobalamin + +

@@ -25461,12 +25377,22 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + + + + + + + + + + + @@ -25476,12 +25402,12 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + @@ -25512,22 +25438,20 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - +
- + -

low-density lipoprotein - -

+

@@ -25535,32 +25459,17 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - - - - - - - - - - - - - - - - + - + - + @@ -25570,20 +25479,24 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + - + -

+

Monocyte Chemotactic Protein 1 + +CCL2 + +

@@ -25591,12 +25504,12 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + @@ -25604,22 +25517,24 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + - + - +
- + -

+

nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 + +

@@ -25627,7 +25542,7 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + @@ -25635,22 +25550,24 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + - + - +
- + -

+

Reduced cobalamin + +

@@ -25658,12 +25575,22 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - + + + + + + + + + + + @@ -25673,22 +25600,22 @@ Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower - + - +
- + -

Triglyceride +

EC 1.15.1.1 -Triacylglycerol +superoxide dismutase 3, extracellular

@@ -25698,12 +25625,7 @@ Triacylglycerol - - - - - - + @@ -25711,26 +25633,22 @@ Triacylglycerol
- + - + - + - + - + -

alpha-1-antichymotrypsin - -serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 - -

+

@@ -25738,17 +25656,17 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + @@ -25756,22 +25674,24 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - + - + -

+

C-reactive protein, pentraxin-related + +

@@ -25779,12 +25699,37 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -25792,22 +25737,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

interleukin 1, beta +

apolipoprotein A-I

@@ -25817,12 +25762,12 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + @@ -25832,20 +25777,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - +
- + -

+

colony stimulating factor 1 (macrophage) + +

@@ -25853,17 +25800,12 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - - - - - - + - + @@ -25871,22 +25813,24 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

5-Formyltetrahydrofolate +

EC 1.11.1.12 + +Selenoprotein-glutathione peroxidase 4

@@ -25896,12 +25840,7 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - - - - - - + @@ -25909,24 +25848,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

solute carrier family 19 (folate transporter), member 1 - -

+

@@ -25934,12 +25871,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + + + + + + + + + + + @@ -25947,22 +25894,24 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - + - + -

+

ATP-binding cassette, sub-family A (ABC1), member 1 + +

@@ -25970,12 +25919,17 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + + + + + + @@ -25983,22 +25937,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

apolipoprotein A-I +

Synthetic folate

@@ -26008,12 +25962,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + + + + + + + + + + + @@ -26021,26 +25985,22 @@ serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), membe - + - + - + - +
- + -

EC 3.4.21.21 - -coagulation factor VII (serum prothrombin conversion accelerator) - -

+

@@ -26048,17 +26008,12 @@ coagulation factor VII (serum prothrombin conversion accelerator) - - - - - - + - + @@ -26066,67 +26021,53 @@ coagulation factor VII (serum prothrombin conversion accelerator) - + - + - + - + - + -

serum amyloid A3 pseudogene - -

+

- - - - - - - - - - - - - - - - + - + - + + + + + + - + - + -

EC 1.15.1.1 - -superoxide dismutase 3, extracellular +

Prostaglandin F2a

@@ -26136,7 +26077,17 @@ superoxide dismutase 3, extracellular - + + + + + + + + + + + @@ -26144,22 +26095,22 @@ superoxide dismutase 3, extracellular - + - + - + - +
- + -

(11R)-hydroxymethylenetetrahydrofolate +

Synthetic folate

@@ -26169,7 +26120,22 @@ superoxide dismutase 3, extracellular - + + + + + + + + + + + + + + + + @@ -26179,20 +26145,20 @@ superoxide dismutase 3, extracellular - + - +
- + -

tumor necrosis factor (TNF superfamily, member 2) +

glycinamide ribonucleotide

@@ -26202,12 +26168,17 @@ superoxide dismutase 3, extracellular - + + + + + + - + @@ -26215,19 +26186,19 @@ superoxide dismutase 3, extracellular - + - + - + - +
- +

@@ -26236,32 +26207,39 @@ superoxide dismutase 3, extracellular + + + + + + + + + + - - - - - - + - + - + - + - + -

+

(11S)-hydroxymethylenetetrahydrofolate + +

@@ -26269,12 +26247,7 @@ superoxide dismutase 3, extracellular - - - - - - + @@ -26284,20 +26257,22 @@ superoxide dismutase 3, extracellular - + - +
- + -

+

tumor necrosis factor (TNF superfamily, member 2) + +

@@ -26305,17 +26280,27 @@ superoxide dismutase 3, extracellular - + - + - + + + + + + + + + + + @@ -26323,24 +26308,22 @@ superoxide dismutase 3, extracellular - + - + - + - +
- + -

interleukin 4 - -

+

@@ -26348,12 +26331,12 @@ superoxide dismutase 3, extracellular - + - + @@ -26361,22 +26344,24 @@ superoxide dismutase 3, extracellular - + - + - + - + - + -

serum amyloid A1 +

Triglyceride + +Triacylglycerol

@@ -26386,17 +26371,12 @@ superoxide dismutase 3, extracellular - - - - - - + - + @@ -26404,24 +26384,22 @@ superoxide dismutase 3, extracellular - + - + - + - +
- + -

Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). - -

+

@@ -26429,12 +26407,7 @@ superoxide dismutase 3, extracellular - - - - - - + @@ -26444,22 +26417,20 @@ superoxide dismutase 3, extracellular - + - + - + -

EC 1.15.1.1 - -superoxide dismutase 2, mitochondrial +

interferon, gamma

@@ -26469,7 +26440,12 @@ superoxide dismutase 2, mitochondrial - + + + + + + @@ -26477,24 +26453,22 @@ superoxide dismutase 2, mitochondrial - + - + - + - +
- + -

high-density lipoprotein cholesterol - -Cholesterol transport +

Nitrous acid

@@ -26504,12 +26478,7 @@ Cholesterol transport - - - - - - + @@ -26519,22 +26488,20 @@ Cholesterol transport - + - +
- + -

interferon, gamma - -

+

@@ -26542,12 +26509,12 @@ Cholesterol transport - + - + @@ -26555,19 +26522,19 @@ Cholesterol transport - + - + - + - + - +

@@ -26578,17 +26545,17 @@ Cholesterol transport - + - + - + @@ -26596,14 +26563,14 @@ Cholesterol transport - + - + - + - + @@ -26636,20 +26603,20 @@ Cholesterol transport - + - + - + -

Tetrahydrofolic acid +

Insulin receptor

@@ -26659,12 +26626,17 @@ Cholesterol transport - + - + + + + + + @@ -26672,22 +26644,24 @@ Cholesterol transport - + - + - + - +
- + -

+

10-formyltetrahydrofolate + +

@@ -26695,7 +26669,12 @@ Cholesterol transport - + + + + + + @@ -26703,26 +26682,22 @@ Cholesterol transport - + - + - + - +
- + -

EC 2.1.1.13 - -5-methyltetrahydrofolate-homocysteine methyltransferase - -Also known as MS +

Adenosine triphosphate

@@ -26732,27 +26707,7 @@ Also known as MS - - - - - - - - - - - - - - - - - - - - - + @@ -26760,26 +26715,22 @@ Also known as MS - + - + - + - +
- + -

high-density lipoprotein - -ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles - -

+

@@ -26787,12 +26738,12 @@ ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of - + - + @@ -26802,22 +26753,22 @@ ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of - + - + - + -

EC 3.5.4.9 +

EC 1.11.1.9 -methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase +Selenoprotein-glutathione peroxidase 1

@@ -26827,12 +26778,7 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - - - - - - + @@ -26840,22 +26786,22 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + - + - +
- + -

Insulin +

folate receptor 1 (adult)

@@ -26865,22 +26811,12 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - - - - - - - - - - - + - + @@ -26888,22 +26824,24 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + - + - +
- + -

+

low density lipoprotein receptor + +

@@ -26911,7 +26849,12 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + + + + + + @@ -26919,22 +26862,22 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + - + - +
- + -

5,10-Methenyltetrahydrofolic acid +

tumor protein p53

@@ -26944,12 +26887,37 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -26957,24 +26925,22 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + - + - +
- + -

hemoglobin, beta - -

+

@@ -26982,12 +26948,7 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - - - - - - + @@ -26995,22 +26956,24 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + - + - + - + -

albumin +

EC 3.5.4.9 + +methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

@@ -27020,12 +26983,12 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - + @@ -27035,22 +26998,20 @@ methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrof - + - +
- + -

EC 4.2.1.22 - -cystathionine-beta-synthase +

tumor necrosis factor (TNF superfamily, member 2)

@@ -27060,17 +27021,12 @@ cystathionine-beta-synthase - - - - - - + - + @@ -27080,22 +27036,22 @@ cystathionine-beta-synthase - + - +
- + -

Monocyte Chemotactic Protein 1 +

EC 2.7.1.26 -CCL2 +riboflavin kinase

@@ -27105,12 +27061,12 @@ CCL2 - + - + @@ -27118,22 +27074,24 @@ CCL2 - + - + - + - +
- + -

low density lipoprotein receptor +

very-low-density lipoprotein-triglyceride + +Triglyceride transport

@@ -27143,12 +27101,12 @@ CCL2 - + - + @@ -27156,24 +27114,22 @@ CCL2 - + - + - + - +
- + -

Nitric oxide synthase - -

+

@@ -27181,12 +27137,12 @@ CCL2 - + - + @@ -27194,19 +27150,19 @@ CCL2 - + - + - + - + - +

@@ -27217,7 +27173,17 @@ CCL2 - + + + + + + + + + + + @@ -27225,22 +27191,26 @@ CCL2 - + - + - + - + - + -

+

EC 3.4.21.5 + +coagulation factor II (thrombin) + +

@@ -27248,7 +27218,17 @@ CCL2 - + + + + + + + + + + + @@ -27256,22 +27236,22 @@ CCL2 - + - + - + - +
- + -

Glutathione disulfide +

Nitrotyrosinated apolipoprotein A-I

@@ -27281,7 +27261,12 @@ CCL2 - + + + + + + @@ -27289,22 +27274,24 @@ CCL2 - + - + - + - +
- + -

+

albumin + +

@@ -27312,12 +27299,12 @@ CCL2 - + - + @@ -27325,19 +27312,19 @@ CCL2 - + - + - + - +
- +

@@ -27348,7 +27335,7 @@ CCL2 - + @@ -27356,22 +27343,26 @@ CCL2 - + - + - + - + - + -

+

high-density lipoprotein + +SAA circulates in plasma as a constituent of high density lipoproteins (HDL). + +

@@ -27379,55 +27370,22 @@ CCL2 - - - - - - + - - - - - - - - - - - - - - - - -
- - - -

EC 1.11.1.6 - -

- -
- - - - + - + - + @@ -27435,37 +27393,39 @@ CCL2 - + - + - + - +
- + -

colony stimulating factor 1 (macrophage) +

EC 4.4.1.1 + +cystathionase

- + - + - + @@ -27475,42 +27435,43 @@ CCL2 - + - +
- + - -

EC 3.4.21.5 - -coagulation factor II (thrombin) - -

+ +

- + - + - + - + + + + + + @@ -27518,47 +27479,42 @@ coagulation factor II (thrombin) - + - + - + - + - + -

Synthetic folate +

oxidized cobalamin

- - - - - - + - + - + - + @@ -27568,40 +27524,40 @@ coagulation factor II (thrombin) - + - +
- + -

Prostaglandin E2 +

serum amyloid A1

- + - + - + - + @@ -27609,19 +27565,19 @@ coagulation factor II (thrombin) - + - + - + - +
- +

@@ -27629,48 +27585,43 @@ coagulation factor II (thrombin) - - - - - - - - - - - + - + - + - + - + + + + + + - + -

(11S)-hydroxymethylenetetrahydrofolate +

Nitrogen dioxide

- + - + @@ -27680,50 +27631,80 @@ coagulation factor II (thrombin) - + - +
- + -

oxidized low-density lipoprotein +

EC 3.4.21.21 + +coagulation factor VII (serum prothrombin conversion accelerator)

- + - + - + - + + + + + + + + + + + + + + + + + +
+ + + +

colony stimulating factor 1 (macrophage) + +

+ +
+ + + - + - + @@ -27731,22 +27712,24 @@ coagulation factor II (thrombin) - + - + - + - +
- + -

solute carrier family 46 (folate transporter), member 1 +

EC 1.15.1.1 + +superoxide dismutase 3, extracellular

@@ -27756,12 +27739,7 @@ coagulation factor II (thrombin) - - - - - - + @@ -27769,22 +27747,26 @@ coagulation factor II (thrombin) - + - + - + - +
- + -

+

reactive nitrogen species + +http://en.wikipedia.org/wiki/Reactive_nitrogen_species + +

@@ -27792,22 +27774,17 @@ coagulation factor II (thrombin) - - - - - - + - + - + @@ -27817,22 +27794,22 @@ coagulation factor II (thrombin) - + - +
- + -

EC 1.11.1.9 +

EC 1.11.1.7 -Selenoprotein-glutathione peroxidase 2 +Myeloperoxidase

@@ -27842,7 +27819,27 @@ Selenoprotein-glutathione peroxidase 2 - + + + + + + + + + + + + + + + + + + + + + @@ -27850,22 +27847,22 @@ Selenoprotein-glutathione peroxidase 2 - + - + - + - +
- + -

Nicotinamide adenine dinucleotide phosphate-Reduced +

interleukin 2

@@ -27875,7 +27872,17 @@ Selenoprotein-glutathione peroxidase 2 - + + + + + + + + + + + @@ -27883,22 +27890,24 @@ Selenoprotein-glutathione peroxidase 2 - + - + - + - +
- + -

+

http://en.wikipedia.org/wiki/Fibrin_degradation_product + +

@@ -27906,12 +27915,17 @@ Selenoprotein-glutathione peroxidase 2 - + - + + + + + + @@ -27919,24 +27933,22 @@ Selenoprotein-glutathione peroxidase 2 - + - + - + - +
- + -

very-low-density lipoprotein-triglyceride - -Triglyceride transport +

scavenger receptor class B, member 1

@@ -27946,12 +27958,12 @@ Triglyceride transport - + - + @@ -27959,24 +27971,22 @@ Triglyceride transport - + - + - + - +
- + -

http://en.wikipedia.org/wiki/Fibrin_degradation_product - -

+

@@ -27984,17 +27994,22 @@ Triglyceride transport - + - + - + + + + + + @@ -28002,22 +28017,22 @@ Triglyceride transport - + - + - + - + - + -

ozone +

solute carrier family 46 (folate transporter), member 1

@@ -28027,7 +28042,12 @@ Triglyceride transport - + + + + + + @@ -28035,22 +28055,26 @@ Triglyceride transport - + - + - + - +
- + -

+

Glycated hemoglobin + +http://en.wikipedia.org/wiki/Glycated_hemoglobin + +

@@ -28058,7 +28082,7 @@ Triglyceride transport - + @@ -28066,24 +28090,22 @@ Triglyceride transport - + - + - + - +
- + -

high-density lipoprotein - -SAA circulates in plasma as a constituent of high density lipoproteins (HDL). +

interleukin 6 (interferon, beta 2)

@@ -28093,22 +28115,17 @@ SAA circulates in plasma as a constituent of high density lipoproteins (HDL). - - - - - - + - + - + @@ -28116,22 +28133,22 @@ SAA circulates in plasma as a constituent of high density lipoproteins (HDL). - + - + - + - +
- + -

tumor necrosis factor (TNF superfamily, member 2) +

Peroxynitrite

@@ -28141,27 +28158,7 @@ SAA circulates in plasma as a constituent of high density lipoproteins (HDL). - - - - - - - - - - - - - - - - - - - - - + @@ -28169,24 +28166,22 @@ SAA circulates in plasma as a constituent of high density lipoproteins (HDL). - + - + - + - +
- + -

Glycated hemoglobin - -http://en.wikipedia.org/wiki/Glycated_hemoglobin +

Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).

@@ -28196,7 +28191,12 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + + + + + + @@ -28204,65 +28204,86 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +
- + -

From intracellular part to the plasma - -

+

- + - + - + - + -

From intracellular part to the plasma +

+ + + + + + + + + + + + + + + + + + + + + + +

is composed of

- + - + - +
- +

@@ -28270,23 +28291,22 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - - + - + - +

From intracellular part to the plasma @@ -28296,19 +28316,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -28316,59 +28336,63 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

is composed of + +

- + - + - +
- + -

+

is composed of + +

- + - + - +
- +

From intracellular part to the plasma @@ -28378,63 +28402,70 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + + - + + + + + - + -

From intracellular part to the plasma - -

+

- + - + + - + + + + + + - +

@@ -28442,19 +28473,26 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + + - + + + + + + + - +

@@ -28462,19 +28500,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -28482,22 +28520,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + + + +

From intracellular part to the plasma + +

+ +
+ + + + + + + + + + + + - - -
- +

From intracellular part to the plasma @@ -28507,41 +28564,39 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of - -

+

- + - + - + - +

is composed of @@ -28551,19 +28606,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

is composed of @@ -28573,103 +28628,109 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of - -

+

- + - + - + + + + - + -

From intracellular part to the plasma - -

+

- + - + - + + + + - + -

+

is composed of + +

- + - + - +
- + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -28677,22 +28738,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - +

@@ -28700,41 +28758,44 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + - + -

is composed of +

From intracellular part to the plasma

- + - + - +
- +

@@ -28742,47 +28803,40 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - - + - - + - - - - - + -

From intracellular part to the plasma - -

+

- + - + - + + - +

@@ -28790,19 +28844,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -28810,19 +28864,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

is composed of @@ -28832,41 +28886,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of +

From intracellular part to the plasma

- + - + - +
- +

@@ -28874,103 +28928,105 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

From intracellular part to the plasma - -

+

- + - + - + - +

@@ -28978,91 +29034,86 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + - + -

From intracellular part to the plasma +

is composed of

- + - + - +
- + -

+

is composed of + +

- + - - + - - + - - -
- + -

From intracellular part to the plasma - -

+

- + - + - + - - - - +

is composed of @@ -29072,64 +29123,61 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - + - - -
- +

@@ -29137,41 +29185,46 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + + + - + -

is composed of +

From intracellular part to the plasma

- + - + - +
- +

@@ -29179,42 +29232,44 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -29222,19 +29277,24 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + + - + + + + + - +

From intracellular part to the plasma @@ -29244,19 +29304,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -29264,24 +29324,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - - + - - + - - - - +

is composed of @@ -29291,42 +29346,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

is composed of + +

- + - + - + - - -
- +

From intracellular part to the plasma @@ -29336,39 +29390,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - - - - - - - - - - - - - - - -

- - - - - + - + - + - +

@@ -29376,67 +29410,69 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + - + -

is composed of +

From intracellular part to the plasma

- + - + - +
- + -

+

From intracellular part to the plasma + +

- + - + - + - +
- +

@@ -29444,19 +29480,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -29464,24 +29500,22 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - + - +

@@ -29489,83 +29523,87 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + + + + - + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

is composed of - -

+

- + - + - + + + + - +

@@ -29573,66 +29611,61 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - - + - - + - - -
- + -

From intracellular part to the plasma - -

+

- + - + - + - +

@@ -29640,39 +29673,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -29680,24 +29715,25 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - - + + - - + + - + + - +

@@ -29705,65 +29741,63 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - - + -

From intracellular part to the plasma +

is composed of

- + - + - +
- + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -29771,19 +29805,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -29793,105 +29827,105 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

From intracellular part to the plasma +

is composed of

- + - + - +
- + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

is composed of +

From intracellular part to the plasma

- + - + - +
- +

@@ -29899,26 +29933,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - - + - - + - - - - - - +

@@ -29926,16 +29953,16 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + @@ -29954,57 +29981,59 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

is composed of - -

+

- + - + + - + + + + + + - +

@@ -30012,44 +30041,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - + -

is composed of +

From intracellular part to the plasma

- + - + - +
- +

@@ -30057,19 +30083,23 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + + - +

@@ -30077,19 +30107,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -30099,19 +30129,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -30121,82 +30151,63 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - - - - - - - - - - - - - - - -

- - - - - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

+

is composed of + +

- + - + - + - - -
- +

@@ -30204,19 +30215,24 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + + - + + + + + - +

@@ -30224,63 +30240,61 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma +

is composed of

- + - + - +
- + -

From intracellular part to the plasma - -

+

- + - + - + - +

@@ -30288,130 +30302,128 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - + - - -
- + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

From intracellular part to the plasma - -

+

- + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -30419,22 +30431,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - +

@@ -30442,47 +30451,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - - + - - + - - - - - + -

is composed of +

From intracellular part to the plasma

- + - + - +
- +

@@ -30490,19 +30493,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

is composed of @@ -30512,41 +30515,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - - - +
- +

From intracellular part to the plasma @@ -30556,7 +30559,7 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + @@ -30565,10 +30568,10 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - +

@@ -30576,19 +30579,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -30598,61 +30601,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma +

is composed of

- - - - - - - - - - - -
- - - -

- - - - - + - + - + - +

From intracellular part to the plasma @@ -30662,19 +30645,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

is composed of @@ -30684,19 +30667,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -30706,41 +30689,39 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - +

@@ -30748,59 +30729,63 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

is composed of + +

- + - + - +
- + -

+

is composed of + +

- + - + - +
- +

From intracellular part to the plasma @@ -30810,19 +30795,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -30832,19 +30817,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -30852,68 +30837,63 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - - - - + -

+

From intracellular part to the plasma + +

- + - + - + - - -
- + -

+

is composed of + +

- + - + - +
- +

@@ -30921,22 +30901,24 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + + - + + - + - +

@@ -30944,22 +30926,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - +

From intracellular part to the plasma @@ -30969,66 +30948,61 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of - -

+

- + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - + - - - - -
- +

@@ -31036,42 +31010,46 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + + + - + -

+

is composed of + +

- + - + - +
- +

@@ -31079,41 +31057,39 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - +

@@ -31121,63 +31097,59 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

is composed of - -

+

- + - + - + - +

@@ -31185,22 +31157,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - - - - +

@@ -31208,63 +31177,61 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

From intracellular part to the plasma +

is composed of

- + - + - +
- +

@@ -31272,61 +31239,64 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of - -

+

- + - + - + + + + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -31334,39 +31304,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -31374,19 +31346,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -31396,19 +31368,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -31418,19 +31390,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -31438,19 +31410,22 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + - +

From intracellular part to the plasma @@ -31460,7 +31435,7 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + @@ -31469,141 +31444,140 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + -

+

is composed of + +

- + - + - +
- + -

From intracellular part to the plasma - -

+

- + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - + - - -
- + -

is composed of +

From intracellular part to the plasma

- + - + - +
- + -

is composed of - -

+

- + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + + + + + - +

@@ -31611,20 +31585,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - - + - +

From intracellular part to the plasma @@ -31634,41 +31607,43 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + + + + + - +

is composed of @@ -31678,19 +31653,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -31698,19 +31673,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -31720,19 +31695,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + + + +

is composed of + +

+ +
+ + + + + + + + + + + + + +
+

@@ -31740,47 +31737,48 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - - + - - + - - + - + -

is composed of - -

+

- + - + - + + + + + + + - +

From intracellular part to the plasma @@ -31790,63 +31788,62 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of - -

+

- + - + - + - + -

is composed of - -

+

- + - + - + + + + - +

@@ -31854,59 +31851,63 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- + -

+

From intracellular part to the plasma + +

- + - + - +
- +

From intracellular part to the plasma @@ -31916,19 +31917,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -31936,41 +31937,39 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

is composed of - -

+

- + - + - + - +

From intracellular part to the plasma @@ -31980,63 +31979,64 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma +

is composed of

- + - + - +
- + -

From intracellular part to the plasma - -

+

- + - + - + + + + - +

@@ -32044,63 +32044,59 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - + -

From intracellular part to the plasma - -

+

- + - + - + - +

From intracellular part to the plasma @@ -32110,19 +32106,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -32132,19 +32128,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -32152,22 +32148,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - - - - +

From intracellular part to the plasma @@ -32177,19 +32170,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

@@ -32197,19 +32190,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -32219,19 +32212,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -32241,19 +32234,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

is composed of @@ -32263,39 +32256,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

From intracellular part to the plasma @@ -32305,19 +32300,19 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - +

From intracellular part to the plasma @@ -32327,39 +32322,41 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + - + -

+

From intracellular part to the plasma + +

- + - + - +
- +

@@ -32367,19 +32364,22 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + + + + - +

@@ -32387,16 +32387,16 @@ http://en.wikipedia.org/wiki/Glycated_hemoglobin - + - + - + diff --git a/sbml/WP176.svg b/sbml/WP176.svg index 6ec14a7..04d769d 100644 --- a/sbml/WP176.svg +++ b/sbml/WP176.svg @@ -8,76 +8,18 @@ />???Group objectGroup object?f5240??Group object??f5240????Group object????????????????????????????????????????????????????????b3e4b???????????b3e4b???????? Glycogenesis Group objectMethylation reactions NFKB1MCP1PGE1Thromboxane B2PGF2aSLC19A1PGE2PGE1p53PGF2aFOLR3Thromboxane B2SLC19A1F2-IsoprostaneNFKB1Thromboxane A2MCP1SLC46A1PGE2PGF2a8-Isoprostaglandin F2aFOLR4p538-Isoprostaglandin F2aFOLR2RELAPGF2aF2-IsoprostaneFOLR3MCP1PGE18-Isoprostaglandin F2aPGE1PGE2RELAFOLR4FOLR1F2-IsoprostaneThromboxane A2Thromboxane B2MTR*MTHFD1*MTHFD2DHFRMSR*MATSHMTMTHFD2MTR*AHCYMATMTHFD1*MSR*CBSNADP+NADP+NADP+NADP+NADP+NADP+NADP+MPOCatalaseNOSMPOCatalaseCysteineThrombinFactor VIItPAPLGPAI-1PLGThrombinPLGThrombinPAI-1Factor VIItPAPLGtPAtPAFactor VIIH2O2FGAR(11S)-hydroxymethylene-THF5-Formyl-THF(11R)-hydroxymethylene-THFGAR5,10-Methenyl-THF5,10-Methylene-THFGAR(11S)-hydroxymethylene-THFFGAR(11R)-hydroxymethylene-THFDihydrofolate10-Formyl-THF5,10-Methylene-THFDihydrofolate5-Formyl-THF5,10-Methenyl-THF5-methyl-THF10-Formyl-THFFolateFolate5-methyl-THFH2OGPX 3GPX 3THFNADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX 6ManganeseManganeseFolic acidFolic acidMTHFSMTHFR*GARTMTHFR*SHMTHomocysteineHomocysteineSOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphateL-ArgininePyridoxal 5'-phosphateSerineGlycineGlycineGlycineL-ArginineTAGHDL/APOA1CholesterolTAGHDLoxLDLVLDL-TAGAPOBCholesterolAPOBLDLRHDLVLDL-TAGSAA3FMNHDLAPOA1HDL-CHDL-CVLDLSAA4TAGLDLoxLDLLDLHDL-CAPOBVLDL/APOBHDL/SAAFMNACTLDLHDLSRB1ABCA1SAA4SAA2APOBLDLAPOA1-NO2TyrCholesterolACTVLDLAPOA1VLDLAPOA1-NO2TyrAPOA1oxLDLSAA3HDL-CVLDL-TAGVLDL/APOBVLDLSAA1oxLDLHDL/SAASRB1ACTACTHDL/APOA1TAGABCA1O2Cob(II)alaminCob(I)alaminFAD8-OHdG8-OHdGCob(I)alaminFADCob(I)alaminFADCob(II)alamin8-OHdGADPADPADPMagnesiumChlorineChlorineChlorineMagnesiumZincZincO3HOClZincHNO2ZincNOHOClNOHNO2NO2O3sICAM-1FibrinogenIL10D-dimerIL4TNFaD-dimerCSF1IFNgHBBHbA1cINSIL1BIL2INSRIL6IL10TNFaFibrinogenIL6FibrinCRPsICAM-1HBBHbA1cHbA1cIFNgFibrinHBA1IL6IL10TNFaHbA1cALBIL4FibrinCRPIFNgD-dimerINSIL1BHBA1FibrinogenCSF1INSALBIL4ALBCSF1D-dimerALBTNFaIL2INSFibrinCSF1IL4FibrinogenIL1BIL2IL6O2Methionine S-Adenosylhomocysteine S-Adenosylmethionine S-AdenosylhomocysteineMethionine S-Adenosylmethionine S-AdenosylmethionineMethionine S-Adenosylhomocysteine S-AdenosylhomocysteineONOO/ONOOHNitrotyrosineTetrahydrobiopterinNitrotyrosineATPNitrotyrosineATPFructosamineATPGlucoseGlucoseFructosamineFructosamineGlucoseFGGSelenoproteinsNecessary stimulationConversionTranscription factorCleavageProtein*LEGENDPlasmaBiomarker for + +is composed ofNegative Effect Negative EffectMicronutrientsCofactor conversionSelenoproteinsOverarching processLipoprotein melabolismis composed of + +is composed ofProstaglandins metabolismOther proteinsProtein tyrosine nitrationStimulationProtein with polymorphism is composed ofBindingReactionSelenium statusCleavageLEGENDProcess or metabolism involved in Se PathwayLipoprotein melabolismMetabolitesCatalysisCofactorsProcess or metabolism involved in Se PathwayEnzymesBiomarker for - -is composed ofInhibitionCatalysisOther proteinsMetabolitesReactionFrom intracellular part to the plasma is composed ofProtein tyrosine nitrationOverarching processApoptosisPlasmaLipid peroxidationProtein*Prostaglandins metabolismIntracellularBindingEnzymesLipid peroxidationApoptosisTranscription factorInhibitionDNA oxidationis composed of - -is composed ofNecessary stimulationStimulationMicronutrients - + @@ -75,16 +75,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. [HeterodimerAssociationReaction:id1a728c5d] Reaction should contain at least 2 reactants. GraphId: id1a728c5d [HeterodimerAssociationReaction:id1e5c48e8] Reaction should contain at least 2 reactants. GraphId: id1e5c48e8 [UnknownTransitionReaction:id7a0d8e51] Self loops are not supported. Removing -[UnknownTransitionReaction:a64eb] Self loops are not supported. Removing -[UnknownTransitionReaction:idb64035fa] Self loops are not supported. Removing -[UnknownTransitionReaction:id432c05c1] Self loops are not supported. Removing -[UnknownTransitionReaction:eaace] Self loops are not supported. Removing [UnknownTransitionReaction:iddd5f4a25] Self loops are not supported. Removing -[UnknownTransitionReaction:id59369fb2] Self loops are not supported. Removing -[UnknownTransitionReaction:idfcf18012] Self loops are not supported. Removing [UnknownTransitionReaction:id92c94eaf] Self loops are not supported. Removing +[UnknownTransitionReaction:idfcf18012] Self loops are not supported. Removing [UnknownTransitionReaction:b84e5] Self loops are not supported. Removing [UnknownTransitionReaction:id38324c84] Self loops are not supported. Removing +[UnknownTransitionReaction:idb64035fa] Self loops are not supported. Removing +[UnknownTransitionReaction:a64eb] Self loops are not supported. Removing +[UnknownTransitionReaction:id59369fb2] Self loops are not supported. Removing +[UnknownTransitionReaction:eaace] Self loops are not supported. Removing +[UnknownTransitionReaction:id432c05c1] Self loops are not supported. Removing [UnknownTransitionReaction:e33e9] Self loops are not supported. Removing

@@ -118,29 +118,43 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - + + - - - + + + + + - + + + + + + + + + + + + + + + - + @@ -151,16 +165,18 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + + + @@ -182,20 +198,13 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - - - - - - - - + @@ -214,25 +223,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - @@ -249,317 +241,354 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + - - + + - - + + - - + + - + + + + + + + + + - - - - - - + + + + + + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - + - + - + - - - + + + - - + + - - - + + + - - + + - 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- - - - - + + + - - + + @@ -869,398 +896,322 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - + - + - + - + - + - + - + - + - - + + - + - + - - - - - - + + + + + + - + - - + + - - + + - - - + + + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - - - + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - - + + - - + + - + - + - + - + - + - + - + - + - + - + - - + + - - + + - - + + - - - - - - - - + + + + - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - - + + - - + + - + - + - + - + - - + + - - + + - - - + + + + + + + + + - - + + - + - - - - - - - - - + - + - + - + - + - + - + - + - + @@ -1282,80 +1233,97 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + + + + + + + + + + + + - - + + - + - + - - + + - - + + - + - + - - + + - - - - - - - - - - + + - - - + + + + + + + + + + - + - - + + - - - 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@@ -8404,7 +8404,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

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@@ -8601,17 +8611,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + @@ -8619,19 +8619,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8642,7 +8642,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + @@ -8652,17 +8667,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -8673,7 +8688,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8681,19 +8696,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8704,7 +8719,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -8712,19 +8732,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8735,7 +8755,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8743,19 +8763,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8766,7 +8786,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8774,19 +8794,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8797,7 +8817,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8805,19 +8825,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8828,12 +8848,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -8843,17 +8863,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -8864,7 +8884,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8872,19 +8892,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8895,17 +8915,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + @@ -8913,19 +8923,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8936,7 +8946,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -8946,55 +8961,43 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

activator recruited cofactor (ARC)-mediator activator complex - -

+

- - - - - - - - - - - + - + - + - + - +

@@ -9003,24 +9006,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -9031,7 +9039,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9039,19 +9047,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9062,7 +9070,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -9070,19 +9083,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9093,12 +9106,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9106,19 +9114,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9127,29 +9135,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9163,19 +9171,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9186,7 +9194,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -9194,19 +9207,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9217,17 +9230,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + @@ -9235,19 +9238,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9258,7 +9261,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9266,19 +9269,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9287,24 +9290,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -9315,7 +9323,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + @@ -9323,19 +9341,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9346,7 +9364,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9354,19 +9372,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9377,7 +9395,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9385,19 +9403,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9408,12 +9426,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9423,17 +9436,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -9444,7 +9457,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -9452,19 +9470,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9473,29 +9491,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9504,29 +9522,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9535,34 +9553,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + - + - + + + + + + - + - +

@@ -9573,7 +9586,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9581,19 +9594,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9602,29 +9615,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9635,7 +9648,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9643,24 +9656,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Inhibition of SREBP1 processing - -

+

@@ -9668,12 +9679,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9681,19 +9687,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9704,7 +9710,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9712,19 +9718,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9735,12 +9741,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9748,19 +9749,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9771,7 +9772,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9779,19 +9780,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9802,22 +9803,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - + @@ -9825,19 +9811,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9846,39 +9832,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - + - + - + + + + + + - + - +

@@ -9889,7 +9865,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9897,19 +9873,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9918,34 +9894,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + - + - + - + - +

@@ -9956,12 +9922,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9969,19 +9930,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9995,24 +9956,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -10023,7 +9984,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -10031,19 +9997,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10054,7 +10020,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -10062,19 +10033,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10083,29 +10054,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -10116,7 +10087,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + @@ -10124,19 +10105,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10147,12 +10128,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -10162,17 +10138,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -10181,29 +10157,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -10217,24 +10188,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -10245,7 +10216,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10253,19 +10224,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10276,7 +10247,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10284,19 +10255,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10305,29 +10276,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10338,12 +10309,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -10351,19 +10317,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10372,24 +10338,39 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + + + + + + - + - + - + - + - +

@@ -10400,7 +10381,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10408,19 +10389,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10429,29 +10410,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10462,7 +10443,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10470,22 +10451,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Inhibition of SREBP1 processing + +

@@ -10493,7 +10476,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -10501,19 +10489,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -10524,7 +10512,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10532,19 +10520,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10555,12 +10543,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -10568,19 +10551,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10591,7 +10574,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + @@ -10599,19 +10592,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10620,29 +10613,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10651,29 +10644,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -10687,19 +10675,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - + - +

@@ -10710,7 +10703,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10718,19 +10711,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10741,7 +10734,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10749,19 +10742,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10772,7 +10765,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10780,19 +10773,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10801,29 +10794,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - - - - + + + + - + - + - + - +

@@ -10834,7 +10827,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10842,19 +10835,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10865,17 +10858,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + @@ -10883,19 +10866,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10906,12 +10889,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -10919,19 +10902,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10940,29 +10923,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10973,7 +10956,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10981,19 +10964,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11002,34 +10985,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + - + - + - + - +

@@ -11040,7 +11013,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11048,19 +11021,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11071,7 +11044,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11079,19 +11052,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11102,7 +11075,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -11110,19 +11088,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11131,24 +11109,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -11157,29 +11140,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -11190,12 +11168,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -11203,19 +11181,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11224,29 +11202,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -11257,7 +11240,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11265,19 +11248,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11286,24 +11269,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -11314,7 +11302,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11322,19 +11310,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11343,34 +11331,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + - + - + - + - +

@@ -11381,12 +11359,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -11394,19 +11367,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11417,7 +11390,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11425,19 +11398,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11448,7 +11421,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11456,22 +11429,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

activator recruited cofactor (ARC)-mediator activator complex + +

@@ -11479,7 +11454,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -11487,19 +11467,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -11508,34 +11488,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + - + - + - + - +

@@ -11546,7 +11516,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11554,19 +11524,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11577,7 +11547,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11585,19 +11555,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11608,12 +11578,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -11621,19 +11586,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11642,24 +11607,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -11670,7 +11640,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11678,19 +11648,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11699,29 +11669,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -11730,29 +11700,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -11763,7 +11733,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11771,19 +11741,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11792,29 +11762,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -11825,12 +11795,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + @@ -11838,19 +11813,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11861,7 +11836,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11869,19 +11844,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11892,7 +11867,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -11900,19 +11880,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11921,62 +11901,55 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - + -

activator recruited cofactor (ARC)-mediator activator complex - -

+

- - - - - - + - + - + - + - +

@@ -11987,7 +11960,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11995,19 +11968,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12016,24 +11989,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -12044,17 +12022,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + @@ -12062,19 +12030,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12085,7 +12053,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12093,19 +12061,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12116,7 +12084,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12124,19 +12092,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12145,24 +12113,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -12173,7 +12146,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12181,19 +12154,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12204,7 +12177,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12212,19 +12185,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12235,7 +12208,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -12245,17 +12223,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -12264,24 +12242,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - + - + - + - + - +

@@ -12295,24 +12278,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -12323,7 +12301,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12331,19 +12309,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12352,29 +12330,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -12383,24 +12366,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + - + - + - + - + - +

@@ -12414,24 +12407,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -12442,7 +12435,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12450,19 +12443,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12473,12 +12466,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -12488,17 +12476,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -12509,7 +12497,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12517,19 +12505,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12538,29 +12526,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -12571,7 +12559,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12579,19 +12567,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12602,7 +12590,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12610,19 +12598,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12633,7 +12621,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12641,19 +12629,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12667,24 +12655,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -12695,7 +12683,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -12703,19 +12696,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12726,7 +12719,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12734,19 +12727,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12755,29 +12748,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -12788,7 +12781,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -12796,19 +12794,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12822,19 +12820,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - + - +

@@ -12843,29 +12846,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + - +

@@ -12874,29 +12872,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -12907,7 +12905,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12915,19 +12913,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12938,7 +12936,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -12946,19 +12949,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -12969,7 +12972,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -12977,19 +12980,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13000,7 +13003,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -13008,19 +13011,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13031,7 +13034,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -13039,19 +13042,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13062,7 +13065,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -13070,19 +13078,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13093,7 +13101,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -13101,19 +13109,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13124,12 +13132,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -13137,22 +13140,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

activator recruited cofactor (ARC)-mediator activator complex + +

@@ -13160,7 +13165,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -13168,19 +13173,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -13191,12 +13196,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -13206,17 +13206,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -13227,7 +13227,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -13235,21 +13235,21 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -13257,19 +13257,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13277,20 +13277,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + - + - +

@@ -13298,19 +13297,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13318,19 +13317,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13338,22 +13337,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -13361,25 +13357,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - - - - +

@@ -13387,19 +13377,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13407,19 +13397,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - +

@@ -13427,19 +13422,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -13447,22 +13445,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -13470,19 +13465,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13490,32 +13485,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - - - - - - - - - +

@@ -13523,19 +13505,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13543,22 +13525,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -13566,19 +13545,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + - + - + + + + - +

@@ -13586,19 +13578,25 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + + - +

@@ -13606,19 +13604,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + - +

@@ -13626,19 +13625,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13646,19 +13645,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13666,19 +13665,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13686,19 +13685,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -13706,19 +13708,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13726,19 +13728,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13746,19 +13748,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13766,19 +13768,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13786,19 +13788,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13806,19 +13808,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - +

@@ -13826,32 +13833,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - + - + - + - - - - +

@@ -13859,19 +13853,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + - + - +

@@ -13879,19 +13874,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + - + - +

@@ -13899,19 +13895,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13919,19 +13915,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13939,19 +13935,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13959,19 +13955,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -13979,22 +13975,23 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + + - +

@@ -14002,19 +13999,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -14022,24 +14019,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + - + - + - - - + + + + + + - +

@@ -14047,20 +14052,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + - + - +

@@ -14068,19 +14072,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -14088,24 +14095,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - - - +

@@ -14113,20 +14115,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - + + + + - +

@@ -14134,19 +14138,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -14154,23 +14158,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - - +

@@ -14178,19 +14178,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -14198,16 +14198,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + diff --git a/sbml/WP1982.svg b/sbml/WP1982.svg index cd0a45a..9876ecb 100644 --- a/sbml/WP1982.svg +++ b/sbml/WP1982.svg @@ -37,167 +37,14 @@ >Nucleusac64bb0c39??AMPKe2b93??a0ec7ad3f2?a5b2dbff8cc3fb9??d60d9c3fb9?ac64b??a0ec7AMPKad3f2a6b19?a5b2dbff8c?d60d9e2b93???a6b19?ab072????b0c39??ab072 vesicleLipogenic enzymesGolgi Lipogenic enzymesCholesterol effluxSRECholesterol effluxCholesterol Cofactorebb89bcef5b86f5LXRmiRNA33bgp78importin betaebb89LPIN1AKTGSK3SREBP2PRKAA1LXRSCAPPRKAB2PRKAG1NFYS1PUFAsPI3KmTORC1GlucoseHMGCRPRKAG3ATF6miRNA33aRBP4INSIG1SIRT1PRKAA1PRKAG2 mTORC1GlutamineTRC8PRKAA2CholesterolOxysterolsPI3KFGF21UFAsAKTnSREBPPRKAA2HMGCRPRKAG2 SIRT1PKAmiRNA33bCAMPNFYCDK8PRKAB1SREBP2PRKAB2PRKAG1PUFAsFGF21ATF6CDK8PRKAG3GlutamineOxysterolsgp78miRNA33aInsulinLPIN1S1PPKARBP4importin betaTRC8nSREBPSCAPc92e8INSIG2c92e8S2Pc0256c0256SCAPSREBP2SREBP1a,-cSREBP1a,-cLegendNegative effectUp regulationStimulationTranscription-TranslationCleavageExact mechanism unknownCatalysisInhibitionStimulationCleavageUp regulationNegative effectPositive effectCatalysisExact mechanism unknown - + @@ -74,263 +74,311 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -341,199 +389,226 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + @@ -555,108 +630,100 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + @@ -667,71 +734,71 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -747,729 +814,662 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + + + + + + + + + + + + + + + + + - - - - + + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + @@ -1478,71 +1478,71 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - - - + - + - - - - + + + + @@ -1599,165 +1599,165 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -1767,812 +1767,812 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - - + + @@ -2581,124 +2581,124 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + @@ -2707,177 +2707,177 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -2887,27 +2887,21 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - + - + - + - + - + - + @@ -2917,189 +2911,183 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -3109,549 +3097,549 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -3661,63 +3649,75 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - + - + - + - + - + + + + + + + + + + + + + - + - + - + - + - + - + @@ -3735,7 +3735,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3743,386 +3743,375 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -4131,334 +4120,359 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + @@ -4467,1752 +4481,1738 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - 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+ - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + - + + + + + + - - - - - - + - + - + - + + + + + + - + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + - - - - - - - - + + + - + - + - + - - - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - - - - - - - - - - + + + + + + + + + + + + + + + + + @@ -6224,7 +6224,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -6238,7 +6238,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -6268,7 +6268,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -6279,12 +6279,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -6292,19 +6287,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6315,7 +6310,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6323,19 +6318,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6346,7 +6341,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6354,19 +6349,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6377,7 +6372,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6385,19 +6380,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6408,7 +6403,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6416,19 +6411,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6439,7 +6434,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6447,19 +6442,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6470,7 +6465,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -6478,19 +6478,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6501,7 +6501,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6509,19 +6509,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6532,7 +6532,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6540,19 +6540,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6561,29 +6561,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -6594,7 +6599,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6602,19 +6607,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6625,7 +6630,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6633,19 +6638,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6656,7 +6661,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6664,19 +6669,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6687,7 +6692,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6695,19 +6700,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6718,7 +6723,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6726,19 +6731,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6747,29 +6752,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -6780,7 +6785,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6788,19 +6793,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6811,7 +6816,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6819,19 +6824,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6842,7 +6847,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6850,19 +6855,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6873,7 +6878,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -6881,19 +6891,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6904,7 +6914,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6912,19 +6922,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6935,7 +6945,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6943,19 +6953,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6966,7 +6976,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6974,19 +6984,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6997,7 +7007,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7005,19 +7015,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7028,7 +7038,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7036,19 +7046,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7059,7 +7069,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7067,19 +7077,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7090,7 +7100,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7098,14 +7108,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -7131,17 +7141,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -7152,7 +7162,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7160,19 +7170,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7183,7 +7193,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7191,19 +7201,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7214,7 +7224,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7222,19 +7232,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7245,7 +7255,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7253,19 +7263,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7276,7 +7286,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7284,19 +7294,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7307,7 +7317,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7315,19 +7325,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7338,7 +7348,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7346,19 +7356,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7369,7 +7379,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7377,19 +7387,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7400,7 +7410,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7408,19 +7418,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7431,7 +7441,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7439,19 +7449,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7460,29 +7470,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -7493,7 +7503,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7501,19 +7511,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7524,7 +7534,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7532,19 +7542,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7555,7 +7565,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7563,19 +7573,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7586,7 +7596,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7594,19 +7604,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7617,7 +7627,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7625,19 +7635,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7646,29 +7656,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -7679,7 +7689,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7687,19 +7697,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7710,7 +7720,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7718,19 +7728,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7741,7 +7751,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7749,19 +7759,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7772,7 +7782,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7780,19 +7790,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7803,7 +7813,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7811,19 +7821,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7832,29 +7842,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -7865,12 +7875,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -7878,19 +7883,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7901,7 +7906,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7909,19 +7914,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7932,7 +7937,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -7940,19 +7945,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7963,7 +7968,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -7971,19 +7981,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -7992,29 +8002,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -8025,7 +8035,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8033,19 +8043,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8056,7 +8066,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -8064,19 +8079,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8087,7 +8102,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8095,19 +8110,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8118,7 +8133,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8126,19 +8141,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8149,7 +8164,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8157,19 +8172,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8180,7 +8195,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8188,19 +8203,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8211,7 +8226,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8219,19 +8234,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8240,29 +8255,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -8273,7 +8288,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8281,19 +8296,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8304,7 +8319,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8312,19 +8327,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8335,7 +8350,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8343,19 +8358,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8366,7 +8381,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8374,19 +8389,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8397,7 +8412,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8405,19 +8420,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8428,7 +8443,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8436,19 +8451,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8459,7 +8474,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8467,19 +8482,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8490,7 +8505,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8498,19 +8513,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8521,7 +8536,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8529,19 +8544,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8552,7 +8567,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8560,19 +8575,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8583,7 +8598,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8591,19 +8606,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8614,7 +8629,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8622,19 +8637,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8645,7 +8660,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8653,19 +8668,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8676,7 +8691,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8684,19 +8699,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8705,29 +8720,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -8738,7 +8753,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -8746,19 +8766,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8769,7 +8789,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8777,19 +8797,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8800,12 +8820,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -8813,19 +8828,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8836,12 +8851,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -8849,19 +8859,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8872,7 +8882,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8880,19 +8890,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8903,12 +8913,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -8916,19 +8921,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -8937,29 +8942,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -8970,7 +8975,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -8978,19 +8983,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9001,7 +9006,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9009,19 +9014,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9032,7 +9037,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9040,19 +9045,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9063,7 +9068,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9071,19 +9076,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9092,29 +9097,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9125,7 +9130,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9133,19 +9138,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9156,7 +9161,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9164,19 +9169,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9187,7 +9192,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9195,19 +9200,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9218,7 +9223,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9226,19 +9231,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9249,7 +9254,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9257,19 +9262,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9280,7 +9285,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9288,19 +9293,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9309,29 +9314,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -9342,7 +9347,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9350,19 +9355,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9373,7 +9378,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9381,19 +9386,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9404,7 +9409,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9412,19 +9417,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9435,7 +9440,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9443,19 +9448,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9464,29 +9469,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9497,7 +9502,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9505,19 +9510,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9528,7 +9533,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9536,19 +9541,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9559,7 +9564,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9567,19 +9572,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9588,29 +9593,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -9621,12 +9626,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9634,19 +9634,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9657,7 +9657,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -9665,19 +9670,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9688,12 +9693,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -9701,19 +9701,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9724,7 +9724,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9732,19 +9732,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9755,7 +9755,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9763,19 +9763,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9786,7 +9786,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9794,19 +9794,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9817,7 +9817,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9825,19 +9825,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9848,7 +9848,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9856,19 +9856,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9879,7 +9879,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9887,19 +9887,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9910,7 +9910,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9918,19 +9918,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9941,7 +9941,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9949,19 +9949,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -9972,7 +9972,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -9980,19 +9980,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10003,7 +10003,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10011,19 +10011,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10034,7 +10034,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10042,19 +10042,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10065,7 +10065,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10073,19 +10073,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10096,7 +10096,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10104,19 +10104,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10127,7 +10127,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10135,19 +10135,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10156,29 +10156,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -10189,7 +10189,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10197,19 +10197,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10220,7 +10220,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10228,19 +10228,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10251,7 +10251,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10259,19 +10259,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10280,29 +10280,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10313,7 +10313,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10321,19 +10321,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10344,7 +10344,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10352,19 +10352,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10375,7 +10375,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10383,19 +10383,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10406,7 +10406,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10414,19 +10414,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10435,29 +10435,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10468,7 +10468,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10476,19 +10476,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10499,12 +10499,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -10512,19 +10507,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10533,29 +10528,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10566,7 +10561,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10574,19 +10569,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10597,7 +10592,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10605,19 +10600,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10628,7 +10623,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10636,19 +10631,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10659,7 +10654,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10667,19 +10662,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10690,7 +10685,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10698,19 +10693,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10721,7 +10716,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10729,19 +10724,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10752,7 +10747,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10760,19 +10755,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10783,7 +10778,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + @@ -10791,19 +10791,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10814,12 +10814,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + @@ -10827,19 +10822,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10850,7 +10845,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10858,19 +10853,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10881,7 +10876,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10889,19 +10884,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10910,29 +10905,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -10943,7 +10938,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10951,19 +10946,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -10974,7 +10969,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -10982,19 +10977,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11005,7 +11000,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11013,19 +11008,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11036,7 +11031,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11044,19 +11039,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11067,7 +11062,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11075,19 +11070,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11098,7 +11093,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11106,19 +11101,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11127,29 +11122,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -11160,7 +11155,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11168,19 +11163,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11189,29 +11184,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -11222,7 +11222,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11230,19 +11230,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11253,7 +11253,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11261,19 +11261,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11284,7 +11284,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -11292,21 +11292,21 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -11314,19 +11314,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + - +

@@ -11334,19 +11335,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -11354,19 +11355,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -11374,17 +11375,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - + diff --git a/sbml/WP2884.svg b/sbml/WP2884.svg index 83372d4..5211eae 100644 --- a/sbml/WP2884.svg +++ b/sbml/WP2884.svg @@ -74,6 +74,10 @@ />fdee3OtherNRF2 target genesfdee3a7f2bSLC2A1ceb59a7f2bCES3ceb59dcf74ME1dcf74ALDH3A1ca661CYP2A6ca661NRF2 target genesOtherNFE2L2TATA boxPhase 2 proteinsTranscriptionGrowth factor and receptorsPhase 1 proteinsAntioxidant proteinsGenesTranscription Factors TransportTranscriptionPhase 2 proteinsGenesAntioxidant proteinsTATA boxPhase 1 proteinsGrowth factor and receptors - + @@ -33,20 +33,14 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 [LINE:c39a2] Invalid interaction type as an input to reaction. [ARROW:db6e2] Invalid interaction type "ARROW" as an output from reaction. [Label:be974] Label cannot be part of reaction. Tranforming to Unknown -[Label:e0398] Label cannot be part of reaction. Tranforming to Unknown [Label:fefbd] Label cannot be part of reaction. Tranforming to Unknown +[Label:b80f4] Label cannot be part of reaction. Tranforming to Unknown [Label:c28ae] Label cannot be part of reaction. Tranforming to Unknown -[Label:c7a74] Label cannot be part of reaction. Tranforming to Unknown [Label:d39b6] Label cannot be part of reaction. Tranforming to Unknown [Label:eac4b] Label cannot be part of reaction. Tranforming to Unknown [Label:fa958] Label cannot be part of reaction. Tranforming to Unknown -[Label:b80f4] Label cannot be part of reaction. Tranforming to Unknown -[Label:bbd7b] Label cannot be part of reaction. Tranforming to Unknown -[Label:d6dc8] Label cannot be part of reaction. Tranforming to Unknown -[Label:e5f64] Label cannot be part of reaction. Tranforming to Unknown [Label:f4f5e] Label cannot be part of reaction. Tranforming to Unknown [Label:f1028] Label cannot be part of reaction. Tranforming to Unknown -[Label:f28cb] Label cannot be part of reaction. Tranforming to Unknown [UnknownPositiveInfluenceReaction:b29f5] Reaction should contain only one reactant and one product. [UnknownPositiveInfluenceReaction:e6f5b] Reaction should contain only one reactant and one product. [UnknownPositiveInfluenceReaction:f3e23] Reaction should contain only one reactant and one product. @@ -120,10 +114,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - + + @@ -170,423 +164,440 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + + + - + - - + + - + - - - - - + + + - - + + - - - + + + - - + + - - - + + + + + + + + + + + + - - + + - + + + + + + + + + + + + + + + + + + + + - + - + - + - - + + - + - - - + + + - - + + - + - + - + - + - + + + + + + + + + - + - + - + - - - + + + - - + + - - - + + + - - + + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - - - + + + - + - - - + + + - - + + - + - + - + - + - - - + + + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + - + + + + + + + + + @@ -597,54 +608,78 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + @@ -653,36 +688,36 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - - + + + - - + + - - - + + + - - + + - + - + @@ -693,80 +728,87 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - - - - + - + - + - + - + - + - - - + + + - - + + - + - + - - + + - - - - - - - - + + + + + + - - + + - - - + + + + + + + + + + + + - - + + + + + + + + + + @@ -776,300 +818,237 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - - - - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - - - - - - - - - + - + - + - + - + - - - - - - - - - + - + - - - - - - - - - + - + - + - + - + - + - - - + + + + + + + + + + + + - - + + - - - + + + - - + + - + - + - + - + - + - - - - - - - - - + - - - - - - - - - + - + - + - + - + - + - - - - - - - - - + - + - + - + - - - + + + - - + + - + - + - + - + - - - - - - - - - + - + - - - + + + - - + + - - - + + + - - + + - + - + - + - + - + - + @@ -1091,422 +1070,554 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - - - - - - + + + - - + + - - - + + + - - + + - - - + + + + + + + + + + + + - - + + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + + + + + + + + + - + - + - + - - - + + + - - + + - - - + + + - - + + - + - + - + - + - + + + + + + + + + - + - + - + - + + + + + + + + + - + - + - + - + - + - + + + + + + + + + - + - - + + + + + + + + + + + + + + + + + + - - - - - - - - + + + + + + - - + + - - - + + + - - + + - + - + - + - + - - - + + + - - + + - - - + + + - - + + - + - + - + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - - - - - + + + + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + - + - + - + - + - + - - + + - - - - - - + + + + + + + + - - + + - + + + + + + + + + - + - + - + - + + + + + + + + + - + - + + + + + + + + + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1525,810 +1636,761 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - - - + + + - - + + - - - + + + - - + + - - - + + + - - + + - + - + - - - + + + - - + + - - - + + + - - + + - + + + + + + + + + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + + + + + + + + + - + - + - + - - - + + + - - + + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + - + - + + + + + + + + + + + + + + + + + - + - + - + - + + + + + + + + + - + - + - + - + - + - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - - - - - - - - - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - + - - - - - - - - - - - - - - - - - - - - - - - - - - + - - - + + + - - + + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - - - - + + + + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - - - + + + - + - - - + + + - - + + - + - + - - - + + + - - - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - - - + + + + + + + + + + + + + + - - + + @@ -2339,14 +2401,14 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - + + + + @@ -2357,241 +2419,217 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - 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- - - + - - - - + + + + + + + - - - - + - - - - + + + + + + + - + - + - + - - - - + + + + @@ -3324,145 +3377,145 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 + + + - + + + + - - - - + + + + - - + + - + - - - - + - - - - + + + + - + - + - + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + - + - + - - - - + + + + - + @@ -3470,14 +3523,14 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - + + + + @@ -3488,35 +3541,35 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - + - - - - + + + + - + - + - + + + + - - - - + + + + @@ -3530,14 +3583,14 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - + + + + @@ -3549,64 +3602,64 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - + - + - - - - + + + + + + + - + @@ -3614,398 +3667,398 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - + + + + - + - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - - + + + - + - - - - + + + + - - - + + + - + - - - - + + + + - + - + - + + + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - - - - + - - - - + + + + - - + + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - - + + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - - - - - - - - + + - - + + - - + + - - - - + + + + - - + + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - - - - - - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - - + + + - + - - - - + + + + - - - - + - + - + - - - - + + + + @@ -4016,42 +4069,42 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - + - - - - + + + + - + - + - + - + - - - - + + + + + + + @@ -4059,220 +4112,220 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 + + + - + - - - - + + + + - - - + + + - + - - - - + + + + - - - + + + + + + - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - + - + + + + - - - - + + + + - - - - - - - - - - + - + - + - - - - + + + + - + - - - - + - - + + - - - - + + + + + + + - - - - - - - + - - - - - + + + + + - + - + - + + + + - - - - + + + + + + + - + + + + - + - - - - + + + + - - - - + @@ -4280,235 +4333,253 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - + + + + - + - + - - - - - - - - - - - + + - + - + - + - - - - + + + + - + - - - - - - - + - - - - + + + + - + - - - - - + + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - + + + + - + - + - + - - - - + + + + - - + + + + + + + + + + + + + + + + + - + - + - - + + - - - - + + + + - + - + + + + + + + + + + + + + + + + + + + - + @@ -4520,349 +4591,334 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - - - - - + - - + + + + + - - - - + + + + - - - + + + - + - - - - + + + + - + - + - - + + + + + - - - - + + + + - - + + - + - - - - + - - - - + + + + - - - - + + + + + + + - - - - + + + + - - + + - + - + - + - - - - + + + + - - - - - - - + - + - + - - - - + + + + - + - - - - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - - - - - + + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - + - + - + - + @@ -4874,32 +4930,47 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - + + + + + + + + + + + + + + + + + + + + - + - - - - + + + + - - - - + @@ -4907,311 +4978,302 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - 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+ @@ -8407,7 +8561,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -8417,7 +8571,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -8429,661 +8583,629 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - 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- - - - - - - - + - - - - - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - - - - - - - - - - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + @@ -11155,7 +11267,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -11165,7 +11277,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -11175,7 +11287,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -11187,133 +11299,155 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -11323,7 +11457,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -11333,7 +11467,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -11343,7 +11477,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + @@ -11355,1258 +11489,1198 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -12615,286 +12689,292 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - - - - - - - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + @@ -12903,124 +12983,142 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + + + + + + + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + + + + + + + @@ -13029,718 +13127,712 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + - - + + - + - + - + - + - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - - - - - - - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - - - + + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - + + + + + + + + + + + + + - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + + + + + + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - - - - - - - - - - - - - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + @@ -13749,907 +13841,889 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + + + + + + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - - - - - - - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - - - - - - - + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + + + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - + - + - + - + - + - + - - - - + + + @@ -14677,7 +14751,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - +

@@ -14686,24 +14760,29 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 + + + + + - + - + - + - + - +

@@ -14712,6 +14791,163 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 + + + + + + + + + + + + + + + + + + + + + + + + + +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

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+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867 + +

+ +
+ + + + + + + + + + + + + + + + + + + + + + + + +
+ + + +

+ + + + + @@ -14719,30 +14955,61 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158 +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792

- + - + @@ -14752,17 +15019,50 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + + + +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813 + +

+ +
+ + + + + + + + + + + + + + + + + + + + + + + + +
+

@@ -14770,10 +15070,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -14783,30 +15083,61 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996

- + - + + + + + + + + + + + + + + + + + + + +
+ + + +

+ + + + + + + + @@ -14814,45 +15145,52 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915 + +

- + + + + + + - + - + - + - +
- +

@@ -14860,10 +15198,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -14873,17 +15211,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -14891,10 +15229,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -14904,30 +15242,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186

- + - + @@ -14937,28 +15275,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270 + +

- + - + @@ -14966,30 +15306,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724 + +

- + - + @@ -14997,19 +15339,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -15017,10 +15359,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15030,28 +15372,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501 + +

- + - + @@ -15059,32 +15403,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838

- + - + @@ -15094,17 +15438,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -15112,10 +15456,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15125,28 +15469,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792 + +

- + - + @@ -15154,32 +15500,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929

- + - + @@ -15189,30 +15535,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768

- + - + @@ -15222,30 +15568,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995

- + - + @@ -15255,17 +15601,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -15273,10 +15619,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15286,30 +15632,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795

- + - + @@ -15319,28 +15665,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487 + +

- + - + @@ -15348,30 +15696,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880 + +

- + - + @@ -15379,32 +15729,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876

- + - + @@ -15412,32 +15762,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285

- + - + @@ -15445,19 +15795,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -15465,12 +15815,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + @@ -15478,30 +15823,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964

- + - + @@ -15511,17 +15856,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -15529,10 +15874,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15542,17 +15887,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -15560,10 +15905,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15573,28 +15918,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802 + +

- + - + @@ -15602,61 +15949,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - - - - - - -
- - - -

- - - - - - - - - - - - - - - - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791 + +

- + - + @@ -15664,32 +15982,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796

- + - + @@ -15697,19 +16015,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -15717,10 +16035,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15730,30 +16048,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867 - -

+

- + - + @@ -15761,19 +16077,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -15781,10 +16097,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15794,30 +16110,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136

- + - + @@ -15827,17 +16143,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -15845,10 +16161,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15858,28 +16174,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009 + +

- + - + @@ -15887,19 +16205,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -15907,10 +16225,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -15920,30 +16238,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861

- + - + @@ -15951,32 +16269,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577

- + - + @@ -15986,28 +16304,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926 + +

- + - + @@ -16015,30 +16335,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450 + +

- + - + @@ -16046,32 +16368,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010 - -

+

- + - + @@ -16079,19 +16399,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -16099,10 +16419,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -16112,30 +16432,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486 - -

+

- + - + @@ -16143,19 +16461,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -16163,10 +16481,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -16176,17 +16494,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -16194,10 +16512,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -16207,30 +16525,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864 - -

+

- + - + @@ -16238,30 +16554,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413 + +

- + - + @@ -16269,32 +16587,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690

- + - + @@ -16304,30 +16622,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939 - -

+

- + - + @@ -16335,30 +16651,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297 + +

- + - + @@ -16366,32 +16684,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481

- + - + @@ -16401,30 +16719,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733 - -

+

- + - + @@ -16432,52 +16748,45 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084 - -

+

- - - - - - + - + - + - + - + - +

@@ -16485,43 +16794,36 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915 - -

+

- + - + @@ -16529,19 +16831,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -16549,10 +16851,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -16562,17 +16864,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -16580,10 +16882,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -16593,17 +16895,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -16611,43 +16913,43 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + + + + + + - - - - - - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289

- + - + @@ -16657,28 +16959,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219 + +

- + - + @@ -16686,32 +16990,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969 - -

+

- + - + @@ -16719,32 +17021,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813 - -

+

- + - + @@ -16752,32 +17052,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297 - -

+

- + - + @@ -16785,32 +17083,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035 - -

+

- + - + @@ -16818,32 +17114,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402 - -

+

- + - + @@ -16851,32 +17145,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996 - -

+

- + - + @@ -16884,32 +17176,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239

- + - + @@ -16917,30 +17209,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035 + +

- + - + @@ -16948,19 +17242,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -16968,10 +17262,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -16981,30 +17275,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759

- + - + @@ -17014,17 +17308,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -17032,10 +17326,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17045,17 +17339,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -17063,10 +17357,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17076,17 +17370,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -17094,10 +17388,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17107,30 +17401,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270 - -

+

- + - + @@ -17138,32 +17430,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962 - -

+

- + - + @@ -17171,19 +17461,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -17191,10 +17481,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17204,17 +17494,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -17222,12 +17512,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + @@ -17235,30 +17520,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735

- + - + @@ -17268,43 +17553,50 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175 + +

- + + + + + + - + - + - + - +
- +

@@ -17312,43 +17604,41 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + - + - + - + + + + + + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861 - -

+

- + - + @@ -17356,19 +17646,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -17376,10 +17666,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17389,30 +17679,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792 - -

+

- + - + @@ -17420,19 +17708,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -17440,10 +17728,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17453,30 +17741,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529

- + - + @@ -17486,63 +17774,51 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795 - -

+

- - - - - - + - + - + - + - + - +

- - - - - - - - - + + + + @@ -17550,30 +17826,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450

- + - + @@ -17581,19 +17857,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -17601,10 +17877,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17614,30 +17890,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804

- + - + @@ -17647,30 +17923,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929

- + - + @@ -17678,30 +17954,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482 + +

- + - + @@ -17709,32 +17987,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972 - -

+

- + - + @@ -17742,32 +18018,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194

- + - + @@ -17777,17 +18053,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -17795,43 +18071,43 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + + + + + + - - - - - - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394

- + - + @@ -17841,30 +18117,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864

- + - + @@ -17874,43 +18150,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - -
- - - -

- - - - - - - - - - - - - - - - - - + - +

@@ -17918,10 +18168,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17931,17 +18181,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -17949,10 +18199,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -17962,30 +18212,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050 - -

+

- + - + @@ -17993,19 +18241,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -18013,10 +18261,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18026,30 +18274,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491

- + - + @@ -18057,19 +18305,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -18077,10 +18325,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18090,17 +18338,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -18108,74 +18356,38 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251

- - - - - - - - - - - - - - - - - - - - - - -
- - - -

- - - - - + - + @@ -18183,19 +18395,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -18203,10 +18415,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18216,30 +18428,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969

- + - + @@ -18249,17 +18461,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -18267,10 +18479,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18280,17 +18492,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -18298,10 +18510,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18311,28 +18523,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010 + +

- + - + @@ -18340,19 +18554,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -18360,30 +18574,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + + + + + + - - - - - - + - + - + - + - +

@@ -18391,10 +18605,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18404,30 +18618,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752

- + - + @@ -18435,32 +18649,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675

- + - + @@ -18468,32 +18682,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472

- + - + @@ -18501,32 +18715,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125 - -

+

- + - + @@ -18534,32 +18746,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062 - -

+

- + - + @@ -18567,32 +18777,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735 - -

+

- + - + @@ -18600,32 +18808,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962

- + - + @@ -18635,17 +18843,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -18653,74 +18861,76 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + + + + + + - - - - - - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050 + +

- + + + + + + - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293

- + - + @@ -18728,19 +18938,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -18748,12 +18958,7 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + @@ -18761,30 +18966,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739 - -

+

- + - + @@ -18792,63 +18995,63 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234 - -

+

- - - - - - + - + - + - + - + + + + + + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181 + +

- + - + @@ -18856,19 +19059,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -18876,10 +19079,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18889,17 +19092,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -18907,10 +19110,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18918,19 +19121,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -18938,10 +19141,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -18951,28 +19154,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490 + +

- + - + @@ -18980,32 +19185,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402

- + - + @@ -19015,17 +19220,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -19033,10 +19238,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19046,28 +19251,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051 + +

- + - + @@ -19075,32 +19282,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136 - -

+

- + - + @@ -19108,19 +19313,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -19128,10 +19333,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19141,28 +19346,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486 + +

- + - + @@ -19170,19 +19377,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -19190,10 +19397,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19203,30 +19410,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491 - -

+

- + - + @@ -19234,19 +19439,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -19254,10 +19459,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19267,30 +19472,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090

- + - + @@ -19300,17 +19505,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -19318,10 +19523,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19331,63 +19536,59 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391 - -

+

- - - - - - + - + - + - + + + + + + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194 - -

+

- + - + @@ -19395,19 +19596,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -19415,10 +19616,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19428,63 +19629,54 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838 - -

+

- - - - - - + - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929 - -

+

- + - + @@ -19492,32 +19684,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921 - -

+

- + - + @@ -19525,32 +19715,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806 - -

+

- + - + @@ -19558,30 +19746,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195 + +

- + - + @@ -19589,32 +19779,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972

- + - + @@ -19624,28 +19814,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084 + +

- + - + @@ -19653,52 +19845,50 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724 - -

+

- - - - - - + - + - + - + + + + + + - + - +

@@ -19706,38 +19896,43 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + + + + + + - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775

- + - + @@ -19745,30 +19940,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234 + +

- + - + @@ -19776,19 +19973,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -19796,10 +19993,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19809,30 +20006,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011

- + - + @@ -19840,19 +20037,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -19860,10 +20057,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19873,17 +20070,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -19891,10 +20088,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19904,30 +20101,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908

- + - + @@ -19937,17 +20134,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -19955,10 +20152,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -19968,63 +20165,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - - - - - - - -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181 - -

- -
- - - - - - - - - - - - - - - - - - - - - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520 - -

+

- + - + @@ -20032,58 +20194,63 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

No homologues found for original id M:MGI:1309515 - -

+

- + + + + + + - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630 + +

- + - + @@ -20091,30 +20258,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973 + +

- + - + @@ -20122,19 +20291,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -20142,10 +20311,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20155,30 +20324,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591

- + - + @@ -20188,30 +20357,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733

- + - + @@ -20221,28 +20390,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921 + +

- + - + @@ -20250,19 +20421,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -20270,10 +20441,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20283,30 +20454,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852

- + - + @@ -20316,30 +20487,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926 - -

+

- + - + @@ -20347,19 +20516,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -20367,10 +20536,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20380,28 +20549,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391 + +

- + - + @@ -20409,32 +20580,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070

- + - + @@ -20442,19 +20613,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -20462,10 +20633,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20475,30 +20646,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939

- + - + @@ -20508,28 +20679,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448 + +

- + - + @@ -20537,19 +20710,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -20557,10 +20730,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20570,30 +20743,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775

- + - + @@ -20601,32 +20774,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125

- + - + @@ -20636,17 +20809,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -20654,10 +20827,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20667,17 +20840,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -20685,10 +20858,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20698,17 +20871,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -20716,10 +20889,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20729,30 +20902,28 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251 - -

+

- + - + @@ -20760,30 +20931,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627 + +

- + - + @@ -20791,32 +20964,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908 - -

+

- + - + @@ -20824,30 +20995,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170 + +

- + - + @@ -20855,32 +21028,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529 - -

+

- + - + @@ -20888,19 +21059,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -20908,10 +21079,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20919,32 +21090,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286

- + - + @@ -20954,17 +21125,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -20972,10 +21143,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -20985,28 +21156,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739 + +

- + - + @@ -21014,30 +21187,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520 + +

- + - + @@ -21045,32 +21220,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806

- + - + @@ -21078,19 +21253,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -21098,10 +21273,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21111,17 +21286,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -21129,38 +21304,41 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + + + + + + - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775 - -

+

- + - + @@ -21168,61 +21346,65 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968 + +

- + + + + + + - - - - - - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062 + +

- + - + @@ -21230,30 +21412,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988 + +

- + - + @@ -21261,30 +21445,32 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797 + +

- + - + @@ -21292,19 +21478,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- +

@@ -21312,30 +21498,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - - - - - - + - + - + - + + + + + + - + - +

@@ -21343,10 +21529,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21356,17 +21542,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -21374,10 +21560,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21387,17 +21573,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -21405,10 +21591,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21418,17 +21604,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -21436,10 +21622,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21449,17 +21635,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - +

@@ -21467,10 +21653,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21480,28 +21666,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158 + +

- + - + @@ -21509,34 +21697,29 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501 +

No homologues found for original id M:MGI:1309515

- - - - - - + @@ -21544,17 +21727,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - +
- +

@@ -21562,10 +21745,10 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + @@ -21575,28 +21758,30 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753 + +

- + - + @@ -21604,54 +21789,52 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009 - -

+

- - - - - - + - + - + - + + + + + + - + - +

@@ -21659,22 +21842,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -21682,19 +21865,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -21702,19 +21888,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -21722,22 +21911,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -21745,22 +21931,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -21768,22 +21954,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -21791,22 +21977,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -21814,19 +22000,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -21834,22 +22023,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -21857,19 +22046,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + + + + - +

@@ -21877,19 +22070,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -21897,22 +22093,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -21920,19 +22113,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -21940,19 +22133,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -21960,22 +22156,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -21983,22 +22176,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22006,22 +22199,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22029,23 +22222,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + - + - +

@@ -22053,19 +22245,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22073,22 +22268,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22096,19 +22288,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + + - +

@@ -22116,22 +22312,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + - + - +

@@ -22139,22 +22336,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22162,19 +22359,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -22182,19 +22379,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22202,22 +22402,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22225,22 +22425,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22248,22 +22445,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22271,23 +22468,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + - + - +

@@ -22295,19 +22491,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22315,23 +22514,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + - - - - +

@@ -22339,22 +22534,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + - + - +

@@ -22362,19 +22558,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -22382,22 +22578,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22405,19 +22601,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22425,22 +22624,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22448,22 +22647,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22471,22 +22667,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22494,19 +22687,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22514,22 +22710,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22537,22 +22733,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22560,24 +22756,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - - + - + - +

@@ -22585,22 +22779,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22608,19 +22799,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22628,22 +22822,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22651,19 +22845,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -22671,22 +22865,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22694,22 +22888,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22717,19 +22911,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + + + + - +

@@ -22737,19 +22935,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -22757,22 +22955,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22780,19 +22975,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22800,22 +22998,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22823,22 +23021,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22846,22 +23044,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22869,22 +23064,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22892,22 +23087,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -22915,22 +23107,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22938,19 +23130,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -22958,22 +23153,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -22981,23 +23176,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - + - + - +

@@ -23005,22 +23199,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23028,19 +23219,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + + + + - +

@@ -23048,22 +23243,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23071,19 +23266,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -23091,19 +23286,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23111,22 +23309,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23134,22 +23332,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + - + - +

@@ -23157,19 +23356,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23177,22 +23379,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23200,22 +23399,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23223,22 +23422,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23246,19 +23445,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23266,22 +23468,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23289,22 +23491,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23312,19 +23514,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -23332,23 +23534,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + - + - +

@@ -23356,22 +23557,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23379,22 +23580,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23402,22 +23600,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23425,19 +23620,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23445,22 +23643,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23468,22 +23663,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23491,22 +23683,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23514,22 +23706,24 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + - + - +

@@ -23537,22 +23731,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23560,22 +23754,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + - + - +

@@ -23583,22 +23778,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23606,22 +23801,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23629,19 +23824,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23649,25 +23847,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - - + - - - - - +

@@ -23675,22 +23867,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23698,23 +23890,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - + - + - +

@@ -23722,19 +23913,24 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + + + - +

@@ -23742,22 +23938,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23765,23 +23961,25 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + + + - + + - +

@@ -23789,19 +23987,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23809,22 +24010,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23832,24 +24030,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - - + - - - - +

@@ -23857,22 +24050,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -23880,19 +24073,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -23900,19 +24096,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -23920,22 +24116,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + - + - +

@@ -23943,22 +24140,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23966,22 +24160,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -23989,20 +24180,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - @@ -24018,16 +24206,16 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -24035,23 +24223,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + - - - - +

@@ -24059,22 +24243,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24082,19 +24266,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24102,22 +24289,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24125,19 +24309,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24145,22 +24332,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24168,23 +24355,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - - +

@@ -24192,22 +24375,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24215,22 +24395,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24238,22 +24418,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24261,22 +24441,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24284,22 +24461,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24307,22 +24484,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24330,19 +24507,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -24350,22 +24527,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24373,17 +24547,20 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + @@ -24399,17 +24576,17 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - - + + - +

@@ -24417,22 +24594,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24440,23 +24614,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - - + - + - + - +

@@ -24464,19 +24637,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24484,19 +24660,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24504,22 +24683,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24527,22 +24706,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24550,22 +24726,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24573,22 +24749,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24596,22 +24772,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24619,19 +24795,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - +

@@ -24639,22 +24815,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24662,19 +24838,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24682,22 +24861,23 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + + - + - + - +

@@ -24705,22 +24885,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + - +

@@ -24728,19 +24908,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24748,22 +24931,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - - - - +

@@ -24771,19 +24951,22 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + + + + - +

@@ -24791,19 +24974,19 @@ This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP6 - + - + - + - + diff --git a/sbml/WP3925.svg b/sbml/WP3925.svg index de3fa86..9ea0d51 100644 --- a/sbml/WP3925.svg +++ b/sbml/WP3925.svg @@ -8,26 +8,24 @@ />??????e9997????????ac221????adb70????????ebc77?ac221??ebc77???????????a277e??adb70??d69a4??c0cfa?????c0cfa???????????a277e?????e9997???????????d69a4?????indole-pyruvateproteinsurea cycleproteinsproteinsproteinsphenylpyruvateOH-phenylpyruvateOH-indole acetaldehydeproteinsproteinsproteinsglutamate metabolismpyruvate metabolismvanillyl mandelateproteinsTCA cycleproteinsdopaproteinsproteinsproteinsOH-phenylpyruvateCystathionineproteinsindole-pyruvateGuanidinoacetateCysteinevanillyl mandelateMPSTproteinsOH-indole acetaldehydeDDC5-OH-TrpAlanineSpermidineADH5FAHHMGCS2AOC3PhenylalanineMalateSDHAGuanidinoacetate PALDH7A1SuccinatemethylhistamineTATPYCR1AspartateTATAsparagineSuccinyl-CoAHistamineAlanineIARSSUCLG1HMGCLFatty acid metabolismArginineisocitrateACSS1LactateTryptamineCarbamoyl-aspartateTryptophanGlutaminecarbamoyl-PArginineBCAT1HALSpermidineP4HA2CystathionineGLSHIBCHUreaAUHmethylmalonyl-CoASDS5-OH-TrpMethionineIndoleacetaldehydeACADMThreonineDLDGSRCPS1TryptophanGstCysteineFumaratePutrescineOGDHMCCC1HMGCLGPT2PKMSDSGSSSRMOATACADMSerotoninCADRARSDDCMelaninOH-indoleacetateoxo-isocaproateSuccinyl-CoAADH1CACADMCysteineCPS1CADOrnithineGlutamineOxaloacetateThreonineMUTSerineWARSPNMTAconitatePyruvateoxo-isovalerateGLUD1AsparagineDihydro-orotateAlanineBCAT1CitrullineTyrosineALDH1A1ACAA1THOTCALDH18A1carbamoyl-PASS1B-OH-butyratePCOxaloacetateEPRSIDH1MPSTACO2ADH4oxo-isocaproateGuanidinoacetatemethylhistamineGLULHistidineMDH1CTHTPH1LDHAAC007325.2MAOASMSDBHEHHADHAP002884.2PCK1MARS2HIBADHG6PC2GlycineGCLMASNSSerotoninLARS2valineOH-indoleacetateOxobutyrateGlutaminePDHA1B-OH-butyrateGLULEthanolhydroxy-prolineHADHCSALDH7A1TATSDSGOT2glycolysis & gluconeogenesisOrnithineACADMThyroxineODC1AC068533.7HistamineAspartateglycolysis & gluconeogenesisHNMTOGDHTDO2CTHMAOAFARSBACO2hydroxy-prolineEHHADHPyruvateGlycineHDCWARSisocitrateFumarateOxobutyrateACADMMAOAGLSDDCFumarateMDH2G6PC2valineALDH7A1Carbamoyl-aspartatePDHXIsoleucinemercaptopyruvateSUCLG1GSRMDH2ALDH18A1PyruvateLeucinePDHA1ARG1SMSLDHAIndoleacetateCSPDK4PDHXMAOAPYCR1GPT2P-enolpyruvatePyruvateGlutamateALDH1A1EHHADHRARSEHHADHPDHA1Dopamineoxo-isovalerateFAHASNSIDH1methylmalonyl-CoAIARSMAOALactateMAOAALDH18A1BHMTDLSTMARS2MDH1HDCTPH1GstBHMTHNMTPDHA1LARS2OxaloacetatePPM1LBCAT1THGPT2CBSARG2DLDADH7DBHGlycineGlutamineFTCDASS1ThyroxineALDH18A1PPM1LGOT1ACADMCitrullineOxaloacetateEthanolGOT1PCGLUD1ACLYPCK1PKMGOT2HADHMethionineIndoleacetaldehydeBCAT1UreaLeucineHistidineALDH7A1ADH5oxo-methyl-valerate Guanidinoacetate PSDSTryptamineMCCC1ODC1CADmercaptopyruvateFHEHHADHSpermineADH7Dihydro-orotateBCAT1IndoleacetateACSS1FumarateDLSTAUHOATMalatePDK4FHDDCCADHomocysteineDopamineFTCDTyrosineGlutamateCitrateP-enolpyruvateARG1AP002884.2FARSBAconitateDDCADH4Creatine PTPOVARSACAA1TATMUTGlycineGSSSDHAADH1CGlucoseDDCCysteineAlanineVARSHMGCS2ProlineCBSARG2OTCHALmethylmalonate semialdehydeAC007325.2HIBCHEHHADHTDO2GPT2HomocysteineFatty acid metabolismSRMEPRSAC068533.7TPOPutrescineSpermineAOC3MelaninHIBADHPNMTProlineACLYoxo-methyl-valerate PhenylalanineCitrateImidazole acetaldehydeFatty acid metabolismTyr-tRNApyruvate metabolismbranched chain amino-acidsTCA cycleurea cycleAmino-acid metabolismglutamate metabolismketone bodiesbranched chain amino-acids - + @@ -64,12 +64,12 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - + + - + @@ -102,146 +102,135 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - + - + - + - - - + + + - - + + - - - + + + - - + + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - + - + @@ -252,79 +241,109 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - + - - - + + + + + + + + + + + + + + - + - + - + - + - + - + - - - - + + + + - + - - - + + + + + + + + + + + + + + - + - + - + + + + + + + + + @@ -335,365 +354,343 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + + + + + + + + + - + - + - + - - - - - - - - - - - - - - + + + - + - + - + - - - + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + + + + + + + + + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - - - - - - - - - - - - - - + + + - + - + - + - + - + - - - + + + - - + + - - - + + + + + + + + + + + + + + - + - + - + - + - + - + - - - - + + + + - + - - - + + + - + - - - - - - - - @@ -713,84 +710,95 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - + - - - + + + - + - + - + - + - + @@ -801,71 +809,71 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - + - - - + + + - + @@ -876,96 +884,91 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - - - + + + - - + + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - + - - - - - - + + + + + + - - - - - - - - - - - - - - - - - - + + @@ -986,268 +989,284 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - + - + - + - + - + - - - - - - - + + + + + + + + + + + + + + + - + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - - - + + + - - + + - + - + + + + + + + + + @@ -1267,39 +1286,28 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - - + + + - - + + - - - - - - - - - - - - - - + + + - + - + - + @@ -1310,201 +1318,193 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - - - - - - - - - + - - - - + + + + - + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + + + + - + - + - - + + - - - - + + + + @@ -1515,43 +1515,46 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + + + + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - + - + - + @@ -1563,59 +1566,56 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - - - + - - + + + + + - - - - + + + + - - - - + - + - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -1626,32 +1626,32 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -1662,25 +1662,46 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - - - + + + + - + + + + + + + + + + + + + + + + + + + + + + - + @@ -1692,170 +1713,149 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - - - - - - - - - - - - - - - - + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - - - - - - - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - - - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -1866,128 +1866,128 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - - - - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - - + + + + + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - - - - + - + - + - - - - + + + + @@ -2026,93 +2026,93 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + @@ -2122,400 +2122,406 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + + + + + + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + @@ -2524,273 +2530,273 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - - + + - + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - - - + + + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + + + + + + + - + - + - + - + - + - + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - + @@ -2800,423 +2806,435 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - - + + + + + + - + - - + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + @@ -3226,7 +3244,7 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + @@ -3236,7 +3254,7 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + @@ -3248,217 +3266,249 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + + + + + + + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + + + + + + + - + @@ -3468,7 +3518,7 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + @@ -3478,7 +3528,7 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + @@ -3490,584 +3540,534 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - - - - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + + + + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - + - - - - - - + + - + - - + + @@ -4076,93 +4076,93 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + @@ -4172,111 +4172,141 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + + + + + + + - + - + + + + + + + - + - + - + - - + + - + - + - + - + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - + - + - + @@ -4286,237 +4316,213 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - - - - - - - - - - - - + - - - - - - - + - + - + - + - - - - - - - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + @@ -4526,46 +4532,46 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + @@ -4574,64 +4580,52 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - - + + - + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - + - + - + - - + + @@ -4640,207 +4634,219 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + + + + + + + - + - + - + - + - + - + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - + @@ -4850,57 +4856,51 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - - - - - - - + - + - + - + - + - + - + @@ -4908,831 +4908,939 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -5741,751 +5849,722 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - - - - + + + + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - - - - + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + + + + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -6494,26 +6573,26 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - + - + - + - + @@ -6522,190 +6601,161 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - - - + + + - - - + + - - - + - - + + + + + + + - - - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - - - - - - + - + - - - - - + - + - + - + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - + + + + - - - - - - - - - - - - - - - + - + - + - + - + @@ -6714,78 +6764,28 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -6811,43 +6811,47 @@ This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP - + -

+

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 +

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180

@@ -6857,7 +6861,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249 - + @@ -6865,24 +6869,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249 - + - + - + - +
- + -

Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 +

Original kegg element: gene;31;mmu:12491 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491

@@ -6892,7 +6896,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 - + @@ -6900,59 +6904,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 - + - + - + - +
- + -

Original kegg element: gene;32;mmu:14077 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 +

Original kegg element: gene;47;mmu:18830 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830

@@ -6962,7 +6962,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070 - + @@ -6970,26 +6970,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070 - + - + - + - +
- + -

Original kegg element: gene;21;mmu:113868 mmu:235674 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868 - -

+

@@ -6997,7 +6993,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868 - + @@ -7005,26 +7001,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868 - + - + - + - + - + -

Original kegg element: gene;43;mmu:16202 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202 - -

+

@@ -7032,7 +7024,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202 - + @@ -7040,26 +7032,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202 - + - + - + - + - + -

Original kegg element: gene;9;mmu:18534 mmu:74551 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534 - -

+

@@ -7067,7 +7055,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534 - + @@ -7075,24 +7063,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534 - + - + - + - + - + -

Original kegg element: gene;8;mmu:14626 mmu:14933 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626 +

Original kegg element: map;52;path:mmu00564

@@ -7100,34 +7086,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626 - - - - - - + - + - + - +
- + -

Original kegg element: gene;29;mmu:108078 +

Original kegg element: gene;9;mmu:18534 mmu:74551 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534

@@ -7137,7 +7118,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078 - + @@ -7145,24 +7126,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078 - + - + - + - +
- + -

Original kegg element: gene;23;mmu:11363 +

Original kegg element: gene;40;mmu:11770 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770

@@ -7172,7 +7153,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363 - + @@ -7180,24 +7161,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363 - + - + - + - +
- + -

Original kegg element: gene;64;mmu:66113 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117

@@ -7207,7 +7188,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113 - + @@ -7215,24 +7196,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113 - + - + - + - +
- + -

Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 +

Original kegg element: gene;11;mmu:12491 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491

@@ -7242,7 +7223,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 - + @@ -7250,55 +7231,59 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430 - + - + - + - +
- + -

+

Original kegg element: gene;59;mmu:22259 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;47;mmu:18830 +

Original kegg element: gene;38;mmu:20411 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411

@@ -7308,7 +7293,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830 - + @@ -7316,14 +7301,14 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830 - + - + - + - + @@ -7353,20 +7338,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894 - + - +
- + -

Original kegg element: map;52;path:mmu00564 +

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140

@@ -7374,29 +7361,34 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894 + + + + + - + - + - + - +
- + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 +

Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182

@@ -7406,7 +7398,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256 - + @@ -7414,59 +7406,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256 - + - + - + - +
- + -

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579 - -

+

- - - - - - + - + - + - + + + + + + - + -

Original kegg element: gene;11;mmu:12491 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802

@@ -7476,7 +7464,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 - + @@ -7484,24 +7472,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 - + - + - + - +
- + -

Original kegg element: gene;56;mmu:56473 +

Original kegg element: gene;65;mmu:17436 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436

@@ -7511,7 +7499,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 - + @@ -7519,19 +7507,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 - + - + - + - +
- +

@@ -7545,64 +7533,60 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473 - + - + - + - + - + - + - + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216739 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;8;mmu:14626 mmu:14933 +

Original kegg element: gene;25;mmu:74147 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147

@@ -7612,7 +7596,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933 - + @@ -7620,59 +7604,50 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933 - + - + - + - +
- + -

Original kegg element: gene;41;mmu:57875 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875 - -

+

- - - - - - + - + - + - + - + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;41;mmu:57875 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875

@@ -7682,7 +7657,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168 - + @@ -7690,26 +7665,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168 - + - + - + - +
- + -

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458 - -

+

@@ -7717,7 +7688,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458 - + @@ -7725,55 +7696,59 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458 - + - + - + - + - + -

+

Original kegg element: gene;21;mmu:113868 mmu:235674 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235674 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;31;mmu:12491 +

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204

@@ -7783,7 +7758,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 - + @@ -7791,22 +7766,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 - + - + - + - +
- + -

+

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216739 + +

@@ -7814,7 +7793,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 - + @@ -7822,81 +7801,94 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491 - + - + - + - +
- + -

+

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20250 + +

+ + + + + - - - - - - + - + - + - +
- + -

+

Original kegg element: gene;60;mmu:104086 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 + +

+ + + + + - + - + - + - +
- + -

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 +

Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181

@@ -7906,7 +7898,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204 - + @@ -7914,24 +7906,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204 - + - + - + - +
- + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;23;mmu:11363 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13119 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363

@@ -7941,7 +7933,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13119 - + @@ -7949,85 +7941,88 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13119 - + - + - + - +
- + -

Original kegg element: map;34;path:mmu04920 - -

+

+ + + + + - + - + - + - + - + -

+

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - -

+

@@ -8035,7 +8030,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - + @@ -8043,24 +8038,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - + - + - + - + - + -

Original kegg element: gene;66;mmu:22227 +

Original kegg element: gene;9;mmu:18534 mmu:74551 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551

@@ -8070,7 +8065,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227 - + @@ -8078,24 +8073,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227 - + - + - + - +
- + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118

@@ -8105,7 +8100,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 - + @@ -8113,24 +8108,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205 - + - + - + - +
- + -

Original kegg element: gene;14;mmu:19013 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013 +

Original kegg element: map;34;path:mmu04920

@@ -8138,34 +8131,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013 - - - - - - + - + - + - +
- + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 +

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459

@@ -8175,7 +8163,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180 - + @@ -8183,22 +8171,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180 - + - + - + - +
- + -

+

Original kegg element: gene;39;mmu:83995 mmu:83996 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995 + +

@@ -8206,7 +8198,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180 - + @@ -8214,24 +8206,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180 - + - + - + - +
- + -

Original kegg element: gene;65;mmu:17436 +

Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181

@@ -8241,7 +8233,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436 - + @@ -8249,24 +8241,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436 - + - + - + - +
- + -

Original kegg element: gene;26;mmu:12896 +

Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430

@@ -8276,7 +8268,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896 - + @@ -8284,24 +8276,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896 - + - + - + - +
- + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;64;mmu:66113 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113

@@ -8311,7 +8303,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 - + @@ -8319,24 +8311,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753 - + - + - + - +
- + -

Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 +

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458

@@ -8346,7 +8338,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 - + @@ -8354,59 +8346,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 - + - + - + - +
- + -

Original kegg element: gene;45;mmu:18607 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 +

Original kegg element: gene;36;mmu:26457 mmu:26569 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457

@@ -8416,7 +8404,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895 - + @@ -8424,24 +8412,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895 - + - + - + - +
- +

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30049 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065

@@ -8459,24 +8447,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30049 - + - + - + - +
- + -

Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 +

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205

@@ -8486,7 +8474,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 - + @@ -8494,22 +8482,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 - + - + - + - +
- + -

Original kegg element: map;51;path:mmu00120 +

Original kegg element: gene;18;mmu:19016 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016

@@ -8517,29 +8507,34 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183 + + + + + - + - + - + - +
- + -

Original kegg element: gene;61;mmu:11806 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:100040843

@@ -8549,7 +8544,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 - + @@ -8557,22 +8552,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 - + - + - + - +
- + -

+

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 + +

@@ -8580,7 +8579,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 - + @@ -8588,55 +8587,59 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 - + - + - + - +
- + -

+

Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;25;mmu:74147 +

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077

@@ -8646,7 +8649,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147 - + @@ -8654,24 +8657,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147 - + - + - + - +
- + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;39;mmu:83995 mmu:83996 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996

@@ -8681,7 +8684,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 - + @@ -8689,22 +8692,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 - + - + - + - +
- + -

+

Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 + +

@@ -8712,7 +8719,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 - + @@ -8720,24 +8727,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117 - + - + - + - +
- + -

Original kegg element: gene;7;mmu:11832 +

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30049

@@ -8747,7 +8754,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832 - + @@ -8755,24 +8762,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832 - + - + - + - +
- + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081 +

Original kegg element: map;50;path:mmu00072

@@ -8780,121 +8785,125 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081 - - - - - - + - + - + - +
- + -

Original kegg element: gene;20;mmu:20280 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280 - -

+

- - - - - - + - + - + + + + + + - + - + -

+

Original kegg element: gene;58;mmu:13124 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124 + +

+ + + + + - - - - - - + - + - + - +
- + -

+

Original kegg element: gene;57;mmu:11814 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814 + +

+ + + + + - + - + - + - +
- +

@@ -8903,102 +8912,98 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280 - - - - - - + - + - + + + + + + - + - + -

+

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845 + +

+ + + + + - - - - - - - - + + + - + - + - +
- + -

Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - -

+

@@ -9006,7 +9011,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - + @@ -9014,22 +9019,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 - + - + - + - + - + -

Original kegg element: map;35;path:mmu00071 +

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079

@@ -9037,29 +9044,34 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182 + + + + + - + - + - + - +
- + -

Original kegg element: gene;59;mmu:22259 +

Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183

@@ -9069,7 +9081,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259 - + @@ -9077,24 +9089,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259 - + - + - + - +
- + -

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168

@@ -9104,7 +9116,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 - + @@ -9112,24 +9124,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 - + - + - + - +
- + -

Original kegg element: gene;9;mmu:18534 mmu:74551 +

Original kegg element: gene;63;mmu:13167 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167

@@ -9139,7 +9151,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551 - + @@ -9147,24 +9159,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551 - + - + - + - +
- + -

Original kegg element: gene;36;mmu:26457 mmu:26569 +

Original kegg element: gene;30;mmu:16956 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956

@@ -9174,7 +9186,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 - + @@ -9182,94 +9194,79 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457 - + - + - + - +
- + -

Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - -

+

- - - - - - + - + - + - + + + + + + - + -

Original kegg element: gene;53;mmu:11450 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450 - -

+

- - - - - - + - + - + - + - + -

Original kegg element: gene;40;mmu:11770 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770 +

Original kegg element: map;35;path:mmu00071

@@ -9277,34 +9274,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770 - - - - - - + - + - + - +
- + -

Original kegg element: gene;10;mmu:103968 +

Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183

@@ -9314,7 +9306,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 - + @@ -9322,22 +9314,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 - + - + - + - +
- + -

+

Original kegg element: gene;10;mmu:103968 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 + +

@@ -9345,7 +9341,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 - + @@ -9353,59 +9349,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968 - + - + - + - +
- + -

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;29;mmu:108078 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:230639 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078

@@ -9415,7 +9407,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:230639 - + @@ -9423,57 +9415,57 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:230639 - + - + - + - +
- + -

+

Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 - -

+

@@ -9481,7 +9473,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 - + @@ -9489,24 +9481,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 - + - + - + - + - + -

Original kegg element: gene;16;mmu:19015 +

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081

@@ -9516,7 +9508,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015 - + @@ -9524,49 +9516,40 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015 - + - + - + - +
- + -

Original kegg element: gene;33;mmu:13122 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122 - -

+

- - - - - - + - + - + - + @@ -9596,22 +9579,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16592 - + - + - + -

Original kegg element: gene;37;mmu:15360 +

Original kegg element: gene;14;mmu:19013 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013

@@ -9621,7 +9604,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 - + @@ -9629,22 +9612,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 - + - + - + - +
- + -

+

Original kegg element: gene;44;mmu:14080 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 + +

@@ -9652,7 +9639,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 - + @@ -9660,19 +9647,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 - + - + - + - +
- +

@@ -9681,34 +9668,34 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 - - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;39;mmu:83995 mmu:83996 +

Original kegg element: gene;16;mmu:19015 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015

@@ -9718,7 +9705,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995 - + @@ -9726,24 +9713,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995 - + - + - + - +
- + -

Original kegg element: gene;39;mmu:83995 mmu:83996 +

Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732

@@ -9753,7 +9740,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996 - + @@ -9761,24 +9748,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996 - + - + - + - +
- + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;36;mmu:26457 mmu:26569 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569

@@ -9788,7 +9775,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 - + @@ -9796,22 +9783,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 - + - + - + - +
- + -

+

Original kegg element: gene;66;mmu:22227 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227 + +

@@ -9819,7 +9810,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 - + @@ -9827,19 +9818,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 - + - + - + - +
- +

@@ -9853,64 +9844,60 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802 - + - + - + - + - + - + - + -

Original kegg element: gene;63;mmu:13167 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;62;mmu:22190 +

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 -No homologues found for original id L:22190 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080

@@ -9918,60 +9905,69 @@ No homologues found for original id L:22190 + + + + + - + - + - + - +
- + -

+

Original kegg element: gene;26;mmu:12896 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 +

Original kegg element: gene;8;mmu:14626 mmu:14933 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626

@@ -9981,7 +9977,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845 - + @@ -9989,24 +9985,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845 - + - + - + - +
- + -

Original kegg element: gene;30;mmu:16956 +

Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895

@@ -10016,7 +10012,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956 - + @@ -10024,59 +10020,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956 - + - + - + - +
- + -

Original kegg element: gene;58;mmu:13124 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 +

Original kegg element: gene;56;mmu:56473 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473

@@ -10086,7 +10078,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 - + @@ -10094,48 +10086,61 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 - + - + - + - +
- + -

+

Original kegg element: gene;61;mmu:11806 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806 + +

+ + + + + - + - + - + - +
- + -

+

Original kegg element: gene;45;mmu:18607 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607 + +

@@ -10143,7 +10148,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 - + @@ -10151,24 +10156,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911 - + - + - + - +
- + -

Original kegg element: gene;18;mmu:19016 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016 +

Original kegg element: map;51;path:mmu00120

@@ -10176,65 +10179,64 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016 - - - - - - + - + - + - +
- + -

+

Original kegg element: gene;37;mmu:15360 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;60;mmu:104086 +

Original kegg element: gene;7;mmu:11832 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832

@@ -10244,7 +10246,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 - + @@ -10252,55 +10254,59 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 - + - + - + - +
- + -

+

Original kegg element: gene;43;mmu:16202 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732 +

Original kegg element: gene;22;mmu:11364 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364

@@ -10310,7 +10316,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 - + @@ -10318,22 +10324,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 - + - + - + - +
- + -

Original kegg element: map;50;path:mmu00072 +

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579

@@ -10341,29 +10349,34 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732 + + + + + - + - + - + - +
- + -

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 +

Original kegg element: gene;62;mmu:22190 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459 +No homologues found for original id L:22190

@@ -10371,34 +10384,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459 - - - - - - + - + - + - +
- + -

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 +

Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182

@@ -10408,7 +10416,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079 - + @@ -10416,22 +10424,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079 - + - + - + - +
- + -

+

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:230639 + +

@@ -10439,7 +10451,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079 - + @@ -10447,24 +10459,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079 - + - + - + - +
- + -

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 +

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457

@@ -10474,7 +10486,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140 - + @@ -10482,24 +10494,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140 - + - + - + - +
- + -

Original kegg element: gene;38;mmu:20411 +

Original kegg element: gene;32;mmu:14077 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077

@@ -10509,7 +10521,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411 - + @@ -10517,26 +10529,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411 - + - + - + - +
- + -

Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077 - -

+

@@ -10544,7 +10552,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077 - + @@ -10552,24 +10560,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077 - + - + - + - + - + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;33;mmu:13122 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:100040843 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122

@@ -10579,7 +10587,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:100040843 - + @@ -10587,24 +10595,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:100040843 - + - + - + - +
- + -

Original kegg element: gene;44;mmu:14080 +

Original kegg element: gene;20;mmu:20280 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280

@@ -10614,7 +10622,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 - + @@ -10622,24 +10630,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080 - + - + - + - +
- + -

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 +

Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183

@@ -10649,7 +10657,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 - + @@ -10657,59 +10665,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790 - + - + - + - +
- + -

Original kegg element: gene;21;mmu:113868 mmu:235674 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235674 - -

+

- - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20250 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753

@@ -10719,7 +10723,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20250 - + @@ -10727,24 +10731,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20250 - + - + - + - +
- + -

Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183 +

Original kegg element: gene;53;mmu:11450 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450

@@ -10754,7 +10758,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - + @@ -10762,24 +10766,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - + - + - + - +
- + -

Original kegg element: gene;57;mmu:11814 +

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249

@@ -10789,7 +10793,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814 - + @@ -10797,24 +10801,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814 - + - + - + - +
- + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;8;mmu:14626 mmu:14933 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933

@@ -10824,7 +10828,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 - + @@ -10832,24 +10836,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118 - + - + - + - +
- + -

Original kegg element: gene;22;mmu:11364 +

Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256

@@ -10859,7 +10863,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364 - + @@ -10867,24 +10871,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364 - + - + - + - +
- + -

Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168

@@ -10892,36 +10894,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 - - - - - - + - + - + - +
- + -

Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - -

+

@@ -10929,7 +10922,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - + @@ -10937,14 +10930,14 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - + - + - + - + @@ -10965,29 +10958,25 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181 - + - + - + - + -

Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065 - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065 - -

+

@@ -10995,7 +10984,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065 - + @@ -11003,55 +10992,59 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065 - + - + - + - + - + -

+

Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070 + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;36;mmu:26457 mmu:26569 +

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13119

@@ -11061,7 +11054,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 - + @@ -11069,14 +11062,14 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569 - + - + - + - + @@ -11106,20 +11099,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807 - + - +
- + -

Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168 +

Original kegg element: gene;21;mmu:113868 mmu:235674 + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868

@@ -11127,50 +11122,51 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807 + + + + + - + - + - + - +
- + -

PCrel;49;17 - -activation; --> - -

+

- + - + - + - +

@@ -11178,22 +11174,19 @@ activation; --> - + - + - + - - - - +

@@ -11201,19 +11194,19 @@ activation; --> - + - + - + - +

@@ -11221,19 +11214,19 @@ activation; --> - + - + - + - +

@@ -11241,43 +11234,39 @@ activation; --> - + - + - + - + -

PCrel;4;15 - -activation; --> - -

+

- + - + - + - +

@@ -11285,19 +11274,19 @@ activation; --> - + - + - + - +

@@ -11305,39 +11294,43 @@ activation; --> - + - + - + - + -

+

PCrel;49;17 + +activation; --> + +

- + - + - +
- +

@@ -11345,19 +11338,22 @@ activation; --> - + - + - + + + + - +

@@ -11365,40 +11361,39 @@ activation; --> - + - + - + + + + - + -

PCrel;4;15 - -activation; --> - -

+

- + - + - + @@ -11415,13 +11410,13 @@ activation; --> - + - + - +

@@ -11429,19 +11424,19 @@ activation; --> - + - + - + - +

@@ -11449,22 +11444,19 @@ activation; --> - + - + - + - - - - +

@@ -11472,43 +11464,39 @@ activation; --> - + - + - + - + -

PCrel;49;17 - -activation; --> - -

+

- + - + - + - +

@@ -11516,39 +11504,43 @@ activation; --> - + - + - + - + -

+

PCrel;4;15 + +activation; --> + +

- + - + - +
- +

@@ -11556,19 +11548,22 @@ activation; --> - + - + - + + + + - +

@@ -11576,43 +11571,39 @@ activation; --> - + - + - + - + -

PCrel;4;15 - -activation; --> - -

+

- + - + - + - +

@@ -11620,19 +11611,19 @@ activation; --> - + - + - + - +

@@ -11640,39 +11631,46 @@ activation; --> - + - + - + + + + - + -

+

PCrel;49;17 + +activation; --> + +

- + - + - +
- +

@@ -11680,42 +11678,43 @@ activation; --> - + - + - + - - - - + -

+

PCrel;4;15 + +activation; --> + +

- + - + - +
- +

@@ -11723,22 +11722,19 @@ activation; --> - + - + - + - - - - +

@@ -11746,42 +11742,43 @@ activation; --> - + - + - + - + -

+

PCrel;1;14 + +activation; --> + +

- + - + - + - - -
- +

@@ -11789,39 +11786,43 @@ activation; --> - + - + - + - + -

+

PCrel;4;15 + +activation; --> + +

- + - + - +
- +

@@ -11829,19 +11830,22 @@ activation; --> - + - + - + + + + - +

@@ -11849,43 +11853,42 @@ activation; --> - + - + - + + + + - + -

PCrel;1;14 - -activation; --> - -

+

- + - + - + - +

@@ -11893,20 +11896,17 @@ activation; --> - + - + - + - - - diff --git a/sbml/WP3942.svg b/sbml/WP3942.svg index ba17003..96ca4d9 100644 --- a/sbml/WP3942.svg +++ b/sbml/WP3942.svg @@ -8,55 +8,44 @@ />KetogenesisKetogenesis?Lipogenesisf49a1d38dfFatty acid transportebf78f49a1Cholesterol metabolismcd2f5Lipid transportFatty acid oxidationccaafb2604mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592Cholesterol metabolisme5513cd2f5ccaafLipogenesismmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592ebf78b2604Fatty acid oxidationFatty acid transportCYP8B1FABP4ACSL1ACSL5FABP7ACADLRXRBFABP4RXRASLC27A5ACAA1FABP1NR1H3CYP4A11PPARGACOX2SCDSLC27A4SLC27A2PDPK1CYP7A1ACSBG2SCDACOX3AQP7RXRAAPOA5APOA1CPT1AACSL3CPT2FADS2SORBS1APOA2RXRGACOX1SCDACSL1ME1SLC27A2CYP4A11Glycerophospholipid metabolismPrimary bile acid biosynthesisPCK2RXRACYP4A11RXRGACADLPCK1RXRGCD36PDPK1Glycerophospholipid metabolismCPT1BFABP5FABP1APOA5RXRGSynthesis and degradation of ketone bodiesMMP1NR1H3EHHADHADIPOQSLC27A5ACAA1SCDILKPPARAFABP3DBIUbcAPOC3OLR1CYP4A11FABP5PCK2ACAA1CPT1CFABP3SLC27A6ACSL6GK2ADIPOQRXRGCPT1CCYP4A11FABP4ACAA1PLTPSCDCYP27A1SCDPLIN1ACSL6APOA2CYP4A11FABP6FABP1CYP4A11FABP2SLC27A1ACSBG1CYP4A11ACSL3CPT1ASynthesis and degradation of ketone bodiesEHHADHSLC27A6APOC3FABP4Fatty acid metabolismACSL5ANGPTL4ILKCYP4A11GK3PDBIFABP2RXRBCYP4A11SCDSCP2CYP7A1CYP4A11Adipocytokine signaling pathwaycytochrome P450 4A14-likeRXRAFABP1ACSL4HMGCS2ME1Adipocytokine signaling pathwayRXRGAPOA1SLC27A1MMP1SLC27A4CYP27A1CYP4A11PPARDLPLSLC27A1RXRBCPT1BACADMSCP2unsaturated fatty acidsRXRBSLC27A1GK3PRXRAAQP7RXRACYP8B1ACSBG2UCP1Fatty acid metabolismCYP4A11CD36FABP7ACOX1unsaturated fatty acidsSLC27A4HMGCS2ACSL4PPARGCD36PLTPMMP1SORBS1ACSBG1LPLOLR1MMP1ANGPTL4SCDRXRBFABP3FABP3RXRBACOX2cytochrome P450 4A14-likePPARDPLIN1UCP1CD36PCK1PPARAGK2CPT2UbcACADMFADS2FABP6ACOX3Primary bile acid biosynthesisGluconeogenesisLiver Skeletal muscleSkeletal muscle AdipocyteLabelAdipocyteAdipocyte differentiationLipid metabolismAdipocyteLiver Skeletal muscleLabelSkeletal muscle AdipocyteGluconeogenesis - + @@ -16,17 +16,17 @@ Additional sources of information: mTORC1 complex is based on [https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin#mTORC1 Wikipedia]. PDGFB and TGFB as targets of HIF1A based on [http://www.genome.jp/kegg-bin/show_pathway?hsa05211 KEGG]. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. -[-:-] lcsb.mapviewer.model.LogMarker@47a8ba87Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@7b2f7b06Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@42cc56e5Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@3ecd8f5bUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: -1.5707963267948966 -[-:-] lcsb.mapviewer.model.LogMarker@3c337687Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 1.5707963267948966 -[-:-] lcsb.mapviewer.model.LogMarker@3c44dd4cUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@1c9fdf5fUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@4e7a2cc0Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@69dafcc6Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@736ef20cUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 -[-:-] lcsb.mapviewer.model.LogMarker@1169ae19Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@2d91309aUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@7997e3f2Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@beaa382Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@4e81e65fUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: -1.5707963267948966 +[-:-] lcsb.mapviewer.model.LogMarker@6ab01af5Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 1.5707963267948966 +[-:-] lcsb.mapviewer.model.LogMarker@2c7eec22Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@72d6ac9cUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@33240f87Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@59a9dca4Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@26d244fUnknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 +[-:-] lcsb.mapviewer.model.LogMarker@4518dad2Unknown attribute of node. Key:org.pathvisio.core.StateRotation; value: 4.71238898038469 [TRANSCRIPTION_TRANSLATION:idb133fbea] Invalid interaction type. [INHIBITION:id7e461c1b] Invalid interaction type. [TRANSCRIPTION_TRANSLATION:idedbf4f63] Invalid interaction type. @@ -35,23 +35,23 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), [LINE:ida1c08b30] Invalid interaction type as an input to reaction. [State:a537f] state for Rna is not supported. [-:-] Miriam data (PUBMED: 23792563) for id72c61b7c already exists. Ignoring... -[Complex:c7790] Empty element is invalid -[Complex:e10cc] Empty element is invalid +[Complex:f13a7] Empty element is invalid +[Complex:af241] Empty element is invalid +[Complex:fac6c] Empty element is invalid [Complex:fd29c] Empty element is invalid +[Complex:c7790] Empty element is invalid +[Complex:f223f] Empty element is invalid [Complex:abb06] Empty element is invalid +[Complex:bebe9] Empty element is invalid +[Complex:c34e8] Empty element is invalid +[Complex:e8977] Empty element is invalid +[Complex:e10cc] Empty element is invalid [Complex:cea42] Empty element is invalid -[Complex:b09eb] Empty element is invalid -[Complex:f223f] Empty element is invalid -[Complex:f9feb] Empty element is invalid [Complex:b3e47] Empty element is invalid -[Complex:f13a7] Empty element is invalid -[Complex:fac6c] Empty element is invalid -[Complex:d4eb0] Empty element is invalid +[Complex:f9feb] Empty element is invalid [Complex:ebdaf] Empty element is invalid -[Complex:e8977] Empty element is invalid -[Complex:bebe9] Empty element is invalid -[Complex:af241] Empty element is invalid -[Complex:c34e8] Empty element is invalid

+[Complex:b09eb] Empty element is invalid +[Complex:d4eb0] Empty element is invalid

@@ -76,10 +76,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - + + @@ -105,6 +105,23 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + + + + + + + + + + + + + @@ -135,32 +152,15 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - - - - - - - - - - - - - - + + - - + + @@ -170,144 +170,147 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - - + + - - + + - + - + - + - + - + - + - - + + + + + + - - - - - - - - + + - - - - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + - + - + - + - + - - - - - - - - - - - - + + + - + + + + - + - + @@ -323,37 +326,37 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - + - + - + - + - + @@ -364,26 +367,26 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - + - + @@ -394,45 +397,34 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + @@ -443,107 +435,130 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - - - - + - + - + - + - - + + - - - - - - + + + + + + + + - - + + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + - + - - + + + + - - - - - - - - - + + + + + + - - + + - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + @@ -552,10 +567,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + @@ -566,26 +581,34 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + + + + + + + + + - + - + @@ -596,92 +619,128 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + @@ -699,72 +758,40 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - + + - - - + + + - - + + - - - - + - + - + - + @@ -775,12 +802,12 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + @@ -791,193 +818,216 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - - + + + + + + + + + + + + + + - - - - - - - - + + - - + + - - + + + - - - - - - - - + + - - - - + - - - + + + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -999,97 +1049,101 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - - - - - - - - - - - - + + + - + + + + - + - + - + @@ -1100,82 +1154,54 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - + - + - - - - - - - - - - - - - - - + - + - + - + - + - + - - - - - - - - - - - - - - @@ -1184,115 +1210,140 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - + + + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - + - + @@ -1303,26 +1354,18 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - - - - + - + - + - + @@ -1333,38 +1376,44 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - - - - - - - - - + - + - + - + + + + + + + + + + + + + + + @@ -1384,180 +1433,131 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - - - + + + - - + + - - + + + + + + + + + + + + + + + - - - + + + + + - - + + + + + + + + - + + + + - + - + - + - + - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + @@ -1566,14 +1566,14 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - - + + + + @@ -1584,43 +1584,25 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - - + + + + - - - - - - - - - - - - - - - - - - - + - + @@ -1632,74 +1614,83 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + + + + - + - - - - + + + + - + + + + - + - + - - - - + + + + - + + + + - + - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -1710,14 +1701,14 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - - + + + + @@ -1726,16 +1717,16 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - - - - + + + + @@ -1744,30 +1735,45 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + + + + + + + + + + + - + - + - - - - + + + + - + - + - + @@ -1779,88 +1785,103 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + + + + + + + + + + + + + + + + - - + + - + - - - - + + + + - + - + - + @@ -1872,16 +1893,16 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + @@ -1893,134 +1914,113 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - - - - - - - - - - - - - - + - + - - - - + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - - - - + - + - - + + - - - - + + + + @@ -2031,14 +2031,14 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - - + + + + @@ -2049,14 +2049,14 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - - - + + + + @@ -2081,239 +2081,239 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -2321,10 +2321,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + @@ -2333,28 +2333,28 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + - + - - + + - + - - + + - + - - + + @@ -2365,1097 +2365,1121 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + + + + + + + - + + + + + + + - + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + + + + + + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - + - - - - - - - + - + - - - - - - - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - - - - - - - - + + - + - - + + - + - - + + - + - + - + - + - - - - - - - - - - - - - + - - + + - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + @@ -3465,7 +3489,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3475,7 +3499,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3487,145 +3511,167 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + - + @@ -3635,7 +3681,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3645,7 +3691,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3657,7 +3703,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3667,7 +3713,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3677,7 +3723,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3687,7 +3733,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -3699,324 +3745,278 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - + + - - - - - - - - - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + @@ -4025,10 +4025,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + @@ -4037,226 +4037,250 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + @@ -4265,93 +4289,105 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + + + + + + + + + + + + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + @@ -4361,280 +4397,280 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4643,46 +4679,40 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - 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@@ -5847,7 +5847,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -5855,19 +5855,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + + + + + + - + - +

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+

+ +

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- +

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@@ -6917,7 +6933,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -6925,19 +6941,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + + + + + + - + - +

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+

+ +

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- +

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@@ -7098,7 +7131,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7106,19 +7139,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7129,7 +7162,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7139,17 +7172,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

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- - - - - - - + + - + - + - + + + + + + - + - +

@@ -7222,7 +7255,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7230,19 +7263,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7253,7 +7286,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7261,19 +7294,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

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+

+ +

@@ -7341,7 +7386,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7349,19 +7394,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + + + + + +
- +

@@ -7372,7 +7422,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7380,19 +7430,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7403,7 +7453,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7413,17 +7463,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -7434,7 +7484,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7442,19 +7492,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7465,7 +7515,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7475,17 +7525,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -7496,7 +7546,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7506,17 +7556,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -7527,7 +7577,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7535,19 +7585,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7558,7 +7608,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7566,19 +7616,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7589,7 +7639,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7599,17 +7649,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -7618,11 +7668,6 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - @@ -7630,17 +7675,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -7651,7 +7696,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7661,17 +7706,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

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@@ -7868,7 +7914,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7876,19 +7922,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -7899,7 +7945,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -7909,17 +7955,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

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@@ -7992,7 +8038,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8002,17 +8048,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

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@@ -8085,7 +8126,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8095,17 +8136,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8116,7 +8157,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8126,17 +8167,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8145,6 +8186,11 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + @@ -8152,27 +8198,20 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + -

- -

+

@@ -8180,7 +8219,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8188,24 +8227,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - + - +

@@ -8216,7 +8250,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8226,17 +8260,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

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- -

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@@ -8316,7 +8343,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8324,19 +8351,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -8347,7 +8374,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8355,19 +8382,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -8376,11 +8403,6 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - @@ -8388,22 +8410,22 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -8412,11 +8434,6 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - @@ -8424,17 +8441,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8443,24 +8460,29 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + - + - + - + - + - +

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@@ -8502,7 +8524,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8512,17 +8534,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8533,7 +8555,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8543,17 +8565,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8562,11 +8584,6 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - @@ -8574,17 +8591,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8595,7 +8612,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8605,17 +8622,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8626,7 +8643,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8634,19 +8651,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -8657,7 +8674,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8667,17 +8684,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8688,7 +8705,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8698,17 +8715,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8719,7 +8736,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8727,19 +8744,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -8748,11 +8765,6 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - @@ -8760,22 +8772,25 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + + + + + + - + - + -

- -

+

@@ -8783,7 +8798,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8791,24 +8806,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - + - +

@@ -8819,7 +8829,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8829,17 +8839,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8850,7 +8860,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8860,22 +8870,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - +

@@ -8884,29 +8889,29 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + + + + + + - + - +

@@ -8917,7 +8922,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8925,19 +8930,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -8948,7 +8953,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8958,17 +8963,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -8979,7 +8984,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -8987,19 +8992,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + + + + + + - + - +

@@ -9008,29 +9018,34 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + - + - + - + - + - + - + - +

@@ -9041,7 +9056,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9051,17 +9066,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9072,7 +9087,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9080,27 +9095,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - + - + -

+

+ +

@@ -9108,7 +9120,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9116,19 +9128,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + + + + + + - +
- +

@@ -9137,29 +9154,29 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + + + + + + - + - +

@@ -9170,7 +9187,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9178,19 +9195,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -9201,7 +9218,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9209,19 +9226,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -9230,29 +9247,29 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - + + + + + + - +

@@ -9261,29 +9278,29 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + + + + + + - + - +

@@ -9292,29 +9309,29 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), + + + + + - - - - - - + - + - + - + - +

@@ -9325,7 +9342,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9333,19 +9350,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - +

@@ -9354,11 +9371,6 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - @@ -9366,17 +9378,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9387,7 +9399,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9397,17 +9409,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9418,7 +9430,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9426,57 +9438,45 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - + - + -

- -

+

- - - - - - - - - - - + - + - + - + - +

@@ -9487,7 +9487,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9497,17 +9497,17 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9518,7 +9518,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9528,19 +9528,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9548,19 +9548,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - +

@@ -9568,24 +9568,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - +

@@ -9593,10 +9588,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + @@ -9604,13 +9599,13 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9618,24 +9613,20 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + + - + - +

@@ -9643,19 +9634,25 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + + + + + + - + + - + - +

@@ -9663,19 +9660,22 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + + + + - +

@@ -9683,7 +9683,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9694,13 +9694,13 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9708,46 +9708,44 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + + + + + + - + - + - + -

AMPK phosphorylates TSC2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735030/) - -

+

- - - - - - + - + - + - +

@@ -9755,7 +9753,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9766,31 +9764,32 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + -

+

PDGFB and TGFB1,2,3 as targets of HIF1A based on KEGG (http://www.genome.jp/kegg-bin/show_pathway?hsa05211) + +

- + - - + - + @@ -9807,13 +9806,13 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - +

@@ -9821,46 +9820,44 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - + -

PDGFB and TGFB1,2,3 as targets of HIF1A based on KEGG (http://www.genome.jp/kegg-bin/show_pathway?hsa05211) - -

+

- + + + + + + - + - + - +

@@ -9868,19 +9865,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - +

@@ -9888,7 +9885,7 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + @@ -9899,14 +9896,13 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - + - +

@@ -9914,19 +9910,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + + + + + + - + - + - +

@@ -9934,22 +9935,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - - - - +

@@ -9957,19 +9955,22 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + + + + - +

@@ -9977,22 +9978,20 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + + - + - - - - +

@@ -10000,24 +9999,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - +

@@ -10025,19 +10019,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + - + - +

@@ -10045,24 +10039,19 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - - - - - - + - + - + - +

@@ -10070,19 +10059,24 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + + + + + + - + - + - +

@@ -10090,40 +10084,46 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - - + - + - + -

+

AMPK phosphorylates TSC2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735030/) + +

- + + + + + + - + - +
- +

@@ -10131,10 +10131,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + @@ -10142,10 +10142,10 @@ Phosphorylation sites were added based on information from PhosphoSitePlus (R), - + - + diff --git a/sbml/WP4018.svg b/sbml/WP4018.svg index 1b8647a..0b8dc84 100644 --- a/sbml/WP4018.svg +++ b/sbml/WP4018.svg @@ -8,20 +8,20 @@ />DEPTORd2a36d2a36d9098efdbad9098Malfunction of epigenetic machineryCell migrationand invasionCAMK1FLT1EFCAB3EGFRAMPKENPP3HK3PDGFRAGlycolysisFLT1Cell proliferationENPP3GlucoseACACASTAT3CAMK1Fatty acid synthesisFASNFatty acid synthesisEFCAB3Cell proliferationGlycolysisProtein translationSTAT3AMPKHK3EGFRGlucoseACACAPAngiogenesisPTENGLUT1?GLUT1TOX2LegendNucleusActivation of PI3K-mTOR pathwaye6209c813dActivating mutationfd254Nucleusb5d23Legendc813dActivation of PI3K-mTOR pathwayInactivating mutatione6209b5d23fd254Inactivating mutation - + @@ -13,10 +13,10 @@ Pathway is based on [https://www.genome.jp/dbget-bin/www_bget?pathway+map00240 K Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4022 CPTAC Assay Portal] -[Complex:a563f] Empty element is invalid +[Complex:cac3c] Empty element is invalid [Complex:a23b9] Empty element is invalid [Complex:b53a9] Empty element is invalid -[Complex:cac3c] Empty element is invalid +[Complex:a563f] Empty element is invalid [BiopaxReference:d2f] Publication type is not supported.

@@ -25,6 +25,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + @@ -41,8 +46,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -76,628 +81,613 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - + - - - - + + + + - + - + - + - + - + - - - - - - - - - - + + - + - - - - - - - - - + - + - - - + + + - - + + - + - + - - - + + + - - + + - + - - - - + + + + - + - - - + + + - - + + - - + + - + - + - - - - - - + + + + + + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + + + + + + + + + - - - - - - + + + + + + - + - - + + - + - + + + + + + + + + - + - + - + - + - + - - - + + + - - + + - - + + - + - - - - - - - - - - - - + + + - - + + - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - + - - - + + + - - + + - + - + - + - + - + - - - - + + + + - + - + - + - - - - - - - - - - - - - - + + + - - + + - - + + + + + + + + + + - - - - - - - - + + + + + + - - + + - + - - - - - - + + + + + + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + + + + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -713,74 +703,98 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + + + + + + + + + - - - - + + + + - + - + + + + + + + + + - + - - - + + + - - + + - + - + - + - + + + + + + + + + @@ -800,84 +814,111 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - + + + - - + + - + - + - - + + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + + + + + + + + + @@ -899,31 +940,15 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + - - - - - - - - - - - - - - - - - - + + - + @@ -939,49 +964,25 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - @@ -1001,407 +1002,341 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - + - + - - - + + + + + + + + + + + + - - + + - + - + - + - + - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - - + + - + - - - + + + + + + + + + + + + - - + + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - - - - - - + + + + + + - + - + + + + + + + + + - - - - - - + + + + + + - + - - - - - - - - - - - - - - - - - - + + - - - - - - + + + + + + + + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - - - + + + - - + + - + - + - - - + + + - - + + - + - + - + + + + + + + + + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - + + + - - + + - + - + - + @@ -1417,174 +1352,177 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - - + + + - - + + - + - + - - - + + + - - + + - - - + + + - - + + - + + + + + + + + + - - - - + + + + - + - + - + - - + + - + - + + + + + + + + + - + - + - + - - + + - + - + - + - + - + - + - - - - - - + + + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - + + @@ -1605,66 +1543,66 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + - + - + - - - - + + + + - + - - - - - - - - - - - - - - - - - + - + - + - - - - + + + + @@ -1672,641 +1610,681 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - - - - - - - - - - - - - - - + - - - - - - + + + + + + - + - - - - - - - - - + - + - - - + + + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - + - + - + - - - - + + + + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - + + - + - + - + - - - + + + - + - + - + - - - + + + - - + + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + + + + + + + + + - + - - + + - + - - - + + + - - + + - + - + - - - + + + - - + + - + - + - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - - + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + + + + + + + + + - + - - - + + + + + + + + + + + + + + - - + + - + + + + + + + + + - + - + - + - - - + + + + + + + + + + + + + + - - + + + + + + + + + + @@ -2327,76 +2305,103 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + @@ -2408,14 +2413,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2429,14 +2434,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2450,14 +2455,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2471,14 +2476,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2492,14 +2497,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2513,14 +2518,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2531,260 +2536,260 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - - - - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - - - + - + - + - - - - + + + + @@ -2798,14 +2803,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2819,14 +2824,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -2840,14 +2845,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + @@ -2856,241 +2861,232 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - - - - - - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - - - - - - - - - - - + + + + + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + @@ -3104,14 +3100,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -3125,14 +3121,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + @@ -3143,461 +3139,470 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - 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+ - + - + - - - + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + - - - + + - + - + - + - + - + - - - - - - - - + + + - + - + - + - - - - - + - + - + - + - + - + - + - - - + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + - + - + - + - + - + - + - + - - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - - + + + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - + + - + - + - + - + - + - + - + - - + + + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - - - + + @@ -13988,7 +13993,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -13999,7 +14004,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14007,19 +14012,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -14030,7 +14035,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14038,19 +14043,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -14059,29 +14064,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -14092,7 +14097,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14100,22 +14105,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c +

Original kegg element: gene;85;mtu:Rv3247c

@@ -14125,7 +14130,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14133,22 +14138,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Original kegg element: gene;25;mtu:Rv0321 +

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c

@@ -14158,7 +14163,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14166,19 +14171,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -14187,29 +14192,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -14220,7 +14225,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14230,17 +14235,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -14251,7 +14256,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14259,19 +14264,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -14282,7 +14287,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14292,17 +14297,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -14311,32 +14316,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - + -

+

Original kegg element: gene;48;mtu:Rv3315c + +

@@ -14344,7 +14351,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14352,19 +14359,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -14375,7 +14382,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14383,52 +14390,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -14439,7 +14444,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14447,19 +14452,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -14470,7 +14475,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14478,19 +14483,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -14499,29 +14504,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -14532,7 +14537,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14542,22 +14547,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

Check literature for directionality of enzyme - -

+

@@ -14565,7 +14568,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14573,19 +14576,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -14599,27 +14602,27 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + -

Original kegg element: gene;26;mtu:Rv1699 +

Check literature for directionality of enzyme

@@ -14629,7 +14632,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14637,19 +14640,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -14660,7 +14663,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14670,20 +14673,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

+

Original kegg element: gene;15;mtu:Rv1381 + +

@@ -14691,7 +14696,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14699,19 +14704,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -14722,7 +14727,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14730,24 +14735,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Deoxythymidine 5'-phosphate - -

+

@@ -14755,7 +14758,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14765,17 +14768,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -14784,29 +14787,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -14817,7 +14820,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14825,24 +14828,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Check literature for directionality of enzyme - -

+

@@ -14850,7 +14851,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14858,22 +14859,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Original kegg element: gene;26;mtu:Rv1699 + +

@@ -14881,7 +14884,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14889,19 +14892,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -14912,7 +14915,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14920,22 +14923,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Original kegg element: gene;111;mtu:Rv1021 + +

@@ -14943,7 +14948,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14951,22 +14956,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Original kegg element: gene;41;mtu:Rv2783c +

Check literature for directionality of enzyme

@@ -14976,7 +14981,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -14984,47 +14989,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

http://www.kegg.jp/dbget-bin/www_bget?mtu00330 - -

+

+ + + + + - + - + - + - + - +

@@ -15035,7 +15043,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15043,19 +15051,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15064,29 +15072,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -15095,34 +15103,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - + -

Original kegg element: gene;111;mtu:Rv1021 - -

+

@@ -15130,7 +15136,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15138,22 +15144,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Original kegg element: gene;25;mtu:Rv0321 + +

@@ -15161,7 +15169,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15169,24 +15177,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c - -

+

@@ -15194,7 +15200,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15202,50 +15208,47 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

http://www.kegg.jp/dbget-bin/www_bget?mtu00030 + +

- - - - - - + - + - + - +
- +

@@ -15259,27 +15262,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + -

+

Check literature for directionality of enzyme + +

@@ -15287,7 +15292,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15295,19 +15300,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -15316,60 +15321,62 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

+

Original kegg element: gene;111;mtu:Rv1021 + +

+ + + + + - - - - - - + - + - + - +
- +

@@ -15378,34 +15385,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

Original kegg element: gene;17;mtu:Rv2139 - -

+

@@ -15413,7 +15418,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15421,19 +15426,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15444,7 +15449,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15452,19 +15457,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15475,7 +15480,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15483,19 +15488,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15504,29 +15509,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -15537,7 +15542,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15545,19 +15550,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15568,7 +15573,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15576,55 +15581,55 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c + +

+ + + + + - - - - - - + - + - + - +
- + -

Original kegg element: gene;26;mtu:Rv1699 - -

+

@@ -15632,7 +15637,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15640,19 +15645,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15663,7 +15668,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15671,19 +15676,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15694,7 +15699,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15702,19 +15707,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15725,7 +15730,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15733,19 +15738,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15756,7 +15761,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15764,19 +15769,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15785,29 +15790,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -15816,34 +15821,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

Check literature for directionality of enzyme - -

+

@@ -15851,7 +15854,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15859,50 +15862,52 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Check literature for directionality of enzyme + +

+ + + + + - - - - - - + - + - + - +
- +

@@ -15913,7 +15918,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15921,24 +15926,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;4;mtu:Rv2883c - -

+

@@ -15946,7 +15949,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -15954,19 +15957,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -15975,29 +15978,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -16006,29 +16009,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -16039,7 +16042,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16047,19 +16050,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16078,22 +16081,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;4;mtu:Rv2883c +

5-Phospho-alpha-D-ribose 1-diphosphate

@@ -16103,7 +16106,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16111,24 +16114,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

http://www.kegg.jp/dbget-bin/www_bget?mtu00410 - -

+

@@ -16139,24 +16140,27 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + + + - + - + -

Original kegg element: gene;111;mtu:Rv1021 - -

+

@@ -16164,7 +16168,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16172,24 +16176,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;4;mtu:Rv2883c - -

+

@@ -16197,7 +16199,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16205,19 +16207,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16228,7 +16230,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16236,22 +16238,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Check literature for directionality of enzyme +

Original kegg element: gene;4;mtu:Rv2883c

@@ -16261,7 +16263,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16269,22 +16271,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

Original kegg element: gene;111;mtu:Rv1021 + +

@@ -16292,7 +16296,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16300,19 +16304,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -16323,7 +16327,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16331,50 +16335,47 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

http://www.kegg.jp/dbget-bin/www_bget?mtu00410 + +

- - - - - - + - + - + - +
- +

@@ -16385,7 +16386,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16393,22 +16394,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Deoxythymidine 5'-triphosphate + +

@@ -16416,7 +16419,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16424,22 +16427,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Original kegg element: gene;26;mtu:Rv1699 +

Original kegg element: gene;17;mtu:Rv2139

@@ -16449,7 +16452,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16457,19 +16460,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -16478,29 +16481,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -16511,7 +16514,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16519,19 +16522,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16542,7 +16545,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16550,19 +16553,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16573,7 +16576,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16581,19 +16584,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16602,65 +16605,65 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

Original kegg element: gene;48;mtu:Rv3315c - -

+

- - - - - - + - + - + + + + + + - + - + -

+

Original kegg element: gene;70;mtu:Rv2697c + +

@@ -16668,7 +16671,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16676,19 +16679,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -16699,7 +16702,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16707,22 +16710,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Original kegg element: gene;41;mtu:Rv2783c + +

@@ -16730,7 +16735,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16738,19 +16743,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -16759,29 +16764,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -16790,29 +16795,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -16826,24 +16831,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -16854,7 +16859,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16862,19 +16867,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16885,7 +16890,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16893,19 +16898,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16914,29 +16919,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -16947,7 +16952,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16955,19 +16960,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -16978,7 +16983,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -16986,50 +16991,47 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

http://www.kegg.jp/dbget-bin/www_bget?mtu00250 + +

- - - - - - + - + - + - +
- +

@@ -17040,7 +17042,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17048,19 +17050,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17071,7 +17073,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17081,50 +17083,48 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

Check literature for directionality of enzyme - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -17135,7 +17135,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17143,53 +17143,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

http://www.kegg.jp/dbget-bin/www_bget?mtu00330 + +

- - - - - - + - + - + - +
- + -

Original kegg element: gene;4;mtu:Rv2883c +

Check literature for directionality of enzyme

@@ -17199,7 +17196,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17207,24 +17204,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Original kegg element: gene;26;mtu:Rv1699 - -

+

@@ -17232,7 +17227,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17240,24 +17235,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;111;mtu:Rv1021 - -

+

@@ -17265,7 +17258,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17273,19 +17266,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17296,7 +17289,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17304,22 +17297,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Deoxythymidine 5'-diphosphate + +

@@ -17327,7 +17322,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17335,22 +17330,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

Check literature for directionality of enzyme + +

@@ -17358,7 +17355,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17366,52 +17363,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

5-Phospho-alpha-D-ribose 1-diphosphate - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -17422,7 +17417,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17430,19 +17425,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17456,24 +17451,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -17487,24 +17482,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -17515,7 +17510,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17523,19 +17518,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17546,7 +17541,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17554,47 +17549,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

http://www.kegg.jp/dbget-bin/www_bget?mtu00410 - -

+

+ + + + + - + - + - + - + - +

@@ -17605,7 +17603,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17613,19 +17611,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17636,7 +17634,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17644,19 +17642,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17667,7 +17665,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17675,19 +17673,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17696,32 +17694,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

+

Original kegg element: gene;4;mtu:Rv2883c + +

@@ -17729,7 +17729,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17737,19 +17737,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -17760,7 +17760,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17768,19 +17768,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17791,7 +17791,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17801,20 +17801,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

+

Original kegg element: gene;26;mtu:Rv1699 + +

@@ -17822,7 +17824,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17830,22 +17832,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Original kegg element: gene;14;mtu:Rv1380 +

Original kegg element: gene;4;mtu:Rv2883c

@@ -17855,7 +17857,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17863,19 +17865,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -17886,7 +17888,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17894,19 +17896,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17917,7 +17919,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17925,19 +17927,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17948,7 +17950,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -17956,19 +17958,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -17977,29 +17979,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -18008,34 +18010,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

Original kegg element: gene;73;mtu:Rv3247c - -

+

@@ -18043,7 +18043,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18051,19 +18051,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18074,7 +18074,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18082,19 +18082,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18103,29 +18103,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -18136,7 +18136,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18144,19 +18144,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18167,7 +18167,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18175,19 +18175,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18196,29 +18196,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -18229,7 +18229,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18237,19 +18237,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18260,7 +18260,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18268,19 +18268,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18289,29 +18289,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -18322,7 +18322,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18330,22 +18330,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Check literature for directionality of enzyme + +

@@ -18353,7 +18355,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18363,22 +18365,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - +
- + -

Original kegg element: gene;26;mtu:Rv1699 - -

+

@@ -18386,7 +18386,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18394,19 +18394,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18417,7 +18417,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18425,52 +18425,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Original kegg element: gene;4;mtu:Rv2883c - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -18479,29 +18477,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -18510,29 +18508,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -18541,29 +18539,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -18574,7 +18572,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18582,19 +18580,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18603,29 +18601,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -18634,29 +18632,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -18665,29 +18663,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -18701,24 +18699,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -18729,7 +18727,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18737,19 +18735,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18758,32 +18756,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

+

Original kegg element: gene;6;mtu:Rv2754c + +

@@ -18791,7 +18791,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18799,22 +18799,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

Original kegg element: gene;4;mtu:Rv2883c + +

@@ -18822,7 +18824,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18830,19 +18832,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -18853,7 +18855,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18861,19 +18863,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18887,24 +18889,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - +

@@ -18915,7 +18917,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18923,19 +18925,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18946,7 +18948,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18954,19 +18956,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -18977,7 +18979,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -18985,19 +18987,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -19008,7 +19010,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -19016,22 +19018,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Original kegg element: gene;4;mtu:Rv2883c + +

@@ -19039,7 +19043,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -19047,19 +19051,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -19070,7 +19074,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -19078,25 +19082,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

-P1,P4-Bis(5'-uridyl) tetraphosphate - -

+

@@ -19104,7 +19105,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19114,17 +19115,17 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - +

@@ -19135,7 +19136,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19143,19 +19144,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19166,7 +19167,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19174,19 +19175,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19195,29 +19196,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate + + + + + - - - - - - + - + - + - + - +

@@ -19228,7 +19229,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19236,19 +19237,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19259,7 +19260,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19267,19 +19268,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19290,7 +19291,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19298,19 +19299,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19321,7 +19322,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19329,50 +19330,47 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

http://www.kegg.jp/dbget-bin/www_bget?mtu00410 + +

- - - - - - + - + - + - +
- +

@@ -19381,29 +19379,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate + + + + + - - - - - - + - + - + - + - +

@@ -19414,7 +19412,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19422,24 +19420,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Deoxythymidine 5'-triphosphate - -

+

@@ -19447,7 +19443,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19455,52 +19451,50 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Original kegg element: gene;6;mtu:Rv2754c - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -19511,7 +19505,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19519,22 +19513,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Original kegg element: gene;25;mtu:Rv0321 + +

@@ -19542,7 +19538,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19550,19 +19546,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -19571,29 +19567,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate + + + + + - - - - - - + - + - + - + - +

@@ -19602,29 +19598,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate + + + + + - - - - - - + - + - + - + - +

@@ -19635,7 +19631,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19643,24 +19639,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

http://www.kegg.jp/dbget-bin/www_bget?mtu00030 - -

+

@@ -19671,19 +19665,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + + + + + + - + - +

@@ -19694,7 +19693,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19702,19 +19701,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19725,7 +19724,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19733,19 +19732,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19756,7 +19755,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19764,19 +19763,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -19787,7 +19786,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19795,14 +19794,14 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + @@ -19828,50 +19827,48 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + -

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -19882,7 +19879,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19890,24 +19887,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Original kegg element: gene;4;mtu:Rv2883c - -

+

@@ -19915,7 +19910,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19923,24 +19918,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Deoxythymidine 5'-diphosphate - -

+

@@ -19948,7 +19941,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19956,22 +19949,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Check literature for directionality of enzyme + +

@@ -19979,7 +19974,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -19987,19 +19982,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -20010,7 +20005,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20018,19 +20013,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -20041,7 +20036,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20049,22 +20044,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c + +

@@ -20072,7 +20069,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20080,19 +20077,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -20103,7 +20100,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20111,19 +20108,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -20134,7 +20131,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20142,24 +20139,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c - -

+

@@ -20167,7 +20162,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20175,22 +20170,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Original kegg element: gene;25;mtu:Rv0321 +

Original kegg element: gene;111;mtu:Rv1021

@@ -20200,7 +20195,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20208,19 +20203,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -20231,7 +20226,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20239,22 +20234,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c + +

@@ -20262,7 +20259,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20270,22 +20267,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- + -

+

Original kegg element: gene;4;mtu:Rv2883c + +

@@ -20293,7 +20292,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20301,19 +20300,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -20324,7 +20323,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20332,19 +20331,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -20355,7 +20354,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20363,22 +20362,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

http://www.kegg.jp/dbget-bin/www_bget?mtu00250 +

Check literature for directionality of enzyme

@@ -20386,24 +20385,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate + + + + + - + - + - + - +
- +

@@ -20412,29 +20416,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - - - - - - + - + - + + + + + + - + - +

@@ -20445,7 +20449,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20453,24 +20457,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Check literature for directionality of enzyme - -

+

@@ -20478,7 +20480,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20486,22 +20488,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Original kegg element: gene;26;mtu:Rv1699 + +

@@ -20509,7 +20513,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20517,22 +20521,25 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- + -

+

+P1,P4-Bis(5'-uridyl) tetraphosphate + +

@@ -20540,7 +20547,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20548,24 +20555,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- + -

Check literature for directionality of enzyme - -

+

@@ -20573,7 +20578,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20581,19 +20586,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -20602,29 +20607,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - - - - - - + - + - + - + + + + + + - +

@@ -20635,7 +20640,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20643,22 +20648,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Original kegg element: gene;26;mtu:Rv1699 + +

@@ -20666,7 +20673,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20674,55 +20681,55 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- + -

Check literature for directionality of enzyme - -

+

- - - - - - + - + - + + + + + + - + - + -

+

Original kegg element: gene;26;mtu:Rv1699 + +

@@ -20730,7 +20737,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20738,19 +20745,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -20759,34 +20766,32 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - - - - - - + - + - + - + + + + + + - + -

Original kegg element: gene;111;mtu:Rv1021 - -

+

@@ -20794,7 +20799,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20802,22 +20807,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Deoxythymidine 5'-phosphate + +

@@ -20825,7 +20832,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20833,19 +20840,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -20854,29 +20861,29 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - - - - - - + - + - + + + + + + - + - +

@@ -20885,34 +20892,32 @@ P1,P4-Bis(5'-uridyl) tetraphosphate + + + + + - - - - - - + - + - + - + - + -

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c - -

+

@@ -20920,7 +20925,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20928,24 +20933,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Check literature for directionality of enzyme - -

+

@@ -20953,7 +20956,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20961,22 +20964,22 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

Original kegg element: gene;70;mtu:Rv2697c +

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c

@@ -20986,7 +20989,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -20994,19 +20997,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

Original kegg element: gene;26;mtu:Rv1699 @@ -21027,22 +21030,24 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

+

Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c + +

@@ -21050,7 +21055,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -21058,19 +21063,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - +
- +

@@ -21081,7 +21086,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -21089,19 +21094,19 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - +

@@ -21112,7 +21117,7 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + @@ -21120,71 +21125,121 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

rn:R00511 +

rn:R02269

- + - + - + - +
- + -

rn:R02806 +

rn:R00512 + +

+ +
+ + + + + + + + + + + + + + + + +
+ + + +

rn:R01080 + +

+ +
+ + + + + + + + + + + + + + + + +
+ + + +

rn:R01664

- + - + - + - +
- +

@@ -21192,121 +21247,116 @@ P1,P4-Bis(5'-uridyl) tetraphosphate - + - + - + - + - + -

rn:R01867 - -

+

- + - + - + - + - + -

rn:R00512 - -

+

- + - + - + - + - + -

rn:R02269 +

rn:R00977

- + - + - + - +
- + -

maplink;14;98 - -compound; 118 - -

+

- + - + - + + + + - +

@@ -21314,121 +21364,116 @@ compound; 118 - + - + - + - + - + -

rn:R00443 +

rn:R01569

- + - + - + - +
- + -

maplink;39;12 - -compound; 147 +

rn:R02094

- + - + - + + + +
- + -

rn:R01667 +

maplink;14;98 + +compound; 118

- + - + - + - - -
- + -

rn:R02484 - -

+

- + - + - + - - - - +

@@ -21436,194 +21481,186 @@ compound; 147 - + - + - + + + + - + -

rn:R00157 +

rn:R01567

- + - + - + - +
- + -

rn:R00570 - -

+

- + - + - + - + - + -

rn:R02098 +

rn:R01668

- + - + - + - +
- + -

rn:R00158 - -

+

- + - + - + - - - - + -

rn:R02330 - -

+

- + - + - + - + - + -

rn:R02100 +

rn:R01663

- + - + - + - +
- + -

rn:R02806 - -

+

- + - + - + - + - +

@@ -21631,22 +21668,24 @@ compound; 147 - + - + + - + + - + - +

@@ -21654,45 +21693,47 @@ compound; 147 - + - + - + - + - + -

+

rn:R00514 + +

- + - + - + - +
- +

rn:R02485 @@ -21702,309 +21743,312 @@ compound; 147 - + - + - + - - - - + -

rn:R01663 +

rn:R02098

- + - + - + - +
- + -

rn:R00378 - -

+

- + - + - + - + - + -

+

rn:R02484 + +

- + - + - + - +
- + -

+

rn:R00377 + +

- + - + - + - +
- + -

rn:R00977 +

rn:R02484

- + - + - + - +
- + -

+

rn:R02806 + +

- + - + - + - +
- + -

maplink;18;10 - -compound; 120 +

rn:R02330

- + - + - + + + +
- - - -

maplink;8;11 - -compound; 7 + + + +

rn:R00963

- + - + - + + + +
- + -

rn:R02484 - -

+

- + - + - + - + - + -

rn:R02485 +

rn:R01876

- + - + - +
- + -

rn:R01668 +

rn:R01867

- + - + - + - +
- + -

+

rn:R00159 + +

- + - + - + - +
- +

@@ -22012,22 +22056,22 @@ compound; 7 - + - + - + - + - +

@@ -22035,217 +22079,214 @@ compound; 7 - + - + - + - + - + -

rn:R00963 +

rn:R01667

- + - + - + - +
- + -

rn:R01664 - -

+

- + - + - + - - - - + -

rn:R02095 +

rn:R00378

- + - + - + - +
- + -

rn:R00442 - -

+

- + - + - + - + - + -

+

rn:R00443 + +

- + - + - + - - +
- + -

+

rn:R02484 + +

- + - + - + - +
- + -

rn:R06613 +

maplink;39;12 + +compound; 147

- + - + - + - - -
- + -

+

rn:R02095 + +

- + - + - + - +
- +

@@ -22253,44 +22294,45 @@ compound; 7 - + - + - + + + + - + -

rn:R00158 - -

+

- + - + - + - + - +

@@ -22298,44 +22340,47 @@ compound; 7 - + - + - + - + - + -

rn:R01876 +

rn:R02100

- + - + - + + + +
- +

@@ -22343,47 +22388,48 @@ compound; 7 - + - + - + - + - + -

rn:R00905 +

rn:R02093

- + - + - + - + +
- +

@@ -22391,317 +22437,296 @@ compound; 7 - + - + - + - + - + -

rn:R00575 +

rn:R00440

- + - + - + - +
- + -

rn:R01080 +

rn:R00965

- - - - - - - - - - - - - - -
- - - -

- - - - - + - - + - - + - + - + -

rn:R02326 +

maplink;18;10 + +compound; 120

- + - + - + - - -
- + -

+

rn:R00905 + +

- + - + - + - +
- + -

rn:R02484 +

rn:R02326

- + - + - + - +
- + -

+

rn:R00157 + +

- + - + - + - +
- + -

+

rn:R02098 + +

- + - + - + - +
- + -

rn:R01993 +

rn:R02806

- + - + - + - +
- + -

rn:R02093 +

rn:R06613

- + - + - + - - +
- + -

rn:R00377 +

rn:R00511

- + - + - + - +
- + -

rn:R00159 +

rn:R01397

- + - + - + - +
- +

@@ -22709,436 +22734,439 @@ compound; 7 - + - + - + - + - + -

+

rn:R02806 + +

- + - + - + + - +
- + -

rn:R00440 - -

+

- + - + - + - + - + -

rn:R01666 - -

+

- + - + - + - + - + -

rn:R00158 +

maplink;8;11 + +compound; 7

- + - + - +
- + -

rn:R01664 +

rn:R02099

- + - + - + - +
- + -

rn:R00965 +

rn:R00158

- + - + - + - +
- + -

rn:R02098 - -

+

- + - + - + - + - + -

rn:R01397 +

rn:R01664

- + - + - + - +
- + -

rn:R00155 +

rn:R00575

- + - + - + - +
- + -

+

rn:R01666 + +

- + - + - + - +
- + -

rn:R02095 +

rn:R00570

- + - + - + - +
- + -

rn:R02806 +

maplink;8;11 + +compound; 7

- + - + - - + - - -
- + -

rn:R01567 +

rn:R01993

- + - + - + - +
- + -

rn:R01569 - -

+

- + - + - + - + + - + -

rn:R01878 +

rn:R00158

- + - + - + - +
- + -

+

rn:R00442 + +

- + - - + - - + - +
- + -

+

rn:R01665 + +

- + - + - + + + +
- +

@@ -23146,120 +23174,119 @@ compound; 7 - + - + - + - + - + -

rn:R02094 +

rn:R00155

- + - + - + - +
- + -

rn:R01665 +

rn:R02485

- + - + - + - +
- + -

rn:R00514 +

rn:R01878

- + - + - + - +
- + -

+

rn:R00158 + +

- + - + - + - - -
- +

@@ -23267,68 +23294,46 @@ compound; 7 - + - + + - + + - + - - - -

maplink;8;11 - -compound; 7 - -

- -
- - - - - - - - - - - - - -
- + -

rn:R02099 +

rn:R02095

- + - + - + - +
diff --git a/sbml/WP4022.svg b/sbml/WP4022.svg index 59f76f3..368c665 100644 --- a/sbml/WP4022.svg +++ b/sbml/WP4022.svg @@ -78,115 +78,65 @@ >c90c9e458fa366ce458fa366cc90c9a1102NUDT2UppppUAK9UppppUNUDT2c204ce31d0d573bd573bea8e6f4a2ef4a2ebc0f4fd48afd48acb1ffcb1ffb5fdfb5fdfcf400c6deec6deed9038d9038ENTPD1b1ac8b1ac8 - + @@ -88,13 +88,13 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - - + + + - @@ -102,47 +102,47 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - + + + + + + + + + + - + - + - - - - - - - - - @@ -161,35 +161,43 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + + + + - - - - - - + + + + + + - + - + - - - - + + + + @@ -198,18 +206,10 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - - - - - - + @@ -226,42 +226,26 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - - - - - - - - - - - - - - - - - + - + - - - - + + + + @@ -270,26 +254,38 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - + + + + + + + + + + + + + + + - - + + - + - - - - + + + + @@ -298,90 +294,101 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - + + + - + - + - + - - + + - - - - - - + + + + + + - - - + + - - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + + + + + + + + + + + + + + + + + - + - + + + + + + + + + @@ -398,37 +405,29 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - - - - - - - + + + + + + + - + - - - - - - - - @@ -449,15 +448,39 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + + + + @@ -466,30 +489,45 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + + + + + + + + + - - - - - - + + + + + + - - - + + - + + + + + + + + + @@ -506,7 +544,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -517,15 +555,31 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + + + + + + + + + + + + - - - - + + + + @@ -534,34 +588,26 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - - - - - - + - + - + - - - - + + + + @@ -570,25 +616,64 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - - - - - - + + + + + + + + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -610,79 +695,87 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - - + + - - - - - - + + + + + + - - + - - - - - - - - - + - - - - - - + + + + + + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + - - - - + + + + @@ -691,54 +784,70 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - + + + + + + + + + - - - - - - + + + + + + - + - - + + + + + + + + + + - - + + - + - - - - + + + + @@ -747,18 +856,18 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - - - - + + + + @@ -767,18 +876,26 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - + + + - + + + + + + + + + - + @@ -795,124 +912,146 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + + + + + + + + + - + - - - - - - - - - - - - - - + + + - - + + - - + + - + + + + + + + + + - + - - - - - - + + + + + + - + - + + + + + + + + + + + + + + + + + - + - + - + - - + + - - - - - - + + + + + + + - + - - - + + + - + - - - + + + - + - + - - - - + + + + @@ -921,26 +1060,26 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - + + + - + - + - - - - + + + + @@ -949,10 +1088,10 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + @@ -969,18 +1108,18 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - - - - + + + + @@ -989,126 +1128,46 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - - - - - - + + + + + + - + - - + + - + - + - - - - + + + + @@ -1117,172 +1176,104 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + + + + - + - - - - + + + + - + - + - + - + - + - - - - + + + + - + + + + + + + - + - - - - + + + + @@ -1291,260 +1282,260 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - - - - - - - - + + - - - - + - + - - - - + + + + - + - + - + - - - - + - + - - - - + + + + - + - + + + + - + - + - + - - - - + + + + - + + + + - + - + - + - - - - + - - - - + + + + - + - - - - - - - - + + - + - - - - + + + + - + + + + + + + + + + - + + + + - + - - - - + + + + - + - + - + + + + - + - - - - + + + + - + - - - - + - + - + - - - - + + + + - - - - + - - - - + - - - - + + + + - + - + - - - - + - - - - + + + + - + + + + + + + + + + + + + + + + @@ -1552,46 +1543,55 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + + + + + + + + + + - + + + + - + - - - - - + + + + + - - - - + - + - + - - - - + + + + @@ -1600,34 +1600,25 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - - - - - - - - + + - + - + - + - - - - + + + + @@ -1638,134 +1629,134 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + + - - - - + + + + - + - + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - - - - + - - - - + + + + - + - - - - + - + - + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - - - - + - + - + @@ -1773,14 +1764,14 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - + + + + @@ -1789,73 +1780,82 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - - - - + + + + + + + + + + + + + - + - - + + + + + - - - - + + + + - + - + - + + + + - + + + + - - - - + + + + - - - - - - - - - - + - + - - - - + + + + @@ -1866,138 +1866,138 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + + - - - - + + + + - + + + + + + + + + + - + - + + + + - - - - + + + + - + - + - - - - + - - - - + + + + - - - - + - - - - - - - + - + - + - - - - + + + + - - - - - - - + - - - - + - - + + - - - - + + + + - + - + - - + + - + - + - - - - + + + + + + + @@ -2013,14 +2013,14 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - - - + + + + @@ -2092,52 +2092,52 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + @@ -2146,333 +2146,327 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + @@ -2482,1525 +2476,1471 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - + - + - - + + - - - - - - - - - - - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - - - - - + + - + - - - - - - + + + + + + + + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - + + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + @@ -4010,7 +3950,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -4020,7 +3960,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -4032,294 +3972,354 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + + + + + + + + + + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + @@ -4340,52 +4340,52 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + @@ -4394,70 +4394,70 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4466,166 +4466,160 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4634,28 +4628,28 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + @@ -4664,63 +4658,63 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + @@ -4730,153 +4724,159 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + @@ -4888,19 +4888,19 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + @@ -4908,100 +4908,123 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + @@ -5010,80 +5033,57 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - + - + - + - - - - - - - - - - - - - - - + - + - - - - - - + - + - + - + - - - - @@ -5138,10 +5138,12 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + -

+

DISEASE + +

@@ -5149,7 +5151,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -5157,22 +5159,22 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - +
- + -

AKA aldose reductase +

tryptophan hydroxylase

@@ -5182,12 +5184,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - - - - - - + @@ -5197,20 +5194,20 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - +
- + -

DISEASE +

aromatic l-amino acid decarboxylase; Wikidata: Q421186

@@ -5220,7 +5217,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -5228,22 +5225,22 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - +
- + -

AKA monoamine oxidase +

"MAO-A and MAO-B were believed to metabolize dopamine, tyramine, and tryptamine; however, recent evidence suggests MAO-B may not be responsible for a significant amount of dopamine degradation." Source: https://en.wikipedia.org/wiki/Monoamine_oxidase

@@ -5253,7 +5250,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -5263,17 +5260,17 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - +
- +

@@ -5284,7 +5281,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -5294,20 +5291,20 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + -

DISEASE +

carbonyl reductase, Wikidata:Q1145916

@@ -5317,7 +5314,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + @@ -5325,24 +5322,22 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - +
- + -

DISEASE - -

+

@@ -5350,12 +5345,7 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - - - - - - + @@ -5363,22 +5353,22 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + - + - + - + -

AKA phenylethanolamine-N-methyltransferase +

AKA carbonyl reductase

@@ -5388,7 +5378,12 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + + + + + + @@ -5398,12 +5393,12 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - + @@ -5431,24 +5426,20 @@ This pathway was inspired by Edition 5, Chapter 20 of the book of Blau (ISBN 978 - + - +
- + -

DISEASE - -aka Dystonia 5, segawa disease - -

+

@@ -5456,7 +5447,7 @@ aka Dystonia 5, segawa disease - + @@ -5464,57 +5455,53 @@ aka Dystonia 5, segawa disease - + - + - + - + - + -

Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM). - -

+

- - - - - - + - + - + + + + + + - + - + -

AKA pterin-4a-carbinolamine dehydratase - -

+

@@ -5522,7 +5509,7 @@ aka Dystonia 5, segawa disease - + @@ -5530,24 +5517,22 @@ aka Dystonia 5, segawa disease - + - + - + - + - + -

"MAO-A and MAO-B were believed to metabolize dopamine, tyramine, and tryptamine; however, recent evidence suggests MAO-B may not be responsible for a significant amount of dopamine degradation." Source: https://en.wikipedia.org/wiki/Monoamine_oxidase - -

+

@@ -5555,7 +5540,7 @@ aka Dystonia 5, segawa disease - + @@ -5563,19 +5548,19 @@ aka Dystonia 5, segawa disease - + - + - + - + - +

@@ -5586,7 +5571,7 @@ aka Dystonia 5, segawa disease - + @@ -5596,22 +5581,20 @@ aka Dystonia 5, segawa disease - + - + - + -

AKA 3-methoxy-4-hydroxyphenylglycol - -

+

@@ -5619,7 +5602,7 @@ aka Dystonia 5, segawa disease - + @@ -5629,17 +5612,17 @@ aka Dystonia 5, segawa disease - + - + - +

@@ -5650,7 +5633,7 @@ aka Dystonia 5, segawa disease - + @@ -5660,20 +5643,20 @@ aka Dystonia 5, segawa disease - + - + - + -

"Serotonin, melatonin, norepinephrine, and epinephrine are mainly broken down by MAO-A." Source: https://en.wikipedia.org/wiki/Monoamine_oxidase +

AKA tetrahydropterin, 5,6,7,8-tetrahydrobiopterin

@@ -5683,7 +5666,17 @@ aka Dystonia 5, segawa disease - + + + + + + + + + + + @@ -5691,19 +5684,19 @@ aka Dystonia 5, segawa disease - + - + - + - +
- +

DISEASE @@ -5716,7 +5709,7 @@ aka Dystonia 5, segawa disease - + @@ -5726,20 +5719,20 @@ aka Dystonia 5, segawa disease - + - + - + -

sepiapterin reductase, gene SPR +

AKA monoamine oxidase

@@ -5749,7 +5742,7 @@ aka Dystonia 5, segawa disease - + @@ -5759,20 +5752,20 @@ aka Dystonia 5, segawa disease - + - +
- + -

phenylalanine-4-hydroxylase +

AKA pterin-4a-carbinolamine dehydratase

@@ -5782,7 +5775,7 @@ aka Dystonia 5, segawa disease - + @@ -5792,20 +5785,20 @@ aka Dystonia 5, segawa disease - + - +
- + -

tyrosine hydroxylase +

sepiapterin reductase, gene SPR

@@ -5815,7 +5808,7 @@ aka Dystonia 5, segawa disease - + @@ -5825,22 +5818,20 @@ aka Dystonia 5, segawa disease - + - +
- + -

aromatic l-amino acid decarboxylase; Wikidata: Q421186 - -

+

@@ -5848,7 +5839,7 @@ aka Dystonia 5, segawa disease - + @@ -5856,19 +5847,19 @@ aka Dystonia 5, segawa disease - + - + - + - + - +

@@ -5879,7 +5870,7 @@ aka Dystonia 5, segawa disease - + @@ -5889,35 +5880,28 @@ aka Dystonia 5, segawa disease - + - + - + -

AKA carbonyl reductase - -

+

- - - - - - - + + - + @@ -5925,22 +5909,22 @@ aka Dystonia 5, segawa disease - + - + - + - + - + -

7,8-dihydrobiopterin +

AKA aldose reductase

@@ -5950,7 +5934,12 @@ aka Dystonia 5, segawa disease - + + + + + + @@ -5958,24 +5947,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

DISEASE - -

+

@@ -5983,7 +5970,7 @@ aka Dystonia 5, segawa disease - + @@ -5991,55 +5978,55 @@ aka Dystonia 5, segawa disease - + - + - + - + - + -

dihydropteridine reductase - -

+

- - - - - - + - + - + + + + + + - + - + -

+

AKA 3-methoxy-4-hydroxyphenylglycol + +

@@ -6047,7 +6034,7 @@ aka Dystonia 5, segawa disease - + @@ -6055,22 +6042,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

homovanillic acid +

"Serotonin, melatonin, norepinephrine, and epinephrine are mainly broken down by MAO-A." Source: https://en.wikipedia.org/wiki/Monoamine_oxidase

@@ -6080,7 +6067,7 @@ aka Dystonia 5, segawa disease - + @@ -6088,24 +6075,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

co-chaperone of PAH - -

+

@@ -6113,7 +6098,7 @@ aka Dystonia 5, segawa disease - + @@ -6121,22 +6106,24 @@ aka Dystonia 5, segawa disease - + - + - + - + - + -

+

DISEASE + +

@@ -6144,7 +6131,7 @@ aka Dystonia 5, segawa disease - + @@ -6152,22 +6139,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

DISEASE +

7,8-dihydrobiopterin

@@ -6177,7 +6164,7 @@ aka Dystonia 5, segawa disease - + @@ -6185,22 +6172,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

carbonyl reductase, Wikidata:Q1145916 +

tyrosine hydroxylase

@@ -6210,7 +6197,7 @@ aka Dystonia 5, segawa disease - + @@ -6220,20 +6207,22 @@ aka Dystonia 5, segawa disease - + - +
- + -

+

DISEASE + +

@@ -6241,7 +6230,7 @@ aka Dystonia 5, segawa disease - + @@ -6249,23 +6238,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

AKA dopamine -β-hydroxylase +

"DNAJC12 interacts with PAH, TH, and the TPHs, which indicates that DNAJC12 is a specific co-­chaperone for the aromatic amino acid hydroxylases that contributes to the maintenance of their intracellular stability"

@@ -6275,7 +6263,7 @@ aka Dystonia 5, segawa disease - + @@ -6285,20 +6273,22 @@ aka Dystonia 5, segawa disease - + - +
- + -

+

phenylalanine-4-hydroxylase + +

@@ -6306,7 +6296,7 @@ aka Dystonia 5, segawa disease - + @@ -6314,22 +6304,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

aka GTP cyclohydrolase I +

DISEASE

@@ -6339,7 +6329,12 @@ aka Dystonia 5, segawa disease - + + + + + + @@ -6347,22 +6342,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

tryptophan hydroxylase +

6-pyruvoyl tetrahydropterin, 6PPH4

@@ -6372,7 +6367,7 @@ aka Dystonia 5, segawa disease - + @@ -6380,52 +6375,50 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

DISEASE - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -6436,7 +6429,7 @@ aka Dystonia 5, segawa disease - + @@ -6444,19 +6437,19 @@ aka Dystonia 5, segawa disease - + - + - + - + - +

@@ -6465,32 +6458,34 @@ aka Dystonia 5, segawa disease + + + + + - - - - - - + - + - + - + - + -

Dihydrobiopterin +

DISEASE + +aka Classic Phenylketonuria

@@ -6500,7 +6495,7 @@ aka Dystonia 5, segawa disease - + @@ -6508,24 +6503,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

AKA 6-pyruvoyl-tetrahydropterin synthase - -

+

@@ -6533,7 +6526,7 @@ aka Dystonia 5, segawa disease - + @@ -6541,22 +6534,22 @@ aka Dystonia 5, segawa disease - + - + - + - + - + -

AKA Vanillylmandelic acid +

aka GTP cyclohydrolase I

@@ -6566,7 +6559,7 @@ aka Dystonia 5, segawa disease - + @@ -6574,22 +6567,24 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

+

AKA 3-ortho-methyldopa (3-OMD) + +

@@ -6597,7 +6592,7 @@ aka Dystonia 5, segawa disease - + @@ -6607,48 +6602,50 @@ aka Dystonia 5, segawa disease - + - +
- + -

+

AKA Vanillylmandelic acid + +

+ + + + + - - - - - - + - + - + - +
- +

DISEASE @@ -6661,7 +6658,7 @@ aka Dystonia 5, segawa disease - + @@ -6671,22 +6668,20 @@ aka Dystonia 5, segawa disease - + - + - + -

AKA 6-lactoyltetrahydropterin (1′-oxoTHP) [PMID:1913029]. - -

+

@@ -6694,12 +6689,7 @@ aka Dystonia 5, segawa disease - - - - - - + @@ -6709,20 +6699,20 @@ aka Dystonia 5, segawa disease - + - + - + -

dihydrofolate reductase +

AKA phenylalanine hydroxylase

@@ -6732,7 +6722,7 @@ aka Dystonia 5, segawa disease - + @@ -6742,20 +6732,20 @@ aka Dystonia 5, segawa disease - + - +
- + -

AKA serotonin N-acetylase; "Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT); an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. " Source: https://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase] +

homovanillic acid

@@ -6765,7 +6755,7 @@ aka Dystonia 5, segawa disease - + @@ -6773,22 +6763,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

AKA hydroxyindole O-methyltransferase, HIOMT (deprecated alias), N-Acetylserotonin O-methyltransferase, also known as ASMT +

Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM).

@@ -6798,7 +6788,7 @@ aka Dystonia 5, segawa disease - + @@ -6806,22 +6796,22 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

aka 7,8-dihydroneopterin 3'-triphosphate, dihydroneopterin triphosphate, dihydroneopterin-PPP +

Dihydrobiopterin

@@ -6831,7 +6821,7 @@ aka Dystonia 5, segawa disease - + @@ -6841,20 +6831,22 @@ aka Dystonia 5, segawa disease - + - +
- + -

+

DISEASE + +

@@ -6862,7 +6854,7 @@ aka Dystonia 5, segawa disease - + @@ -6870,22 +6862,24 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

+

5-hydroxyindoleacetic acid + +

@@ -6893,7 +6887,7 @@ aka Dystonia 5, segawa disease - + @@ -6903,20 +6897,20 @@ aka Dystonia 5, segawa disease - + - +
- + -

AKA 3-ortho-methyldopa (3-OMD) +

DISEASE

@@ -6926,7 +6920,7 @@ aka Dystonia 5, segawa disease - + @@ -6934,22 +6928,23 @@ aka Dystonia 5, segawa disease - + - + - + - +
- + -

6-pyruvoyl tetrahydropterin, 6PPH4 +

AKA dopamine +β-hydroxylase

@@ -6959,7 +6954,7 @@ aka Dystonia 5, segawa disease - + @@ -6967,19 +6962,19 @@ aka Dystonia 5, segawa disease - + - + - + - +
- +

@@ -6990,7 +6985,7 @@ aka Dystonia 5, segawa disease - + @@ -7000,12 +6995,12 @@ aka Dystonia 5, segawa disease - + - + @@ -7035,20 +7030,22 @@ aka Segawa syndrome - + - + - + -

+

Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM). + +

@@ -7056,7 +7053,7 @@ aka Segawa syndrome - + @@ -7064,19 +7061,19 @@ aka Segawa syndrome - + - + - + - +
- +

@@ -7087,7 +7084,7 @@ aka Segawa syndrome - + @@ -7097,20 +7094,22 @@ aka Segawa syndrome - + - + - + -

+

AKA phenylethanolamine-N-methyltransferase + +

@@ -7118,7 +7117,7 @@ aka Segawa syndrome - + @@ -7126,19 +7125,19 @@ aka Segawa syndrome - + - + - + - +
- +

@@ -7149,7 +7148,7 @@ aka Segawa syndrome - + @@ -7157,19 +7156,19 @@ aka Segawa syndrome - + - + - + - + - +

@@ -7180,7 +7179,7 @@ aka Segawa syndrome - + @@ -7190,20 +7189,20 @@ aka Segawa syndrome - + - + - + -

AKA phenylalanine hydroxylase +

AKA serotonin N-acetylase; "Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT); an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. " Source: https://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase]

@@ -7213,7 +7212,7 @@ aka Segawa syndrome - + @@ -7223,20 +7222,24 @@ aka Segawa syndrome - + - +
- + -

+

DISEASE + +aka Dystonia 5, segawa disease + +

@@ -7244,7 +7247,7 @@ aka Segawa syndrome - + @@ -7252,24 +7255,22 @@ aka Segawa syndrome - + - + - + - +
- + -

DISEASE - -aka Classic Phenylketonuria +

AKA hydroxyindole O-methyltransferase, HIOMT (deprecated alias), N-Acetylserotonin O-methyltransferase, also known as ASMT

@@ -7279,7 +7280,7 @@ aka Classic Phenylketonuria - + @@ -7287,22 +7288,24 @@ aka Classic Phenylketonuria - + - + - + - +
- + -

+

dihydropteridine reductase + +

@@ -7310,7 +7313,7 @@ aka Classic Phenylketonuria - + @@ -7318,22 +7321,22 @@ aka Classic Phenylketonuria - + - + - + - +
- + -

Necessary cofactor for enzymatic reaction (lead by enzyme catechol-O-methyltransferase) is s-adenosyl methionine (SAM). +

AKA 6-pyruvoyl-tetrahydropterin synthase

@@ -7343,7 +7346,7 @@ aka Classic Phenylketonuria - + @@ -7351,24 +7354,22 @@ aka Classic Phenylketonuria - + - + - + - +
- + -

5-hydroxyindoleacetic acid - -

+

@@ -7376,7 +7377,7 @@ aka Classic Phenylketonuria - + @@ -7386,20 +7387,20 @@ aka Classic Phenylketonuria - + - + - + -

AKA tetrahydropterin, 5,6,7,8-tetrahydrobiopterin +

dihydrofolate reductase

@@ -7409,17 +7410,7 @@ aka Classic Phenylketonuria - - - - - - - - - - - + @@ -7427,53 +7418,62 @@ aka Classic Phenylketonuria - + - + - + - +
- + -

+

AKA 6-lactoyltetrahydropterin (1′-oxoTHP) [PMID:1913029]. + +

+ + + + + + + + + + - - - - - - + - + - + - +
- + -

+

aka 7,8-dihydroneopterin 3'-triphosphate, dihydroneopterin triphosphate, dihydroneopterin-PPP + +

@@ -7481,7 +7481,7 @@ aka Classic Phenylketonuria - + @@ -7491,39 +7491,19 @@ aka Classic Phenylketonuria - + - +
- - - -

- - - - - - - - - - - - - - - - - +

@@ -7531,10 +7511,10 @@ aka Classic Phenylketonuria - + - + @@ -7542,65 +7522,17 @@ aka Classic Phenylketonuria - - - - - - - - - - - - -

- - - - - - - - - - - - - - - - - - - - - - - -

Alternative PW - -

- -
- - - - - - - - - + - + + - +
- +

@@ -7608,24 +7540,23 @@ aka Classic Phenylketonuria - - - - - - + - + - + + + + + - +

@@ -7633,10 +7564,15 @@ aka Classic Phenylketonuria - + - + + + + + + @@ -7644,16 +7580,18 @@ aka Classic Phenylketonuria - + - + + + - + - +

@@ -7661,7 +7599,17 @@ aka Classic Phenylketonuria - + + + + + + + + + + + @@ -7672,18 +7620,18 @@ aka Classic Phenylketonuria - + - - + + + - - + - +

@@ -7691,28 +7639,23 @@ aka Classic Phenylketonuria - - - - - - + - + - - + + - + - +

@@ -7720,25 +7663,29 @@ aka Classic Phenylketonuria - + + + + + + - - + + - - - + + - + - +

@@ -7746,7 +7693,7 @@ aka Classic Phenylketonuria - + @@ -7754,7 +7701,12 @@ aka Classic Phenylketonuria - + + + + + + @@ -7762,17 +7714,19 @@ aka Classic Phenylketonuria - + - + - + + + - +

@@ -7780,7 +7734,7 @@ aka Classic Phenylketonuria - + @@ -7791,13 +7745,13 @@ aka Classic Phenylketonuria - + - + - +

@@ -7805,27 +7759,25 @@ aka Classic Phenylketonuria - - - - - - + - + + - + + + - + - +

@@ -7833,10 +7785,10 @@ aka Classic Phenylketonuria - + - + @@ -7854,17 +7806,17 @@ aka Classic Phenylketonuria - + - - + + - + - +

@@ -7872,20 +7824,10 @@ aka Classic Phenylketonuria - - - - - - - - - - - + - + @@ -7893,18 +7835,16 @@ aka Classic Phenylketonuria - + - - - + - + - +

@@ -7912,10 +7852,10 @@ aka Classic Phenylketonuria - + - + @@ -7923,16 +7863,16 @@ aka Classic Phenylketonuria - + - + - + - +

@@ -7940,30 +7880,39 @@ aka Classic Phenylketonuria - - - - - - + - - + + + + + + + +

+ + + + + + + + + + - - + + + - - - - +

@@ -7971,33 +7920,27 @@ aka Classic Phenylketonuria - + - - - - - - + - + - - + - +

@@ -8005,7 +7948,7 @@ aka Classic Phenylketonuria - + @@ -8016,13 +7959,13 @@ aka Classic Phenylketonuria - + - + - +

@@ -8030,19 +7973,54 @@ aka Classic Phenylketonuria - + + + + + + - + - + + + + - + + + +

Alternative PW + +

+ +
+ + + + + + + + + + + + + + + + + + +
+

@@ -8050,19 +8028,33 @@ aka Classic Phenylketonuria - + + + + + + + + + + + - + - + + + + + - +

@@ -8070,23 +8062,23 @@ aka Classic Phenylketonuria - + - + - - + + - + - +

@@ -8094,19 +8086,27 @@ aka Classic Phenylketonuria - + + + + + + - + - + + + + - +

@@ -8114,32 +8114,19 @@ aka Classic Phenylketonuria - - - - - - - - - - - + - + - + - - - - +

@@ -8147,23 +8134,27 @@ aka Classic Phenylketonuria - + + + + + + - + - - + - + - +

@@ -8171,19 +8162,24 @@ aka Classic Phenylketonuria - + + + + + + - + - + - +

@@ -8191,20 +8187,10 @@ aka Classic Phenylketonuria - - - - - - - - - - - + - + @@ -8212,19 +8198,18 @@ aka Classic Phenylketonuria - + - + + - - - - + + - +

Alternative PW @@ -8234,24 +8219,22 @@ aka Classic Phenylketonuria - + - - + - + - - + - +

@@ -8259,27 +8242,19 @@ aka Classic Phenylketonuria - - - - - - + - + - + - - - - +

@@ -8287,10 +8262,10 @@ aka Classic Phenylketonuria - + - + @@ -8298,51 +8273,66 @@ aka Classic Phenylketonuria - - + - - + + - + + - + -

+

non-enzymatic, twodirectional [PMID:19130291] + +

- + + + + + + + + + + + - + - +
- + -

non-enzymatic, twodirectional [PMID:19130291] - -

+

- + - + + + + + + @@ -8355,13 +8345,17 @@ aka Classic Phenylketonuria - + - + + + + + - +

@@ -8369,10 +8363,10 @@ aka Classic Phenylketonuria - + - + @@ -8380,16 +8374,19 @@ aka Classic Phenylketonuria - + + - + + + - + - +

@@ -8397,25 +8394,19 @@ aka Classic Phenylketonuria - + - - + - - - + - - - - +

@@ -8423,10 +8414,15 @@ aka Classic Phenylketonuria - + - + + + + + + @@ -8434,18 +8430,16 @@ aka Classic Phenylketonuria - + - - + - - + - +

@@ -8453,20 +8447,35 @@ aka Classic Phenylketonuria - - - - - - + + + + + + + + + + + + + + + +

+ + + + + - + - + @@ -8474,17 +8483,17 @@ aka Classic Phenylketonuria - + - - + - + + - +

@@ -8492,31 +8501,22 @@ aka Classic Phenylketonuria - - - - - - - - - - - + - + + - - - + + + - + diff --git a/sbml/WP4156.svg b/sbml/WP4156.svg index 65ef2dd..6fada53 100644 --- a/sbml/WP4156.svg +++ b/sbml/WP4156.svg @@ -8,32 +8,57 @@ />??????a765a?a765aGTP cyclohydrolase deficiencyPCDHVANeopterinCRnorepinephrineTPHDBHO23-OMDBH4PAH5-OH-TrpN-acetylserotoninPTPPheDHFRSRCR5-OH-TrpSNADopamine7,8-BH2THNeurotransmitters(dopamine/serotonin)DHPRHVAoxo-PH4NeopterinARNADPHPhenyl-alanine5HIAAq-BH2PrimapterinTrpNeurotransmitters(dopamine/serotonin)GTPCHMAOADopamineSRSAMCRPAHCOMTSerotoninDHPR3-OMDNH2TPASMTPTPtyr7,8-BH2PTPSSAMPhePNMTsepiapterinBiopterinSNAL-DOPATPHHO-BH4MAOATHARq-BH2O2ASMTPCDPTPSDBHDNAJC12GTPBiopterinPhenyl-alaninenorepinephrine5HIAAMAOPAHPNMTBH4PAHCOMTPrimapterinDNAJC12oxo-PH4sepiapterinN-acetylserotoninDNAJC12 interacts with PAH, TH, and the TPHsCatalysisComplexNon-enzymatic - -"Sepiapterin synthase, ?" [PMID:21550412]DNAJC12 is a co-chaperone of PAHBiomarkercofactorProtein1Disease?Connection to disease PathwaycofactorProteinConversionDNAJC12 is a co-chaperone of PAHComplexDNAJC12 interacts with PAH, TH, and the TPHsPathwayStimulationNon-enzymatic + +"Sepiapterin synthase, ?" [PMID:21550412]Connection to disease ?LegendDiseaseConversionBiomarkerCatalysis - + @@ -31,8 +31,8 @@ - + @@ -64,44 +64,44 @@ - + - - + + + + - + - - + + - - - + - + @@ -112,77 +112,89 @@ - + - + - + - - - - - - + + + + + + - + - + - + - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - + - + - - - + + + + + + + + + + + + - - + + - + - + @@ -193,176 +205,140 @@ - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + @@ -373,79 +349,47 @@ - - - + + + - - + + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + @@ -461,90 +405,58 @@ - + - - - - - - - - - - - - - - - - - + - - - + + + - + - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - + - + - + - - - - - - - - @@ -553,289 +465,321 @@ - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + + + + + + + + + + - - + + - + - + - - - + + + - - + + - + - + - + - + - + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - - + + - - + + - - + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - + + + - - + + - + - + - + - + - - - + + + - - + + - + + + + + + + + + - + - + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - - - + + + - - + + @@ -845,147 +789,203 @@ - + - + - + + + + + + + + + - + - + + + + + + + + + - + - + - + - + + + + + + + + + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + - + - - + + - - - - + + + + @@ -999,16 +999,16 @@ - + - - - - - - + + + + + + @@ -1020,14 +1020,14 @@ - + - - - - + + + + @@ -1039,111 +1039,93 @@ + + + - + - - - - + + + + - - - - - - - - - - - - - - - - - - - + - + - + - - - - + + + + - + - + - - - - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + @@ -1155,34 +1137,37 @@ - + - - + + - + + + + - - - - + + + + - + - + - + - + @@ -1194,272 +1179,278 @@ - - + + - - + + - - + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - - - - + - + - + - - - - + + + + - + - + - + + + + - + - - - - + + + + + + + - - - - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - + - + - - - - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + + + + - + - - - - + + + + @@ -1468,51 +1459,36 @@ - + + + + - + - - - - + + + + - - - - - - - - - - - - - - - - - - - + - + - + - + @@ -1524,47 +1500,62 @@ - + - + + + + + + + + + + + + + + + + + + + - + - - - - + + + + - - - - + - + - + - - - - + + + + @@ -1578,140 +1569,149 @@ - + - - - - + + + + - + - - - - + - - + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + + + + - + - - + + + + + + + + + + + - + - + + + + - - - - + + + + - - - - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + @@ -1725,14 +1725,14 @@ - + - - - - + + + + @@ -1743,56 +1743,56 @@ - - - - + - - - - + + + + - + - + - + - + - - - - + + + + + + + - + - + - - + + - - - - + + + + @@ -1806,14 +1806,14 @@ - + - - - - + + + + @@ -1847,10 +1847,10 @@ - + - - + + @@ -1859,10 +1859,10 @@ - + - - + + @@ -1873,995 +1873,959 @@ - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - + - - + + - + - - + + - + - + - + - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - - - - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -2871,7 +2835,7 @@ - + @@ -2881,7 +2845,7 @@ - + @@ -2891,7 +2855,7 @@ - + @@ -2903,39 +2867,49 @@ - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + @@ -2945,7 +2919,7 @@ - + @@ -2955,7 +2929,7 @@ - + @@ -2965,7 +2939,7 @@ - + @@ -2977,619 +2951,617 @@ - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + - - + + + + + + + + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - + + - - - - - - - - + + + + + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + @@ -3599,7 +3571,7 @@ - + @@ -3609,7 +3581,7 @@ - + @@ -3619,7 +3591,7 @@ - + @@ -3629,7 +3601,7 @@ - + @@ -3641,588 +3613,616 @@ - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4231,10 +4231,10 @@ - + - - + + @@ -4243,52 +4243,46 @@ - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - + + - + - - + + @@ -4297,118 +4291,106 @@ - - - - - - - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4417,46 +4399,46 @@ - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4465,100 +4447,94 @@ - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - 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@@ -5505,7 +5505,7 @@ - + @@ -5515,22 +5515,20 @@ - + - + - + -

The ChEBI ID with the correct charge is: 57292 - -

+

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+

The ChEBI ID with the correct charge is: 57292 + +

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+

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@@ -8920,19 +8920,19 @@ - + - + - + - + diff --git a/sbml/WP4290.svg b/sbml/WP4290.svg index a2f2087..07c2d0c 100644 --- a/sbml/WP4290.svg +++ b/sbml/WP4290.svg @@ -24,82 +24,6 @@ />?ddbdcddbdc?NucleusMitochondriaNucleusa0697PYCR1GLUD1PSAT13PHPKGlipidsAsparagineSLC1A5PhosphoserineIMPglutamate3PHPNH3Cell cycleProliferationG6PDGOT2ICGLUD1glucosePYCR1glutamateKGIMPGLSG6PDSLC1A5PPATlipidsGOT2PSAT1ICNH3PhosphoserineAmino acid synthesisGlycolysisOxidative phosphorylationLipid synthesisTCA cycle3Carbon sourceAmino acid synthesisGlycolysisOxidative phosphorylationWarburg effectPentose phosphate pathwayLipid synthesis - + @@ -57,22 +57,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - + + + - - - @@ -98,6 +95,9 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + @@ -122,172 +122,187 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + + + + + + + + + - - - - - - + + + + + + - + - + - + - + - + - + - + - - - + + + - - + + - - - + + + + + + + + + + + + + + - - + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - + + - + - + - + - + - - - + + + - - + + + + + + + + + + @@ -308,30 +323,46 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - + + + - - + + - + - + + + + + + + + + + + + + + + + + @@ -340,6 +371,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + + + @@ -348,14 +387,30 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + - + + + + + + + + + @@ -364,20 +419,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -400,81 +455,36 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - + + - + - - - - - - - - - - - - - + - + - + - + - - - - - - - - - + - + @@ -485,36 +495,55 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - - + + + + + + + + + + + + + + - - + + - + + + + + + + + + - + - + - + @@ -525,417 +554,406 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - + + + + + + + + + + + + + + - - + + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + + + + + + + + + - + - - + + - - - - - - + + + + + + + - - - - - - - - - - + + - + - + - + - + - - - + + + - - + + - - - + + + - - + + - - + + - - - - - - + + + + + + + - - - - - - - - - - - - - - - - - - + + - + - + - - - - - - - - - + - + - - + + - - - - - - - - + + + + + + - - - - - - - - - - + + - + - + - + - + - - + + - - - - + + + + - + - - - - + - + - - - - + + + + + + + - + - + - - - - + + + + + + + + + + + + + + + + + + + + + + + + + - - - - - - - - + + - - + + - + - - + + - - - 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- - - + - - - - + + + + - + - + + + + + + + + + + + + + - + + + + - + - - - - + + + + - - - - + - + - + - - + + - - - - + + + + @@ -1346,50 +1355,41 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - + + + + - + - + - - - - - - - - - - - + + - + - + - + - - - - + + + + @@ -1420,16 +1420,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + @@ -1440,1680 +1440,1680 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - 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+ - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - - - - - - - - + + + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + + + + + - + - - + + + + + + + + + + + + @@ -3128,112 +3128,124 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + @@ -3242,22 +3254,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + @@ -3266,16 +3290,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + + + + + + + + + + + + + + + + - - + + - + - - + + @@ -3284,16 +3326,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + @@ -3302,76 +3344,64 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -3380,70 +3410,58 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + @@ -3452,10 +3470,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + @@ -3464,34 +3482,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + @@ -3500,45 +3500,45 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + @@ -3550,13 +3550,13 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + @@ -3564,169 +3564,160 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + - + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + + - + - + - + - + - + @@ -3735,40 +3726,26 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - - - - - - - - - - - - - + - + - + - + - + - + @@ -3777,152 +3754,161 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + - + - + - + - - + + + + + + - + - + - + - + - + @@ -3931,25 +3917,39 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + + + + + + + + + + + + + + + @@ -3973,7 +3973,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -3987,7 +3987,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -4017,7 +4017,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - +

@@ -4028,7 +4028,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4036,19 +4036,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4059,7 +4059,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4069,17 +4069,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4090,7 +4090,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4098,19 +4098,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4119,29 +4119,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -4150,29 +4150,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -4183,7 +4183,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4193,17 +4193,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4214,7 +4214,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4224,17 +4224,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4245,7 +4245,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4255,17 +4255,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4276,7 +4276,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4284,19 +4284,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4305,29 +4305,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -4338,7 +4338,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4346,19 +4346,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4369,7 +4369,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4377,19 +4377,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4400,7 +4400,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4408,19 +4408,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4431,7 +4431,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4439,19 +4439,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4462,7 +4462,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4470,19 +4470,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4493,7 +4493,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4503,17 +4503,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4522,29 +4522,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -4555,7 +4555,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4563,19 +4563,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4584,29 +4584,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -4617,7 +4617,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4627,17 +4627,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4648,7 +4648,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4656,19 +4656,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4679,7 +4679,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4687,19 +4687,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4710,7 +4710,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4718,19 +4718,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4741,7 +4741,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4749,19 +4749,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4772,7 +4772,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4782,17 +4782,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4803,7 +4803,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4811,19 +4811,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4834,7 +4834,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4842,19 +4842,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4865,7 +4865,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4873,19 +4873,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4906,17 +4906,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -4927,7 +4927,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4935,19 +4935,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4958,7 +4958,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4966,19 +4966,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4989,7 +4989,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4997,19 +4997,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5020,7 +5020,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5028,19 +5028,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5051,7 +5051,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5059,19 +5059,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5082,7 +5082,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5090,19 +5090,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5113,7 +5113,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5121,19 +5121,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5144,7 +5144,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5154,17 +5154,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5175,7 +5175,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5185,17 +5185,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5206,7 +5206,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5214,19 +5214,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5235,29 +5235,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - +

@@ -5268,7 +5268,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5278,17 +5278,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5299,7 +5299,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5307,19 +5307,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5330,7 +5330,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5338,19 +5338,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5361,7 +5361,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5369,19 +5369,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5390,29 +5390,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + - + + + + + + - +

@@ -5423,7 +5423,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5431,19 +5431,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5454,7 +5454,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5464,17 +5464,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5485,7 +5485,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5493,19 +5493,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5516,7 +5516,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5526,17 +5526,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5547,7 +5547,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5555,19 +5555,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5576,29 +5576,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -5609,7 +5609,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5619,17 +5619,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5640,7 +5640,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5648,19 +5648,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5671,7 +5671,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5681,17 +5681,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5702,7 +5702,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5710,19 +5710,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5733,7 +5733,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5743,17 +5743,17 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -5762,29 +5762,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -5795,7 +5795,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5803,19 +5803,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5826,7 +5826,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5834,19 +5834,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5857,7 +5857,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5865,19 +5865,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5888,7 +5888,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5896,19 +5896,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5917,29 +5917,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - +

@@ -5950,7 +5950,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5958,19 +5958,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5981,7 +5981,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5991,19 +5991,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -6011,22 +6011,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6034,22 +6034,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -6057,19 +6054,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -6077,24 +6077,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - - + - + - + - +

@@ -6102,19 +6100,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -6122,22 +6123,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6145,22 +6146,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -6168,22 +6166,23 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + - + - +

@@ -6191,22 +6190,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6214,22 +6213,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6237,22 +6236,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6260,7 +6259,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6269,13 +6268,13 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - +

@@ -6283,22 +6282,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6306,19 +6305,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -6326,22 +6328,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -6349,22 +6348,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6372,22 +6371,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6395,19 +6394,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +

@@ -6415,22 +6414,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6438,22 +6437,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -6461,23 +6457,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - + - - - - +

@@ -6485,19 +6477,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -6505,22 +6500,23 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + + - +

@@ -6528,19 +6524,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -6548,7 +6547,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6557,10 +6556,13 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + + + - +

@@ -6568,22 +6570,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -6591,22 +6590,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - +

@@ -6614,23 +6610,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - - +

@@ -6638,22 +6630,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6661,19 +6653,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + + + + - +

@@ -6681,17 +6676,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + - + + + + diff --git a/sbml/WP430.svg b/sbml/WP430.svg index 3e3a3ef..01dc46a 100644 --- a/sbml/WP430.svg +++ b/sbml/WP430.svg @@ -30,18 +30,12 @@ >?Group objectbb3fb??e12d0??Group object???bb3fbe12d0???Peripheral tissuesLiver cellLiver cellPeripheral tissuesEnterocyteAPOA5StatinAPOC1Cholesterol esterAPOEPhospholipidSqualeneLDLABCG8LIPCAPOC2ABCG5CholesterolMevalonateCholesterolAPOC1MIR33AMIR33BABCG8LipoproteinsSCARB1LDLAPOA4APOC2APOA2IDLSQLETriglycerideABCG5HDLMevalonateAcyl-CoA synthetaseAPOA1ABCA1HMG-CoADAGPLTPLRP1CholesterolLCATAPOC3Cholesterol esterSCARB1HMGCRSqualeneAPOBMIR33ACholesterolCholesterolCholesterolAcyl-CoAStatinFatty acidMevalonate armin more detailAPOC3LPLSOAT1LRP1VLDLDGAT1ABCA1MIR33BCholic AcidDAGAcyl-CoA synthetasePLTPTriglycerideCYP7A1APOA4CholesterolLDLRIDLPhospholipidCholic AcidAPOA5CETPFDFT1HMG-CoAAPOEAPOA1HDLSOAT1ABCA1VLDLMevalonate armin more detailAPOA2Acyl-CoAFatty acidLipoproteinsLDLRFDFT1APOBCholesterolTriglyceride?CatalysisTransportActivationPlasmaCatalysisInhibitionPlasmaTransport - + @@ -100,8 +100,8 @@ [Label:a70e0] Label cannot be part of reaction. Tranforming to Unknown [Label:da643] Label cannot be part of reaction. Tranforming to Unknown [Label:b4453] Label cannot be part of reaction. Tranforming to Unknown -[:babb9] RECTANGLE cannot be part of a complex. Skipping. [:ecad9] RECTANGLE cannot be part of a complex. Skipping. +[:babb9] RECTANGLE cannot be part of a complex. Skipping. [HeterodimerAssociationReaction:id859e2b99] Reaction should contain at least 2 reactants. GraphId: id859e2b99 [HeterodimerAssociationReaction:idbd396ec] Reaction should contain at least 2 reactants. GraphId: idbd396ec [ReducedPhysicalStimulationReaction:id8d780d66] Reaction should contain only one reactant and one product. @@ -116,8 +116,8 @@ [HeterodimerAssociationReaction:df3b9] Reaction should contain at least 2 reactants. GraphId: df3b9 [ReducedPhysicalStimulationReaction:e53d3] Reaction should contain only one reactant and one product. [HeterodimerAssociationReaction:ffd3f] Reaction should contain at least 2 reactants. GraphId: ffd3f -[Complex:bedba] Empty element is invalid -[Complex:beb55] Empty element is invalid

+[Complex:beb55] Empty element is invalid +[Complex:bedba] Empty element is invalid

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@@ -9029,7 +9029,7 @@ - +

@@ -9059,7 +9059,7 @@ - +

@@ -9070,7 +9070,7 @@ - + @@ -9078,19 +9078,19 @@ - + - + - + - + - +

@@ -9101,7 +9101,7 @@ - + @@ -9109,19 +9109,19 @@ - + - + - + - + - +

@@ -9132,7 +9132,7 @@ - + @@ -9142,17 +9142,17 @@ - + - + - +

@@ -9161,29 +9161,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9194,7 +9194,7 @@ - + @@ -9202,19 +9202,19 @@ - + - + - + - + - +

@@ -9223,29 +9223,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9256,7 +9256,7 @@ - + @@ -9264,19 +9264,19 @@ - + - + - + - + - +

@@ -9285,29 +9285,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9316,29 +9316,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9349,7 +9349,7 @@ - + @@ -9357,19 +9357,19 @@ - + - + - + - + - +

@@ -9378,29 +9378,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -9409,29 +9409,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9440,24 +9440,29 @@ + + + + + - + - + - + - + - +

@@ -9468,7 +9473,7 @@ - + @@ -9476,24 +9481,22 @@ - + - + - + - + - + -

AKA interferon-α/β receptor (IFNAR) - -

+

@@ -9501,7 +9504,7 @@ - + @@ -9509,19 +9512,19 @@ - + - + - + - + - +

@@ -9532,7 +9535,7 @@ - + @@ -9540,19 +9543,19 @@ - + - + - + - + - +

@@ -9563,7 +9566,7 @@ - + @@ -9571,19 +9574,19 @@ - + - + - + - + - +

@@ -9592,29 +9595,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -9625,7 +9628,7 @@ - + @@ -9633,19 +9636,19 @@ - + - + - + - + - +

@@ -9656,7 +9659,7 @@ - + @@ -9664,19 +9667,19 @@ - + - + - + - + - +

@@ -9687,7 +9690,7 @@ - + @@ -9695,24 +9698,22 @@ - + - + - + - + - + -

The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains - -

+

@@ -9720,7 +9721,7 @@ - + @@ -9728,19 +9729,19 @@ - + - + - + - + - +

@@ -9751,7 +9752,7 @@ - + @@ -9759,19 +9760,19 @@ - + - + - + - + - +

@@ -9782,7 +9783,7 @@ - + @@ -9790,19 +9791,19 @@ - + - + - + - + - +

@@ -9811,29 +9812,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9844,7 +9845,7 @@ - + @@ -9852,19 +9853,19 @@ - + - + - + - + - +

@@ -9873,29 +9874,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9904,29 +9905,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -9937,7 +9938,7 @@ - + @@ -9945,19 +9946,19 @@ - + - + - + - + - +

@@ -9968,7 +9969,7 @@ - + @@ -9976,19 +9977,19 @@ - + - + - + - + - +

@@ -9999,7 +10000,7 @@ - + @@ -10007,19 +10008,19 @@ - + - + - + - + - +

@@ -10030,7 +10031,7 @@ - + @@ -10038,19 +10039,19 @@ - + - + - + - + - +

@@ -10059,29 +10060,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -10092,7 +10093,7 @@ - + @@ -10100,19 +10101,19 @@ - + - + - + - + - +

@@ -10123,7 +10124,7 @@ - + @@ -10131,19 +10132,19 @@ - + - + - + - + - +

@@ -10152,29 +10153,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -10185,7 +10186,7 @@ - + @@ -10193,19 +10194,19 @@ - + - + - + - + - +

@@ -10214,29 +10215,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -10245,29 +10246,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -10276,29 +10277,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -10307,29 +10308,24 @@ - - - - - - + - + - + - + - +

@@ -10340,7 +10336,7 @@ - + @@ -10348,19 +10344,19 @@ - + - + - + - + - +

@@ -10371,7 +10367,7 @@ - + @@ -10379,22 +10375,24 @@ - + - + - + - + - + -

+

Enzyme family, EC 3.1.1.4 [https://en.wikipedia.org/wiki/Phospholipase_A2] + +

@@ -10402,7 +10400,7 @@ - + @@ -10410,19 +10408,19 @@ - + - + - + - +
- +

@@ -10433,7 +10431,7 @@ - + @@ -10441,19 +10439,19 @@ - + - + - + - + - +

@@ -10462,24 +10460,29 @@ + + + + + - + - + - + - + - +

@@ -10490,7 +10493,7 @@ - + @@ -10498,19 +10501,19 @@ - + - + - + - + - +

@@ -10521,7 +10524,7 @@ - + @@ -10529,19 +10532,19 @@ - + - + - + - + - +

@@ -10550,29 +10553,29 @@ - - - - - - + - + - + + + + + + - + - +

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@@ -10614,7 +10617,7 @@ - + @@ -10622,19 +10625,19 @@ - + - + - + - + - +

@@ -10645,7 +10648,7 @@ - + @@ -10653,19 +10656,19 @@ - + - + - + - + - +

@@ -10676,7 +10679,7 @@ - + @@ -10684,19 +10687,19 @@ - + - + - + - + - +

@@ -10707,7 +10710,7 @@ - + @@ -10715,19 +10718,19 @@ - + - + - + - + - +

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@@ -10769,7 +10772,7 @@ - + @@ -10777,19 +10780,19 @@ - + - + - + - + - +

@@ -10800,7 +10803,7 @@ - + @@ -10808,19 +10811,19 @@ - + - + - + - + - +

@@ -10831,7 +10834,7 @@ - + @@ -10839,19 +10842,19 @@ - + - + - + - + - +

@@ -10865,24 +10868,24 @@ - + - + - + - + - + - + - +

@@ -10893,7 +10896,7 @@ - + @@ -10901,19 +10904,19 @@ - + - + - + - + - +

@@ -10924,7 +10927,7 @@ - + @@ -10932,19 +10935,19 @@ - + - + - + - + - +

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@@ -11015,24 +11018,29 @@ + + + + + - + - + - + - + - +

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@@ -11072,29 +11080,24 @@ - - - - - - + - + - + - + - +

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@@ -11167,7 +11170,7 @@ - + @@ -11175,19 +11178,19 @@ - + - + - + - + - +

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@@ -11227,24 +11230,29 @@ + + + + + - + - + - + - + - +

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@@ -11348,7 +11356,7 @@ - + @@ -11356,19 +11364,19 @@ - + - + - + - + - +

@@ -11379,7 +11387,7 @@ - + @@ -11387,19 +11395,19 @@ - + - + - + - + - +

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@@ -11441,7 +11449,7 @@ - + @@ -11449,19 +11457,19 @@ - + - + - + - + - +

@@ -11472,7 +11480,7 @@ - + @@ -11480,19 +11488,19 @@ - + - + - + - + - +

@@ -11503,7 +11511,7 @@ - + @@ -11511,19 +11519,19 @@ - + - + - + - + - +

@@ -11534,7 +11542,7 @@ - + @@ -11542,19 +11550,19 @@ - + - + - + - + - +

@@ -11563,29 +11571,29 @@ - - - - - - + - + - + - + + + + + + - +

@@ -11594,29 +11602,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -11627,7 +11635,7 @@ - + @@ -11635,19 +11643,19 @@ - + - + - + - + - +

@@ -11656,29 +11664,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -11687,24 +11695,29 @@ + + + + + - + - + - + - + - +

@@ -11715,7 +11728,7 @@ - + @@ -11723,19 +11736,19 @@ - + - + - + - + - +

@@ -11744,29 +11757,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -11777,7 +11790,7 @@ - + @@ -11785,19 +11798,19 @@ - + - + - + - + - +

@@ -11808,7 +11821,7 @@ - + @@ -11816,19 +11829,19 @@ - + - + - + - + - +

@@ -11839,7 +11852,7 @@ - + @@ -11847,50 +11860,52 @@ - + - + - + - + - + -

+

The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains + +

+ + + + + - - - - - - + - + - + - +
- +

@@ -11901,7 +11916,7 @@ - + @@ -11909,19 +11924,19 @@ - + - + - + - + - +

@@ -11932,7 +11947,7 @@ - + @@ -11940,19 +11955,19 @@ - + - + - + - + - +

@@ -11963,7 +11978,7 @@ - + @@ -11971,19 +11986,19 @@ - + - + - + - + - +

@@ -12002,19 +12017,19 @@ - + - + - + - + - +

@@ -12028,24 +12043,24 @@ - + - + - + - + - + - + - +

@@ -12056,7 +12071,7 @@ - + @@ -12064,19 +12079,19 @@ - + - + - + - + - +

@@ -12087,7 +12102,7 @@ - + @@ -12095,19 +12110,19 @@ - + - + - + - + - +

@@ -12116,29 +12131,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -12147,29 +12162,24 @@ - - - - - - + - + - + - + - +

@@ -12180,7 +12190,7 @@ - + @@ -12188,19 +12198,19 @@ - + - + - + - + - +

@@ -12209,29 +12219,24 @@ - - - - - - + - + - + - + - +

@@ -12242,7 +12247,7 @@ - + @@ -12250,19 +12255,19 @@ - + - + - + - + - +

@@ -12273,7 +12278,7 @@ - + @@ -12281,19 +12286,19 @@ - + - + - + - + - +

@@ -12304,7 +12309,7 @@ - + @@ -12312,19 +12317,19 @@ - + - + - + - + - +

@@ -12335,7 +12340,7 @@ - + @@ -12343,19 +12348,19 @@ - + - + - + - + - +

@@ -12364,29 +12369,24 @@ - - - - - - + - + - + - + - +

@@ -12397,7 +12397,7 @@ - + @@ -12405,19 +12405,19 @@ - + - + - + - + - +

@@ -12426,29 +12426,29 @@ - - - - - - + - + - + - + + + + + + - +

@@ -12457,29 +12457,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -12488,29 +12488,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -12521,7 +12521,7 @@ - + @@ -12529,22 +12529,24 @@ - + - + - + - + - + -

+

The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains + +

@@ -12552,7 +12554,7 @@ - + @@ -12560,19 +12562,19 @@ - + - + - + - +
- +

@@ -12581,29 +12583,24 @@ - - - - - - + - + - + - + - +

@@ -12612,29 +12609,29 @@ - - - - - - + - + - + - + + + + + + - +

@@ -12653,19 +12650,19 @@ - + - + - + - + - +

@@ -12679,24 +12676,24 @@ - + - + - + - + - + - + - +

@@ -12707,7 +12704,7 @@ - + @@ -12715,19 +12712,19 @@ - + - + - + - + - +

@@ -12736,29 +12733,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -12769,7 +12766,7 @@ - + @@ -12777,19 +12774,19 @@ - + - + - + - + - +

@@ -12798,29 +12795,29 @@ - - - - - - + - + - + - + + + + + + - +

@@ -12831,7 +12828,7 @@ - + @@ -12839,19 +12836,19 @@ - + - + - + - + - +

@@ -12860,29 +12857,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -12891,34 +12888,32 @@ + + + + + - - - - - - + - + - + - + - + -

The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains - -

+

@@ -12926,7 +12921,7 @@ - + @@ -12934,19 +12929,19 @@ - + - + - + - + - +

@@ -12957,7 +12952,7 @@ - + @@ -12965,19 +12960,19 @@ - + - + - + - + - +

@@ -12988,7 +12983,7 @@ - + @@ -12996,19 +12991,19 @@ - + - + - + - + - +

@@ -13017,29 +13012,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -13050,7 +13045,7 @@ - + @@ -13058,19 +13053,19 @@ - + - + - + - + - +

@@ -13079,29 +13074,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -13115,24 +13110,24 @@ - + - + - + - + - + - + - +

@@ -13143,7 +13138,7 @@ - + @@ -13151,19 +13146,19 @@ - + - + - + - + - +

@@ -13172,34 +13167,32 @@ - - - - - - + - + - + + + + + + - + - - - -

Enzyme family, EC 3.1.1.4 [https://en.wikipedia.org/wiki/Phospholipase_A2] - -

+ + + +

@@ -13207,7 +13200,7 @@ - + @@ -13215,19 +13208,19 @@ - + - + - + - + - +

@@ -13238,7 +13231,7 @@ - + @@ -13246,19 +13239,19 @@ - + - + - + - + - +

@@ -13272,24 +13265,24 @@ - + - + - + - + - + - + - +

@@ -13298,24 +13291,29 @@ + + + + + - + - + - + - + - +

@@ -13326,7 +13324,7 @@ - + @@ -13334,19 +13332,19 @@ - + - + - + - + - +

@@ -13357,7 +13355,7 @@ - + @@ -13365,19 +13363,19 @@ - + - + - + - + - +

@@ -13388,7 +13386,7 @@ - + @@ -13396,19 +13394,19 @@ - + - + - + - + - +

@@ -13417,29 +13415,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -13450,7 +13448,7 @@ - + @@ -13458,19 +13456,19 @@ - + - + - + - + - +

@@ -13479,29 +13477,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -13512,7 +13510,7 @@ - + @@ -13520,22 +13518,24 @@ - + - + - + - + - + -

+

AKA interferon-α/β receptor (IFNAR) + +

@@ -13543,7 +13543,7 @@ - + @@ -13551,19 +13551,19 @@ - + - + - + - +
- +

@@ -13574,7 +13574,7 @@ - + @@ -13582,19 +13582,19 @@ - + - + - + - + - +

@@ -13605,7 +13605,7 @@ - + @@ -13613,19 +13613,19 @@ - + - + - + - + - +

@@ -13636,7 +13636,7 @@ - + @@ -13644,19 +13644,19 @@ - + - + - + - + - +

@@ -13670,24 +13670,24 @@ - + - + - + - + - + - + - +

@@ -13698,7 +13698,7 @@ - + @@ -13706,19 +13706,19 @@ - + - + - + - + - +

@@ -13729,7 +13729,7 @@ - + @@ -13737,19 +13737,19 @@ - + - + - + - + - +

@@ -13760,7 +13760,7 @@ - + @@ -13768,19 +13768,19 @@ - + - + - + - + - +

@@ -13791,7 +13791,7 @@ - + @@ -13799,21 +13799,21 @@ - + - + - + - + - +

@@ -13821,19 +13821,19 @@ - + - + - + - +

@@ -13841,19 +13841,19 @@ - + - + - + - +

@@ -13861,19 +13861,19 @@ - + - + - + - +

@@ -13881,19 +13881,19 @@ - + - + - + - +

@@ -13901,19 +13901,19 @@ - + - + - + - +

@@ -13921,19 +13921,19 @@ - + - + - + - +

@@ -13941,19 +13941,19 @@ - + - + - + - +

@@ -13961,19 +13961,19 @@ - + - + - + - +

@@ -13981,19 +13981,19 @@ - + - + - + - +

@@ -14001,19 +14001,19 @@ - + - + - + - +

@@ -14021,19 +14021,19 @@ - + - + - + - +

@@ -14041,19 +14041,19 @@ - + - + - + - +

@@ -14061,19 +14061,19 @@ - + - + - + - +

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@@ -18765,19 +18774,19 @@ - + - + - + - +

@@ -18785,19 +18794,19 @@ - + - + - + - +

@@ -18805,19 +18814,19 @@ - + - + - + - +

@@ -18825,19 +18834,19 @@ - + - + - + - +

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@@ -18885,16 +18894,16 @@ - + - + - + diff --git a/sbml/WP4396.svg b/sbml/WP4396.svg index a27931d..e498b60 100644 --- a/sbml/WP4396.svg +++ b/sbml/WP4396.svg @@ -19,40 +19,42 @@ >Mitochondria dysfunctionDevelopment of steatoheptisise4b4fec591f19c9dfd59f2318a0726e4d95baf7e????be0f1e4b4f?b8e43e179ae179ab0bf9ec591??be0f1df00fc1abd?a0726dfd59eddef?baf7ec1abd?f2318df00feddefb8e43f19c9e4d95MitochondriaDevelopment of steatoheptisisER stressER stress Insulin resistanceCxIVCxIICxIIICxIICxIVCxICDC42AKT2NDUFB9NDUFA13NDUFB7COX1JNK2MLXIPNDUFA11EIF2AK3COX7A1GSK3AINSRMAP3K11NDUFA3CASP7NDUFA4L2XBP1PPAR signalingFXREIF2S1Insulin signalingNDUFA9CYTBPRKAB1NDUFS8COX7CPRKAA1NDUFB11UQCR10NDUFC1COX2COX7B2BIDFatty acid biosynthesisADIPOR1NDUFB4TGF signalingFatty acidsPRKAA2NDUFA4AKT3UQCRC1AKT2CASP3UQCRBmir21JUNNDUFB1IRS2GSK3APRKAB1NDUFA6ITCHNDUFB6PIK3R1PRKAG3SDHBApoptosisD-glucoseIL1ACOX8CCxICOX6A1COX1BBC3NDUFA12PRKAB2UQCRQNDUFS5PIK3R3NDUFV2NDUFB10COX5ATGF signalingMAP3K5TGFB1NDUFV1PIK3CBFASROSIKBKBCOX6A2ERN1IL1BSREBF1NDUFA1CASP8RXRABAK1ADIPOR2CYC1COX8AIL1AIL6RCOX7A2PRKAG3NDUFV2COX3NDUFB11ADIPOR1COX7A2LInsulin signalingCASP7ATF4NDUFA3SelonsertibCOX7CLEPRCOX2PRKAA2PIK3R2COX4I1ROSCOX6B2RELAMLXIPMLXIPLSDHCNDUFA10AKT1GSK3BINSRCOX7BFASLGCOX6CNDUFC2NDUFA9NDUFA2SDHAUQCRHNDUFA12COX6B1NDUFS8NDUFS6NDUFV3NDUFB5Lipogenic enzymesEIF2AK3COX5BCOX7A1Oxidative phosphorylationPRKAA1NFKB1NDUFS3PRKAG1UQCR10NR1H3XBP1JNK1UQCRC1MLXFASPKLRNDUFS2CEBPANDUFA4PIK3CDTNFINSUQCRC2ADIPOQNDUFA11NDUFS7PRKAG2AKT3BIDNDUFB6CYP2E1BBC3BAK1NDUFB8D-glucoseSDHDNDUFB5CXCL8TNF signalingNDUFC2-KCTD14NDUFA4L2PI3K-AKT signalingBAXPIK3R1Fatty acid biosynthesisCOX7A2LNDUFS6NR1H3RELANDUFA5NDUFS4OxysterolsPIK3CANDUFS1COX5BSelonsertibUQCR11COX8CIL1BUQCRBUQCRC2FXRmir21ERN1PRKAB2GSK3BCEBPALEPRMLXPRKAG1SOCS3RAC1NDUFA13NDUFAB1UQCRHLNDUFA8BAXPPARASDHDNDUFS1PIK3R3COX8ANDUFA7CYTBUQCR11COX7A2Fatty acidsIL6CYCSNDUFB8DDIT3NDUFB9COX4I2NDUFC1PIK3R2NDUFA1NDUFA10PIK3CAOxidative phosphorylationUQCRHLApoptosisPRKAG2RXRANDUFS4NFKB1IRS2NDUFS7CASP8NDUFA6MAP3K5IRS1IL6RCOX5ANDUFA2COX6CTNFR1CxISDHAUQCRFS1LEPPPAR signalingTRAF2NDUFB7ADIPOQNDUFC2-KCTD14NDUFB2PIK3CBLEPUQCRFS1ADIPOR2NDUFB4MAP3K11CYP2E1NDUFAB1COX7BMLXIPLTNF signalingCOX6A1PPARALipogenic enzymesITCHUQCRQCOX4I2FASLGCOX6B2SDHBCDC42NDUFV1EIF2S1SREBF1NDUFS5TNFCYCSJNK1COX6A2IL6OxysterolsNDUFS3AKT1NDUFS2UQCRHATF4NDUFB10INSJUNPKLRRAC1NDUFB3TGFB1DDIT3PI3K-AKT signalingNDUFA8COX4I1SDHCNDUFB1NDUFV3PIK3CDSMAD7LegendHepatocyteMitochondria dysfunctionLegend - + @@ -7,7 +7,7 @@

Cytosolic DNA and RNA can lead to innate immune sensing via three paths. DNA is sensed by cGAS, which activates STING. RNA is sensed by MDA5 and RIG-I, which activates MAVS. An activation of STING or MAVS lead to phosphorylation of IFR3, which triggers innate immune responses. -This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau (in press). +This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau. [-:-] Unknown node in line: Anchor [-:-] Unknown node in line: Anchor @@ -69,25 +69,25 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - + - + + + - + - + @@ -98,12 +98,12 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + @@ -114,16 +114,18 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + + + @@ -137,38 +139,36 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - - - + - + - + - + - + - + @@ -179,7 +179,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -196,43 +196,28 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - - - - - - + + + + + + - + - - - - - - - - - - - - - - - - - + + @@ -248,11 +233,11 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - - + + @@ -263,19 +248,11 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - - - - - - - + - - + + @@ -286,26 +263,30 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - - + + - - - - + + + + + + + + - - + + - - + + @@ -321,59 +302,56 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - - + + - - - - - - - - - + + + + + + - - + + - + - - - - - - + + + + + + - + - - - + + + - - + + - - + + @@ -389,10 +367,18 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - + + + + + + + + + @@ -409,94 +395,69 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - - - - + + + + + + + + - - + + - + - - - - + + + + + + + + + - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + - - - - - - - - - + - + @@ -513,26 +474,28 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - - - - + + + + + + - - + + - - + + @@ -543,33 +506,56 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - + - + + + + + + + + + + + + + - + - - + + + + + + + + + + - - - - - - + + + + + + + + + - - + + @@ -590,7 +576,15 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + + + + + + + + + @@ -602,45 +596,48 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - - - - - - - - + + + + - - + + - - - + + + - - + + - - - + + + + + + + + + + - - + + - + @@ -657,28 +654,31 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - - - - - - + + + + + + + + + - - + + - - + + @@ -689,87 +689,89 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - - + + - - - - - - - - + + + + - - + + - - + + - - - - - - - - - + + + + - - + + - - + + + + + + + + + + - - - - - - - - - + + + + - - + + - + - - - + + + - + - - + + + + + + + + + + @@ -780,28 +782,8 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - - - - - - - - - - - - - - - - - - - - + + @@ -826,16 +808,16 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - + + + - - + + - - + + @@ -851,10 +833,10 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - + @@ -866,37 +848,9 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -909,80 +863,79 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - - - - - - - - - - - - - - - + + - + - - - - - - - - - + + + + - + - + + + + + + + + + - - - + + + - + - - + + - - - - - - + + + + + + + + + - - + + - + + + + + + + + + @@ -998,11 +951,11 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - - + + @@ -1018,10 +971,10 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - + + - + @@ -1038,23 +991,70 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - - - - + + + + @@ -1063,16 +1063,16 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - - - - + + + + @@ -1083,14 +1083,14 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - - - + + + + @@ -1099,16 +1099,16 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - - - - + + + + @@ -1117,34 +1117,34 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -1155,14 +1155,14 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - - - + + + + @@ -1173,32 +1173,32 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - - - + + + + - + - + - + - - - - + + + + @@ -1209,14 +1209,14 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - - - + + + + @@ -1227,274 +1227,250 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - - - - - - - - - - - - - - - + + - + - - - - + + + + - + - - - - - - - - + + - + - - - - + + + + - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - - - - - + + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - - + + - + + + + - - - - + + + + - + - - + + - + - - - - + + + + - - + + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - - - - + - - - - + + + + - + - + - + - + @@ -1506,149 +1482,173 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - - + + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + - + - + - - - - + + + + @@ -1657,16 +1657,16 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - - - - + + + + @@ -1688,13 +1688,13 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + @@ -1704,16 +1704,16 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - + - - + + @@ -1730,429 +1730,373 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - + - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - - + + - + - - + + + + + + + + + + - + - - + + - + @@ -2162,7 +2106,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -2172,7 +2116,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -2184,727 +2128,739 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - + - - - - - - + + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + - + - - + + - + - - - - - - + + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + + + + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + - + @@ -2914,7 +2870,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -2924,7 +2880,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -2934,7 +2890,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -2954,314 +2910,358 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - - + + + + + + + + + + + + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + @@ -3270,261 +3270,249 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - - - - - - + + + + + + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + @@ -3540,105 +3528,117 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + + + + + + + - + - + - + - - + + - + - - + + - + - + - + - + - + - + + + + + + + - + - + - + - + @@ -3650,17 +3650,17 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + @@ -3669,12 +3669,12 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + @@ -3683,157 +3683,157 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + @@ -3843,67 +3843,67 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + @@ -3917,7 +3917,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - +

@@ -3931,7 +3931,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - +

@@ -3975,12 +3975,10 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + -

Cytosolic deoxyribonuclease anchored in the outer nuclear membrane. A lack of TREX1 causes DNA accumulation, both within the nucleus and the cytosol. - -

+

@@ -3988,7 +3986,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -3998,25 +3996,32 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + -

+

The presence of ribonucleotides in genomic DNA enhances photodimerization of adjacent pyrimidines, which are repaired by nucleotide excision repair + +

+ + + + + @@ -4024,22 +4029,20 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - +
- + -

single-stranded DNA - -

+

@@ -4047,7 +4050,7 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + @@ -4055,26 +4058,22 @@ This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau ( - + - + - + - + - + -

cytosolic RNA sensor - -Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in constitutive type I IFN signaling. - -

+

@@ -4082,7 +4081,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4090,19 +4089,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - +

@@ -4113,7 +4112,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4121,52 +4120,50 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

single-stranded DNA - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -4177,7 +4174,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4187,22 +4184,20 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + -

Noncatalytic subunit - -

+

@@ -4210,7 +4205,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4218,24 +4213,22 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

Catalytic subunit - -

+

@@ -4243,7 +4236,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4251,19 +4244,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - +

@@ -4274,7 +4267,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4282,19 +4275,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - +

@@ -4305,7 +4298,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4315,22 +4308,20 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + -

mitochondrial antiviral signaling (MAVS) - -

+

@@ -4338,7 +4329,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4346,22 +4337,26 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

+

cytosolic RNA sensor + +Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in constitutive type I IFN signaling. + +

@@ -4369,7 +4364,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4377,19 +4372,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- +

@@ -4398,32 +4393,34 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - + - + - + - + + + + + + - + -

+

Catalytic subunit + +

@@ -4431,7 +4428,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4439,27 +4436,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - + - + - + - +
- + -

+

Noncatalytic subunit + +

@@ -4467,7 +4461,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4475,22 +4469,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- + -

+

Noncatalytic subunit + +

@@ -4498,7 +4494,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4506,19 +4502,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- +

@@ -4527,37 +4523,27 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - - - - - - + - + - + - + - + -

cGAS which signals via STING (encoded by TMEM173) +

single-stranded DNA

@@ -4567,7 +4553,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4575,24 +4561,22 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- + -

Noncatalytic subunit - -

+

@@ -4600,7 +4584,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4608,22 +4592,29 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + + + + + + - + - + -

+

SAMHD1 has also ribonuclease activity, suggesting that a loss of SAMHD1 may lead to RNA accumulation. + +

@@ -4631,7 +4622,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4639,86 +4630,86 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- + -

The presence of ribonucleotides in genomic DNA enhances photodimerization of adjacent pyrimidines, which are repaired by nucleotide excision repair - -

+

- - - - - - + - + - + - + + + + + + - + -

+

cGAS which signals via STING (encoded by TMEM173) + +

+ + + + + - - - - - - + - + - + - +
- + -

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. +

single-stranded DNA

@@ -4728,7 +4719,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4738,17 +4729,17 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - +
- +

@@ -4762,24 +4753,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - + - + - + - + - +

@@ -4790,7 +4776,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4798,22 +4784,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

+

Cytosolic deoxyribonuclease anchored in the outer nuclear membrane. A lack of TREX1 causes DNA accumulation, both within the nucleus and the cytosol. + +

@@ -4821,7 +4809,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4829,24 +4817,22 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- + -

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing - -

+

@@ -4854,17 +4840,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - - - - - - + @@ -4874,20 +4850,22 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + -

+

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. + +

@@ -4895,7 +4873,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4903,19 +4881,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- +

@@ -4924,29 +4902,29 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c + + + + + - - - - - - + - + - + - + - +

@@ -4957,7 +4935,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4965,24 +4943,22 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

DNA sensor - -

+

@@ -4990,7 +4966,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -4998,19 +4974,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - +

@@ -5019,39 +4995,9 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - - - - - - - - - - - - - - - -

Cytosolic RNA sensor - -Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in constitutive type I IFN signaling. - -

- -
- - - - + @@ -5059,19 +5005,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- +

@@ -5079,7 +5025,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5087,17 +5033,17 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - +

@@ -5105,7 +5051,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5123,17 +5069,17 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - +

@@ -5141,38 +5087,53 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + + + + + + - + - + - + - + - + -

interferon-responsive genes +

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing

- + - + + + + + + + + + + + @@ -5180,19 +5141,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- +

@@ -5200,10 +5161,10 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + @@ -5211,22 +5172,50 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - +

+ + + + + + + + + + + + + + + + + + + + + + + + + +

interferon-responsive genes + +

@@ -5234,7 +5223,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5242,24 +5231,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - - - - - - + - + - + - +
- +

@@ -5270,7 +5254,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5278,22 +5262,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

+

mitochondrial antiviral signaling (MAVS) + +

@@ -5301,7 +5287,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5311,20 +5297,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - +
- + -

+

Cytosolic RNA sensor + +Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in constitutive type I IFN signaling. + +

@@ -5332,7 +5322,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5340,22 +5330,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- + -

+

DNA sensor + +

@@ -5363,7 +5355,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5371,19 +5363,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +
- +

@@ -5394,7 +5386,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5402,24 +5394,22 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - + -

SAMHD1 has also ribonuclease activity, suggesting that a loss of SAMHD1 may lead to RNA accumulation. - -

+

@@ -5427,7 +5417,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5435,19 +5425,24 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + + + + + + - + - +

@@ -5458,7 +5453,7 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + @@ -5466,91 +5461,75 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + - - - -

- - - - - - - - - - - - - - - - - + -

+

Within the cytosol, ssDNA metabolites with stem loops or dsDNA are sensed by the DNA sensor cGAS + +

- + - + - + - + -

+

Both RNA sensors, MDA5 and RIG-I signal via mitochondrial antiviral signaling (MAVS) to activate type I IFN + +

- + - + - +
- + -

Both RNA sensors, MDA5 and RIG-I signal via mitochondrial antiviral signaling (MAVS) to activate type I IFN +

short RNA fragments that act as ligand for RIG-I

- + @@ -5559,142 +5538,134 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - +
- + -

Within the cytosol, ssDNA metabolites with stem loops or dsDNA are sensed by the DNA sensor cGAS +

Binds ssDNA and degrades cDNA from reverse transcription of endogenous retroelements

- + - + - +
- + -

short RNA fragments that act as ligand for RIG-I - -

+

- + - + - + - + -

Reverse transcribed - -

+

- + - + - + - + -

Both RNA sensors, MDA5 and RIG-I signal via mitochondrial antiviral signaling (MAVS) to activate type I IFN +

Binds ssDNA and degrades ssDNA derived from DNA repair

- + - + - +
- + -

RNase T2 degrades ribosomal RNA in lysosomes. A lack of RNase T2 causes RNA accumulation which may activate RNA sensors. - -

+

- + - + - + - + -

Transcription - -

+

- + - + - + - +

@@ -5702,89 +5673,91 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + -

activates expression of the IFNB gene and numerous interferon-responsive genes (ISG). +

ADAR modifies dsRNA through deamination of adenosine to inosine

- + + + + + + - + - + + + +
- + -

Phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) +

RNase T2 degrades ribosomal RNA in lysosomes. A lack of RNase T2 causes RNA accumulation which may activate RNA sensors.

- + - + - + - - - -
- + -

Binds ssDNA and degrades cDNA from reverse transcription of endogenous retroelements - -

+

- + - + - + - +

@@ -5792,49 +5765,39 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + -

ADAR modifies dsRNA through deamination of adenosine to inosine - -

+

- - - - - - + - + - + - - - - +

@@ -5842,41 +5805,39 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + -

Binds ssDNA and degrades ssDNA derived from DNA repair - -

+

- + - + - + - +

@@ -5884,39 +5845,44 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + + + + - + -

+

Reverse transcribed + +

- + - +
- +

@@ -5924,19 +5890,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +

@@ -5944,62 +5910,61 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + -

Activation of RNase L leads to formation of short RNA fragments that act as ligand for RIG-I +

Within the cytosol, ssDNA metabolites with stem loops or dsDNA are sensed by the DNA sensor cGAS

- + - + - +
- + -

+

Activation of RNase L leads to RNA degradation + +

- + - + - + - - -
@@ -6017,14 +5982,14 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - - + + - +

@@ -6032,19 +5997,19 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - +

@@ -6052,39 +6017,71 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + -

+

SAMHD1 degrades deoxynucleoside triphosphates (dNTP) + +

- + + + + + + - + - + + + +
- + + + +

Both RNA sensors, MDA5 and RIG-I signal via mitochondrial antiviral signaling (MAVS) to activate type I IFN + +

+ +
+ + + + + + + + + + + + + +
+

@@ -6092,130 +6089,128 @@ Activating mutations in RIG-I and MDA5 increase receptor affinity resulting in c - + - + - + - + -

Within the cytosol, ssDNA metabolites with stem loops or dsDNA are sensed by the DNA sensor cGAS - -

+

- + - + - + - + -

Activation of RNase L leads to RNA degradation +

Transcription

- + - + - +
- + -

+

Phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) + +

- + - + - + + + + +
- + -

SAMHD1 degrades deoxynucleoside triphosphates (dNTP) +

activates expression of the IFNB gene and numerous interferon-responsive genes (ISG).

- - - - - - + - + - + - - -
- + -

+

Activation of RNase L leads to formation of short RNA fragments that act as ligand for RIG-I + +

- + - + - +
diff --git a/sbml/WP4705.svg b/sbml/WP4705.svg index 59c57d2..c334b28 100644 --- a/sbml/WP4705.svg +++ b/sbml/WP4705.svg @@ -60,18 +60,18 @@ >excision repair?e20a5e20a5repairdsRNASAMHD1dsRNAdsRNAdsRNArRNAByproducts of DNA repairDegradationType I IFN activiationDNA damageByproducts of DNA repair - + @@ -48,8 +48,8 @@ New PW, homology converted [UnknownPositiveInfluenceReaction:ida2f1181b] Reaction should contain only one reactant and one product. [UnknownPositiveInfluenceReaction:a92d2] Reaction should contain only one reactant and one product. [-:-] Miriam data (PUBMED: 23558541) for e98b2 already exists. Ignoring... -[Complex:ae0aa] Empty element is invalid [Complex:b6286] Empty element is invalid +[Complex:ae0aa] Empty element is invalid [Complex:a7a65] Empty element is invalid

@@ -76,9 +76,9 @@ New PW, homology converted - + @@ -88,20 +88,6 @@ New PW, homology converted - - - - - - - - - - - - - - @@ -143,6 +129,20 @@ New PW, homology converted + + + + + + + + + + + + + + @@ -161,49 +161,37 @@ New PW, homology converted - - - - - - - - - - - - - - - + + + - - + + - - + + - - + + - + - + - - - + + + - - + + @@ -213,55 +201,58 @@ New PW, homology converted - - + + + + + + + + + + - - - - - - + + + + + + - - + + + + + + + + + - + - - - - - - - - - - - - - + - + - + - - - - + + + + @@ -270,63 +261,40 @@ New PW, homology converted - + - + - + - + - - - - - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - + + + - - + + @@ -336,167 +304,160 @@ New PW, homology converted - - - + + + - - + + - + - + - - + + - - - - - - + + + + + + - - - + + - + - + - - - + + + + + + + + + + + + + + + - - + + - + - + - - - - - - - - - - - + + + - - + + - - + + - - - - - - + + + + + + + - - - - - - - - - - + + - + - + - - + + - - - - - - - - - + + + + + + - - + + - + - + - + - + - + - + - + - + @@ -507,91 +468,57 @@ New PW, homology converted - - - - - - - - - - + + - - - - - - - - + + + + + + - - + + - - - - - - - - - - - - - - - + + + - - + + - - + + - - + + - + - + - - - - - - - - - - - - - - - + + + - - + + - - + + @@ -607,73 +534,57 @@ New PW, homology converted - - + + - + - - - - - - + + + + + + - + - - - - - - - - - + - - - - - - + + + + + + - + - + - + - - - - - - - - - + @@ -690,34 +601,18 @@ New PW, homology converted - - - - - - - - - + - - - - - - - - - + - - - - + + + + @@ -725,193 +620,180 @@ New PW, homology converted - + - + - + - + - + - + + + + + + + + + - - - - - - + + + + + + - + - + - - - - - - - - - - - - - + - + - + - + - + - + - + - + - - + + - - - - - - + + + + + + - - - + + - + - - - - - - + + + + + + - - - - - - - - - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - - - - + + + + @@ -920,162 +802,125 @@ New PW, homology converted - + - - - - - - - - - + - + - + - + - - - + + + - - + + - + - + - + - + - - - + + + - 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- + + + + - - - - + - + - + - - - - + + + + @@ -2227,93 +2227,111 @@ New PW, homology converted - - - - + - + - - - - + + + + + + + - + + + + + + + + + + + + + + + + + + + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + @@ -2325,40 +2343,40 @@ New PW, homology converted - + - + - + - + - - - - + + + + - + - + - + - + - + @@ -2370,370 +2388,385 @@ New PW, homology converted - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - + + - - - - + + + + - + - - + + + + + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - - + + + + + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + @@ -2745,154 +2778,175 @@ New PW, homology converted - - - - - + + - - + + - - + + - - - - + + + + - + - - + + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + + + + - + + + + - - - - + + + + - - + + - - + + - - + + + + + + + + + + + - - + + + + + + + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + @@ -2904,199 +2958,190 @@ New PW, homology converted - + - + - - - - + - - - - + + + + - + - - - - - + + - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - - + + - - + + + + + - - - - + + + + - + - - - - + - + - - - - + + + + - - + + - - + + - - + + - - + + - - - - + + + + - + - + - + @@ -3108,37 +3153,37 @@ New PW, homology converted - + - + - + - + - - - - + + + + - + - + - + - + @@ -3150,149 +3195,104 @@ New PW, homology converted - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + + + + + + + + + + + + + + + + + + + @@ -3322,28 +3322,28 @@ New PW, homology converted - + - - + + - + - - + + - + - - + + - + - - + + @@ -3352,148 +3352,148 @@ New PW, homology converted - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + @@ -3502,430 +3502,406 @@ New PW, homology converted - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - + - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - 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+ - - + + - - + + - + - + - - + + - - + + - + @@ -5406,707 +5438,745 @@ New PW, homology converted - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - - - - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - - + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -6116,7 +6186,7 @@ New PW, homology converted - + @@ -6126,7 +6196,7 @@ New PW, homology converted - + @@ -6136,7 +6206,7 @@ New PW, homology converted - + @@ -6148,289 +6218,339 @@ New PW, homology converted - + - - + + - + - - + + + + + + + + + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - - - - - + + + + + + + + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -6440,7 +6560,7 @@ New PW, homology converted - + @@ -6454,7 +6574,7 @@ New PW, homology converted - + @@ -6466,383 +6586,353 @@ New PW, homology converted - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - - - - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - + + - + @@ -6852,7 +6942,7 @@ New PW, homology converted - + @@ -6870,7 +6960,7 @@ New PW, homology converted - + @@ -6882,57 +6972,49 @@ New PW, homology converted - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - + + - + @@ -6942,7 +7024,7 @@ New PW, homology converted - + @@ -6952,7 +7034,7 @@ New PW, homology converted - + @@ -6962,7 +7044,7 @@ New PW, homology converted - + @@ -6974,298 +7056,216 @@ New PW, homology converted - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - - - - - - - - + + - - - - - - - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - - - - - - - - - - - - - - - - - - - - + + - - - - - - - - + + - + - - + + @@ -7274,610 +7274,586 @@ New PW, homology converted - - - - - - - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -7886,63 +7862,75 @@ New PW, homology converted - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + + + + + + + - + - + + + + + + + @@ -7952,189 +7940,201 @@ New PW, homology converted - + - + + + + + + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + @@ -8142,396 +8142,496 @@ New PW, homology converted - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - - - - - - - - - - - - - + + + - + + + + + + + + + + + + + + + - + - + - + - + @@ -8540,128 +8640,120 @@ New PW, homology converted - + - + - + - + - + - + + + + + + - + + + + + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + @@ -8670,17 +8762,17 @@ New PW, homology converted - + - + - + @@ -8690,147 +8782,109 @@ New PW, homology converted - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + @@ -8839,12 +8893,12 @@ New PW, homology converted - + - + @@ -8853,324 +8907,270 @@ New PW, homology converted - + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - - - - - - + - + - - - - - + - + - + - + + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + + + + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + + + + + + + + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - - + + @@ -9198,12 +9198,10 @@ New PW, homology converted - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071 - -

+

@@ -9211,7 +9209,7 @@ New PW, homology converted - + @@ -9219,32 +9217,29 @@ New PW, homology converted - + - + - + - + - + -

+

C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H + +

- - - - - @@ -9252,20 +9247,20 @@ New PW, homology converted - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278

@@ -9275,7 +9270,7 @@ New PW, homology converted - + @@ -9283,22 +9278,22 @@ New PW, homology converted - + - + - + - +
- + -

C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243

@@ -9306,19 +9301,24 @@ New PW, homology converted + + + + + - + - + - + - + @@ -9346,20 +9346,20 @@ New PW, homology converted - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 +

C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H

@@ -9367,65 +9367,58 @@ New PW, homology converted - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 - -

+

- - - - - - + - + - + + + + + + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652

@@ -9435,7 +9428,7 @@ New PW, homology converted - + @@ -9443,22 +9436,22 @@ New PW, homology converted - + - + - + - +
- + -

C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796

@@ -9466,27 +9459,32 @@ New PW, homology converted + + + + + - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262

@@ -9496,7 +9494,7 @@ New PW, homology converted - + @@ -9504,32 +9502,29 @@ New PW, homology converted - + - + - + - +
- + -

+

C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H SMILES + +

- - - - - @@ -9537,53 +9532,53 @@ New PW, homology converted - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855 + +

+ + + + + - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920 - -

+

@@ -9591,7 +9586,7 @@ New PW, homology converted - + @@ -9599,22 +9594,24 @@ New PW, homology converted - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715 + +

@@ -9622,7 +9619,7 @@ New PW, homology converted - + @@ -9630,22 +9627,24 @@ New PW, homology converted - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920 + +

@@ -9653,7 +9652,7 @@ New PW, homology converted - + @@ -9661,22 +9660,22 @@ New PW, homology converted - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 +

No homologues found for original id En:ENSMUSG00000072949

@@ -9684,34 +9683,27 @@ New PW, homology converted - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883 - -

+

@@ -9719,7 +9711,7 @@ New PW, homology converted - + @@ -9727,19 +9719,19 @@ New PW, homology converted - + - + - + - + - +

@@ -9748,32 +9740,32 @@ New PW, homology converted - - - - - - + - + - + - + + + + + + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360

@@ -9783,7 +9775,7 @@ New PW, homology converted - + @@ -9791,22 +9783,24 @@ New PW, homology converted - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 + +

@@ -9814,7 +9808,7 @@ New PW, homology converted - + @@ -9822,22 +9816,24 @@ New PW, homology converted - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 + +

@@ -9845,7 +9841,7 @@ New PW, homology converted - + @@ -9853,53 +9849,55 @@ New PW, homology converted - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357 + +

+ + + + + - - - - - - + - + - + - +
- + -

C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0

@@ -9907,27 +9905,34 @@ New PW, homology converted + + + + + - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 +

aka Sc4mol + +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234

@@ -9937,7 +9942,7 @@ New PW, homology converted - + @@ -9945,52 +9950,45 @@ New PW, homology converted - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754 - -

+

- - - - - - + - + - + - + - +

@@ -10001,7 +9999,7 @@ New PW, homology converted - + @@ -10009,22 +10007,22 @@ New PW, homology converted - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293

@@ -10034,7 +10032,7 @@ New PW, homology converted - + @@ -10042,22 +10040,22 @@ New PW, homology converted - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137

@@ -10067,7 +10065,7 @@ New PW, homology converted - + @@ -10077,22 +10075,20 @@ New PW, homology converted - + - +
- + -

Assuming this is omega-7 type - -

+

@@ -10100,7 +10096,7 @@ New PW, homology converted - + @@ -10108,14 +10104,14 @@ New PW, homology converted - + - + - + - + @@ -10141,22 +10137,20 @@ New PW, homology converted - + - + - + -

C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H SMILES - -

+

@@ -10167,19 +10161,19 @@ New PW, homology converted - + - + - + - + - +

@@ -10188,34 +10182,32 @@ New PW, homology converted + + + + + - - - - - - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6 - -

+

@@ -10223,7 +10215,7 @@ New PW, homology converted - + @@ -10231,22 +10223,22 @@ New PW, homology converted - + - + - + - + - + -

C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463

@@ -10254,29 +10246,32 @@ New PW, homology converted + + + + + - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030 - -

+

@@ -10284,7 +10279,7 @@ New PW, homology converted - + @@ -10292,22 +10287,22 @@ New PW, homology converted - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6

@@ -10317,7 +10312,7 @@ New PW, homology converted - + @@ -10327,17 +10322,17 @@ New PW, homology converted - + - +
- +

@@ -10351,27 +10346,29 @@ New PW, homology converted - + - + - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 + +

@@ -10379,7 +10376,7 @@ New PW, homology converted - + @@ -10387,22 +10384,22 @@ New PW, homology converted - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 +

aka 24-dehydrolathosterol

@@ -10412,7 +10409,7 @@ New PW, homology converted - + @@ -10420,22 +10417,22 @@ New PW, homology converted - + - + - + - +
- + -

Assuming this is omega-7 type +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4

@@ -10445,7 +10442,7 @@ New PW, homology converted - + @@ -10453,55 +10450,53 @@ New PW, homology converted - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137 - -

+

- - - - - - + - + - + + + + + + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987

@@ -10511,7 +10506,7 @@ New PW, homology converted - + @@ -10521,17 +10516,17 @@ New PW, homology converted - + - +
- +

@@ -10542,7 +10537,7 @@ New PW, homology converted - + @@ -10552,17 +10547,17 @@ New PW, homology converted - + - + - +

@@ -10571,67 +10566,65 @@ New PW, homology converted + + + + + - - - - - - + - + - + - + - + -

- -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - -

+

- - - - - - + - + - + + + + + + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 + +

@@ -10639,7 +10632,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10647,53 +10640,55 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

+

Aka C18:1 (omega 9) + +

+ + + + + - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262 +

Annotated while assuming this compound is actually presqualene-diphosphate

@@ -10703,7 +10698,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10711,22 +10706,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 + +

@@ -10734,7 +10731,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10742,19 +10739,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- +

@@ -10763,32 +10760,32 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - - - - - - + - + - + + + + + + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116 +

No homologues found for original id S:P13011

@@ -10796,34 +10793,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5 - -

+

@@ -10831,7 +10821,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10839,24 +10829,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 - -

+

@@ -10864,7 +10852,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10872,24 +10860,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538 - -

+

@@ -10897,7 +10883,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10905,22 +10891,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - + - + -

+

+ +

@@ -10928,7 +10916,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10938,17 +10926,17 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - +
- +

@@ -10959,7 +10947,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10969,20 +10957,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593 + +

@@ -10990,7 +10980,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -10998,22 +10988,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4

@@ -11023,7 +11013,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11031,19 +11021,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- +

@@ -11054,7 +11044,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11064,22 +11054,20 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 - -

+

@@ -11087,7 +11075,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11095,22 +11083,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121

@@ -11120,7 +11108,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11128,22 +11116,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156 + +

@@ -11151,7 +11141,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11159,19 +11149,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- +

@@ -11182,7 +11172,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11192,20 +11182,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754 + +

@@ -11213,7 +11205,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11221,22 +11213,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

Annotated while assuming this compound is actually presqualene-diphosphate +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226

@@ -11246,7 +11238,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11254,22 +11246,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360 +

Assuming this is omega-7 type

@@ -11279,7 +11271,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11287,19 +11279,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- +

@@ -11310,7 +11302,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11320,27 +11312,30 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC=[C@@]21C - -

+

+ + + + + @@ -11348,79 +11343,84 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754 - -

+

- - - - - - + - + - + + + + + + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196 + +

+ + + + + - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9

@@ -11430,7 +11430,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11438,19 +11438,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- +

@@ -11461,7 +11461,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11471,51 +11471,53 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883 + +

+ + + + + - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490

@@ -11525,7 +11527,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11533,22 +11535,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360

@@ -11556,60 +11558,63 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 + + + + + - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349 - -

+

- - - - - - + - + - + + + + + + - + - + -

Aka C18:1 (omega 9) +

C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H

@@ -11617,32 +11622,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - - - - - - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754 + +

@@ -11650,7 +11652,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11658,22 +11660,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554 +

@@ -11683,7 +11685,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11691,22 +11693,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

Assuming this is omega 7-type +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071

@@ -11716,7 +11718,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11724,19 +11726,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- +

@@ -11747,7 +11749,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11757,48 +11759,53 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + -

No homologues found for original id En:ENSMUSG00000072949 - -

+

+ + + + + - + - + - + - + - + -

+

Assuming this is omega-7 type + +

@@ -11806,7 +11813,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + @@ -11814,26 +11821,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 - + - + - + - +
- + -

aka 14-demethyl-14-dehydrolanosterol - -C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILES - -

+

@@ -11841,7 +11844,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -11851,20 +11854,22 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665 + +

@@ -11872,7 +11877,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -11880,19 +11885,19 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + - +
- +

@@ -11906,27 +11911,22 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - - - - - - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030

@@ -11936,7 +11936,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -11944,19 +11944,19 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + - +
- +

@@ -11965,63 +11965,65 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C + + + + + - - - - - - + - + - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554 + +

+ + + + + - - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175

@@ -12031,7 +12033,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -12039,86 +12041,81 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593 - -

+

- - - - - - + - + - + - + + + + + + - + -

+

No homologues found for original id L:320581 + +

- - - - - - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108

@@ -12128,7 +12125,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -12136,22 +12133,22 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364

@@ -12161,7 +12158,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -12169,22 +12166,22 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603

@@ -12194,7 +12191,7 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + @@ -12202,22 +12199,22 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + - +
- + -

+

C12CC[C@@]3([H])C(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H

@@ -12225,11 +12222,6 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - - - - - @@ -12237,43 +12229,45 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601 + +

+ + + + + - - - - - - + - + - + - + @@ -12301,22 +12295,20 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - +
- + -

No homologues found for original id L:320581 - -

+

@@ -12327,22 +12319,29 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - + - + - + + + + + + - + - + -

+

C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H + +

@@ -12353,31 +12352,22 @@ C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])C - - - - - - + - + - + - +
- + -

aka Sc4mol - -Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - -

+

@@ -12385,7 +12375,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12393,19 +12383,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -12419,19 +12409,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + + + + + + - + - +

@@ -12442,7 +12437,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12452,17 +12447,17 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - +

@@ -12471,34 +12466,32 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - + + + + + + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603 - -

+

@@ -12506,7 +12499,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12514,22 +12507,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116

@@ -12539,7 +12532,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12549,20 +12542,20 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194

@@ -12572,7 +12565,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12580,24 +12573,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595 - -

+

@@ -12605,7 +12596,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12613,14 +12604,14 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + @@ -12641,27 +12632,25 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987 - -

+

@@ -12669,7 +12658,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12677,22 +12666,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775

@@ -12702,7 +12691,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12712,22 +12701,20 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796 - -

+

@@ -12735,7 +12722,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12743,24 +12730,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - + -

C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H - -

+

@@ -12771,53 +12756,62 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + + + + + + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349 + +

+ + + + + - - - - - - + - + - + - +
- + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5 + +

@@ -12825,7 +12819,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12833,24 +12827,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

No homologues found for original id S:P13011 - -

+

@@ -12861,22 +12853,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + + + + + + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 + +

@@ -12884,7 +12883,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12892,22 +12891,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0

@@ -12917,7 +12916,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12925,22 +12924,26 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

+

aka 14-demethyl-14-dehydrolanosterol + +C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILES + +

@@ -12948,7 +12951,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -12958,20 +12961,20 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243 +

C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC=[C@@]21C

@@ -12979,29 +12982,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - +
- +

@@ -13012,7 +13010,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13022,20 +13020,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + -

+

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153 + +

@@ -13043,7 +13043,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13051,19 +13051,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- +

@@ -13074,7 +13074,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13084,20 +13084,20 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086

@@ -13107,7 +13107,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13115,24 +13115,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278 - -

+

@@ -13140,7 +13138,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13148,22 +13146,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652 +

Assuming this is omega 7-type

@@ -13173,7 +13171,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13181,19 +13179,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- +

@@ -13202,34 +13200,32 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 + + + + + - - - - - - - - + + + - + - + - + - + -

- -

+

@@ -13237,7 +13233,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13247,17 +13243,17 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - +

@@ -13268,7 +13264,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13278,20 +13274,20 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 +

C12CC[C@@]3([H])C(C)[C](=O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC[C]21H

@@ -13299,58 +13295,62 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - +
- + -

+

+ +Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 + +

+ + + + + - + - + - + - +
- + -

aka 24-dehydrolathosterol +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538

@@ -13360,7 +13360,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13368,22 +13368,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595

@@ -13393,7 +13393,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13401,22 +13401,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- + -

Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 +

Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166

@@ -13426,7 +13426,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13434,21 +13434,21 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +
- +

@@ -13456,19 +13456,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -13476,35 +13476,33 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - + -

Desmosterol significantly increases protein levels of Nr1h3 (see ref. for more details) - -

+

- + - + @@ -13512,13 +13510,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + + + + - +

@@ -13526,7 +13527,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13537,16 +13538,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -13554,19 +13555,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + + + + - +

@@ -13574,27 +13578,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - + - +

@@ -13602,7 +13601,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13613,16 +13612,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - +

@@ -13630,7 +13629,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13641,16 +13640,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -13658,19 +13657,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -13678,7 +13677,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13689,16 +13688,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -13706,7 +13705,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -13717,38 +13716,36 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + -

From the LipidMaps drawing, it is unclear if only Nr1h3 influences Srebf1, or the group Nr1h2/3 does this. - -

+

- + - + - + - +

@@ -13756,19 +13753,41 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + + + +

From the LipidMaps drawing, it is unclear if only Nr1h3 influences Srebf1, or the group Nr1h2/3 does this. + +

+ +
+ + + + + + + + + + + + + +
+

@@ -13776,22 +13795,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -13799,22 +13818,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + - + - +

@@ -13822,19 +13846,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -13842,42 +13866,52 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - + -

+

multi-step process + +

- + + + + + + - + - + + + +
- +

@@ -13885,23 +13919,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - - + - + - + - +

@@ -13909,22 +13942,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -13932,27 +13965,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - + - +

@@ -13960,22 +13988,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - - - - +

@@ -13983,22 +14008,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - - - - +

@@ -14006,7 +14028,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14017,16 +14039,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14034,27 +14056,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - + - +

@@ -14062,19 +14079,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14082,19 +14099,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + @@ -14123,16 +14140,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14140,19 +14157,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + - + @@ -14169,17 +14191,17 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - - + + - +

@@ -14187,7 +14209,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14198,16 +14220,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14215,22 +14237,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -14238,19 +14260,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + + + + - +

@@ -14258,19 +14288,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14278,22 +14308,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + - + - +

@@ -14301,46 +14336,45 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + + + + - + -

multi-step process - -

+

- - - - - - + - + - + + + + - +

@@ -14348,19 +14382,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14368,27 +14402,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - + - +

@@ -14396,7 +14425,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14407,16 +14436,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14424,19 +14453,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14444,22 +14473,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + - + - +

@@ -14467,7 +14501,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14478,16 +14512,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14495,22 +14529,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -14518,19 +14552,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + + + + - +

@@ -14538,19 +14580,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + + + + - +

@@ -14558,7 +14603,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14569,16 +14614,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14586,19 +14631,24 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + - + @@ -14615,16 +14665,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14632,27 +14682,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - - - - +

@@ -14660,19 +14702,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14680,22 +14722,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -14703,30 +14745,36 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + + - + + + + - + -

+

Desmosterol significantly increases protein levels of Nr1h3 (see ref. for more details) + +

- + - + @@ -14737,11 +14785,8 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - - -
@@ -14757,16 +14802,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14774,7 +14819,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14785,13 +14830,36 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + + + + + + + + + +

+ + + + + + + + + + + + + + - + @@ -14808,13 +14876,13 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - +

@@ -14822,22 +14890,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - - - - +

@@ -14845,30 +14910,29 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - - - - + -

+

multi-step process + +

- + @@ -14879,16 +14943,13 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - - -
- +

@@ -14896,22 +14957,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -14919,22 +14980,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -14942,7 +15003,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + @@ -14953,16 +15014,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -14970,19 +15031,27 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + + + + + + - + - + + + + - +

@@ -14990,20 +15059,19 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - - + - +

@@ -15011,25 +15079,18 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + + - - - @@ -15045,32 +15106,30 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + -

Multiple steps involved - -

+

- + - + - + @@ -15090,16 +15149,16 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - +

@@ -15107,22 +15166,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - + - +

@@ -15130,27 +15189,22 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - + - + - + - + - +

@@ -15158,32 +15212,7 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - - - - - - - - - - - - - -

multi-step process - -

- -
- - - + @@ -15194,67 +15223,41 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - - - - - - - - -
- - - -

- - - - - - - - - - - + - + - + - + -

+

Multiple steps involved + +

- - - - - - + - + - + - +
- +

@@ -15262,20 +15265,17 @@ Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 - + - + - + - - - diff --git a/sbml/WP4718.svg b/sbml/WP4718.svg index 8b47739..45fd8c5 100644 --- a/sbml/WP4718.svg +++ b/sbml/WP4718.svg @@ -28,133 +28,88 @@ >b514b?b4b55bf311c731c?others?cf9f1b666fc3e0acf9f1?b514b?others?c1a72ef561c731c?c1a72?b4b55ef561b666fc3e0a???bf311be5a1DHCR24Acetyl-CoACH25HABCA1SOAT1FASNBloch PathwaySREBF1HMGCR7alpha-hydroxycholesterolAcetyl-CoANR1H3ABCA1CE(16:1)DHCR7SOAT1NR1H39Z-palmitoleic acidHMGCRDHCR7Bloch PathwaySREBF1FASNCholesterolSC5DEBPNSDHLCYP51A1TM7SF2MSMO1HSD17B7DHCR24Cholesteryl esters (CE)CYP46A1CYP27A1Acyl-CoASOAT2ACAT2a0779HMGCS1HMGCS2MVKPMVKMVDSQLEIDI1Idi2FDFT1GGPS1FDPSLSSPreSqualeneCYP51A1DHCR7DHCR24CE(18:1)NR1H2ABCG1MYLIPSREBF2ACSL1ACSL3ACSL4ELOVL2ELOVL3ELOVL4ELOVL5FADS1FADS2SCDScd2Acot1ACOT2Fatty acid biosynthesisOleic acid4-methyl zymostenol4-methyl zymostenone4-methyl-4-carboxyzymostenonedihydro-FF-MASdihydro-T-MASa19bfCYP51A1TM7SF2MSMO1NSDHLLBR4-methyl zymosterol4-methyl zymosterone4-methyl-4-carboxyzymosteroneFF-MAST-MASebd54TM7SF2MSMO1NSDHLLBRHSD17B7e58e8?MSMO1NSDHLHSD17B7CYP51A1HSD17B7Sterol biosynthesisLXRalpha/betaSterol effluxLDLR degradationLXRalpha/betaSterol biosynthesis - + @@ -16,6 +16,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + @@ -51,60 +56,60 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -115,79 +120,87 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + + + + + + - + - + - + + + + + + + + + @@ -198,20 +211,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -222,594 +235,594 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - + + + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -833,55 +846,55 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + @@ -891,339 +904,339 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + @@ -1233,159 +1246,165 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + @@ -1425,45 +1444,45 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + @@ -1473,51 +1492,57 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + + + + + + + @@ -1527,15 +1552,15 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -1545,267 +1570,261 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + @@ -1815,159 +1834,165 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + + + + + + + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + @@ -1975,100 +2000,100 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -2077,989 +2102,1004 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + + + + + - + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -3068,222 +3108,222 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -3292,70 +3332,70 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + - + + - - - - + + + + + - + + + + + + + - - - - - - - + + + + + + - - - - - - + + + + + - + + @@ -3383,10 +3423,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + -

+

No E. coli homologue + +

@@ -3394,7 +3436,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3402,22 +3444,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

E. coli S7

@@ -3427,7 +3469,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3435,24 +3477,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

@@ -3460,7 +3500,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3468,24 +3508,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli S10 - -

+

@@ -3493,7 +3531,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3501,22 +3539,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Also known as L16e. E. coli L11. +

No E. coli homologue

@@ -3526,7 +3564,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3534,22 +3572,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

No E. coli homologue + +

@@ -3557,7 +3597,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3565,22 +3605,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S11 +

E. coli L23

@@ -3590,7 +3630,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3598,14 +3638,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -3633,20 +3673,20 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - +
- + -

Also known as L33e. No E. coli homologue. +

E. coli L2

@@ -3656,7 +3696,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3664,22 +3704,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli L23 +

E. coli L7/L12

@@ -3689,7 +3729,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3697,22 +3737,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S17 +

E. coli L6

@@ -3722,7 +3762,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3730,24 +3770,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

@@ -3755,7 +3793,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3763,22 +3801,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

E. coli S2 + +

@@ -3786,7 +3826,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3794,22 +3834,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

Also known as L33e. No E. coli homologue. + +

@@ -3817,7 +3859,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3825,19 +3867,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -3851,27 +3893,29 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + - + - + -

+

No E. coli homologue + +

@@ -3879,7 +3923,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3887,22 +3931,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

E. coli L24 + +

@@ -3910,7 +3956,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3918,24 +3964,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S9 - -

+

@@ -3943,7 +3987,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3951,22 +3995,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

E. coli S17 + +

@@ -3974,7 +4020,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -3982,24 +4028,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S8 - -

+

@@ -4007,7 +4051,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4015,22 +4059,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli S14 +

E. coli S8

@@ -4040,7 +4084,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4048,24 +4092,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

also known as L1e. No E. coli homologue - -

+

@@ -4073,7 +4115,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4081,19 +4123,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4104,7 +4146,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4112,22 +4154,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L30 +

No E. coli homologue

@@ -4137,7 +4179,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4145,24 +4187,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S7 - -

+

@@ -4170,7 +4210,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4178,24 +4218,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L7/L12 - -

+

@@ -4203,7 +4241,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4211,24 +4249,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

Also known as S22e. - -

+

@@ -4236,7 +4272,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4244,22 +4280,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L6 +

E. coli L14

@@ -4269,7 +4305,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4277,22 +4313,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli L1 +

E. coli S14

@@ -4302,7 +4338,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4310,22 +4346,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

No E. coli homologue + +

@@ -4333,7 +4371,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4341,22 +4379,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

No E. coli homologue + +

@@ -4364,7 +4404,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4372,22 +4412,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli L18 +

No E. coli homologue

@@ -4397,7 +4437,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4405,22 +4445,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S4 +

E. coli L7/L12

@@ -4430,7 +4470,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4438,19 +4478,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -4461,7 +4501,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4469,22 +4509,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

E. coli S5 + +

@@ -4492,7 +4534,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4500,22 +4542,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

E. coli S15 + +

@@ -4523,7 +4567,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4531,24 +4575,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- - - -

No E. coli homologue - -

+ + + +

@@ -4556,7 +4598,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4564,19 +4606,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -4587,7 +4629,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4595,22 +4637,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

E. coli L1 + +

@@ -4618,7 +4662,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4626,22 +4670,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

Also known as L16e. E. coli L11.

@@ -4651,7 +4695,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4659,19 +4703,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -4682,7 +4726,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4690,22 +4734,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L13 +

No E. coli homologue

@@ -4715,7 +4759,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4723,22 +4767,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S15 +

E. coli S3

@@ -4748,7 +4792,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4756,19 +4800,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -4777,32 +4821,34 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

+

No E. coli homologue + +

@@ -4810,7 +4856,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4818,24 +4864,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S12 - -

+

@@ -4843,7 +4887,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4851,22 +4895,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

No E. coli homologue + +

@@ -4874,7 +4920,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4882,24 +4928,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

@@ -4907,7 +4951,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4915,22 +4959,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

E. coli S11 + +

@@ -4938,7 +4984,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -4946,19 +4992,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -4967,32 +5013,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - - - - - + - + - + + + + + + - + - + -

E. coli L22 +

E. coli L29

@@ -5002,7 +5048,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5010,22 +5056,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

No E. coli homologue + +

@@ -5033,7 +5081,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5041,22 +5089,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

E. coli S4 + +

@@ -5064,7 +5114,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5072,19 +5122,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -5095,7 +5145,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5103,19 +5153,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

No E. coli homologue @@ -5128,7 +5178,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5136,22 +5186,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli S2 +

also known as L1e. No E. coli homologue

@@ -5161,7 +5211,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5169,22 +5219,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

E. coli S9

@@ -5194,7 +5244,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5202,24 +5252,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

@@ -5227,7 +5275,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5235,22 +5283,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L10. +

No E. coli homologue

@@ -5260,7 +5308,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5268,22 +5316,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

Also known as L25e. +

E. coli L30

@@ -5293,7 +5341,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5301,22 +5349,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

E. coli L13

@@ -5326,7 +5374,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5334,22 +5382,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

E. coli L5 + +

@@ -5357,7 +5407,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5365,22 +5415,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli L14 +

E. coli L15

@@ -5390,7 +5440,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5398,24 +5448,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

@@ -5423,7 +5471,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5431,14 +5479,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -5466,20 +5514,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + -

+

No E. coli homologue + +

@@ -5487,7 +5537,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5495,24 +5545,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

@@ -5520,7 +5568,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5528,22 +5576,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

Also known as L25e. + +

@@ -5551,7 +5601,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5559,22 +5609,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

Also known as S22e.

@@ -5584,7 +5634,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5592,22 +5642,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

+

E. coli L10. + +

@@ -5615,7 +5667,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5623,22 +5675,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli L3 +

No E. coli homologue

@@ -5648,7 +5700,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5656,52 +5708,50 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -5712,7 +5762,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5720,24 +5770,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L15 - -

+

@@ -5745,7 +5793,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5753,22 +5801,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L5 +

E. coli S12

@@ -5778,7 +5826,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5786,22 +5834,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

E. coli L18

@@ -5811,7 +5859,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5819,19 +5867,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- +

@@ -5842,7 +5890,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5850,22 +5898,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L29 +

E. coli S10

@@ -5875,7 +5923,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5883,24 +5931,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli S5 - -

+

@@ -5908,7 +5954,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5916,19 +5962,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5939,7 +5985,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -5947,19 +5993,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -5968,34 +6014,32 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + + - - - - - - + - + - + - + - + -

E. coli S3 - -

+

@@ -6003,7 +6047,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6011,24 +6055,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli S19 - -

+

@@ -6036,7 +6078,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6044,22 +6086,24 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

+

No E. coli homologue + +

@@ -6067,7 +6111,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6075,22 +6119,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

E. coli L22

@@ -6100,7 +6144,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6108,24 +6152,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

E. coli L2 - -

+

@@ -6133,7 +6175,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6141,19 +6183,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6164,7 +6206,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6172,24 +6214,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L24 - -

+

@@ -6197,7 +6237,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6205,19 +6245,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - +

@@ -6228,7 +6268,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6236,22 +6276,22 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + - + -

E. coli L7/L12 +

E. coli S19

@@ -6261,7 +6301,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -6269,32 +6309,63 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - +
- + -

No E. coli homologue +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

E. coli L3

- + - + @@ -6302,14 +6373,14 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + @@ -6330,10 +6401,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + diff --git a/sbml/WP477.svg b/sbml/WP477.svg index 697cb08..e01b629 100644 --- a/sbml/WP477.svg +++ b/sbml/WP477.svg @@ -1,13 +1,13 @@ -Large (60S) Subunitc6783Small (40S) Subunitf820fRPL30Large (60S) SubunitRPL36ARPL15MRPL19RPL10ARPS10RPL11RPS6KB1RPS9RPS7RPLP0RPS15RPL38RPS18RPS3RPSARPL10RPS26RPL9RPL18RPL26RPL27ARPL23RPL36RPL4RPL26RPS11RPS14RPL17RPS5RPS6KA1RPS11RPS29RPL10RPLP2RPS16RPS2RPL5RPS25RPS6KA3RPS21RPL23ARPS18RPL39RPS12RPS23RPL5RPL41RPS3ARPLP0RPS15ARPL7RPL38RPL18RPS6KB2RPL6RPL3RPS23RPLP2RPL8RPL35FAURPS6KA1RPS5RPL22RPS3ARPL7ARPS19RPS4XRPS24RPL13RPL10ARPL37ARPL32RPS6RPLP1RPS3UBA52RPL12RPL35RPS12RPL29MRPL19RPL23ARPL6RPS6KB2RPL8RPL36RPS6KA2RPS16RPL37RPS6KA3RPS27ARPL37RPS6KA6RPL31RPL28RPL7RPL9RPL19RPL18ARPL27RPL34RPL17RPL12RPS17RPL41RPS4Y1RPS20RPL15RPLP1RPL21RPL32RPL11RPL31RPL24RPL22RPS14RPL23RPL13RPL36ARPL27ARPS28RPS26RPS25RPS27FAURPS15UBA52RPS28RPL13ARPS7RPS10RPL3RPS2RPSARPS29RPL37ARPS27RPL39RPL34RPS4XRPL35ARPS4Y1RPL3LRPS27ARPL14RPS13RPS9RPS6KA6RPS24RPL35ARPL30RPS17RPL18ARPS8RPS21RPS6RPL24RPL3LRPS13RPL14RPS19RPL27RPS8RPL13ARPL21RPS6KA2RPL29RPL28RPL4 - + @@ -14,12 +14,18 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. [CONVERSION:id18e10d3f] Curved connections are not supported. [CONVERSION:id262c22a9] Curved connections are not supported. +[-:-] Unknown gpml interaction type: mim-translocation +[-:-] Unknown gpml interaction type: mim-translocation +[-:-] Unknown gpml interaction type: mim-translocation [LINE:id4cb20e14] Invalid interaction type. +[LINE:idb42bf92] Invalid interaction type. [LINE:idc8295a55] Invalid interaction type. [LINE:id953cd359] Invalid interaction type. +[LINE:id4dc479a8] Invalid interaction type. [LINE:id1ae2c86c] Invalid interaction type. [LINE:id87a84cd1] Invalid interaction type. [LINE:id60daebd3] Invalid interaction type. +[LINE:id74467624] Invalid interaction type. [LINE:id8bf24cc5] Invalid interaction type. [LINE:daa2b] Invalid interaction type. [LINE:id950944a] Invalid interaction type. @@ -71,64 +77,64 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - + + - - - - + - + - + - + + + + + + + + + + + + + - + - + - - - - - - - - - - + - + @@ -139,12 +145,12 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + @@ -155,124 +161,186 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - + + + - - + + - + - + - + - + - + - - - + + + - - + + - + - + - + - + + + + + + + + + - + - + + + + + + + + + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - - - + + + - - + + - + - + - + + + + + + + + + - + - - - + + + + + + + + + + + + + + - + @@ -283,92 +351,68 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - + - - - - - - - - - + - + - + - + - + - - - + + + - + - + - + - + - + - - - + + + - - + + - - - - - - - - - + - + @@ -379,106 +423,175 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - + + + - + - + + + + + + + + + - - - - - - + + + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + - + @@ -500,38 +613,14 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - - - + + + - + - - - - - - - - - - - - - - - - @@ -551,119 +640,84 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - - - + + + - - + + - + - + - + - + - - - - - - - - - - - - - - + + + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - + - + - + @@ -674,335 +728,296 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - - - - - - - - - + - + - + - + - - - + + + - + - + - + - - - - - - - - - - - - - - - - - + - + - + - - - - - - - - - + - + - - - - - - - - - + - + - + - - - + + + - + - + - + - - + + + + + - - - - + + + + - - - - + - + - - + + - - - - + + + + - + - - - - + - - + + - - - - + + + + + + + - + + + + - + - - - - + + + + - - - + + + - + - - - - + + + + - - - - + - - - - - - - + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + + + + + + + + + + + + + + + + - + - + - - - - + + + + - + @@ -1010,149 +1025,140 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - - - + + + + - + - + - - - - - - - - - - - + + - - - - + - - + + - - - - + + + + - + - + - - - - - - - + - - - - + + + + - + - + + + + - + + + + - + - - - - + + + + - + - + - + - - - - + + + + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -1176,145 +1182,145 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - - - + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + - + - - - - - - - - - - + - - - - + + + + + + + + + + + + + - + - + - + - - - - + + + + - + - + - - + + - - - - + + + + - + @@ -1322,172 +1328,106 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - - - + + + + - + - - - - + - - - - + + + + - - - - + - - - - - - - - - - - - - - - - - - - + - + - + - - - - + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - + + + + - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - + + + + - + - + - + - + @@ -1499,34 +1439,34 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - + + - - + + - - + + - - - - + + + + - + - + - + - + @@ -1538,115 +1478,115 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - + + - - + + - - + + + + + - - - - + + + + - - - - - + + - + - - + + - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - + - - - - + - - - - + + + + - - + + - + - + + + + - - - - + + + + - + - + - + @@ -1658,78 +1598,144 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - - - - - - - - - - - - - - - - - - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1759,22 +1765,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + - + - + - - + + @@ -1791,196 +1797,196 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + + + + + + + @@ -1989,377 +1995,425 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + - - + + - + @@ -2369,7 +2423,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -2379,7 +2433,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -2389,7 +2443,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -2401,556 +2455,524 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + - + - - + + - - - - - - - - + + + + + + - + - - - - - - + + - + - - + + - + - - + + + + + + + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + + + + + + + + + - + - - + + @@ -2997,1128 +3019,1112 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + - + - - + + - + - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + + + + + + + - - + + + + + + + + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - - + + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - - - - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - - - - - - - - + + - + - - + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - + + - - - - - - - - - - - - - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + @@ -4127,10 +4133,10 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + @@ -4139,10 +4145,10 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + @@ -4151,106 +4157,100 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + @@ -4259,88 +4259,94 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + + + + + + + @@ -4349,88 +4355,88 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -4439,136 +4445,106 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + @@ -4577,9 +4553,15 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + + + + + + + @@ -4589,6 +4571,30 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + + + + + + + + + + + + + + + + + + + + @@ -4603,31 +4609,31 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - + @@ -4635,105 +4641,124 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -4742,40 +4767,40 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - + - + - + @@ -4784,12 +4809,12 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + @@ -4798,44 +4823,25 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - - - - - - - - - - - - - - - - - - - @@ -4845,7 +4851,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - +

@@ -4859,7 +4865,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - +

@@ -4903,7 +4909,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - +

@@ -4914,7 +4920,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -4922,19 +4928,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -4943,24 +4949,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - +

@@ -4971,7 +4982,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -4981,17 +4992,17 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -5002,7 +5013,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5010,19 +5021,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5033,7 +5044,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5041,19 +5052,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5064,7 +5075,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5072,19 +5083,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5095,7 +5106,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5103,19 +5114,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5126,7 +5137,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5136,32 +5147,25 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + -

DISEASE - -

+

- - - - - @@ -5169,17 +5173,17 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -5190,7 +5194,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5198,19 +5202,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5219,32 +5223,34 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + + + + + + - + -

+

DISEASE + +

@@ -5252,7 +5258,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5260,19 +5266,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- +

@@ -5283,7 +5289,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5291,19 +5297,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5314,7 +5320,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5324,17 +5330,17 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -5343,34 +5349,27 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + - + -

DISEASE - -

+

@@ -5378,7 +5377,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5386,55 +5385,48 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

- - - - - - - + + - + - + - + - + - + -

DISEASE - -

+

@@ -5442,7 +5434,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5450,19 +5442,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5471,29 +5463,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + + + + + + - + - +

@@ -5504,7 +5496,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5512,19 +5504,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5535,7 +5527,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5543,19 +5535,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5566,7 +5558,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5574,19 +5566,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5595,24 +5587,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - +

@@ -5621,24 +5618,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - +

@@ -5649,7 +5651,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5657,19 +5659,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5680,7 +5682,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5690,17 +5692,17 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -5711,7 +5713,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5719,19 +5721,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -5740,29 +5742,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - - - - - - + - + - + - + - +

@@ -5771,32 +5773,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + - + -

+

DISEASE + +

@@ -5804,7 +5803,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5812,19 +5811,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- +

@@ -5840,22 +5839,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

DISEASE @@ -5868,7 +5867,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5878,20 +5877,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + -

+

DISEASE + +

@@ -5899,7 +5900,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5907,19 +5908,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- +

@@ -5928,32 +5929,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + - + -

+

DISEASE + +

@@ -5961,7 +5959,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -5969,19 +5967,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- +

DISEASE @@ -5994,7 +5992,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6004,51 +6002,55 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + -

+

DISEASE + +

+ + + + + - - - - - - + - + - + - +
- + -

+

DISEASE + +

@@ -6056,7 +6058,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6064,24 +6066,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- + -

DISEASE - -

+

@@ -6089,7 +6089,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6097,19 +6097,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6118,27 +6118,34 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - + -

+

DISEASE + +

@@ -6146,7 +6153,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6154,19 +6161,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- +

@@ -6175,34 +6182,32 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - - - - - - + - + - + - + - + -

DISEASE - -

+

@@ -6210,7 +6215,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6218,19 +6223,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6239,24 +6244,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - +

@@ -6267,7 +6277,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6277,48 +6287,50 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + -

+

DISEASE + +

+ + + + + - - - - - - + - + - + - +
- +

@@ -6327,34 +6339,32 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + + + + + + - + - + -

DISEASE - -

+

@@ -6362,7 +6372,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6370,19 +6380,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6391,29 +6401,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + + + + + + - + - +

@@ -6422,29 +6432,32 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - + -

DISEASE - -

+

@@ -6452,7 +6465,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6462,17 +6475,17 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -6483,7 +6496,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6491,19 +6504,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6512,32 +6525,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + - + -

+

DISEASE + +

@@ -6545,7 +6555,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6553,19 +6563,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +
- +

@@ -6576,7 +6586,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6584,19 +6594,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6605,34 +6615,27 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + - + -

DISEASE - -

+

@@ -6640,7 +6643,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6648,19 +6651,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6671,7 +6674,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6679,24 +6682,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - + -

DISEASE - -

+

@@ -6704,7 +6705,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6712,19 +6713,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -6733,24 +6734,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. + + + + + - + - + - + - + - +

@@ -6761,7 +6767,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6771,17 +6777,17 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -6792,7 +6798,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -6800,14 +6806,14 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + @@ -6835,19 +6841,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -6855,19 +6861,52 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + + + + - +

@@ -6875,27 +6914,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - - - - +

@@ -6903,27 +6934,54 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + + + + + + + + + + +

+ + + + + + + + + + - + + - + + - + - +

@@ -6942,16 +7000,16 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -6959,22 +7017,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - - - - +

@@ -6982,34 +7037,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - - - + - - + - - - - - - + + - +

@@ -7017,19 +7057,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7037,19 +7077,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7057,19 +7097,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7077,15 +7117,10 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + @@ -7093,17 +7128,16 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - - + - +

@@ -7111,22 +7145,27 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + - + - + - + - +

@@ -7134,19 +7173,33 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + + + + + + - + - + + + + + - +

@@ -7154,19 +7207,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7174,23 +7227,34 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + + + + + + - + + - + + - - + - +

@@ -7198,52 +7262,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - - - - +

@@ -7251,15 +7282,10 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + @@ -7267,13 +7293,16 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + + + + - +

@@ -7281,19 +7310,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7301,19 +7330,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7321,19 +7350,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7341,22 +7370,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - - - - +

@@ -7364,19 +7390,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + + + + - +

@@ -7384,19 +7413,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7404,19 +7433,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7424,7 +7453,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -7440,18 +7469,18 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - + + - - + + - + - +

@@ -7459,19 +7488,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7479,19 +7508,42 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + + + + + + + + + + + + +

+ + + + + + + + + + + - + - +

@@ -7499,22 +7551,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -7522,22 +7574,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - - - - +

@@ -7545,7 +7594,7 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + @@ -7581,16 +7630,16 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7598,47 +7647,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - + - - - -

- - - - - - - - - - - - - - - - - +

@@ -7646,19 +7670,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7666,54 +7690,27 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - - - - - - + - - + - + - - - -

- - - - - - - - - - - - - - - - - +

@@ -7721,22 +7718,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -7744,19 +7741,23 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + + + + + - +

@@ -7764,27 +7765,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - - - - +

@@ -7792,19 +7785,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7812,34 +7805,27 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - - - - - - - + - - + - + - +

@@ -7847,19 +7833,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7867,22 +7853,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - + - +

@@ -7890,19 +7876,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + - +

@@ -7910,19 +7896,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - +

@@ -7930,19 +7916,29 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + + + + + + - + - + - +

@@ -7950,27 +7946,19 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - - - - - - + - + - + - - - - +

@@ -7978,19 +7966,22 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + - + - + + + + - +

@@ -7998,17 +7989,32 @@ For further details, see [https://www.ncbi.nlm.nih.gov/pubmed/31286677]. - + + + + + + + + + + + - + + + + + + diff --git a/sbml/WP4784.svg b/sbml/WP4784.svg index 90f6a80..bb24264 100644 --- a/sbml/WP4784.svg +++ b/sbml/WP4784.svg @@ -8,16 +8,45 @@ />???Desbuquois dysplasia 1OMIM:600972Achondrogenesis, type IBOMIM:251450Desbuquois dysplasia 1OMIM:600972Achondrogenesis, type IBOMIM:251450Desbuquois dysplasia 1???ff46c??????????ff46c??GlcUA-Gal-Gal-Xyl-proteinPG core proteinChondroitin sulfateGlcUA-Gal-Gal-Xyl-proteinCytoplasmPG core protein Glycosylated proteoglycanSulfation ofproteoglycanNewly synthesizedproteoglycanProteoglycan core synthesized inrough endoplasmic reticulumGlycosylated proteoglycanSulfur-containing amino acid metabolismNewly synthesizedproteoglycane63e3B3GALT6EXT2UMPEXT1ChlorideEXTL3CHST14IMPAD1XyloseUDPSLC35B2CHST3UDP xyloseSLC26A2CSGALNACT1UDP galactoseGalactoseSLC35B3D-glucuronic acidCHSY1Phosphoadenosine phosphatePO4(.2-)CHST3IMPAD1B4GALT7ChloridePAPSS2N-AcetylgalactosamineSulfate ion (SO42-)PAPSCANT1PO4(.2-)Uridine diphosphateglucuronic acidCHSY1GalactoseSLC35B2SLC35B3CHST14UDPUDP galactoseEXT1XYLT2B3GALT6Phosphoadenosine phosphateXyloseCSGALNACT1N-AcetylgalactosamineUMPXYLT1Uridine diphosphateglucuronic acidUDP xylosePAPSS2ADENOSINE MONOPHOSPHATEEXT2CANT1PAPSOMIM:251450Desbuquois dysplasia 1OMIM:617719Epiphyseal dysplasia, multiple, 7OMIM:251450Desbuquois dysplasia 1OMIM:133700Exostoses, multiple, type IOMIM:251450Desbuquois dysplasia 1OMIM:133700Exostoses, multiple, type IGolgi apparatusnnExtracellular spaceHeparan sulfatenDermatan sulfatenExtracellular space - + @@ -127,13 +127,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat [Label:de785] Label cannot be part of reaction. Tranforming to Unknown [Label:f0ca2] Label cannot be part of reaction. Tranforming to Unknown [Label:cbbfa] Label cannot be part of reaction. Tranforming to Unknown +[Complex:f6373] Empty element is invalid [Complex:cf069] Empty element is invalid -[Complex:f6373] Empty element is invalid

+[BiopaxReference:e3b] Publication type is not supported.

+ + + + + @@ -143,10 +149,10 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - + + @@ -227,192 +233,229 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - - - - + - + - + + + + + + + + + - + - - - + + + - - + + - + - + - + - + + + + + + + + + - + - + - + - - - + + + - - + + - - - + + + - + - + - + - + + + + + + + + + - + - - - - - - - - - - - - - - + + + - + - + - + - + - - - + + + - + - + + + + + + + + + + + + + + + + + - + - + + + + + + + + + - + - + - - - + + + - + - - - + + + - + - + + + + + + + + + - + - - - + + + - + - - - + + + - + - - - + + + - - + + @@ -433,240 +476,211 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + + + + + + + + + - + - - - + + + - + - - - + + + - + - + - + - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - - - + + + - + - + - + - - - - - - - - - - - + + + - - + + - + - - - - - - + + + + + + - - - - - - - - - - - - - - - - - - + + - + - + - - - - - - - - - + - + - + - + - + - - - + + + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - - - + + + - + - + - + - + - + - - - + + + - - + + @@ -676,39 +690,31 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - + + + - - + + - + - + - - - - - - - - - + - + - + @@ -724,108 +730,116 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - - - - - - - - - - - - - - - - - + - - - - - - + + + + + + - + + + + + + + + + - + + + + + + + + + - + - - - + + + - - + + - + - + - + - + - - - + + + - - + + - - + + - - + + - + - + - + - + - + + + + + + + + + @@ -834,244 +848,255 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + + + + + + + + + - + - + - + + + + + + + + + - + - + - + - + - + - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - + - + - + - - - - - - - - - - - - - - - - - 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- - + + + - + - + - + - - - + + + - - + + - - - + + + - + - + - + - + + + + + + + + + @@ -1435,87 +1417,71 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - - - - - - - - - + - + - + - + - + - - - - - - - - - + - + - - - + + + - - + + - + - + - - - + + + - - + + - + - + - + - + @@ -1526,103 +1492,143 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - + + + + + + + + + + + + + + - - + + - + - + - + + + + + + + + + - + - - - + + + - - + + - + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - + - - - + + + - + - + - + - + + + + + + + + + @@ -1652,257 +1658,248 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - - - - + + + + - + - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - - - - + - - - - - - - - - - - + + - - - - + - - + + - - - - + + + + - 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DISEASE - -

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@@ -9329,7 +9333,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9337,19 +9341,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -9358,29 +9362,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -9391,7 +9390,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9401,17 +9400,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -9422,7 +9421,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9430,19 +9429,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -9451,27 +9450,34 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - + -

+

DISEASE + +

@@ -9479,7 +9485,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9487,19 +9493,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
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@@ -9510,7 +9516,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9518,24 +9524,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + -

DISEASE - -

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@@ -9543,7 +9547,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9551,24 +9555,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + -

DISEASE - -

+

@@ -9576,7 +9578,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9584,19 +9586,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -9605,24 +9607,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

@@ -9631,29 +9638,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -9662,29 +9664,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - +

@@ -9695,7 +9697,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9705,17 +9707,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -9724,24 +9726,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

@@ -9757,17 +9764,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -9778,7 +9785,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9788,17 +9795,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -9814,17 +9821,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -9833,29 +9840,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -9864,29 +9866,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - +

@@ -9895,24 +9897,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

DISEASE @@ -9925,7 +9932,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9935,20 +9942,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + -

+

DISEASE + +

@@ -9956,7 +9965,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -9964,19 +9973,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
- +

@@ -9985,24 +9994,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

@@ -10013,7 +10027,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10023,17 +10037,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -10047,22 +10061,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + + + - + - + -

+

DISEASE + +

@@ -10070,7 +10091,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10078,19 +10099,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
- +

@@ -10099,32 +10120,34 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - + -

+

DISEASE + +

@@ -10132,7 +10155,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10140,19 +10163,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
- +

@@ -10163,7 +10186,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10171,52 +10194,50 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + -

DISEASE - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -10227,7 +10248,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10235,19 +10256,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -10256,29 +10277,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + + + + + + - +

@@ -10294,20 +10315,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + -

+

DISEASE + +

@@ -10315,7 +10338,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10323,19 +10346,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
- +

@@ -10346,7 +10369,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10354,34 +10377,27 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + -

DISEASE - -

+

- - - - - @@ -10389,17 +10405,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -10408,29 +10424,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -10441,7 +10452,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10449,19 +10460,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -10472,7 +10483,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10480,19 +10491,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -10503,7 +10514,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10513,17 +10524,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -10532,29 +10543,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - +

@@ -10563,29 +10574,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + + + + + + - + - +

@@ -10594,29 +10605,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + + + + + + - + - +

@@ -10630,24 +10641,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -10658,7 +10664,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10668,22 +10674,20 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + -

DISEASE - -

+

@@ -10691,7 +10695,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10699,19 +10703,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -10722,7 +10726,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10732,17 +10736,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -10751,27 +10755,34 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - + -

+

DISEASE + +

@@ -10779,7 +10790,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10787,24 +10798,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
- + -

DISEASE - -

+

@@ -10812,7 +10821,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10820,22 +10829,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + -

+

DISEASE + +

@@ -10843,7 +10854,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10851,19 +10862,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +
- +

@@ -10874,7 +10885,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10884,17 +10895,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -10905,7 +10916,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -10913,19 +10924,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -10934,24 +10945,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

@@ -10960,29 +10976,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -10993,7 +11004,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11001,19 +11012,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11022,24 +11033,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

@@ -11048,29 +11064,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + + + + + + - + - +

@@ -11081,7 +11097,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11089,19 +11105,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11110,29 +11126,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -11143,7 +11154,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11151,19 +11162,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11179,17 +11190,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11198,29 +11209,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - +

@@ -11231,7 +11242,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11239,19 +11250,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11262,7 +11273,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11270,19 +11281,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11293,7 +11304,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11303,17 +11314,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11324,7 +11335,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11332,19 +11343,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11358,19 +11369,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + + + + + + - +

@@ -11379,24 +11395,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - + - + - + - + - +

@@ -11405,29 +11426,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - +

@@ -11438,7 +11459,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11448,17 +11469,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11469,7 +11490,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11477,19 +11498,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11498,29 +11519,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat + + + + + - - - - - - + - + - + - + - +

@@ -11529,29 +11550,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -11567,17 +11583,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11591,24 +11607,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - + - + - +

@@ -11617,29 +11633,24 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -11650,7 +11661,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11658,19 +11669,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11681,7 +11692,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11689,19 +11700,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11712,7 +11723,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11720,19 +11731,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11741,29 +11752,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + + + + + + - + - +

@@ -11774,7 +11785,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11782,19 +11793,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -11805,7 +11816,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11815,17 +11826,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11836,7 +11847,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11846,17 +11857,17 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11865,29 +11876,29 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + + + + + + - + - +

@@ -11901,24 +11912,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - - - - - - + - + - + - + - +

@@ -11929,7 +11935,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -11939,12 +11945,12 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + @@ -11965,13 +11971,13 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -11979,22 +11985,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12002,19 +12008,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12022,19 +12031,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12042,19 +12051,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12062,22 +12071,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12085,19 +12094,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12105,19 +12117,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - +

@@ -12125,19 +12137,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12145,19 +12157,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12165,19 +12177,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12185,22 +12200,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12208,22 +12220,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12231,19 +12243,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12251,19 +12266,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12271,22 +12289,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12294,22 +12309,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12317,22 +12329,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12340,22 +12349,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12363,19 +12372,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12383,7 +12392,7 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + @@ -12392,10 +12401,13 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + + + + - +

@@ -12403,19 +12415,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12423,19 +12438,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12443,22 +12458,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12466,19 +12481,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12486,22 +12504,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12509,22 +12524,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12532,22 +12547,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12555,22 +12570,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12578,22 +12593,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12601,22 +12616,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12624,22 +12636,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12647,22 +12656,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12670,22 +12679,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12693,19 +12702,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12713,22 +12722,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12736,22 +12745,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12759,19 +12765,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12779,22 +12785,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12802,19 +12805,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12822,22 +12828,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12845,22 +12848,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12868,22 +12868,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -12891,19 +12888,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12911,19 +12911,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12931,19 +12931,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -12951,22 +12951,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -12974,19 +12974,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -12994,22 +12997,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13017,19 +13020,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13037,22 +13040,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13060,22 +13060,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13083,22 +13080,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13106,22 +13103,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13129,22 +13126,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13152,22 +13146,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13175,19 +13169,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13195,22 +13192,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13218,22 +13212,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13241,19 +13235,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13261,22 +13255,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13284,22 +13278,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13307,19 +13301,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13327,22 +13324,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13350,22 +13347,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13373,22 +13367,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13396,19 +13387,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13416,19 +13407,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13436,19 +13430,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13456,22 +13453,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13479,19 +13476,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13499,22 +13496,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13522,19 +13516,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13542,22 +13536,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13565,22 +13556,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13588,19 +13579,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13608,19 +13602,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13628,19 +13625,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13648,22 +13645,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - - - - +

@@ -13671,19 +13665,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13691,22 +13688,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13714,19 +13711,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13734,22 +13734,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13757,19 +13757,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13777,19 +13780,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13797,22 +13800,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13820,19 +13823,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + + + + - +

@@ -13840,19 +13846,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - +

@@ -13860,22 +13866,22 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + - +

@@ -13883,19 +13889,19 @@ Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutat - + - + - + - + diff --git a/sbml/WP4815.svg b/sbml/WP4815.svg index 6f44435..7f24791 100644 --- a/sbml/WP4815.svg +++ b/sbml/WP4815.svg @@ -8,31 +8,12 @@ />??cf3b7????e3d90f50ef???cf3b7?????????????db49d????db49df50ef??cda58??????cda58e3d90??GlcAbetaChondroitin sulfate biosynthesisDermatan sulfate(GalNAc)2 (GlcA)1 (S)1HYAL4(GalNAc)2 (GlcA)1 (LIdoA)1 (S)3NAGLUHPSE2(GlcA)1 (GlcNAc)2GeneProductGlcAbetaGeneProductGUSBARSBHGSNATHYAL4GUSB(GalNAc)1 (GlcA)1 (S)1hyaluronan(GlcA)2 (GlcNAc)1 (S)1NAGLUHPSEKeratan sulfate(GlcA)1 (GlcNAc)1 (S)1Heparan sulfateGALNS(GalNAc)2 (GlcA)1 (LIdoA)1 (S)3(GalNAc)2 (GlcA)1 (S)1GUSBHYAL1(GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)3GUSBGNSHYAL2(GalNAc)2 (GlcA)1 (LIdoA)1 (S)2(GalNAc)1 (GlcA)1 (S)1IDSSGSH(GalNAc)2 (GlcA)1 (S)2GNSARSBhyaluronan(GlcA)2 (GlcNAc)2IDUAHeparan sulfateIDSSGSH(GlcA)2 (GlcNAc)1 (S)1(GlcA)1 (GlcNAc)2HGSNATHEXAGALNS(GlcA)1 (GlcNAc)1 (S)1GeneProductGLB1GNS(GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)4HYAL4GUSBGUSB(GlcA)2 (GlcN)1 (GlcNAc)1 (LIdoA)1 (S)3Keratan sulfateGNSHPSE2GLB1(GalNAc)2 (GlcA)1 (LIdoA)1 (S)2GALNSDermatan sulfateIDUAGeneProductHYAL4OMIM:230500Gm1-Gangliosidosis, Type IOMIM:253010Mucopolysaccharidosis, Type IVBOMIM:230500Gm1-Gangliosidosis, Type IOMIM:253010Mucopolysaccharidosis, Type IVBOMIM:230500Gm1-Gangliosidosis, Type IOMIM:253010Mucopolysaccharidosis, Type IVBChondroitin sulfateHeparan sulfateHyaluronanHeparan sulfateDermatan sulfateKeratan sulfateChondroitin sulfate - + @@ -14,10 +14,10 @@ [UnknownPositiveInfluenceReaction:d796d] Reacion was marked as reversible but it cannot be reversible [UnknownPositiveInfluenceReaction:daacd] Reacion was marked as reversible but it cannot be reversible [UnknownPositiveInfluenceReaction:a1e1e] Reacion was marked as reversible but it cannot be reversible -[Complex:c9ccc] Empty element is invalid -[Complex:cf4c2] Empty element is invalid -[Complex:d1a13] Empty element is invalid [Complex:ed9e2] Empty element is invalid +[Complex:d1a13] Empty element is invalid +[Complex:cf4c2] Empty element is invalid +[Complex:c9ccc] Empty element is invalid [BiopaxReference:cdc] Publication type is not supported.

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+[Complex:c37b0] Empty element is invalid +[Complex:a9d84] Empty element is invalid +[Complex:b5b5c] Empty element is invalid +[Complex:d4eb1] Empty element is invalid +[Complex:fc325] Empty element is invalid

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+[Complex:c7787] Empty element is invalid +[Complex:c159c] Empty element is invalid +[Complex:d0b3b] Empty element is invalid +[Complex:adfd7] Empty element is invalid +[Complex:bfaf7] Empty element is invalid

@@ -148,16 +148,16 @@ The relation between neuroinflammation and glutamatergic signaling - - - - + + + - + + @@ -167,51 +167,42 @@ The relation between neuroinflammation and glutamatergic signaling - + - - + + - + - - - + - - + + - + + + - - - - - - - - - - + - + @@ -238,6 +229,15 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + @@ -257,329 +257,326 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - - + + - - - - - - - - + + + + + + - - + + - - + + - - + + - - - + + + - - + + - + - + - + - + - - - + + + - - + + - - + + + + + + - - - - - - + + - - - - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - - - - + + + + - + - - - - - - - - - + - + - + - - - - - - + + + + + + - + - + + + + + + + + + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + @@ -588,39 +585,39 @@ The relation between neuroinflammation and glutamatergic signaling - - - + + + - - + + - + - + - + - + - + - - - - + + + + @@ -628,136 +625,79 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + @@ -768,504 +708,485 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - + + + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - + - + - + - - - - - - + + + + + + - + - - - + + + - - + + - + - + - - + + + + + + + + + + - - - - - - + + + + + + + + - - + + - - - + + + - - + + - + + + + + + + + + - + - + - + - + - + - + - - - - - - - - - - - + + + - - + + - + - + - - - + + + - - + + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - - - - - - + + + + + + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - - - + + + - - + + - + - + - + - - - - + + + + - + - + + + + + + + + + - - - - + + + + @@ -1273,627 +1194,509 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - + + + - - + + - + - - - - + + + + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - - - - - - - - - + - + - - - + + + - - + + - + - + - + - + - - - - - - - - - + - + - 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+ - + @@ -2102,18 +1853,18 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + @@ -2129,300 +1880,259 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - - - - - - + - + - + - + - + - + - + - - - + + + - - + + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - - - - - - - - - + - + - + - + - - - - - - - - - + - + - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - - - - - - + + + + + + - + - + - + - - - + + + - - + + - + - + - + + + + + + + + + + + + + + + + + + + + - + - + - + - - + + + + + + + + + + - - - - - - + + + + + + + + - - + + - + - + - + - + - + - + - + + + + + + + + + - + - + @@ -2438,53 +2148,59 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - + + + - - + + - - + + - - - - - - - - + + + + + + - - + + - - - + + + - - + + - + - + - + + + + + + + + + @@ -2500,101 +2216,109 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + + + + + + + + + + + + + + + + + - - - - + + + + - + - - - - - - - - - + - + - + - - - - + + + + - + - + - + - + - + - + - + @@ -2605,133 +2329,58 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - + - - - - + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - + @@ -2747,158 +2396,133 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + - - - - - - + + + + + + - + - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + @@ -2914,18 +2538,27 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - + + + + + + + + + + + + - - + + - + @@ -2941,157 +2574,104 @@ The relation between neuroinflammation and glutamatergic signaling - + - - + + + + + + + + + + - - - - - - - - + + + + + + - - - - - - - - - - - - - - - - - - - - - + + - - - + + + - - + + - - - - - - - - - - - - + + + - - + + - + - + - + - + - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - - - - - - - - - - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - + @@ -3111,83 +2691,125 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + + + + + + + + + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - - - - - - + + + + + + - - - + + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + @@ -3203,149 +2825,216 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - + + + - - + + - + - + - + - + - - + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + + + + + + + + + - - - - - - + + + + + + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + + + + + + + + + + - - + + - + - + - - - + + + + + + + + + + + + + + - - + + - + @@ -3359,67 +3048,59 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - - + + + + + + + + + + + + - - + + - + - + - - - + + + - - + + - + - + - - - - - - - - - - - - - - - - - - + @@ -3435,152 +3116,187 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + + + + + - + - + + + + + + + + + - - - - + + + + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + + + + + + + + + + + + - - + + - + - + - - - + + + - - + + - + + + + + + + + + - + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + @@ -3596,43 +3312,50 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + + + + + + + + + + + + + + + + + @@ -3646,323 +3369,609 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - - - - - + + + + - - + + - - + + - - - - + + + + + + + + - - + + - - + + + + - - + + - - - - - - - - - - + + + - - - - - + + - - - - - - - - - - + + + - - - - - + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + + + + + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + + + + + + + + + + + + + + + + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + - + - - - - + + + + - + - - + + - - + + + + + + + + + + + + + + - + - + - + - - - - + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - - - - + + + + - + - + - + - - - - + + + + - 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- - - + - - - - + + + + - + + + + - + - - - - + + + + @@ -4166,117 +4184,168 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + + + + + + + + + + + - - + + - + - - - - + + + + - + - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - - - - - + + - - + + - + - - + + - - - - + + + + - + - + - + - + @@ -4288,31 +4357,13 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - - - - - - - - - + - + - + @@ -4324,56 +4375,23 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - + + + + @@ -4382,16 +4400,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - + + + + @@ -4402,64 +4420,67 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - + + + + - + - + - - + + + + + + + + - - - - + + + + - + - - - - - + + - + - - - - + + + + - + - + - + @@ -4471,247 +4492,223 @@ The relation between neuroinflammation and glutamatergic signaling - - - - + - + - - - - - - - - - - - + + - + - + - - + + + + + + + + - - - - + + + + - - - - - - - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - - - - - - - - - - - - - - - - - - - - - + - - + + - - - - - - - - + + + + + + + + - + - - + + + + + - + - - - - + + + + - + - + + + + - + + + + - - - - + + + + - + - - - - + - - + + - - - - + + + + - + + + + - + - - - - + + + + - + - + - - - - + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - + @@ -4723,206 +4720,191 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - - - + + + + - + - + - - - - + - - - - + + + + - + + + + + + + - + - + + + + - - - - + + + + - + - + - + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - + - + - - + + - + - - - - + + + + - - - - + - - - - - - - - - - - + + - + - + - + - - - - + + + + - + - + - - - - - - - - - - - + + - + - + - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -4933,32 +4915,32 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -4967,16 +4949,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - + + + + @@ -4987,14 +4969,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - + + + + @@ -5003,259 +4985,268 @@ The relation between neuroinflammation and glutamatergic signaling - - - - + - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - - - - + + + + - + - - + + - + - - - - + + + + + + + - + + + + - + + + + - - - - + + + + - - - - - - - + - - - - + - - + + - - - - + + + + + + + - + - + - - + + + + + - - - - + + + + - + - + + + + - + - - - - + + + + - + - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - - + + - + - - - - + + + + - - - - - - - + - - - - + - - + + - - - - + + + + + + + - + - - + + + + + + + + + + + - + - + - - + + - - - - + + + + @@ -5267,16 +5258,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - + + + + @@ -5285,16 +5276,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - + + + + @@ -5305,14 +5296,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - - + + + + + @@ -5323,14 +5314,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - + + + + @@ -5339,340 +5330,331 @@ The relation between neuroinflammation and glutamatergic signaling - - - - + - + - - - - + + + + - + - + - + - - - - + + + + - + - - - - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + + + + - + - - - - + + + + + + + - + - + - - + + + + + - - - - + + + + - + - + - + - - - - + + + + - - - - + - - - - - - - - - - - + + - - - - + - + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - 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- - - + - - - - + + + + - + - + - + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - - - - + + + + + + + - + - + - - + + + + + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - - - - + - + - + - - - - - + + + + + @@ -6052,182 +6043,191 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - + + + + - + - + - - + + + + + + + + + + + - + + + + - + + + + - - - - + + + + - + - + - + - - - - + + + + - - - - - - - + - + - - - - - - - + - - + + - - - - + + + + - + - + - + - - - - + + + + - + - + - - + + - + - - - - + + + + - + - + - + - - - - + + + + - + - - + + + + + - + - - - - + + + + + + + - + - + - - + + - - - - + + + + @@ -6238,14 +6238,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - - - - + + + + @@ -6345,13 +6345,13 @@ The relation between neuroinflammation and glutamatergic signaling
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+ @@ -11537,7 +11257,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -11547,7 +11267,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -11557,7 +11277,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -11567,7 +11287,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -11577,7 +11297,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -11587,7 +11307,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -11599,209 +11319,337 @@ The relation between neuroinflammation and glutamatergic signaling - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + - - + + + + + + + + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - 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+ - + - + - + @@ -19086,608 +19051,643 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - - + + + + + + + + - + - + - + - + + + + + + + + + + + + + + + - + + + + + + + + + + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - - + + - + - + - + - + - + - + + + + + + + + + + + + + + + - + - - - + + + + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + - + - - - - - - + - + - + - + - - - - - - - - - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - - + + + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - - - - - - - + + + + + + + + - 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@@ -19740,7 +19740,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -19748,19 +19748,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -19769,29 +19769,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -19802,12 +19802,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -19815,19 +19810,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -19864,7 +19864,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -19872,19 +19872,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -19903,19 +19903,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -19957,7 +19957,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -19965,19 +19965,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -19988,7 +19988,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -19996,19 +19996,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -20081,7 +20081,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20089,19 +20089,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20112,7 +20112,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20120,19 +20120,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20143,7 +20143,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20151,19 +20151,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + + + + + + - + - +

@@ -20174,7 +20179,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20182,19 +20187,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20205,7 +20210,17 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + + + + + + @@ -20213,19 +20228,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -20432,7 +20437,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20440,19 +20445,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20463,7 +20468,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20471,19 +20476,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -20556,12 +20561,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -20569,19 +20569,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20595,24 +20595,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -20623,7 +20623,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20631,19 +20631,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -20721,7 +20716,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20729,19 +20724,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

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@@ -20874,29 +20869,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -20907,7 +20902,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -20915,19 +20915,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20938,7 +20938,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20946,19 +20946,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -20969,7 +20969,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -20977,19 +20977,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21000,7 +21000,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21008,19 +21008,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21031,7 +21031,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21039,19 +21039,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21060,29 +21060,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -21093,7 +21093,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21101,14 +21101,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + @@ -21134,17 +21134,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -21155,7 +21155,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21163,19 +21163,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21186,12 +21186,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -21199,19 +21194,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21222,7 +21217,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21230,19 +21225,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21253,7 +21248,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21261,19 +21256,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21284,7 +21279,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21292,19 +21287,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21313,29 +21308,34 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -21346,7 +21346,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21354,24 +21354,22 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + -

Synonym: Jacob - -

+

@@ -21379,7 +21377,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21387,19 +21385,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21410,7 +21408,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21418,19 +21416,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21441,7 +21439,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21449,19 +21447,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21472,7 +21470,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21480,19 +21478,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21503,7 +21501,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21511,19 +21509,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21532,34 +21530,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + - + - + - +

@@ -21570,7 +21563,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21578,19 +21571,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21599,29 +21592,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -21632,7 +21625,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21640,19 +21633,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21661,29 +21654,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -21694,7 +21687,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21702,19 +21695,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21725,7 +21718,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21733,19 +21726,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21756,7 +21749,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21764,19 +21757,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21787,7 +21780,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21795,19 +21788,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21818,7 +21811,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21826,19 +21819,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21849,7 +21842,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21857,19 +21850,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21880,7 +21873,17 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + + + + + + @@ -21888,19 +21891,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21911,7 +21914,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21919,19 +21922,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -21940,29 +21943,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -21973,7 +21976,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -21981,19 +21984,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22004,7 +22007,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22012,19 +22015,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22035,7 +22038,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22043,19 +22046,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22064,29 +22067,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -22097,7 +22100,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22105,19 +22108,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22126,29 +22129,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -22157,29 +22160,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -22190,7 +22193,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22198,19 +22201,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22219,29 +22222,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -22252,7 +22255,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22260,19 +22263,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22283,7 +22286,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22291,19 +22294,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22314,7 +22317,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22322,19 +22325,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22345,7 +22348,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22353,19 +22356,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22374,29 +22377,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -22405,29 +22408,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -22438,7 +22441,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22446,19 +22449,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22469,7 +22472,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22477,19 +22480,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22500,7 +22503,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22508,19 +22511,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22534,24 +22537,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + - +

@@ -22560,29 +22558,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -22591,29 +22589,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -22622,29 +22620,39 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -22653,29 +22661,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -22686,17 +22694,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + @@ -22704,19 +22702,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22730,24 +22728,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -22758,7 +22756,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22766,19 +22764,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22789,7 +22787,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22797,19 +22795,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22820,7 +22818,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22828,19 +22826,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22851,7 +22849,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22859,19 +22857,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22882,7 +22880,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22890,19 +22888,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22913,7 +22911,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22921,19 +22919,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22944,7 +22942,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -22952,19 +22950,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -22973,34 +22971,24 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + - + - + - + - +

@@ -23011,7 +22999,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23019,19 +23007,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23042,7 +23030,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23050,19 +23038,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23073,7 +23061,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23081,19 +23069,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23104,12 +23092,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -23117,19 +23100,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23138,29 +23121,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -23171,12 +23154,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -23184,19 +23162,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23207,7 +23185,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23215,19 +23193,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23238,7 +23216,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23246,19 +23224,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23269,7 +23247,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23277,19 +23255,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23300,12 +23278,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -23313,19 +23286,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23336,12 +23309,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -23349,19 +23317,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23372,7 +23340,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23380,19 +23348,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23403,7 +23371,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23411,19 +23379,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23432,29 +23400,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -23463,29 +23431,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -23496,7 +23464,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23504,19 +23472,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23527,7 +23495,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23535,14 +23503,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + @@ -23568,17 +23536,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -23589,7 +23557,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23597,19 +23565,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23620,7 +23588,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23628,19 +23596,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23651,12 +23619,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -23664,19 +23627,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23685,29 +23648,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -23718,7 +23681,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23726,19 +23689,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23747,29 +23710,39 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -23778,29 +23751,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -23811,7 +23784,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23819,19 +23792,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23842,7 +23815,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -23850,19 +23828,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23873,7 +23851,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23881,19 +23859,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23904,7 +23882,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23912,19 +23890,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23935,7 +23913,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23943,19 +23921,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23966,7 +23944,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -23974,19 +23952,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -23997,7 +23975,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24005,19 +23983,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24028,7 +24006,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24036,19 +24014,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24059,7 +24037,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24067,19 +24045,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24088,29 +24066,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -24121,7 +24099,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24129,19 +24107,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24152,7 +24130,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24160,19 +24138,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24181,29 +24159,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -24212,29 +24190,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -24243,29 +24221,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -24276,12 +24254,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -24289,19 +24262,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24310,29 +24283,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -24341,29 +24314,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -24374,7 +24347,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24382,19 +24355,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24403,29 +24376,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -24436,7 +24409,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24444,19 +24417,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24465,29 +24438,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -24498,7 +24471,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24506,19 +24479,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24532,24 +24505,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -24560,7 +24533,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24568,19 +24541,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24589,29 +24562,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -24622,7 +24595,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24630,19 +24603,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24653,7 +24626,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24661,19 +24634,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24684,7 +24657,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24692,19 +24665,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24713,29 +24686,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -24746,7 +24719,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24754,19 +24727,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24777,7 +24750,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24785,19 +24758,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24808,7 +24781,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24816,19 +24789,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24839,7 +24812,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -24847,19 +24825,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24870,7 +24848,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24878,19 +24856,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24899,29 +24877,34 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -24932,7 +24915,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24940,19 +24923,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24963,7 +24946,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -24971,19 +24954,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -24992,29 +24975,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -25025,7 +25008,17 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + + + + + + @@ -25033,19 +25026,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25056,7 +25049,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25064,19 +25057,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25087,7 +25080,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25095,19 +25088,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25116,29 +25109,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -25147,29 +25140,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -25180,7 +25173,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25188,19 +25181,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25214,24 +25207,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -25242,7 +25235,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25250,19 +25243,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25271,24 +25264,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - + - + - + - + - +

@@ -25297,29 +25295,24 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + - +

@@ -25330,7 +25323,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25338,19 +25331,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25364,24 +25357,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -25390,29 +25383,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -25423,7 +25416,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -25431,19 +25429,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25454,7 +25452,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25462,19 +25460,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25485,7 +25483,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25493,19 +25491,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25516,7 +25514,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25524,19 +25522,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25545,29 +25543,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + + + + + + - +

@@ -25578,7 +25576,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25586,19 +25584,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25609,7 +25607,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25617,19 +25615,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25640,7 +25638,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25648,19 +25646,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25669,29 +25667,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -25702,7 +25700,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -25712,17 +25715,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -25731,29 +25734,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -25762,24 +25765,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + + + + + + - - - - - - + - + - + - + @@ -25805,17 +25813,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -25826,7 +25834,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25834,19 +25842,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25857,7 +25865,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25865,19 +25873,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25886,29 +25894,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -25919,7 +25927,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -25927,19 +25935,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -25950,7 +25958,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -25958,14 +25971,14 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + @@ -25996,17 +26009,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -26015,29 +26028,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -26048,7 +26061,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26056,19 +26069,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26079,7 +26092,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26087,19 +26100,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26108,29 +26121,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -26141,7 +26154,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26149,19 +26162,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26170,29 +26183,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -26203,7 +26216,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26211,19 +26224,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26234,7 +26247,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26242,19 +26255,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26268,24 +26281,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -26296,7 +26309,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26304,19 +26317,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26327,7 +26340,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26335,19 +26348,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26361,24 +26374,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -26389,12 +26402,12 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -26402,19 +26415,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26423,29 +26436,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -26454,29 +26467,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -26487,7 +26500,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26495,19 +26508,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26518,7 +26531,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26526,19 +26539,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26549,7 +26562,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -26557,19 +26575,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26580,7 +26598,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26588,19 +26606,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26611,7 +26629,17 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + + + + + + @@ -26619,19 +26647,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26640,29 +26668,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -26673,7 +26701,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26681,19 +26709,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26704,7 +26732,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26712,19 +26740,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26735,7 +26763,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -26743,19 +26776,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26766,7 +26799,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -26776,17 +26814,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -26797,7 +26835,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26805,19 +26843,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26828,7 +26866,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26836,19 +26874,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26859,7 +26897,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26869,17 +26907,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -26888,29 +26926,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -26921,7 +26959,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26929,19 +26967,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26952,7 +26990,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -26960,19 +26998,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -26981,29 +27019,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -27014,7 +27052,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27022,19 +27060,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27045,7 +27083,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27053,19 +27091,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27073,30 +27111,30 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + + + + + + - + - +

@@ -27107,12 +27145,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -27120,19 +27153,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27143,7 +27176,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27151,19 +27184,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27172,29 +27205,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -27203,39 +27236,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - - - - - - + - + - + + + + + + - + - +

@@ -27246,7 +27269,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27254,19 +27277,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27277,7 +27300,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27285,19 +27308,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27308,7 +27331,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27316,19 +27339,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27337,29 +27360,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -27370,7 +27393,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27378,19 +27401,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27401,7 +27424,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27409,19 +27432,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27432,7 +27455,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27440,19 +27463,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27463,7 +27486,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27471,19 +27494,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27497,24 +27520,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -27525,7 +27548,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -27535,17 +27563,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -27559,24 +27587,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -27585,29 +27613,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -27616,29 +27644,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -27647,29 +27675,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -27680,7 +27708,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27688,19 +27716,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27711,7 +27739,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27719,19 +27747,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27745,24 +27773,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -27773,7 +27801,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -27783,17 +27816,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -27802,29 +27835,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -27835,7 +27868,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27843,19 +27876,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27866,7 +27899,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27874,19 +27907,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27897,7 +27930,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -27905,19 +27938,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -27926,50 +27959,40 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + + + + + + - +

- - - - - - - - - - - - + + - + @@ -27977,19 +28000,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28000,7 +28023,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28008,19 +28031,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28029,29 +28052,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -28060,29 +28083,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -28091,29 +28114,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -28124,7 +28147,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28132,19 +28155,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28153,29 +28176,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -28186,7 +28209,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28194,19 +28217,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28217,7 +28240,12 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + @@ -28225,19 +28253,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28248,7 +28276,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28256,19 +28284,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28279,7 +28307,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28287,19 +28315,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28310,7 +28338,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28318,19 +28346,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28341,7 +28369,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28349,19 +28377,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28372,7 +28400,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28380,19 +28408,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28401,29 +28429,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -28434,7 +28462,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28442,19 +28470,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28463,29 +28491,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -28496,7 +28524,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28504,19 +28532,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28527,7 +28555,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28535,19 +28563,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28558,7 +28586,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28566,19 +28594,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28589,7 +28617,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28597,19 +28625,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28620,12 +28648,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -28633,19 +28656,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28656,7 +28679,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28664,19 +28687,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28685,29 +28708,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -28718,7 +28741,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28726,19 +28749,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28749,7 +28772,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28757,19 +28780,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28780,7 +28803,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28788,19 +28811,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28811,17 +28834,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + @@ -28829,19 +28842,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28850,29 +28863,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -28883,7 +28896,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28891,19 +28904,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -28912,29 +28925,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - +

@@ -28943,39 +28956,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - - - - - - + - + - + + + + + + - + - +

@@ -28986,7 +28989,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -28994,19 +28997,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -29017,7 +29020,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29025,19 +29028,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -29046,29 +29049,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -29077,29 +29080,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - + + + + + + - +

@@ -29108,29 +29111,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + + + - + - +

@@ -29139,32 +29142,34 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - - - - - - + - + - + - + - + -

+

Synonym: Jacob + +

@@ -29172,7 +29177,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29180,19 +29185,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +
- +

@@ -29203,7 +29208,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29211,19 +29216,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -29232,24 +29237,29 @@ The relation between neuroinflammation and glutamatergic signaling + + + + + - + - + - + - + - +

@@ -29260,7 +29270,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29268,19 +29278,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -29294,24 +29304,24 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - + - + - +

@@ -29322,7 +29332,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29330,19 +29340,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -29351,34 +29361,29 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + - + - + + + + + + - + - +

@@ -29389,12 +29394,7 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + @@ -29402,21 +29402,21 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - + - +

@@ -29424,10 +29424,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29435,17 +29435,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - - +

@@ -29453,32 +29449,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + - + - + - - - - +

@@ -29486,19 +29469,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -29506,10 +29489,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29517,13 +29500,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -29531,27 +29514,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - - - - +

@@ -29559,24 +29534,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -29584,10 +29554,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29595,13 +29565,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -29609,27 +29579,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - - - - - + + - +

@@ -29637,7 +29599,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29648,18 +29610,16 @@ The relation between neuroinflammation and glutamatergic signaling - - + - - + - + - +

@@ -29667,19 +29627,28 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + + - +

@@ -29687,19 +29656,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -29707,10 +29676,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29718,16 +29687,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -29735,27 +29701,32 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - + - +

@@ -29763,19 +29734,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -29783,35 +29754,15 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - - - - - - - - - - - -

- - - - - - + @@ -29819,13 +29770,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -29833,24 +29787,22 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + - +

@@ -29858,10 +29810,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29869,13 +29821,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -29883,10 +29838,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29894,16 +29849,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -29911,10 +29863,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29922,13 +29874,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -29936,10 +29888,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -29947,13 +29899,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -29961,24 +29916,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -29986,7 +29936,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -29997,16 +29947,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -30014,28 +29961,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - - - - - +

@@ -30043,10 +29981,15 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + + @@ -30054,16 +29997,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -30071,10 +30011,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30082,13 +30022,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -30096,28 +30036,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - - + - - - - +

@@ -30125,20 +30056,10 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + - + @@ -30146,16 +30067,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -30163,10 +30081,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30174,13 +30092,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -30188,19 +30109,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30208,28 +30129,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - - + - + - - - - +

@@ -30237,10 +30149,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30248,16 +30160,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30265,19 +30177,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -30285,19 +30205,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -30305,19 +30233,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30325,10 +30253,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30336,13 +30264,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -30350,29 +30278,22 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + - + - + + + + - +

@@ -30380,10 +30301,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30391,13 +30312,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -30405,19 +30329,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30425,19 +30349,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -30445,10 +30377,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30456,16 +30388,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -30473,19 +30402,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30493,10 +30422,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30504,16 +30433,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + + - +

@@ -30521,19 +30451,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30541,27 +30471,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - - - - +

@@ -30569,19 +30491,31 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + + + - + + + + + + - +

@@ -30589,24 +30523,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -30614,10 +30543,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30625,16 +30554,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -30642,19 +30568,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -30662,10 +30588,20 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + + + + + + + @@ -30673,13 +30609,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -30687,22 +30626,28 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - + + - +

@@ -30710,24 +30655,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -30735,10 +30675,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30746,17 +30686,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - + - +

@@ -30764,24 +30703,22 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + - +

@@ -30789,24 +30726,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -30814,19 +30746,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -30834,22 +30771,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - - - +

@@ -30857,10 +30791,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30868,13 +30802,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -30882,10 +30816,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30893,13 +30827,18 @@ The relation between neuroinflammation and glutamatergic signaling - + + - + + + + + - +

@@ -30907,10 +30846,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30918,13 +30857,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -30932,10 +30871,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -30943,16 +30882,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -30960,19 +30896,22 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + + + + - +

@@ -30980,19 +30919,28 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + + - +

@@ -31000,19 +30948,29 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + + + - +

@@ -31020,19 +30978,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31040,19 +30998,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31060,19 +31018,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31080,19 +31038,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -31100,15 +31063,10 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + @@ -31116,13 +31074,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -31130,19 +31088,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31150,10 +31108,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31161,16 +31119,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -31178,10 +31133,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31189,13 +31144,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -31203,19 +31158,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -31223,10 +31183,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31234,13 +31194,18 @@ The relation between neuroinflammation and glutamatergic signaling - + + - + + + + + - +

@@ -31248,19 +31213,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31268,10 +31233,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31279,18 +31244,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - + + - +

@@ -31298,19 +31262,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -31318,19 +31290,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31338,24 +31310,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -31363,19 +31330,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31383,10 +31350,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31394,13 +31361,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -31408,10 +31375,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31419,18 +31386,13 @@ The relation between neuroinflammation and glutamatergic signaling - - + - - + - - - - +

@@ -31438,10 +31400,30 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + + + + + + + + + + +

+ + + + + - + @@ -31449,17 +31431,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - + - +

@@ -31467,15 +31448,10 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + @@ -31483,16 +31459,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -31500,19 +31473,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -31520,19 +31498,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -31540,24 +31523,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - +

@@ -31565,27 +31543,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - - - - +

@@ -31593,19 +31563,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31613,10 +31583,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31624,16 +31594,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -31641,19 +31608,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31661,10 +31628,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31672,13 +31639,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -31686,19 +31656,28 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + + - +

@@ -31706,19 +31685,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31726,19 +31705,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -31746,19 +31733,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31766,24 +31753,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -31791,19 +31773,32 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + + + + + + - + - + + + + - +

@@ -31811,19 +31806,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31831,10 +31826,15 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + + @@ -31842,17 +31842,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - - +

@@ -31860,19 +31856,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -31880,19 +31884,28 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + + - + + + + - +

@@ -31900,10 +31913,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -31911,16 +31924,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -31928,15 +31941,10 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + @@ -31944,16 +31952,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -31961,19 +31966,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -31981,22 +31991,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - - - - +

@@ -32004,22 +32016,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - - - +

@@ -32027,28 +32036,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - - - - - +

@@ -32056,24 +32056,22 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + + + + - +

@@ -32081,19 +32079,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -32101,7 +32099,7 @@ The relation between neuroinflammation and glutamatergic signaling - + @@ -32112,16 +32110,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -32129,19 +32124,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -32149,10 +32144,15 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + + @@ -32160,13 +32160,17 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + - +

@@ -32174,19 +32178,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -32194,10 +32203,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32205,13 +32214,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -32219,25 +32228,17 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - - - @@ -32253,13 +32254,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -32267,10 +32268,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32278,16 +32279,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -32295,10 +32293,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32306,13 +32304,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -32320,10 +32321,15 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + + + @@ -32331,16 +32337,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - - - +

@@ -32348,19 +32351,28 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + + - +

@@ -32368,19 +32380,24 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + - +

@@ -32388,24 +32405,19 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + - + - +

@@ -32413,22 +32425,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - - - - +

@@ -32436,10 +32445,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32447,13 +32456,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -32461,15 +32470,10 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - + - + @@ -32477,17 +32481,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - - + - +

@@ -32495,10 +32498,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32506,13 +32509,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -32520,10 +32523,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32531,20 +32534,16 @@ The relation between neuroinflammation and glutamatergic signaling - - - + - + - - - + - +

@@ -32552,19 +32551,19 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -32572,10 +32571,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32583,16 +32582,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - + - +

@@ -32600,10 +32599,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32611,13 +32610,13 @@ The relation between neuroinflammation and glutamatergic signaling - + - + - +

@@ -32625,10 +32624,10 @@ The relation between neuroinflammation and glutamatergic signaling - + - + @@ -32636,13 +32635,16 @@ The relation between neuroinflammation and glutamatergic signaling - + - + + + + - +

@@ -32650,19 +32652,27 @@ The relation between neuroinflammation and glutamatergic signaling - + + + + + + - + - + + + + - +

@@ -32670,26 +32680,16 @@ The relation between neuroinflammation and glutamatergic signaling - - - - - - - - - - - + - + - + diff --git a/sbml/WP5083.svg b/sbml/WP5083.svg index f43fe1d..02c354f 100644 --- a/sbml/WP5083.svg +++ b/sbml/WP5083.svg @@ -8,36 +8,14 @@ /> fdfb6b7caab7caafdfb6e05fae1fb9e1fb9b014db014da76ff?fe034e3048a5e4bd7040d7040a5e4bb8facb8faca659cb0aeab07beb0aeacc918ee580c307ab2af2ad889fef36ad889ad975af2c7ad975f5053?f24fcf5053f24fcff222ff222de1e9e3e37d06bad06baa797ba797bfbaefc9670?f9af1f9af1ac570ecee8cb05fcb05fd3e70Spine shrinkageMechanical StrengthIL13RA1NFKB2IL1R2LIFTRAF5IL4TNFRSF1BIL4RCell SurvivalGFAPsuperoxideIL6SMAD2a90a9SMAD2NGFIL1AIL6STIFNGTGFBR2PI3K/AKT signalingSTAT3TNFRSF1ANH3(+)BDNFTGFB1LTAIL13IL13IL10RBJAK1STAT1TGFBR3DAOSTAT3IL12ASOCS3STAT1STAT6IL10RAIRS1AKT1TGFB2IL6RSMAD3IL1R1TGFBR1SMAD7INSRIL12BFGF2NOS1TGFB3STAT6LPSCell survivalIL1BSMAD4H2O2nitric oxideNFKB1GRIN1TCA cycleLong-term potentiationAcetyl-CoAec7feGRM8GRIK4GRIN2AGRIK3glutamatePPP1CCGRIN2DglutamateGRIK5GRM7L-AspartateCAMKK2MAPK1SHMT1GSCAMK4PHGDHGOT1CAMK2AGlycolysisPHPLRRC8BLRRC8ELRRC8ASRRGRIN2CPP3glutamineSLC1A42-oxoglutarateMg2+MAPK Signaling PathwayGRIA3PSPHGRIA4GRIK2GRIA2GRM4GRIN3BPLCB2PRKACAPRKCGL-serineApoptosisADCY1LRRC8DPSAT1PRKCBH+PLCB1PPP1CBSLC38A1D-serineSLC6A9CAMK2GPDHA1GRM1ADCY3PRKCAMAPK3cAMPCAMKK1PLCB31,3-diglyceridesPPP1CANSMFGlycineGRIN2BSLC1A63PGSHMT2DLATDLDADCY81,2-diglyceridesNeuroprotectionDISC1LRRC8CSLC38A2CFL1TRPM4PLCB4CAMK2B3-PhosphoserineGRM2GRIK1CAMK2DpyruvateGRIA1SLC1A1NAD+CALM1DepolarisationGRIN3ACa2+2-ketoglutarateLong term depressionNADHglutamineGLSGLS2glutamateSLC17A6SLC17A7 glutamateSLC38A5SLC38A3glutamateGRM5GRIN2BGRIN1GRIN2CGRIN2DGlycineD-serineD-serineL-serineSRRSLC7A10SLC7A10SLC6A9Glycine NFKB1CREB1fd453CREB1Protein biosynthesisTranslocationmim-stimulationGeneProductMetabolitePre-synaptic neuronPost-synaptic neuronPeripheral macrophages, T cells, inflammatory markersPro-inflammatory factorsmim-transcription-translationAstrocyteVesicle releaseM2 Microglia mim-catalysisPost-synaptic neuronProtein biosynthesisD-Serine metabolismEnd-product of pathwayProtein biosynthesisAstrocytemim-inhibitionmim-conversionResting Microglia PathwayData node for a gene or its productLegendMetaboliteData node for a metaboliteProtein biosynthesisGlutamine-glutamate metabolismProtein biosynthesisLegendD-Serine metabolismResting Microglia PathwayVesicle releaseAnti-inflammatory factorsGeneProductmim-conversionmim-transcription-translationData node for a pathwayProtein biosynthesismim-catalysisData node for a gene or its productPM1 Microglia TranslocationPre-synaptic neuronmim-stimulationPeripheral macrophages, T cells, inflammatory markers - + @@ -80,34 +80,34 @@ - + - + - + - + - + - + @@ -122,38 +122,70 @@ - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + - + + + + + + + + + + + + + + + + + @@ -162,334 +194,302 @@ - + + + + + + + + + - - - - + + + + - + - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - - - - + + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + @@ -497,131 +497,131 @@ - - - - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + - - - - + + + + + + + - + - + - - + + - - - - + + + + @@ -632,14 +632,14 @@ - + - - - - + + + + @@ -653,25 +653,31 @@ - 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@@ -3004,7 +3004,7 @@ - + @@ -3014,17 +3014,17 @@ - + - + - +

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@@ -4137,30 +4129,10 @@ - - - - - - - - - - - - - - - - - - - - - + - + @@ -4168,34 +4140,24 @@ - + - + - - - - + -

transport - -

+

- - - - - - + - + @@ -4203,13 +4165,13 @@ - + - + - +

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@@ -4325,7 +4318,12 @@ - + + + + + + @@ -4334,10 +4332,10 @@ - + - +

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+

transport + +

- - - - - - + - + @@ -4421,18 +4423,13 @@ - + - + - - - - - - +

@@ -4440,10 +4437,10 @@ - + - + @@ -4451,13 +4448,16 @@ - + - + + + + - +

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+

transport + +

- + @@ -4504,45 +4498,33 @@ - + - + - - - - -
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+

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@@ -4550,20 +4532,10 @@ - - - - - - - - - - - + - + @@ -4571,16 +4543,13 @@ - + - + - - - - +

transport @@ -4590,10 +4559,10 @@ - + - + @@ -4606,13 +4575,13 @@ - + - + - +

@@ -4620,21 +4589,16 @@ - - - - - - + - + - + @@ -4666,16 +4630,16 @@ - + - + - + - +

@@ -4683,7 +4647,7 @@ - + @@ -4694,23 +4658,24 @@ - + - + + + + - + -

transport - -

+

- + @@ -4726,28 +4691,40 @@ + + + + + - + -

+

transport + +

- + + + + + + - + - +
- +

@@ -4755,10 +4732,20 @@ - + - + + + + + + + + + + + @@ -4766,13 +4753,16 @@ - + - + + + + - +

@@ -4780,20 +4770,10 @@ - - - - - - - - - - - + - + @@ -4801,16 +4781,13 @@ - + - + - - - - +

@@ -4818,19 +4795,37 @@ - + + + + + + + + + + + + + + + + - + - + + + + - +

transport @@ -4840,21 +4835,26 @@ - + + + + + + - + - + diff --git a/sbml/WP5112.svg b/sbml/WP5112.svg index 97a1a88..f58bc15 100644 --- a/sbml/WP5112.svg +++ b/sbml/WP5112.svg @@ -8,14 +8,25 @@ />Chylomicron increaseVLDL increaseChylomicron increaseHyperlipoproteinemia type Ve613bce290ce290f8b5bVLDLAPOA2CholesterolHDLLDLLRP1APOA4LipoproteinIDLBindingLiverStimulationTransport ConversionLegendMutationsMetaboliteBindingxGene/proteinStimulationLiverTransport CatalysisLegendMutationsxConversion - + @@ -8,11 +8,15 @@ There are two known disorders concerning the uptake transports of galactose (SGLT1 and GLUT2 deficiency) and three known disorders of galactose metabolism: galactokinase deficiency (GALK-D), galactose 1-phosphate uridyltransferase deficiency (galactosemia, GALT-D) and uridine diphosphate galactose 4-epimerase deficiency (GALE-D). Among these, galactosemia is the most common and most severe. This pathway was inspired by Chapter 18, figure 18.3 of the book of Blau (4th edition; ISBN: 978-3-642-40337-8). +[-:-] Unknown gpml interaction type: mim-translocation [CONVERSION:e7a6e] Curved connections are not supported. +[-:-] Unknown gpml interaction type: mim-translocation [CONVERSION:e7aaa] Curved connections are not supported. [CONVERSION:cecc9] Curved connections are not supported. [CONVERSION:a84b2] Curved connections are not supported. [CONVERSION:ee7b6] Curved connections are not supported. +[LINE:f075d] Invalid interaction type. +[LINE:a4ae6] Invalid interaction type. [ARROW:a5819] Invalid interaction type "ARROW" as an output from reaction. [ARROW:ec0ac] Invalid interaction type as an input to reaction. [ARROW:d0176] Invalid interaction type as an input to reaction. @@ -59,9 +63,9 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - + + @@ -113,12 +117,12 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + @@ -129,28 +133,28 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - - - + + + - + - - - + + + - + @@ -161,54 +165,70 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - - - + + + - - + + - - - + + + - + - + - + - - - + + + - + - + - + + + + + + + + + + + + + + + + + @@ -217,52 +237,76 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + + + + + + + + + - + - - - + + + - + - + + + + + + + + + - + - + - + - + - + - - - + + + - + + + + + + + + + @@ -273,44 +317,44 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - + + + - - + + - - - + + + - - + + - + - + - - - + + + - - + + - - - + + + - + @@ -321,12 +365,12 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + @@ -337,6 +381,22 @@ Among these, galactosemia is the most common and most severe. This pathway was i + + + + + + + + + + + + + + + + @@ -357,85 +417,20 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - - - + - + @@ -446,37 +441,46 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - - - + + + - - + + - - - + + + + + + + + + + + + - - + + @@ -514,140 +518,122 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - - - - - - - - + + - + - + - - - - - - - - - - - + + - + - - - - - - - + - + - - - - + + + + - + - - - - + - + - + - - - - + + + + - - + + - + - - + + - - + + - + - - - - + + + + - + - + + + + - + + + + - - - - + + + + - + - + - + + + + - - - - + + + + @@ -659,60 +645,81 @@ Among these, galactosemia is the most common and most severe. This pathway was i + + + - + - - - - + + + + - + - + - + + + + + + + + + + + + + + + + - + - + + + + - - - - + + + + - + - + - + - + - + - + @@ -724,61 +731,61 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - - - - - - - - - - + - + - - + + + + + + + + + + + - + - + + + + - + - - - - + + + + - - - - + + + + - + @@ -790,23 +797,20 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - + - + - - - - + + + + @@ -867,22 +871,22 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - + - - + + @@ -893,16 +897,16 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + @@ -911,196 +915,196 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -1109,28 +1113,28 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - - - - + + + + - + - - + + - + - - + + @@ -1191,323 +1195,265 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + @@ -1517,7 +1463,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1527,7 +1473,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1537,7 +1483,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1549,233 +1495,297 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + - + - - + + - + - - + + - + - - + + - + @@ -1785,7 +1795,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1795,7 +1805,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1805,7 +1815,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1815,7 +1825,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -1827,42 +1837,36 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + - - - - - - - - + + - + - - + + @@ -1927,10 +1931,10 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + @@ -1939,22 +1943,22 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + - + - - + + @@ -1963,196 +1967,196 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -2161,81 +2165,81 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - + - + @@ -2243,30 +2247,30 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - + - + - + - + - + - + @@ -2275,12 +2279,12 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + @@ -2289,12 +2293,12 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + @@ -2303,12 +2307,12 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + @@ -2322,7 +2326,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - +

@@ -2336,7 +2340,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - +

@@ -2366,7 +2370,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - +

@@ -2377,7 +2381,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -2385,19 +2389,19 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - +

@@ -2408,7 +2412,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -2416,19 +2420,19 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - +

@@ -2449,20 +2453,22 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + -

+

GYS2: specific to liver + +

@@ -2470,12 +2476,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - - - + @@ -2485,17 +2486,17 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - +
- +

@@ -2506,12 +2507,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - - - + @@ -2519,24 +2515,22 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - + -

search for glucose 6-phosphate - -

+

@@ -2544,7 +2538,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -2552,24 +2546,22 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - + -

GYS2: specific to liver - -

+

@@ -2577,7 +2569,12 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + + + + + + @@ -2587,17 +2584,17 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - +

@@ -2608,7 +2605,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -2616,19 +2613,19 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + - + - +

@@ -2639,7 +2636,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + @@ -2649,17 +2646,17 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - +

@@ -2670,12 +2667,7 @@ Among these, galactosemia is the most common and most severe. This pathway was i - - - - - - + @@ -2685,24 +2677,20 @@ Among these, galactosemia is the most common and most severe. This pathway was i - + - + - + -

Glycogenin-1 is involved in the biosynthesis of glycogen. It is capable of self-glucosylation, forming an oligosaccharide primer that serves as a substrate for glycogen synthase. It also plays a role in glycogen metabolism regulation - -expressed mostly in muscles - -

+

@@ -2710,7 +2698,7 @@ expressed mostly in muscles - + @@ -2720,17 +2708,17 @@ expressed mostly in muscles - + - + - +

@@ -2741,7 +2729,12 @@ expressed mostly in muscles - + + + + + + @@ -2749,19 +2742,19 @@ expressed mostly in muscles - + - + - + - + - +

@@ -2772,7 +2765,7 @@ expressed mostly in muscles - + @@ -2780,19 +2773,19 @@ expressed mostly in muscles - + - + - + - + - +

@@ -2803,7 +2796,12 @@ expressed mostly in muscles - + + + + + + @@ -2811,26 +2809,22 @@ expressed mostly in muscles - + - + - + - + - + -

GSD 6 -HERS DISEASE -PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - -

+

@@ -2838,7 +2832,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -2848,20 +2842,22 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + -

+

GYG1 + +

@@ -2869,7 +2865,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -2879,17 +2875,17 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - +
- +

@@ -2900,12 +2896,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - - - - - - + @@ -2913,19 +2904,19 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - + - +

@@ -2936,7 +2927,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -2944,19 +2935,19 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - + - +

@@ -2967,7 +2958,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -2975,24 +2966,22 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - + - + -

GYG1 - -

+

@@ -3000,7 +2989,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -3008,24 +2997,22 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - + - + -

adult form - -

+

@@ -3033,7 +3020,12 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + + + + + + @@ -3041,22 +3033,26 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - + - + -

+

GSD 6 +HERS DISEASE +PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER + +

@@ -3064,7 +3060,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -3072,22 +3068,22 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - +
- + -

GYS2 +

search for glucose 6-phosphate

@@ -3097,7 +3093,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -3105,22 +3101,24 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER
- + - + - + - +
- + -

+

GYS1 + +

@@ -3128,7 +3126,7 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + @@ -3136,26 +3134,22 @@ PHOSPHORYLASE DEFICIENCY GLYCOGEN-STORAGE DISEASE OF LIVER - + - + - + - +
- + -

catalyzes the rate-limiting step in glycogen synthesis in the liver and in skeletal muscle: the transfer of glucose monomers from UDP-glucose to the terminal branch of the growing glycogen chain via the formation of α(1→4) glycosidic bonds - -GYS1: specific to skeletal muscle - -

+

@@ -3163,7 +3157,7 @@ GYS1: specific to skeletal muscle - + @@ -3173,22 +3167,20 @@ GYS1: specific to skeletal muscle - + - + - + -

"This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose." Source: [https://enzyme.expasy.org/EC/1.1.1.48] - -

+

@@ -3196,12 +3188,7 @@ GYS1: specific to skeletal muscle - - - - - - + @@ -3209,22 +3196,24 @@ GYS1: specific to skeletal muscle - + - + - + - + - + -

+

GYS2 + +

@@ -3232,7 +3221,7 @@ GYS1: specific to skeletal muscle - + @@ -3240,24 +3229,22 @@ GYS1: specific to skeletal muscle - + - + - + - +
- + -

expressed mainly in liver, cardiac muscle and other types of tissue, but not in skeletal muscle. - -

+

@@ -3265,7 +3252,7 @@ GYS1: specific to skeletal muscle - + @@ -3273,22 +3260,26 @@ GYS1: specific to skeletal muscle - + - + - + - + - + -

+

catalyzes the rate-limiting step in glycogen synthesis in the liver and in skeletal muscle: the transfer of glucose monomers from UDP-glucose to the terminal branch of the growing glycogen chain via the formation of α(1→4) glycosidic bonds + +GYS1: specific to skeletal muscle + +

@@ -3296,7 +3287,7 @@ GYS1: specific to skeletal muscle - + @@ -3304,19 +3295,19 @@ GYS1: specific to skeletal muscle - + - + - + - +
- +

@@ -3327,7 +3318,7 @@ GYS1: specific to skeletal muscle - + @@ -3335,19 +3326,19 @@ GYS1: specific to skeletal muscle - + - + - + - + - +

@@ -3358,7 +3349,7 @@ GYS1: specific to skeletal muscle - + @@ -3366,22 +3357,22 @@ GYS1: specific to skeletal muscle - + - + - + - + - + -

GYS1 +

"This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose." Source: [https://enzyme.expasy.org/EC/1.1.1.48]

@@ -3391,7 +3382,12 @@ GYS1: specific to skeletal muscle - + + + + + + @@ -3399,19 +3395,19 @@ GYS1: specific to skeletal muscle - + - + - + - +
- +

@@ -3422,7 +3418,7 @@ GYS1: specific to skeletal muscle - + @@ -3430,22 +3426,24 @@ GYS1: specific to skeletal muscle - + - + - + - + - + -

+

expressed mainly in liver, cardiac muscle and other types of tissue, but not in skeletal muscle. + +

@@ -3453,7 +3451,7 @@ GYS1: specific to skeletal muscle - + @@ -3463,17 +3461,17 @@ GYS1: specific to skeletal muscle - + - +
- +

glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain @@ -3496,17 +3494,17 @@ GYS1: specific to skeletal muscle - + - + - +

GYG1 @@ -3519,7 +3517,7 @@ GYS1: specific to skeletal muscle - + @@ -3529,20 +3527,22 @@ GYS1: specific to skeletal muscle - + - + - + -

+

adult form + +

@@ -3550,7 +3550,7 @@ GYS1: specific to skeletal muscle - + @@ -3560,20 +3560,24 @@ GYS1: specific to skeletal muscle - + - +
- + -

+

Glycogenin-1 is involved in the biosynthesis of glycogen. It is capable of self-glucosylation, forming an oligosaccharide primer that serves as a substrate for glycogen synthase. It also plays a role in glycogen metabolism regulation + +expressed mostly in muscles + +

@@ -3581,7 +3585,7 @@ GYS1: specific to skeletal muscle - + @@ -3589,19 +3593,19 @@ GYS1: specific to skeletal muscle - + - + - + - +
- +

@@ -3612,7 +3616,7 @@ GYS1: specific to skeletal muscle - + @@ -3620,14 +3624,14 @@ GYS1: specific to skeletal muscle - + - + - + - + @@ -3653,17 +3657,17 @@ GYS1: specific to skeletal muscle - + - + - - + + - +

@@ -3671,10 +3675,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3682,17 +3686,23 @@ GYS1: specific to skeletal muscle - + - + - + + + + + + + - +

@@ -3700,10 +3710,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3711,13 +3721,16 @@ GYS1: specific to skeletal muscle - + - + + + + - +

@@ -3725,12 +3738,7 @@ GYS1: specific to skeletal muscle - - - - - - + @@ -3739,14 +3747,14 @@ GYS1: specific to skeletal muscle - - + + - + - +

@@ -3764,13 +3772,13 @@ GYS1: specific to skeletal muscle - + - + - +

@@ -3778,10 +3786,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3789,17 +3797,16 @@ GYS1: specific to skeletal muscle - + - + - - + - +

@@ -3807,10 +3814,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3818,11 +3825,15 @@ GYS1: specific to skeletal muscle - + - + + + + + @@ -3838,13 +3849,13 @@ GYS1: specific to skeletal muscle - + - + - +

@@ -3852,10 +3863,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3863,16 +3874,17 @@ GYS1: specific to skeletal muscle - + - + - + + - +

@@ -3880,23 +3892,29 @@ GYS1: specific to skeletal muscle - + + + + + + - + - - + + + - + - +

@@ -3904,10 +3922,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3915,18 +3933,13 @@ GYS1: specific to skeletal muscle - + - - - + - - - - +

@@ -3934,10 +3947,10 @@ GYS1: specific to skeletal muscle - + - + @@ -3945,20 +3958,14 @@ GYS1: specific to skeletal muscle - + - + - - - - - - - - + + @@ -3983,14 +3990,14 @@ GYS1: specific to skeletal muscle - - + + - + - +

@@ -3998,10 +4005,10 @@ GYS1: specific to skeletal muscle - + - + @@ -4009,14 +4016,11 @@ GYS1: specific to skeletal muscle - + - + - - - @@ -4037,14 +4041,14 @@ GYS1: specific to skeletal muscle - + - - + + - + diff --git a/sbml/WP5173.svg b/sbml/WP5173.svg index 5faf5d6..d45a967 100644 --- a/sbml/WP5173.svg +++ b/sbml/WP5173.svg @@ -20,32 +20,32 @@ > ??PathwayCatalysisConnection to disease Legend(Liver) CellProteinDiseaseEnterocytesConversionEnterocytesDisease(Liver) CellCatalysisMetaboliteProteinConnection to disease - + @@ -94,12 +94,12 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn [Label:b9802] Label cannot be part of reaction. Tranforming to Unknown [Label:b0872] Label cannot be part of reaction. Tranforming to Unknown [Label:aa859] Label cannot be part of reaction. Tranforming to Unknown -[:e11c0] OVAL cannot be part of a complex. Skipping. -[:e65c5] OVAL cannot be part of a complex. Skipping. [:f6a07] OVAL cannot be part of a complex. Skipping. -[:f2a80] OVAL cannot be part of a complex. Skipping. [:c3979] ROUNDED_RECTANGLE cannot be part of a complex. Skipping. +[:f2a80] OVAL cannot be part of a complex. Skipping. [:bb4fa] OVAL cannot be part of a complex. Skipping. +[:e65c5] OVAL cannot be part of a complex. Skipping. +[:e11c0] OVAL cannot be part of a complex. Skipping. [Complex:b32c4] Empty element is invalid [BiopaxReference:e99] Publication is invalid. [BiopaxReference:a14] Publication is invalid.

@@ -127,11 +127,11 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + @@ -140,65 +140,57 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + + + + + + + + + + - + - + - - - - - - - - - - + - + - - - - - - - - @@ -207,117 +199,77 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - + - + - + - + - - + + - - + + - + - - - - - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + @@ -339,68 +291,44 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - + - + - + - - - - - - - - - + - + - + @@ -423,63 +351,55 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - + @@ -496,18 +416,10 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - - - - - - + @@ -524,42 +436,10 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + @@ -576,15 +456,15 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - + + + - + @@ -595,96 +475,85 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - - + + - - - - - - + + + + + + + - - - - - - - - - - - - - - - - - + - + - + - + - + - - - + + + - + - + - + - + - + - - - + + + + + + + + + + + + + + + - - + + @@ -694,97 +563,101 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - - + + - - - - - - + + + + + + + - + - + - + - - - - - - - - - + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + - + - + - + - - - + + + - - + + - + - + + + + + + + + + @@ -805,164 +678,136 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - + + + - + - - - + + + - - + + - - - + + + - - + + - + - + - + + + + + + + + + - + - - - - - - - - - - - - - - - + + + - - + + - - - + + + - + - + - + - - - + + + - - + + - + - - - - - - + + + + + + - - - - - - - - - + - - - - - - - - - + - + - - - + + + - + - + - - - - - - - - - + - + - + @@ -982,47 +827,39 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - - - - - - - - - + - + - + - - - - + + + + @@ -1031,15 +868,39 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1059,119 +920,71 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - - - + + + - + - + - + + + + + + + + + + + + + - + - - - - - - - - - - - + + + - + - + - + + + + + + + + + + + + + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + @@ -1188,18 +1001,26 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + + + + + + + + + - - - - + + + + @@ -1208,78 +1029,125 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + + + + + + + + + + + + + + + + + - - - - - - + + + + + + - - + - + - + - + + + + + + + + + - + - + + + + + + + + + - + - + - + - + + + + + + + + + - + - + + + + + + + + + @@ -1296,10 +1164,18 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + + + + + + + + + @@ -1316,27 +1192,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - - - - - - - - - - - - - + @@ -1347,31 +1203,23 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - + - + - - - + + + - - + + - + @@ -1388,50 +1236,202 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - - - + + + - - + + - + - + - - - + + + - + - + + + + + + + + + + + + + + + + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1448,26 +1448,34 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + + + + + + + + + - - - - + + + + @@ -1476,7 +1484,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -1487,97 +1495,89 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - + - + - - + + + + + + + + - - - - + + + + - + - + - + + + + - + - - - - + + + + - + - - - - + - + - + - - - - + + + + - - - - - - - + - + - + - - - - + + + + @@ -1594,14 +1594,14 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - + + + + @@ -1618,20 +1618,20 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - + + + + - + @@ -1642,14 +1642,14 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - + + + + @@ -1661,55 +1661,64 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - + - - - - + + + + - + - + + + + + + + + + + + + + + + + + + + - + - - - - + + + + - - - - + @@ -1717,14 +1726,14 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - + + + + @@ -1741,14 +1750,14 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - + + + + @@ -1765,590 +1774,572 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - - - + + + + - + - + + + + + + + - - - - + + + + - - - - - - - + - - + + + + + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + - - - - + + + + - - - - + - - - - + - - - - + + + + - + - + - + - + - + - - - - + + + + - - - - - + + - - + + - - + + - - - - + + + + - + - + + + + - + + + + - - - - + + + + - - + + - + - + - - - - + + + + - + - + - + - + - + - - - - + + + + - + - + - + - + - + - - - - + + + + - + - + - + - + - + - - - - + + + + + + + - + - + - - + + + + + - - - - + + + + - - - - + + + + - + - - - - + + + + - - - - + + + + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - + - - - - + + + + - + - - - - - - - - - - - - - - - - + - - - - + - - - - + + + + - + - + - 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+ - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -5355,7 +5451,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -5365,7 +5461,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -5377,1410 +5473,1314 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - + + - - - - - - - - - - - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + + + + + - + - - + + - + - - - - - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - - - - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - - - - - + + - + - - + + - + - - + + @@ -6789,16 +6789,10 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - + - - + + @@ -6807,100 +6801,118 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - + + + + + + + + + + + + - + - + - + - + + + + + + + - + - - + + - + - + + + + + + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -6915,112 +6927,100 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - + - + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -7029,64 +7029,70 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -7095,142 +7101,142 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -7239,316 +7245,316 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -7557,57 +7563,51 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - + - + - + - + - + - + - + - + @@ -7621,156 +7621,156 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -7779,68 +7779,68 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -7849,64 +7849,64 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - - - + + + + - - + - - + + - - - - - - - - - + + + + - + - + - + - + - + - + - + + + + + + - + @@ -7920,7 +7920,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -7934,7 +7934,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -7948,7 +7948,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -7962,7 +7962,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -7976,7 +7976,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -8004,7 +8004,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -8034,7 +8034,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - +

@@ -8045,7 +8045,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8053,24 +8053,22 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - + -

AKA Bile acid-CoA ligase, gene symbol: SLC27A5, Long-chain fatty acid transport protein 5 - -

+

@@ -8078,7 +8076,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8086,19 +8084,19 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - +

@@ -8109,7 +8107,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8119,22 +8117,20 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + -

Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoA [Source: UniProt] - -

+

@@ -8142,7 +8138,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8152,20 +8148,20 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + -

AKA SLC10A1 +

AKA FABP6

@@ -8175,7 +8171,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8183,19 +8179,19 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - +
- +

@@ -8206,7 +8202,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8216,22 +8212,20 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + -

Alternative name: Cerebrotendinous Xanthomatosis (CTX) - -

+

@@ -8239,17 +8233,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - - - - - - - - - - - + @@ -8257,24 +8241,22 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - + -

AKA FABP6 - -

+

@@ -8282,7 +8264,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8290,22 +8272,22 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - + - + -

OMIM for gene, no disease available yet. +

AKA cholyltaurine

@@ -8315,7 +8297,7 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + @@ -8323,24 +8305,22 @@ This pathway is based on Chapter 34 of Blau’s ‘Physicians Guide to the Diagn - + - + - + - +
- + -

Alternative name: Rotor syndrome - -OMIM identifier of Rotor syndrome: 605495 +

C27-carboxylic acid

@@ -8350,12 +8330,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + @@ -8363,22 +8338,24 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

+

AKA SLCO1B1 + +

@@ -8386,7 +8363,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8394,22 +8371,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

AKA THC-CoA +

AKA sterol 27-hydroxylase

@@ -8419,7 +8396,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8427,19 +8404,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- +

@@ -8450,7 +8427,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8458,19 +8435,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - +

@@ -8481,7 +8458,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8489,24 +8466,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

Full name: 3β-Hydroxy-Δ5-C27-steroid dehydrogenase/isomerase deficiency (C27-3β-HSD) - -

+

@@ -8514,22 +8489,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - - - - - - - - - - - + @@ -8537,24 +8497,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

AKA cholyltaurine - -

+

@@ -8562,7 +8520,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8572,20 +8530,20 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + -

AKA SLCO1B1 +

Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoA [Source: UniProt]

@@ -8595,7 +8553,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8603,22 +8561,24 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

+

AKA ABCC2 + +

@@ -8626,7 +8586,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8634,22 +8594,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

Alternative name: Progressive familial intrahepatic cholestasis type 3 +

AKA SLCO1B3

@@ -8659,12 +8619,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + @@ -8672,19 +8627,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- +

@@ -8695,7 +8650,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8703,24 +8658,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

Alternative name: 3β,7α-Dihydroxy-5-cholestenoic acid - -

+

@@ -8728,7 +8681,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8738,17 +8691,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - +

@@ -8759,7 +8712,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8767,32 +8720,63 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

AKA THCA, trihydroxycholestanoic acid, 3α,7α,12α-trihydroxy-5β-cholestanoic acid +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

AKA THC-CoA

- + - + @@ -8802,30 +8786,30 @@ OMIM identifier of Rotor syndrome: 605495 - + - +
- + -

AKA ABCC3 +

Alternative name: 5β-Cholestan-3α,7α,27-triol

- + - + @@ -8833,19 +8817,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- +

Full name: Bile acid-CoA: amino acid N-acyltransferase (BAAT) deficiency @@ -8855,7 +8839,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -8873,30 +8857,28 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + -

AKA ABCB1A (PMID:21103970), UniProt: ABCB1 (ABCB1A is used for mouse). MDR1A in Figure (PMID:21103970) - -

+

- + - + @@ -8904,19 +8886,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - +

@@ -8924,10 +8906,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -8937,28 +8919,30 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + -

+

AKA ABCC3 + +

- + - + @@ -8966,19 +8950,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- +

@@ -8986,15 +8970,10 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + - + @@ -9002,30 +8981,34 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

+

Full name: very long chain acyl-CoA synthase (VLCS)/di-/trihydroxycholestanoic acid-CoA ligase + +Check annotation of this enzyme! + +

- + - + @@ -9033,38 +9016,30 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

amino acid N-acyltransferase (BAAT), which has -a dual localization (peroxisome and cytosol) - -

+

- - - - - - + - + @@ -9072,19 +9047,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - +

Full name: Δ4-3-Oxosteroid-5β-reductase (SRD5B1) deficiency @@ -9094,7 +9069,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9122,17 +9097,17 @@ a dual localization (peroxisome and cytosol) - + - + - +

@@ -9140,95 +9115,78 @@ a dual localization (peroxisome and cytosol) - - - - - - + - - - - - - + - + - - - - - -

- - - - - - - - - - - - - - - - + - + - + - + - + -

+

Alternative name: Cerebrotendinous Xanthomatosis (CTX) + +

+ + + + + + + + + + + + + + + - - - - - - + - + - + - +
- + -

+

Alternative name: Progressive familial intrahepatic cholestasis type 3 + +

@@ -9236,7 +9194,12 @@ a dual localization (peroxisome and cytosol) - + + + + + + @@ -9244,19 +9207,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - +
- +

@@ -9267,7 +9230,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9275,19 +9238,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - +

@@ -9298,7 +9261,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9306,19 +9269,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - +

@@ -9329,7 +9292,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9339,20 +9302,22 @@ a dual localization (peroxisome and cytosol) - + - + - + -

+

Abbreviation: BA CoA LD + +

@@ -9360,7 +9325,12 @@ a dual localization (peroxisome and cytosol) - + + + + + + @@ -9368,19 +9338,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - +
- +

@@ -9391,7 +9361,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9399,19 +9369,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - +

@@ -9422,7 +9392,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9432,17 +9402,17 @@ a dual localization (peroxisome and cytosol) - + - + - +

AKA CBaS5 @@ -9465,17 +9435,17 @@ a dual localization (peroxisome and cytosol) - + - + - +

@@ -9486,7 +9456,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9496,20 +9466,20 @@ a dual localization (peroxisome and cytosol) - + - + - + -

AKA THC-CoA +

OMIM for gene, no disease available yet.

@@ -9519,7 +9489,7 @@ a dual localization (peroxisome and cytosol) - + @@ -9527,19 +9497,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - +
- +

@@ -9548,29 +9518,29 @@ a dual localization (peroxisome and cytosol) + + + + + - - - - - - + - + - + - + - +

@@ -9591,20 +9561,20 @@ a dual localization (peroxisome and cytosol) - + - + - + -

Full name: 3β-Hydroxy-Δ5-C27-steroid dehydrogenase/isomerase deficiency (C27-3β-HSD) +

AKA ABBC4 (PMID:21103970); according to UniProt ABCC4 is the correct gene name.

@@ -9614,22 +9584,38 @@ a dual localization (peroxisome and cytosol) - - - - - - - - - - - + + + + + + + + + + + + + + + + + +
+ + + +

+ + + + + - + @@ -9637,32 +9623,42 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - + -

C27-carboxylic acid +

Alternative name: Oxysterol 7α-hydroxylase deficiency

- + - + + + + + + + + + + + @@ -9670,19 +9666,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - +
- +

@@ -9690,10 +9686,10 @@ a dual localization (peroxisome and cytosol) - + - + @@ -9703,37 +9699,37 @@ a dual localization (peroxisome and cytosol) - + - + - + -

Alternative name: Dubin-Johnson syndrome (DJS) +

Alternative name: Rotor syndrome -Second OMIM identifier: 601107 +OMIM identifier of Rotor syndrome: 605495

- + - + - + @@ -9743,17 +9739,17 @@ Second OMIM identifier: 601107 - + - +
- +

@@ -9761,30 +9757,25 @@ Second OMIM identifier: 601107 - - - - - - + - + - + - + - + - +

@@ -9792,10 +9783,10 @@ Second OMIM identifier: 601107 - + - + @@ -9803,19 +9794,19 @@ Second OMIM identifier: 601107 - + - + - + - + - +

@@ -9823,10 +9814,10 @@ Second OMIM identifier: 601107 - + - + @@ -9834,30 +9825,33 @@ Second OMIM identifier: 601107 - + - + - + - + - + -

+

amino acid N-acyltransferase (BAAT), which has +a dual localization (peroxisome and cytosol) + +

- + - + @@ -9865,32 +9859,37 @@ Second OMIM identifier: 601107 - + - + - + - +
- + -

AKA cholyltaurine +

- + - + + + + + + @@ -9898,19 +9897,19 @@ Second OMIM identifier: 601107 - + - + - + - +
- +

@@ -9918,10 +9917,15 @@ Second OMIM identifier: 601107 - + - + + + + + + @@ -9929,19 +9933,19 @@ Second OMIM identifier: 601107 - + - + - + - + - +

@@ -9949,10 +9953,10 @@ Second OMIM identifier: 601107 - + - + @@ -9962,35 +9966,28 @@ Second OMIM identifier: 601107 - + - + - + -

Abbreviation: BA CoA LD - -

+

- - - - - - + - + @@ -9998,32 +9995,32 @@ Second OMIM identifier: 601107 - + - + - + - + - + -

AKA SLCO1B3 +

AKA THCA, trihydroxycholestanoic acid, 3α,7α,12α-trihydroxy-5β-cholestanoic acid

- + - + @@ -10031,49 +10028,47 @@ Second OMIM identifier: 601107 - + - + - + - +
- + -

Abbreviation: DBP deficiency - -Alternative names: 17-beta-hydroxysteroid dehydrogenase IV deficiency, Peroxisomal bifunctional enzyme (PBFE) deficiency +

Full name: α-Methylacyl-CoA racemase deficiency

- + - + - + - + - + @@ -10083,59 +10078,42 @@ Alternative names: 17-beta-hydroxysteroid dehydrogenase IV deficiency, Peroxisom - + - +
- + -

+

AKA conjugated bile acid hydrolase, or CBAH, bacterial conversion + +Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), C. perfringens, based on Table 1 from PMID: 30098054 + +

- + - + - - - - - - - - - - - - - - - - -
- - - -

- - - - - - + + + + + + @@ -10143,19 +10121,19 @@ Alternative names: 17-beta-hydroxysteroid dehydrogenase IV deficiency, Peroxisom - + - + - + - + - +

amino acid N-acyltransferase (BAAT), which has @@ -10172,6 +10150,11 @@ a dual localization (peroxisome and cytosol) + + + + + @@ -10179,20 +10162,22 @@ a dual localization (peroxisome and cytosol) - + - + - + -

+

heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51B based on UniProt entry (gene name not mentioned in publication) + +

@@ -10200,7 +10185,7 @@ a dual localization (peroxisome and cytosol) - + @@ -10208,19 +10193,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - +
- +

@@ -10231,7 +10216,7 @@ a dual localization (peroxisome and cytosol) - + @@ -10241,20 +10226,22 @@ a dual localization (peroxisome and cytosol) - + - + - + -

+

AKA SLC10A1 + +

@@ -10262,7 +10249,7 @@ a dual localization (peroxisome and cytosol) - + @@ -10270,24 +10257,22 @@ a dual localization (peroxisome and cytosol) - + - + - + - +
- + -

Alternative name: Oxysterol 7α-hydroxylase deficiency - -

+

@@ -10295,17 +10280,7 @@ a dual localization (peroxisome and cytosol) - - - - - - - - - - - + @@ -10313,19 +10288,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - +

@@ -10334,24 +10309,29 @@ a dual localization (peroxisome and cytosol) + + + + + - + - + - + - + - +

@@ -10362,7 +10342,7 @@ a dual localization (peroxisome and cytosol) - + @@ -10370,19 +10350,19 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - +

@@ -10391,29 +10371,29 @@ a dual localization (peroxisome and cytosol) - - - - - - + - + - + + + + + + - + - +

@@ -10424,7 +10404,7 @@ a dual localization (peroxisome and cytosol) - + @@ -10434,17 +10414,17 @@ a dual localization (peroxisome and cytosol) - + - + - +

@@ -10455,7 +10435,7 @@ a dual localization (peroxisome and cytosol) - + @@ -10463,26 +10443,22 @@ a dual localization (peroxisome and cytosol) - + - + - + - + - + -

Full name: very long chain acyl-CoA synthase (VLCS)/di-/trihydroxycholestanoic acid-CoA ligase - -Check annotation of this enzyme! - -

+

@@ -10490,7 +10466,7 @@ Check annotation of this enzyme! - + @@ -10498,24 +10474,22 @@ Check annotation of this enzyme! - + - + - + - + - + -

Alternative name: Progressive familial intrahepatic cholestasis type 2 (PFIC2) - -

+

@@ -10523,12 +10497,7 @@ Check annotation of this enzyme! - - - - - - + @@ -10536,19 +10505,19 @@ Check annotation of this enzyme! - + - + - + - + - +

@@ -10559,7 +10528,7 @@ Check annotation of this enzyme! - + @@ -10567,22 +10536,24 @@ Check annotation of this enzyme! - + - + - + - + - + -

+

AKA cholyltaurine + +

@@ -10590,7 +10561,7 @@ Check annotation of this enzyme! - + @@ -10600,17 +10571,17 @@ Check annotation of this enzyme! - + - +
- +

@@ -10621,7 +10592,7 @@ Check annotation of this enzyme! - + @@ -10631,20 +10602,24 @@ Check annotation of this enzyme! - + - + - + -

+

Abbreviation: DBP deficiency + +Alternative names: 17-beta-hydroxysteroid dehydrogenase IV deficiency, Peroxisomal bifunctional enzyme (PBFE) deficiency + +

@@ -10652,7 +10627,22 @@ Check annotation of this enzyme! - + + + + + + + + + + + + + + + + @@ -10660,19 +10650,19 @@ Check annotation of this enzyme! - + - + - + - +
- +

@@ -10683,7 +10673,7 @@ Check annotation of this enzyme! - + @@ -10693,20 +10683,22 @@ Check annotation of this enzyme! - + - + - + -

+

AKA Bile acid-CoA ligase, gene symbol: SLC27A5, Long-chain fatty acid transport protein 5 + +

@@ -10714,7 +10706,7 @@ Check annotation of this enzyme! - + @@ -10722,24 +10714,22 @@ Check annotation of this enzyme! - + - + - + - +
- + -

aka sterol 7α-hydroxylase - -

+

@@ -10747,7 +10737,7 @@ Check annotation of this enzyme! - + @@ -10755,22 +10745,24 @@ Check annotation of this enzyme! - + - + - + - + - + -

+

AKA SLC10A2 + +

@@ -10778,7 +10770,7 @@ Check annotation of this enzyme! - + @@ -10786,22 +10778,26 @@ Check annotation of this enzyme! - + - + - + - +
- + -

+

Alternative name: Rotor syndrome + +OMIM identifier of Rotor syndrome: 605495 + +

@@ -10809,7 +10805,12 @@ Check annotation of this enzyme! - + + + + + + @@ -10817,22 +10818,24 @@ Check annotation of this enzyme! - + - + - + - +
- + -

+

Alternative name: Progressive familial intrahepatic cholestasis type 1 (PFIC1) + +

@@ -10840,7 +10843,12 @@ Check annotation of this enzyme! - + + + + + + @@ -10848,22 +10856,22 @@ Check annotation of this enzyme! - + - + - + - +
- + -

+

AKA ABCB11

@@ -10873,12 +10881,7 @@ Check annotation of this enzyme! - - - - - - + @@ -10886,19 +10889,19 @@ Check annotation of this enzyme! - + - + - + - +
- +

@@ -10909,7 +10912,7 @@ Check annotation of this enzyme! - + @@ -10919,17 +10922,17 @@ Check annotation of this enzyme! - + - + - +

@@ -10940,7 +10943,7 @@ Check annotation of this enzyme! - + @@ -10950,22 +10953,20 @@ Check annotation of this enzyme! - + - + - + -

Alternative name: 5β-Cholestan-3α,7α,27-triol - -

+

@@ -10973,7 +10974,7 @@ Check annotation of this enzyme! - + @@ -10983,20 +10984,22 @@ Check annotation of this enzyme! - + - + - + -

AKA ABCB11 +

Alternative name: Dubin-Johnson syndrome (DJS) + +Second OMIM identifier: 601107

@@ -11006,7 +11009,12 @@ Check annotation of this enzyme! - + + + + + + @@ -11014,26 +11022,22 @@ Check annotation of this enzyme! - + - + - + - +
- + -

AKA conjugated bile acid hydrolase, or CBAH, bacterial conversion - -Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), C. perfringens, based on Table 1 from PMID: 30098054 - -

+

@@ -11041,17 +11045,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - - - - - - - - - - - + @@ -11059,19 +11053,19 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + - + - +

@@ -11082,7 +11076,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11092,22 +11086,20 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + -

heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51A based on UniProt entry (gene name not mentioned in publication) - -

+

@@ -11115,7 +11107,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11123,19 +11115,19 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + - + - +

@@ -11146,7 +11138,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11156,20 +11148,22 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + -

+

aka sterol 7α-hydroxylase + +

@@ -11177,7 +11171,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11187,20 +11181,22 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - +
- + -

+

Full name: 3β-Hydroxy-Δ5-C27-steroid dehydrogenase/isomerase deficiency (C27-3β-HSD) + +

@@ -11208,7 +11204,22 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + + + + + + + + + + + + + + + + @@ -11216,19 +11227,19 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + - +
- +

@@ -11239,7 +11250,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11249,22 +11260,20 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + -

Alternative name: Progressive familial intrahepatic cholestasis type 1 (PFIC1) - -

+

@@ -11272,12 +11281,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - - - - - - + @@ -11285,22 +11289,22 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + - + - + -

AKA ABCC2 +

Alternative name: 3β,7α-Dihydroxy-5-cholestenoic acid

@@ -11310,7 +11314,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11318,24 +11322,22 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + - +
- + -

heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51B based on UniProt entry (gene name not mentioned in publication) - -

+

@@ -11343,7 +11345,7 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + @@ -11351,26 +11353,22 @@ Tentatively annotated for species Clostridium perfringens (strain 13 / Type A), - + - + - + - + - + -

Alternative name: Rotor syndrome - -OMIM identifier of Rotor syndrome: 605495 - -

+

@@ -11378,12 +11376,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + @@ -11391,22 +11384,24 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

+

Full name: 3β-Hydroxy-Δ5-C27-steroid dehydrogenase/isomerase deficiency (C27-3β-HSD) + +

@@ -11414,7 +11409,22 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + + + + + + + + + + + @@ -11422,22 +11432,24 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

+

Alternative name: Progressive familial intrahepatic cholestasis type 2 (PFIC2) + +

@@ -11445,7 +11457,12 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + @@ -11453,24 +11470,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

AKA SLC10A2 - -

+

@@ -11478,7 +11493,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11486,19 +11501,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - +

@@ -11509,7 +11524,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11519,17 +11534,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - +

@@ -11540,7 +11555,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11550,20 +11565,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + -

+

AKA THC-CoA + +

@@ -11571,7 +11588,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11579,24 +11596,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

Full name: α-Methylacyl-CoA racemase deficiency - -

+

@@ -11604,22 +11619,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - - - - - - - - - - - + @@ -11627,22 +11627,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

AKA ABBC4 (PMID:21103970); according to UniProt ABCC4 is the correct gene name. +

AKA ABCB1A (PMID:21103970), UniProt: ABCB1 (ABCB1A is used for mouse). MDR1A in Figure (PMID:21103970)

@@ -11652,7 +11652,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11660,19 +11660,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- +

@@ -11683,7 +11683,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11693,17 +11693,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - +

@@ -11714,7 +11714,7 @@ OMIM identifier of Rotor syndrome: 605495 - + @@ -11722,22 +11722,22 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - + - + -

Abbreviation: CBAS6 +

heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51A based on UniProt entry (gene name not mentioned in publication)

@@ -11747,17 +11747,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - - - - - - + @@ -11765,22 +11755,24 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- + -

+

Abbreviation: CBAS6 + +

@@ -11788,7 +11780,17 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + + + + + + @@ -11796,41 +11798,21 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +
- - - -

- - - - - - - - - - - - - - - - - +

@@ -11838,10 +11820,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -11849,16 +11831,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + - + - +

@@ -11866,10 +11849,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -11877,30 +11860,28 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

Hydroxylation - -

+

- + - + @@ -11908,30 +11889,29 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - + - + -

Previous annotation Reactome R-HSA-194083 +

Enzymatic step: intraluminal bacterial deconjugation

- + - + @@ -11939,17 +11919,13 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - - -
- +

@@ -11957,10 +11933,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -11968,17 +11944,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -11986,41 +11962,39 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + - + - - + + - + - + -

Activated to CoA-ester at the endoplasmic reticulum. - -

+

- - - - - - + - + @@ -12028,18 +12002,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - - + - +

@@ -12047,10 +12020,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12058,28 +12031,29 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - + - + -

+

Enzymatic step: intraluminal bacterial deconjugation + +

- + - + @@ -12087,17 +12061,13 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - - -
- +

@@ -12105,10 +12075,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12116,17 +12086,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12134,10 +12104,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12145,17 +12115,16 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - + - +

@@ -12163,19 +12132,28 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + - + - + + + + + - +

@@ -12183,10 +12161,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12194,16 +12172,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + - + - +

@@ -12211,10 +12190,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12222,17 +12201,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12240,28 +12219,19 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + - + - - + - - - - +

@@ -12269,10 +12239,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12280,14 +12250,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + + + + - +

@@ -12295,10 +12268,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12306,17 +12279,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12324,58 +12297,39 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + - + - - + - - - - + -

Enzymatic step: intraluminal bacterial deconjugation. Hydrolysis of taurocholic acid yields taurine. - -

+

- - - - - - + - + - + - - - - +

@@ -12383,19 +12337,28 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + - + - + + + + + - +

@@ -12403,19 +12366,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +

@@ -12423,10 +12386,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12434,28 +12397,30 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

+

Enzymatic step: intraluminal bacterial deconjugation + +

- + - + @@ -12463,28 +12428,26 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - - -
- + -

+

Previous annotation Reactome R-HSA-194083 + +

- + - + @@ -12492,17 +12455,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - +
- +

@@ -12510,19 +12473,28 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + - + - + + + + + - +

@@ -12530,10 +12502,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12541,17 +12513,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12559,10 +12531,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12570,30 +12542,28 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

Enzymatic step: intraluminal bacterial deconjugation - -

+

- + - + @@ -12601,11 +12571,15 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + + + + @@ -12628,30 +12602,28 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

Enzymatic step: intraluminal bacterial deconjugation - -

+

- + - + @@ -12659,13 +12631,16 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + + + - +

@@ -12673,10 +12648,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12684,17 +12659,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12702,10 +12677,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12713,39 +12688,46 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

Assummed to be a spontenous conversion - -

+

- + + + + + + - + - + + + + + - +

@@ -12753,19 +12735,25 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + - + - + + - +

@@ -12773,10 +12761,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12784,67 +12772,68 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + - + - + -

+

Assummed to be a spontenous conversion + +

- - - - - - + - + - - + - - -
- + -

Assummed to be a spontenous conversion - -

+

- + + + + + + - + + + + + - +

@@ -12852,19 +12841,28 @@ OMIM identifier of Rotor syndrome: 605495 - + + + + + + - + - + + + + + - +

@@ -12872,10 +12870,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12883,17 +12881,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12901,10 +12899,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12912,17 +12910,16 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - + - +

@@ -12930,10 +12927,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12941,17 +12938,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -12959,10 +12956,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -12970,30 +12967,28 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

Enzymatic step: intraluminal bacterial deconjugation - -

+

- + - + @@ -13001,13 +12996,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + + + + - +

@@ -13015,19 +13014,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +

@@ -13035,10 +13034,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13046,17 +13045,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -13064,28 +13063,19 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + - + - - + - - - - +

@@ -13093,28 +13083,19 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + - + - - + - - - - +

@@ -13122,28 +13103,19 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + - + - - + - - - - +

@@ -13151,10 +13123,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13162,28 +13134,30 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

+

Enzymatic step: intraluminal bacterial deconjugation. Hydrolysis of taurocholic acid yields taurine. + +

- + - + @@ -13191,17 +13165,16 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + - +
- +

@@ -13209,10 +13182,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13220,17 +13193,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -13238,10 +13211,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13249,17 +13222,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -13267,12 +13240,7 @@ OMIM identifier of Rotor syndrome: 605495 - - - - - - + @@ -13281,14 +13249,10 @@ OMIM identifier of Rotor syndrome: 605495 - - + - - - - +

@@ -13296,10 +13260,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13307,17 +13271,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -13325,10 +13289,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13336,28 +13300,35 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - + -

+

Activated to CoA-ester at the endoplasmic reticulum. + +

- + - + + + + + + @@ -13365,17 +13336,18 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + +
- +

@@ -13383,19 +13355,19 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + - +

@@ -13403,10 +13375,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13414,16 +13386,39 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + - + - + + + +

Assummed to be a spontenous conversion + +

+ +
+ + + + + + + + + + + + + +
+

@@ -13431,10 +13426,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13442,16 +13437,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - + + - + - +

@@ -13459,10 +13455,10 @@ OMIM identifier of Rotor syndrome: 605495 - + - + @@ -13470,17 +13466,17 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - + - +

@@ -13488,30 +13484,36 @@ OMIM identifier of Rotor syndrome: 605495 - + - + - + + + + + - + -

+

Hydroxylation + +

- + - + @@ -13519,14 +13521,14 @@ OMIM identifier of Rotor syndrome: 605495 - + - - + + - +
diff --git a/sbml/WP5176.svg b/sbml/WP5176.svg index f984e39..5c6226c 100644 --- a/sbml/WP5176.svg +++ b/sbml/WP5176.svg @@ -74,145 +74,24 @@ >CANALICULUS?cf3c5?cf3c5Bile acid-CoAligase deficiencySCPx3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acidBilirubin disposal3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoATaurine3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid3alpha,7alpha-dihydroxy-5beta-cholestan-26-alBACSglycocholateCBHBilirubin disposal(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoAACOX23alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al5beta-cholestane-3alpha,7alpha,26-triol(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA3α,7α,12α-trihydroxy-24-oxo-5β-cholestan-26-oyl-CoAtaurocholateSCPx3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoACBH3α,7α,12α-trihydroxy-24-oxo-5β-cholestan-26-oyl-CoAACOX2BACS3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoATaurine3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA3alpha,7alpha-dihydroxy-5beta-cholestan-26-al3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid5beta-cholestane-3alpha,7alpha,26-triol(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoAASBTMore significant in adults.Assummed to be spontenous conversions (pH difference)'Acidic' pathway + +also known as 'Alternative' pathway; More prominant early in life.More prominant early in life.- Side-chain shortening through β-oxidation - Converting C27-bile acids (cholestanoids) to C24-bile acids (cholanoids). - Amidation of newly synthesized bile acidsMore significant in adults.HEPATOCYTEAssummed to be spontenous conversions (pH difference)DiseaseConnection to diseaseTransporters:MetaboliteProteinCatalysisConversionDiseaseConnection to diseaseGeneProductProteinLegendConversion- Amidation of recycled bile acids'Acidic' pathway - -also known as 'Alternative' pathway; More prominant early in life.- Side-chain shortening through β-oxidation - Converting C27-bile acids (cholestanoids) to C24-bile acids (cholanoids). - Amidation of newly synthesized bile acidsPORTAL BLOOD SYSTEM - + @@ -76,9 +76,9 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. + - @@ -147,14 +147,6 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - - - - - @@ -163,12 +155,12 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + @@ -179,212 +171,204 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - - + + - - - - - - - - - - + + - - - + + + - + - + - + - - - + + + - + - - - + + + - + - + - + - + - + - - - + + + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - - - + + + - - + + - + + + + + + + + + - + @@ -395,52 +379,36 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - - - - - - + - + - - - - - - - - - + - + - - - + + + - + - + - + @@ -451,12 +419,28 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + + + + + + + + + + + + + + + + + @@ -467,87 +451,62 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - + + + - - + + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - - - - - - - - - - - - - - - - - @@ -556,70 +515,78 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - + + + - - + + - + - + - + - + - + - + - - - + + + - + - + - + - - - + + + - + - + - + + + + + + + + + @@ -628,110 +595,134 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - - - + + + - + - + + + + + + + + + + + + + + + + + + - + - - - + + + - - + + - - - + + + - + - + - + + + + + + + + + + + + + + + + + - - - - - - - - - - - + + - + - + - - - - + - - - - + + + + - + + + + - + - + - - - - + + + + @@ -742,79 +733,52 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - - - - - - - + - - - - + + + + - + - + - - - - - - - - - - - - - - - - - + + - + - - - - + - + - - - - + + + + - + - + - + @@ -826,19 +790,19 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + - + - + @@ -850,169 +814,199 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - - - + + + + - + - + - - - - + - - - - + - + - - - - + + + + - - + + - + - - - - - - - + - - - - + + + + - + - + - + - - - - + + + + - + - + - - + + - + - + - - - - + + + + - + - + - + + + + + + + + + + + + + + + + + + + - + - + - - - - + + + + + + + + + + + + + + + + + + + + + + - + - + - + + + + + + + - - - - + + + + - + - + - + @@ -1024,14 +1018,29 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - + + + + + + + + + + + + + + + + + - + - + @@ -1040,12 +1049,15 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + + + + @@ -1057,38 +1069,26 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - + - - - - - - - - - - - + + - + - + - - + + - - - - + + + + @@ -1100,10 +1100,10 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + @@ -1127,19 +1127,19 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + - - - - + + + + @@ -1169,37 +1169,37 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + + + + - + - - - - + + + + - - - - + - + - + - - - - + + + + @@ -1210,74 +1210,74 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + + + + - - - - + + + + - - - - + - - + + + + + - - - - + + + + - + - + + + + - + - - - - + + + + - - - - - - - + - + - - + + - - - - + + + + @@ -1329,34 +1329,34 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - - - - + - + - - + + - + - + - - + + + + + + + + @@ -1367,256 +1367,250 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - + - - - - - - - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + + + + + + + - + - - + + @@ -1625,227 +1619,263 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - + + + + + + + - + - + + + + + + + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - - - - - - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -1855,7 +1885,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -1865,7 +1895,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -1879,7 +1909,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -1889,7 +1919,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -1899,7 +1929,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -1911,545 +1941,523 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + + + + + + + + + + + + + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -2459,7 +2467,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -2473,7 +2481,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -2483,47 +2491,47 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -2535,64 +2543,52 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - + + - + - - + + - - - - - - - - - - - - - + - - + + - + - - + + @@ -2633,22 +2629,22 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + - + @@ -2665,52 +2661,52 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -2749,95 +2745,59 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - - - - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + @@ -2847,7 +2807,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -2857,7 +2817,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -2869,116 +2829,156 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + + + + + + + + + + + + + - - + + + + + + + + + + + + @@ -2987,22 +2987,16 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - - - - + - - + + @@ -3011,160 +3005,154 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - - - - - - - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -3173,51 +3161,51 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + @@ -3227,46 +3215,52 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + + + + + + + - + - - + + @@ -3275,21 +3269,33 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - + + + + + + + - + - + + + + + + + @@ -3299,46 +3305,40 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -3347,51 +3347,51 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + @@ -3403,19 +3403,19 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + @@ -3427,37 +3427,37 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + - + - + - + @@ -3465,49 +3465,49 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + - + + + + + + - + - + - + - + - + - + - + - - - - - - + - + - + - + @@ -3516,12 +3516,12 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + @@ -3535,7 +3535,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - +

@@ -3549,7 +3549,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - +

@@ -3579,7 +3579,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - +

@@ -3590,7 +3590,7 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + @@ -3598,19 +3598,24 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. - + - + - + + + + + + - + - +

@@ -3619,30 +3624,32 @@ This pathway is based on the fructose metabolism pathway (Chapter 18, Figure 18. + + + + + - + - + - + - + - + -

Mutation results in nonspherocytic hemolytic anemia. -The deficiency is only detected in erythrocytes. - -

+

@@ -3650,7 +3657,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3658,19 +3665,19 @@ The deficiency is only detected in erythrocytes. - + - + - + - + - +

@@ -3681,7 +3688,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3689,19 +3696,19 @@ The deficiency is only detected in erythrocytes. - + - + - + - + - +

@@ -3712,7 +3719,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3720,19 +3727,19 @@ The deficiency is only detected in erythrocytes. - + - + - + - + - +

@@ -3743,7 +3750,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3751,19 +3758,19 @@ The deficiency is only detected in erythrocytes. - + - + - + - + - +

@@ -3774,7 +3781,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3784,22 +3791,22 @@ The deficiency is only detected in erythrocytes. - + - + - + - +

@@ -3810,7 +3817,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3818,24 +3825,22 @@ The deficiency is only detected in erythrocytes. - + - + - + - + - + -

Mutation results in global developmental delay, variable visual defects and variable structural brain abnormalities. - -

+

@@ -3843,7 +3848,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3851,19 +3856,19 @@ The deficiency is only detected in erythrocytes. - + - + - + - + - +

@@ -3872,6 +3877,11 @@ The deficiency is only detected in erythrocytes. + + + + + @@ -3879,20 +3889,22 @@ The deficiency is only detected in erythrocytes. - + - + - + -

+

+ +

@@ -3900,7 +3912,7 @@ The deficiency is only detected in erythrocytes. - + @@ -3910,30 +3922,20 @@ The deficiency is only detected in erythrocytes. - - - - - - + - +
- + -

Mutation results in night blindness, patchy vision, -potential loss of central vision, and a -slow rate of vision loss, - - -

+

@@ -3941,7 +3943,12 @@ slow rate of vision loss, - + + + + + + @@ -3949,19 +3956,19 @@ slow rate of vision loss, - + - + - + - + - +

@@ -3972,7 +3979,7 @@ slow rate of vision loss, - + @@ -3982,20 +3989,22 @@ slow rate of vision loss, - + - + - + -

+

Mutation results in global developmental delay, variable visual defects and variable structural brain abnormalities. + +

@@ -4003,12 +4012,7 @@ slow rate of vision loss, - - - - - - + @@ -4016,19 +4020,19 @@ slow rate of vision loss, - + - + - + - +
- +

@@ -4039,7 +4043,7 @@ slow rate of vision loss, - + @@ -4047,19 +4051,19 @@ slow rate of vision loss, - + - + - + - + - +

@@ -4068,24 +4072,34 @@ slow rate of vision loss, + + + + + - + - + - + + + + + + - + - +

@@ -4096,7 +4110,7 @@ slow rate of vision loss, - + @@ -4106,17 +4120,17 @@ slow rate of vision loss, - + - + - +

@@ -4125,29 +4139,24 @@ slow rate of vision loss, - - - - - - + - + - + - + - +

@@ -4158,7 +4167,7 @@ slow rate of vision loss, - + @@ -4166,19 +4175,19 @@ slow rate of vision loss, - + - + - + - + - +

@@ -4187,29 +4196,24 @@ slow rate of vision loss, - - - - - - + - + - + - + - +

@@ -4220,7 +4224,12 @@ slow rate of vision loss, - + + + + + + @@ -4228,19 +4237,19 @@ slow rate of vision loss, - + - + - + - + - +

@@ -4256,17 +4265,17 @@ slow rate of vision loss, - + - + - +

@@ -4277,7 +4286,7 @@ slow rate of vision loss, - + @@ -4285,24 +4294,27 @@ slow rate of vision loss, - + - + - + + + + + + - + - + -

- -

+

@@ -4310,7 +4322,7 @@ slow rate of vision loss, - + @@ -4320,17 +4332,17 @@ slow rate of vision loss, - + - + - +

@@ -4341,7 +4353,7 @@ slow rate of vision loss, - + @@ -4351,20 +4363,25 @@ slow rate of vision loss, - + - + - + -

+

Mutation results in night blindness, patchy vision, +potential loss of central vision, and a +slow rate of vision loss, + + +

@@ -4372,7 +4389,7 @@ slow rate of vision loss, - + @@ -4380,19 +4397,19 @@ slow rate of vision loss, - + - + - + - +
- +

@@ -4403,12 +4420,7 @@ slow rate of vision loss, - - - - - - + @@ -4416,19 +4428,19 @@ slow rate of vision loss, - + - + - + - + - +

@@ -4439,12 +4451,7 @@ slow rate of vision loss, - - - - - - + @@ -4452,19 +4459,19 @@ slow rate of vision loss, - + - + - + - + - +

@@ -4475,7 +4482,7 @@ slow rate of vision loss, - + @@ -4485,22 +4492,17 @@ slow rate of vision loss, - - - - - - + - + - +

@@ -4511,7 +4513,7 @@ slow rate of vision loss, - + @@ -4521,17 +4523,17 @@ slow rate of vision loss, - + - + - +

@@ -4542,7 +4544,7 @@ slow rate of vision loss, - + @@ -4550,22 +4552,25 @@ slow rate of vision loss, - + - + - + - + - + -

+

Mutation results onset of distal muscle weakness, eventually resulting in difficulty walking. +other symptoms include distal sensory impairment, upper limb tremor, and scoliosis. + +

@@ -4573,7 +4578,7 @@ slow rate of vision loss, - + @@ -4581,25 +4586,22 @@ slow rate of vision loss, - + - + - + - +
- + -

Mutation results onset of distal muscle weakness, eventually resulting in difficulty walking. -other symptoms include distal sensory impairment, upper limb tremor, and scoliosis. - -

+

@@ -4607,7 +4609,12 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + @@ -4617,17 +4624,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - +

@@ -4636,24 +4643,29 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios + + + + + - + - + - + - + - +

@@ -4662,29 +4674,24 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - + - +

@@ -4695,7 +4702,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -4703,19 +4710,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - +

@@ -4726,12 +4733,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + @@ -4739,19 +4741,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - +

@@ -4762,7 +4764,12 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + @@ -4770,24 +4777,22 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - + -

Peripheral neuropathy characterized by onset of distal lower limb weakness and muscle atrophy resulting in walking difficulties. - -

+

@@ -4795,7 +4800,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -4803,19 +4808,24 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + + + + + + - + - +

@@ -4841,17 +4851,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - +

@@ -4862,7 +4872,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -4870,19 +4880,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - +

@@ -4893,7 +4903,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -4903,22 +4913,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - +

@@ -4929,7 +4934,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -4939,17 +4944,22 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + - + - +

@@ -4960,7 +4970,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -4968,24 +4978,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - + - +

@@ -4996,7 +5001,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5006,17 +5011,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - +

@@ -5027,7 +5032,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5037,17 +5042,22 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + - + - +

@@ -5058,7 +5068,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5066,24 +5076,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - + - +

@@ -5094,7 +5099,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5102,22 +5107,22 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - + -

Mutation results in nonspherocytic hemolytic anemia. Resulted in a deficiency of erythrocyte and granulocyte enzyme activity. +

Characterized by congenital hemolytic anemia, and progressive neuromuscular dysfunction. Additional signs can be dystonic posturing and/or spasticity.

@@ -5127,7 +5132,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5137,17 +5142,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - +
- +

@@ -5158,12 +5163,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + @@ -5173,20 +5173,21 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + -

Characterized by congenital hemolytic anemia, and progressive neuromuscular dysfunction. Additional signs can be dystonic posturing and/or spasticity. +

Mutation results in nonspherocytic hemolytic anemia. +The deficiency is only detected in erythrocytes.

@@ -5196,7 +5197,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5206,17 +5207,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - +
- +

@@ -5227,7 +5228,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5235,19 +5236,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - +

@@ -5258,7 +5259,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5266,19 +5267,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - + - +

@@ -5289,7 +5290,12 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + @@ -5299,20 +5305,22 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + -

+

Peripheral neuropathy characterized by onset of distal lower limb weakness and muscle atrophy resulting in walking difficulties. + +

@@ -5320,7 +5328,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5328,22 +5336,24 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - +
- + -

+

Mutation results in nonspherocytic hemolytic anemia. Resulted in a deficiency of erythrocyte and granulocyte enzyme activity. + +

@@ -5351,7 +5361,7 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + @@ -5359,24 +5369,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - +
- +

@@ -5385,11 +5390,6 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - @@ -5397,19 +5397,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - +

@@ -5417,32 +5417,36 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + + + + + + + - + -

this is the reaction as it is in the referred book. This reaction should not be possible in humans according to databases. However, it is possible in E.coli K12 bacteria which are part of the human intestinal flora. - -

+

- + - + @@ -5450,17 +5454,16 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - + - + - +

@@ -5468,16 +5471,16 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + @@ -5499,18 +5502,18 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - - + + + - +

@@ -5518,27 +5521,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - - - - +

@@ -5546,10 +5541,10 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + @@ -5557,17 +5552,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - + + - + - +

@@ -5575,19 +5570,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - +

@@ -5595,10 +5590,10 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + @@ -5606,17 +5601,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - + + - + - +

@@ -5624,19 +5619,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - +

@@ -5644,25 +5639,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - - - + - - - - - +

@@ -5670,10 +5659,10 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + @@ -5681,17 +5670,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - + - + + - +

@@ -5699,19 +5688,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - +

@@ -5719,10 +5708,10 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + @@ -5730,17 +5719,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - + + - + - +

@@ -5748,28 +5737,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - - + - - - - +

@@ -5777,17 +5757,26 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + - + - + + + + + @@ -5803,13 +5792,13 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - +

@@ -5817,31 +5806,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - - - - - - - - +

@@ -5849,19 +5826,31 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + - + - + + + + + + + + - +

@@ -5869,17 +5858,26 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + - + - + + + + + @@ -5900,29 +5898,31 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - - + + + - + -

+

this is the reaction as it is in the referred book. This reaction should not be possible in humans according to databases. However, it is possible in E.coli K12 bacteria which are part of the human intestinal flora. + +

- + - + @@ -5930,14 +5930,14 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + + - - + @@ -5954,13 +5954,13 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - +

@@ -5968,10 +5968,10 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + @@ -5979,14 +5979,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - - + + + + + - +

@@ -5994,27 +5997,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - + - - - - +

@@ -6022,19 +6017,27 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + - + - + + + + - +

@@ -6042,19 +6045,19 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + - + - + - +

@@ -6062,7 +6065,12 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + + + + + @@ -6071,10 +6079,11 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - + + - +

@@ -6082,26 +6091,17 @@ other symptoms include distal sensory impairment, upper limb tremor, and scolios - - - - - - + - + - - + - - - diff --git a/sbml/WP5178.svg b/sbml/WP5178.svg index 14f9ce6..604e6b4 100644 --- a/sbml/WP5178.svg +++ b/sbml/WP5178.svg @@ -64,45 +64,47 @@ > alternative conversion or conversionin alternative entryFanconi-Bickel syndromeconversionalternative conversion or conversionin alternative entrySLC2A2 SorbitolSLC2A2Retinitis pigmentosa 79GeneIn fibroblastsERIn erythrocytesOccurs in erythrocytesDiseaseIn erythrocytesERMetabolite in alternative pathway for second entry into main pathwayDiseaseLiver cellGeneIn fibroblastsOccurs in erythrocytesMetaboliteLegendEnterocytesIn Schwann cellsMetabolitePathwayIn erythrocytesIn Schwann cells - + @@ -32,11 +32,11 @@ Metabolic Process - + - + @@ -68,34 +68,34 @@ Metabolic Process - + - + - + - + - + - + @@ -110,122 +110,74 @@ Metabolic Process - + - + - - - - - - - - - - - - - - - - - - - - + - - - + + + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - - - - - - - - - - - - - - - - @@ -243,6 +195,14 @@ Metabolic Process + + + + + + + + @@ -251,114 +211,136 @@ Metabolic Process - - - + + + - - + + - + - - - - + + + + - + - - - + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + + + + + + + + + + + + - - + + - + - - - - + + + + - + @@ -369,61 +351,61 @@ Metabolic Process - + - + - + - + - - - + + + - - + + - - - + + + - - + + - - - + + + - - + + - + - + - - - + + + - - + + @@ -444,91 +426,58 @@ Metabolic Process - - - - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - + - - - - + + + + - + - + - + - - - - - - - - - + - - - - + + + + @@ -536,221 +485,215 @@ Metabolic Process - + - + - + - + - + - - - + + + - - + + - + - - - - + + + + - + - - - + + + - - + + - + - + - + - + - - - - - - - - - - - - - - + + + - - + + - - - + + + - - + + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - - - + + + - - + + - + - + - + - + - - - + + + - - + + - + + + + + + + + + - - - - + + + + - + - + + + + + + + + + - + - + - + - + - + + + + + + + + + @@ -759,31 +702,71 @@ Metabolic Process - + + + + + + + + + - - - - + + + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + @@ -794,112 +777,129 @@ Metabolic Process - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - - - + + + - - + + - + - + - - - + + + - - + + - - + + - - - - - - - - + + + + + + - - + + - + - + - + - + - + - + - + + + + + + + + + - + - - - + + + - - + + @@ -909,378 +909,369 @@ Metabolic Process - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - - - + + + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - - + + - - - - + + + + - + - + - - + + + + + - - - - + + + + - - - - + - + - - + + + + + - - - - + + + + - - - - + - - + + + + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - - + + - + - - + + - - - - + + + + - - - - + + + + - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - - + + - - + + - - + + - - - - + + + + - - - - - - - + - - - - - - - - - - - + + - - - - + - - + + - - - - + + + + - + + + + - + - - - - + + + + - + - + - - + + + + + - - - - + + + + - - - - + - + - + - - - - + + + + - + - + - + - - + + - - - - + + + + @@ -1294,77 +1285,77 @@ Metabolic Process - + - - - - + + + + - + - + - + - - + + - - - - + + + + - + - + - + - - + + - - - - + + + + - + - + - + - - + + - - - - + + + + @@ -1378,14 +1369,14 @@ Metabolic Process - + - - - - + + + + @@ -1420,35 +1411,35 @@ Metabolic Process - + - - - - + + + + - + - + - + - - + + - - - - + + + + @@ -1459,218 +1450,218 @@ Metabolic Process - - - - + - - - - + + + + + + + - + - + - - - - + + + + - + - - - - + - - + + - - - - + + + + - + - + - + - + - - - - + + + + + + + - + - - - - + - - + + - - - - + + + + - + - + - - - - + - - - - + + + + - + - + - + - + - - - - + + + + - - + + - - + + - - + + - - + + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - - + + - - - - + + + + @@ -1684,89 +1675,98 @@ Metabolic Process - - - - + - - - - + + + + + + + - + - - + + + + + + + + + + + - + - - + + + + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - - - - - - - + - - + + + + + - - - - + + + + - - - - + @@ -1774,137 +1774,137 @@ Metabolic Process - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - + - + - + + + + - - - - + + + + - + - + - + - + - - - - + + + + - - - - - - - + - - + + + + + - - - - + + + + - + - + - + - + - - - - + + + + - - - - + - + - - - - + + + + @@ -1931,478 +1931,478 @@ Metabolic Process - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - - - - - - - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - - - - - - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - - + + - + - + - + - + - + + + + + + + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - + - + - - + + @@ -2411,1191 +2411,1211 @@ Metabolic Process - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + @@ -3605,7 +3625,7 @@ Metabolic Process - + @@ -3615,7 +3635,7 @@ Metabolic Process - + @@ -3625,7 +3645,7 @@ Metabolic Process - + @@ -3637,690 +3657,670 @@ Metabolic Process - + - - + + - + - - + + - + - - + + + + + + - + - - + + - + - - + + - + - - - - - - + + - + - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - - + + - - - - - - - - - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - + + - + - - + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - - - - - - - - - + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - - - - - - - - + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - - - - - - - - + - - + + - + - - + + @@ -4335,94 +4335,118 @@ Metabolic Process - + - - + + - + - - + + - + - - + + - + - + + + + + + + - + - + - + - - + + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - - + + - + - + - + + + + + + + + + + + + + + + + + + + - - + + @@ -4431,45 +4455,39 @@ Metabolic Process - + - + - - - - - - - + - + - + - + - + - + - + - - + + - + - + @@ -4479,178 +4497,172 @@ Metabolic Process - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - + - - - - - - - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + @@ -4659,46 +4671,40 @@ Metabolic Process - + - - + + - + - + - + - + - + - - + + - + - + - - - - - - - + - - + + @@ -4707,27 +4713,15 @@ Metabolic Process - - - - - - - - - - - - - + - - + + - + - + @@ -4737,76 +4731,82 @@ Metabolic Process - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - + + + + + + + - + - + - + - + - + - - + + @@ -4815,51 +4815,51 @@ Metabolic Process - + - - + + - + - - + + - + - + - + - + - + - - + + - + - + - + - - + + - + @@ -4867,110 +4867,124 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + - + + + + + + - - - - - - + - + - + - + + + + + + - + + + + + + - + - + - + - + - + @@ -4979,745 +4993,731 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - - + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - + + + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + - + - - - - - - - - - - - + - + - - - - - - - - - - - + - + - + - + + + + + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + - - - - - - + - + - + - + - - - - - - + - + - + - + - + - + - + - - - + + + @@ -5759,10 +5759,12 @@ Metabolic Process - + -

+

Gck is mainly active in liver + +

@@ -5770,7 +5772,7 @@ Metabolic Process - + @@ -5778,19 +5780,19 @@ Metabolic Process - + - + - + - +
- +

@@ -5799,29 +5801,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -5832,7 +5834,7 @@ Metabolic Process - + @@ -5840,19 +5842,19 @@ Metabolic Process - + - + - + - + - +

@@ -5861,34 +5863,32 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - + -

D-Glucose-6-Phosphate (2-) open form - -

+

@@ -5896,7 +5896,7 @@ Metabolic Process - + @@ -5904,19 +5904,19 @@ Metabolic Process - + - + - + - + - +

@@ -5927,7 +5927,7 @@ Metabolic Process - + @@ -5937,17 +5937,17 @@ Metabolic Process - + - + - +

@@ -5958,7 +5958,7 @@ Metabolic Process - + @@ -5966,19 +5966,19 @@ Metabolic Process - + - + - + - + - +

@@ -5989,7 +5989,7 @@ Metabolic Process - + @@ -5997,19 +5997,19 @@ Metabolic Process - + - + - + - + - +

@@ -6020,7 +6020,7 @@ Metabolic Process - + @@ -6028,19 +6028,19 @@ Metabolic Process - + - + - + - + - +

@@ -6051,7 +6051,7 @@ Metabolic Process - + @@ -6059,19 +6059,19 @@ Metabolic Process - + - + - + - + - +

@@ -6080,29 +6080,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -6113,7 +6113,7 @@ Metabolic Process - + @@ -6121,22 +6121,24 @@ Metabolic Process - + - + - + - + - + -

+

phosphoglucose isomerase (PGI) + +

@@ -6144,7 +6146,7 @@ Metabolic Process - + @@ -6152,19 +6154,19 @@ Metabolic Process - + - + - + - +
- +

@@ -6175,7 +6177,7 @@ Metabolic Process - + @@ -6183,19 +6185,19 @@ Metabolic Process - + - + - + - + - +

@@ -6206,7 +6208,7 @@ Metabolic Process - + @@ -6214,19 +6216,19 @@ Metabolic Process - + - + - + - + - +

@@ -6235,32 +6237,34 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - + -

+

Glucose-6-Phosphate (2-) + +

@@ -6268,7 +6272,7 @@ Metabolic Process - + @@ -6278,17 +6282,17 @@ Metabolic Process - + - +
- +

@@ -6297,29 +6301,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -6328,29 +6332,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -6359,29 +6363,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -6392,7 +6396,7 @@ Metabolic Process - + @@ -6402,17 +6406,17 @@ Metabolic Process - + - + - +

@@ -6423,7 +6427,7 @@ Metabolic Process - + @@ -6431,24 +6435,22 @@ Metabolic Process - + - + - + - + - + -

glucose-6-phosphate isomerase - -

+

@@ -6456,7 +6458,7 @@ Metabolic Process - + @@ -6464,19 +6466,19 @@ Metabolic Process - + - + - + - + - +

@@ -6487,7 +6489,7 @@ Metabolic Process - + @@ -6495,19 +6497,19 @@ Metabolic Process - + - + - + - + - +

@@ -6516,29 +6518,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -6549,7 +6551,7 @@ Metabolic Process - + @@ -6557,19 +6559,19 @@ Metabolic Process - + - + - + - + - +

@@ -6580,7 +6582,7 @@ Metabolic Process - + @@ -6588,19 +6590,19 @@ Metabolic Process - + - + - + - + - +

@@ -6611,7 +6613,7 @@ Metabolic Process - + @@ -6619,19 +6621,19 @@ Metabolic Process - + - + - + - + - +

@@ -6640,32 +6642,34 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - + -

+

glucose-6-phosphate isomerase + +

@@ -6673,7 +6677,7 @@ Metabolic Process - + @@ -6681,19 +6685,19 @@ Metabolic Process - + - + - + - +
- +

@@ -6704,7 +6708,7 @@ Metabolic Process - + @@ -6712,19 +6716,19 @@ Metabolic Process - + - + - + - + - +

@@ -6733,34 +6737,32 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - + -

fructose-6-phosphate (2-) open form - -

+

@@ -6768,7 +6770,7 @@ Metabolic Process - + @@ -6776,19 +6778,19 @@ Metabolic Process - + - + - + - + - +

@@ -6802,24 +6804,24 @@ Metabolic Process - + - + - + - + - + - + - +

@@ -6830,7 +6832,7 @@ Metabolic Process - + @@ -6838,24 +6840,22 @@ Metabolic Process - + - + - + - + - + -

phosphoglucose isomerase (PGI) - -

+

@@ -6863,7 +6863,7 @@ Metabolic Process - + @@ -6873,17 +6873,17 @@ Metabolic Process - + - + - +

@@ -6894,7 +6894,7 @@ Metabolic Process - + @@ -6902,19 +6902,19 @@ Metabolic Process - + - + - + - + - +

@@ -6923,29 +6923,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -6954,29 +6954,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -6987,7 +6987,7 @@ Metabolic Process - + @@ -6995,19 +6995,19 @@ Metabolic Process - + - + - + - + - +

@@ -7018,7 +7018,7 @@ Metabolic Process - + @@ -7028,48 +7028,50 @@ Metabolic Process - + - + - + -

+

D-Glucose-6-Phosphate (2-) open form + +

+ + + + + - - - - - - + - + - + - +
- +

@@ -7080,7 +7082,7 @@ Metabolic Process - + @@ -7088,19 +7090,19 @@ Metabolic Process - + - + - + - + - +

@@ -7111,7 +7113,7 @@ Metabolic Process - + @@ -7119,19 +7121,19 @@ Metabolic Process - + - + - + - + - +

@@ -7142,7 +7144,7 @@ Metabolic Process - + @@ -7150,19 +7152,19 @@ Metabolic Process - + - + - + - + - +

@@ -7171,29 +7173,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -7204,7 +7206,7 @@ Metabolic Process - + @@ -7214,17 +7216,17 @@ Metabolic Process - + - + - +

@@ -7235,7 +7237,7 @@ Metabolic Process - + @@ -7243,19 +7245,19 @@ Metabolic Process - + - + - + - + - +

@@ -7266,7 +7268,7 @@ Metabolic Process - + @@ -7274,19 +7276,19 @@ Metabolic Process - + - + - + - + - +

@@ -7295,29 +7297,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -7328,7 +7330,7 @@ Metabolic Process - + @@ -7336,19 +7338,19 @@ Metabolic Process - + - + - + - + - +

@@ -7357,60 +7359,62 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - + -

+

fructose-6-phosphate (2-) open form + +

+ + + + + - - - - - - - - + + + - + - + - +
- +

@@ -7421,7 +7425,7 @@ Metabolic Process - + @@ -7429,22 +7433,24 @@ Metabolic Process - + - + - + - + - + -

+

Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway + +

@@ -7452,7 +7458,7 @@ Metabolic Process - + @@ -7460,19 +7466,19 @@ Metabolic Process - + - + - + - +
- +

@@ -7483,7 +7489,7 @@ Metabolic Process - + @@ -7491,19 +7497,19 @@ Metabolic Process - + - + - + - + - +

@@ -7514,7 +7520,7 @@ Metabolic Process - + @@ -7522,19 +7528,19 @@ Metabolic Process - + - + - + - + - +

@@ -7545,7 +7551,7 @@ Metabolic Process - + @@ -7553,19 +7559,19 @@ Metabolic Process - + - + - + - + - +

@@ -7576,7 +7582,7 @@ Metabolic Process - + @@ -7584,19 +7590,19 @@ Metabolic Process - + - + - + - + - +

@@ -7610,24 +7616,24 @@ Metabolic Process - + - + - + - + - + - + - +

@@ -7638,7 +7644,7 @@ Metabolic Process - + @@ -7646,19 +7652,19 @@ Metabolic Process - + - + - + - + - +

@@ -7669,7 +7675,7 @@ Metabolic Process - + @@ -7677,24 +7683,22 @@ Metabolic Process - + - + - + - + - + -

Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway - -

+

@@ -7702,7 +7706,7 @@ Metabolic Process - + @@ -7712,17 +7716,17 @@ Metabolic Process - + - + - +

@@ -7733,7 +7737,7 @@ Metabolic Process - + @@ -7741,19 +7745,19 @@ Metabolic Process - + - + - + - + - +

@@ -7762,29 +7766,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -7795,7 +7799,7 @@ Metabolic Process - + @@ -7805,17 +7809,17 @@ Metabolic Process - + - + - +

@@ -7824,29 +7828,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -7857,7 +7861,7 @@ Metabolic Process - + @@ -7865,19 +7869,19 @@ Metabolic Process - + - + - + - + - +

@@ -7888,7 +7892,7 @@ Metabolic Process - + @@ -7896,19 +7900,19 @@ Metabolic Process - + - + - + - + - +

@@ -7919,7 +7923,7 @@ Metabolic Process - + @@ -7927,24 +7931,22 @@ Metabolic Process - + - + - + - + - + -

Gck is mainly active in liver - -

+

@@ -7952,7 +7954,7 @@ Metabolic Process - + @@ -7960,24 +7962,22 @@ Metabolic Process - + - + - + - + - + -

Glucose-6-Phosphate (2-) - -

+

@@ -7985,7 +7985,7 @@ Metabolic Process - + @@ -7993,19 +7993,19 @@ Metabolic Process - + - + - + - + - +

@@ -8016,7 +8016,7 @@ Metabolic Process - + @@ -8024,19 +8024,19 @@ Metabolic Process - + - + - + - + - +

@@ -8045,29 +8045,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -8078,7 +8078,7 @@ Metabolic Process - + @@ -8086,19 +8086,19 @@ Metabolic Process - + - + - + - + - +

@@ -8109,7 +8109,7 @@ Metabolic Process - + @@ -8117,19 +8117,19 @@ Metabolic Process - + - + - + - + - +

@@ -8140,7 +8140,7 @@ Metabolic Process - + @@ -8148,19 +8148,19 @@ Metabolic Process - + - + - + - + - +

@@ -8171,7 +8171,7 @@ Metabolic Process - + @@ -8179,14 +8179,14 @@ Metabolic Process - + - + - + - + @@ -8212,17 +8212,17 @@ Metabolic Process - + - + - +

@@ -8233,7 +8233,7 @@ Metabolic Process - + @@ -8241,19 +8241,19 @@ Metabolic Process - + - + - + - + - +

@@ -8262,29 +8262,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -8295,7 +8295,7 @@ Metabolic Process - + @@ -8303,19 +8303,19 @@ Metabolic Process - + - + - + - + - +

@@ -8326,7 +8326,7 @@ Metabolic Process - + @@ -8336,17 +8336,17 @@ Metabolic Process - + - + - +

@@ -8357,7 +8357,7 @@ Metabolic Process - + @@ -8367,17 +8367,17 @@ Metabolic Process - + - + - +

@@ -8388,7 +8388,7 @@ Metabolic Process - + @@ -8398,17 +8398,17 @@ Metabolic Process - + - + - +

@@ -8417,31 +8417,31 @@ Metabolic Process - - - - - - + - + - + - + + + + + + - +

@@ -8449,22 +8449,22 @@ Metabolic Process - + - + - + - +

@@ -8472,19 +8472,22 @@ Metabolic Process - + - + - + + + + - +

@@ -8492,22 +8495,22 @@ Metabolic Process - + - + - + - + - +

@@ -8515,19 +8518,22 @@ Metabolic Process - + - + - + + + + - +

@@ -8535,22 +8541,22 @@ Metabolic Process - + - + - + - + - +

@@ -8558,22 +8564,22 @@ Metabolic Process - + - + - + - + - +

@@ -8581,19 +8587,19 @@ Metabolic Process - + - + - + - +

@@ -8601,22 +8607,22 @@ Metabolic Process - + - + - + - + - +

@@ -8624,22 +8630,22 @@ Metabolic Process - + - + - + - + - +

@@ -8647,22 +8653,22 @@ Metabolic Process - + - + - + - + - +

@@ -8670,19 +8676,23 @@ Metabolic Process - + - + + + + + - +

@@ -8690,22 +8700,22 @@ Metabolic Process - + - + - + - + - +

@@ -8713,19 +8723,19 @@ Metabolic Process - + - + - + - +

@@ -8733,22 +8743,22 @@ Metabolic Process - + - + - + - + - +

@@ -8756,22 +8766,22 @@ Metabolic Process - + - + - + - + - +

@@ -8779,22 +8789,22 @@ Metabolic Process - + - + - + - + - +

@@ -8802,22 +8812,22 @@ Metabolic Process - + - + - + - + - +

@@ -8825,22 +8835,22 @@ Metabolic Process - + - + - + - + - +

@@ -8848,22 +8858,22 @@ Metabolic Process - + - + - + - + - +

@@ -8871,22 +8881,22 @@ Metabolic Process - + - + - + - + - +

@@ -8894,22 +8904,22 @@ Metabolic Process - + - + - + - + - +

@@ -8917,22 +8927,22 @@ Metabolic Process - + - + - + - + - +

@@ -8940,22 +8950,19 @@ Metabolic Process - + - + - + - - - - +

@@ -8963,22 +8970,22 @@ Metabolic Process - + - + - + - + - +

@@ -8986,19 +8993,19 @@ Metabolic Process - + - + - + - +

@@ -9006,22 +9013,22 @@ Metabolic Process - + - + - + - + - +

@@ -9029,22 +9036,22 @@ Metabolic Process - + - + - + - + - +

@@ -9052,20 +9059,17 @@ Metabolic Process - + - + - + - - - @@ -9081,16 +9085,16 @@ Metabolic Process - + - + - + - +

@@ -9098,22 +9102,22 @@ Metabolic Process - + - + - + - + - +

@@ -9121,22 +9125,22 @@ Metabolic Process - + - + - + - + - +

@@ -9144,19 +9148,22 @@ Metabolic Process - + - + - + + + + - +

@@ -9164,19 +9171,22 @@ Metabolic Process - + - + - + + + + - +

@@ -9184,22 +9194,22 @@ Metabolic Process - + - + - + - + - +

@@ -9207,23 +9217,19 @@ Metabolic Process - + - + - + - - - - - +

@@ -9231,22 +9237,22 @@ Metabolic Process - + - + - + - + - +

@@ -9254,22 +9260,22 @@ Metabolic Process - + - + - + - + - +

@@ -9277,22 +9283,19 @@ Metabolic Process - + - + - + - - - - +

@@ -9300,23 +9303,23 @@ Metabolic Process - + - + - + - +

@@ -9324,22 +9327,22 @@ Metabolic Process - + - + - + - + - +

@@ -9347,19 +9350,22 @@ Metabolic Process - + - + - + + + + - +

@@ -9367,22 +9373,22 @@ Metabolic Process - + - + - + - + - +

@@ -9390,22 +9396,19 @@ Metabolic Process - + - + - - - - +

@@ -9413,22 +9416,22 @@ Metabolic Process - + - + - + - + - +

@@ -9436,20 +9439,17 @@ Metabolic Process - + - + - + - - - diff --git a/sbml/WP534.svg b/sbml/WP534.svg index 48d77eb..26c8e27 100644 --- a/sbml/WP534.svg +++ b/sbml/WP534.svg @@ -8,93 +8,65 @@ />cb7c6f9a70ad0b5b5d1fe4a6de4a6dcb7c6ca349f9a70ad0b5b5d1fe13bcMitochondriond645debf7ee189ea26a8e189eebf7ed645dPyruvateDLATGlycogen metabolismP-enolpyruvateG6PCENO11,3BP-GlyceratePDHA1PGAM2OxaloacetatePyruvateDLATAspartateFructose-1,6BPFBP1Dihydroxyacetone-PLDHAGlycogen metabolismALDOAMalatePCK1Fructose-1,6BPSLC2A4HK1FBP1HK3GAPDHSLC2A5TPI1PyruvateSLC2A3LDHBMPC1FBP2HK1Fructose 6PMalateGlucosePCSLC2A3Acetyl-CoAGlucoseALDOBDLDGlucose-6PPCMDH1ALDOCPGK2LDHAL6BPFKPPFKMSLC2A2PKM2Glucose-6PGlyceraldehyde 3PPFKLENO23P-GlycerateSLC2A4PGAM1GAPDHPGAM2MPC1GlucoseMPC2MDH2GlucoseAspartateOxaloacetateTriglyceride synthesisPKM1HK21,3BP-GlycerateALDOBPGK1PGK2TCA cyclePyruvate2P-GlyceratePentose phosphate pathwayLDHAPGK1SLC2A1LDHCHK2G6PCGOT2Glyceraldehyde 3POxaloacetateENO3LactatePKM2GOT2MDH1LDHBTPI1ENO2ENO1TCA cyclePKLRDLDAspartateOxaloacetateMalatePCK1Fructose 6PDihydroxyacetone-PGCKPentose phosphate pathwayLDHAL6BPKM12P-GlycerateP-enolpyruvateSLC2A5LDHC3P-GlycerateGOT1PFKPFBP2ENO3ALDOCPGAM1PFKMPFKLMPC2GOT1AspartateAcetyl-CoAHK3PDHA1Triglyceride synthesisLactateCytosolGluconeogenesisGlycolysisCytosol - + -

This pathway lists several genes involved in mechanisms involved in disorders of mitochondrial homeostatis, dynamics, protein import, and quality control. This pathway was inspired by Figure 46.1 of Edition 5, Chapter 46 of the book of Blau (ISBN 9783030677268). +

This pathway lists several genes involved in mechanisms involved in disorders of mitochondrial homeostatis, dynamics, protein import, and quality control. This pathway was inspired by Figure 46.1 of Edition 5, Chapter 46 of the book of Blau (ISBN 9783030677268). Genes linked to a disease in this book chapter are depicted in red. -[LABEL:c31e7] Don't know how to process href: https://www.iembase.com/disorder/1198 -[STIMULATION:iddc9f627b] Invalid interaction type. -[STIMULATION:id19782e13] Invalid interaction type. -[MODIFICATION:idd1a3c459] Invalid interaction type. -[Label:a95e8] Label cannot be part of reaction. Tranforming to Unknown -[Label:ec38a] Label cannot be part of reaction. Tranforming to Unknown -[Label:b9540] Label cannot be part of reaction. Tranforming to Unknown -[Label:bfefd] Label cannot be part of reaction. Tranforming to Unknown -[Label:d35d0] Label cannot be part of reaction. Tranforming to Unknown -[Label:e73cd] Label cannot be part of reaction. Tranforming to Unknown -[Label:d3cb7] Label cannot be part of reaction. Tranforming to Unknown -[Label:c83dc] Label cannot be part of reaction. Tranforming to Unknown -[Label:c3d30] Label cannot be part of reaction. Tranforming to Unknown -[Label:ab779] Label cannot be part of reaction. Tranforming to Unknown -[Label:d2992] Label cannot be part of reaction. Tranforming to Unknown -[Label:e772c] Label cannot be part of reaction. Tranforming to Unknown -[Label:af0fb] Label cannot be part of reaction. Tranforming to Unknown -[Label:cf3d4] Label cannot be part of reaction. Tranforming to Unknown -[Label:b8fbf] Label cannot be part of reaction. Tranforming to Unknown -[Label:a8322] Label cannot be part of reaction. Tranforming to Unknown -[Label:aad38] Label cannot be part of reaction. Tranforming to Unknown -[Label:e783f] Label cannot be part of reaction. Tranforming to Unknown -[Label:aa894] Label cannot be part of reaction. Tranforming to Unknown -[Label:b3f93] Label cannot be part of reaction. Tranforming to Unknown -[Label:e3a57] Label cannot be part of reaction. Tranforming to Unknown -[Label:ff03b] Label cannot be part of reaction. Tranforming to Unknown -[Label:c31e7] Label cannot be part of reaction. Tranforming to Unknown -[Label:cdea5] Label cannot be part of reaction. Tranforming to Unknown -[Label:e4efd] Label cannot be part of reaction. Tranforming to Unknown -[Label:fa3ea] Label cannot be part of reaction. Tranforming to Unknown -[Label:ccf92] Label cannot be part of reaction. Tranforming to Unknown -[Label:e98d5] Label cannot be part of reaction. Tranforming to Unknown -[Label:aaf09] Label cannot be part of reaction. Tranforming to Unknown -[Label:e8dd7] Label cannot be part of reaction. Tranforming to Unknown -[Label:c6de6] Label cannot be part of reaction. Tranforming to Unknown -[Label:c272d] Label cannot be part of reaction. Tranforming to Unknown -[Label:f3b8e] Label cannot be part of reaction. Tranforming to Unknown -[Label:a40c5] Label cannot be part of reaction. Tranforming to Unknown -[Label:e25cb] Label cannot be part of reaction. Tranforming to Unknown -[Label:a5dab] Label cannot be part of reaction. Tranforming to Unknown -[Label:da20d] Label cannot be part of reaction. Tranforming to Unknown -[Label:db4d2] Label cannot be part of reaction. Tranforming to Unknown -[Label:f54b7] Label cannot be part of reaction. Tranforming to Unknown -[Label:c3aa5] Label cannot be part of reaction. Tranforming to Unknown -[Label:b4dda] Label cannot be part of reaction. Tranforming to Unknown -[Label:b941a] Label cannot be part of reaction. Tranforming to Unknown -[Label:bc43d] Label cannot be part of reaction. Tranforming to Unknown -[Label:ea5e6] Label cannot be part of reaction. Tranforming to Unknown -[Label:afb34] Label cannot be part of reaction. Tranforming to Unknown -[Label:f8639] Label cannot be part of reaction. Tranforming to Unknown -[Label:f34bf] Label cannot be part of reaction. Tranforming to Unknown -[:e8886] Shape can not be part of reaction. Tranforming to Unknown -[:f5620] Shape can not be part of reaction. Tranforming to Unknown -[HeterodimerAssociationReaction:id83eaa8bf] Reaction should contain at least 2 reactants. GraphId: id83eaa8bf -[PositiveInfluenceReaction:idd1a3c459] Reaction should contain only one reactant and one product. -[-:-] Miriam data (PUBMED: 39075050) for id8828d868 already exists. Ignoring... -[-:-] Miriam data (PUBMED: 39075050) for id8828d868 already exists. Ignoring...

+[LABEL:c7359] Don't know how to process href: https://www.iembase.com/disorder/1198 +[LABEL:f840e] Don't know how to process href: https://www.iembase.com/disorder/1035 +[LABEL:be9db] Don't know how to process href: https://www.iembase.com/disorder/1234 +[-:-] Unknown gpml interaction type: mim-translocation +[-:-] Unknown gpml interaction type: mim-translocation +[MODIFICATION:c3249] Interaction is not connected +[MODIFICATION:fb6d5] Invalid interaction type. +[STIMULATION:dc157] Invalid interaction type. +[MODIFICATION:b7798] Invalid interaction type. +[STIMULATION:f91b7] Invalid interaction type. +[MODIFICATION:f1b88] Invalid interaction type. +[STIMULATION:b6e51] Invalid interaction type. +[MODIFICATION:d1326] Invalid interaction type. +[LINE:dbb70] Invalid interaction type. +[STIMULATION:a10a8] Invalid interaction type. +[LINE:e0d33] Invalid interaction type. +[MODIFICATION:b2d20] Invalid interaction type. +[MODIFICATION:c84b7] Invalid interaction type. +[Label:ef49a] Label cannot be part of reaction. Tranforming to Unknown +[Label:eacc7] Label cannot be part of reaction. Tranforming to Unknown +[Label:fbd15] Label cannot be part of reaction. Tranforming to Unknown +[Label:b0609] Label cannot be part of reaction. Tranforming to Unknown +[Label:d6ffb] Label cannot be part of reaction. Tranforming to Unknown +[Label:b386b] Label cannot be part of reaction. Tranforming to Unknown +[Label:f6126] Label cannot be part of reaction. Tranforming to Unknown +[Label:c3c10] Label cannot be part of reaction. Tranforming to Unknown +[Label:cdeb9] Label cannot be part of reaction. Tranforming to Unknown +[Label:d5e5d] Label cannot be part of reaction. Tranforming to Unknown +[Label:dbd7e] Label cannot be part of reaction. Tranforming to Unknown +[Label:b8bd9] Label cannot be part of reaction. Tranforming to Unknown +[Label:fcaf6] Label cannot be part of reaction. Tranforming to Unknown +[Label:f840e] Label cannot be part of reaction. Tranforming to Unknown +[Label:b56b7] Label cannot be part of reaction. Tranforming to Unknown +[Label:e4858] Label cannot be part of reaction. Tranforming to Unknown +[Label:e7cb3] Label cannot be part of reaction. Tranforming to Unknown +[Label:dae41] Label cannot be part of reaction. Tranforming to Unknown +[Label:c7697] Label cannot be part of reaction. Tranforming to Unknown +[Label:c3ec5] Label cannot be part of reaction. Tranforming to Unknown +[Label:f97f6] Label cannot be part of reaction. Tranforming to Unknown +[Label:c2ef6] Label cannot be part of reaction. Tranforming to Unknown +[Label:c2204] Label cannot be part of reaction. Tranforming to Unknown +[Label:bb24d] Label cannot be part of reaction. Tranforming to Unknown +[Label:c43b2] Label cannot be part of reaction. Tranforming to Unknown +[Label:d1ee0] Label cannot be part of reaction. Tranforming to Unknown +[Label:b4112] Label cannot be part of reaction. Tranforming to Unknown +[Label:e0ebc] Label cannot be part of reaction. Tranforming to Unknown +[Label:a6eee] Label cannot be part of reaction. Tranforming to Unknown +[Label:efc96] Label cannot be part of reaction. Tranforming to Unknown +[Label:ad43f] Label cannot be part of reaction. Tranforming to Unknown +[Label:ccfcb] Label cannot be part of reaction. Tranforming to Unknown +[Label:be9db] Label cannot be part of reaction. Tranforming to Unknown +[Label:fc6c0] Label cannot be part of reaction. Tranforming to Unknown +[Label:c3fb1] Label cannot be part of reaction. Tranforming to Unknown +[Label:f5ac7] Label cannot be part of reaction. Tranforming to Unknown +[Label:b502b] Label cannot be part of reaction. Tranforming to Unknown +[Label:f5a0b] Label cannot be part of reaction. Tranforming to Unknown +[Label:f4049] Label cannot be part of reaction. Tranforming to Unknown +[Label:c0a49] Label cannot be part of reaction. Tranforming to Unknown +[Label:b817d] Label cannot be part of reaction. Tranforming to Unknown +[Label:e403b] Label cannot be part of reaction. Tranforming to Unknown +[Label:b5838] Label cannot be part of reaction. Tranforming to Unknown +[Label:d37dc] Label cannot be part of reaction. Tranforming to Unknown +[Label:e730f] Label cannot be part of reaction. Tranforming to Unknown +[Label:b3895] Label cannot be part of reaction. Tranforming to Unknown +[Label:ad60d] Label cannot be part of reaction. Tranforming to Unknown +[Label:e838c] Label cannot be part of reaction. Tranforming to Unknown +[Label:d98fb] Label cannot be part of reaction. Tranforming to Unknown +[Label:e5e91] Label cannot be part of reaction. Tranforming to Unknown +[Label:e9842] Label cannot be part of reaction. Tranforming to Unknown +[Label:c7359] Label cannot be part of reaction. Tranforming to Unknown +[Label:a9988] Label cannot be part of reaction. Tranforming to Unknown +[Label:a7cb6] Label cannot be part of reaction. Tranforming to Unknown +[Label:f32bc] Label cannot be part of reaction. Tranforming to Unknown +[Label:ed9d8] Label cannot be part of reaction. Tranforming to Unknown +[Label:f5f9b] Label cannot be part of reaction. Tranforming to Unknown +[Label:c9bf0] Label cannot be part of reaction. Tranforming to Unknown +[Label:a0f85] Label cannot be part of reaction. Tranforming to Unknown +[Label:eb5b1] Label cannot be part of reaction. Tranforming to Unknown +[Label:f82e1] Label cannot be part of reaction. Tranforming to Unknown +[Label:cb759] Label cannot be part of reaction. Tranforming to Unknown +[:cd98a] Shape can not be part of reaction. Tranforming to Unknown +[:fc319] Shape can not be part of reaction. Tranforming to Unknown +[-:-] Miriam data (PUBMED: 38891822) for b7798 already exists. Ignoring... +[PositiveInfluenceReaction:b7798] Reaction should contain only one reactant and one product. +[-:-] Miriam data (PUBMED: 39075050) for fa57c already exists. Ignoring... +[-:-] Miriam data (PUBMED: 39075050) for fa57c already exists. Ignoring... +[PositiveInfluenceReaction:d1326] Reaction should contain only one reactant and one product. +[-:-] Miriam data (PUBMED: 38891822) for c84b7 already exists. Ignoring... +[PositiveInfluenceReaction:c84b7] Reaction should contain only one reactant and one product. +[HeterodimerAssociationReaction:b8974] Reaction should contain at least 2 reactants. GraphId: b8974 +[Complex:ce6bd] Empty element is invalid

@@ -84,18 +118,34 @@ - - - - + + + + + + + + + + + + + + + + + + + + @@ -112,18 +162,18 @@ - + - + - + @@ -137,362 +187,352 @@ - + - - + + - + - - + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + + + - - + + - - - + + + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - - - + + + - - + + - + - - - - - - - - - + + + + + + + + + + + + + - + - - - - - - - - - - - + + + - + - + - + - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - - - + + + - - + + - + - + - + - + - + - + + + + + + + + + + + + + - + - + @@ -509,354 +549,394 @@ - + - + + + + + + + + + + + + + + + + + + + + + - + - + - + - - - + + + + + + + + + + + + + + + - - + + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - - - + + + - + - - - - - - - - - + - + - + - + - - - + + + - - + + - + - + - - + + - - + + - 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- - - - - - - - - + + - - - + + + - - + + - + - + - + - + - - - - - - - - - + - + - + - + - - - - - - - - - + - - - - + + + + @@ -1189,12 +1248,36 @@ - + - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1209,18 +1292,66 @@ - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + - - - - + + + + @@ -1229,42 +1360,70 @@ - + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + + + + + + + + + - - - - + + + + @@ -1273,36 +1432,27 @@ - + - + - + - - - - - - - - - - - - + + + - - + + - - + + @@ -1318,118 +1468,197 @@ - - + + - + - + - - + + - - + + - + - - - - - - + + + + + + - + - + + + + + + + + + - + - - + + + + + + + + + + - - - - - - + + + + + + + + + - - + + - - - + + + + + + + + + + + + + + + - - + + + + + + + + + + - + - + - + - + - - - + + + + + + + + + + + + + + + - - + + - + - + + + + + + + + + + + + + + + + + + + + + - + - + - + - + + + + + + + + + @@ -1446,18 +1675,10 @@ - + - - - - - - - - - + @@ -1474,163 +1695,289 @@ - 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@@ -7623,26 +12108,43 @@ - + + + + + + - - - - + + + + + + + + + + + + + + -

+

Autosomal recessive spastic ataxia of Charlevoix-Saguenay + +

- + - + @@ -7650,19 +12152,19 @@ - + - + - + - +
- +

@@ -7670,10 +12172,41 @@ - + + + + + + + + + + + + + + + + + + + + + + + + + + +

+ + + + + - + @@ -7681,32 +12214,32 @@ - + - + - + - + - + -

3-methylglutaconic aciduria type 7, with cataracts, neurologic involvement and neutropenia +

COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 37

- + - + @@ -7716,28 +12249,32 @@ - + - +
- + -

+

MAGMAS deficiency + +Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type + +

- + - + @@ -7745,19 +12282,124 @@ - + - + - + + + + + + +
+ + + +

Optic Atrophy 1 and deafness + +

+ +
+ + + + + + + + + + + + + + + + + + + + + + + + +
+ + + +

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 68 + +DEE68 + +early infantile epileptic encephalopathy 68 + +

+ +
+ + + + + + + + + + + + + + + + + + + + + + + + +
+ + + +

Combined oxidative phosphorylation deficiency type 31 + +Mitochondrial intermediate peptidase deficiency + +

+ +
+ + + + + + + + + + + + + + + + + + + - +
- +

@@ -7765,10 +12407,38 @@ - + + + + + + + + + + + + + + + + + + + + + +

Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay + +

+ +
+ + + - + @@ -7776,32 +12446,72 @@ - + + + + + + + + + + + +
+ + + +

Dynamin-like protein 1 deficiency + +encephalopathy due to defective mitochondrondrial and peroxisomal fission + +

+ +
+ + + + + + + + + + + + + + - + - + - +
- + -

Autosomal dominant spastic paraplegia type 13 +

cofactor to PYCR3

- + - + + + + + + @@ -7809,34 +12519,27 @@ - + - + - + - +
- + -

Hypomyelinating leukodystrophy type 4 (recessive) - -

+

- - - - - - + @@ -7844,28 +12547,30 @@ - + - + - + -

+

Optic atrophy type 11 + +

- + - + @@ -7873,19 +12578,19 @@ - + - + - + - +
- +

@@ -7893,10 +12598,10 @@ - + - + @@ -7906,28 +12611,30 @@ - + - + - + -

+

Listed as XNPEP3 in the chapter. + +

- + - + @@ -7937,17 +12644,17 @@ - + - +
- +

@@ -7955,10 +12662,10 @@ - + - + @@ -7968,17 +12675,17 @@ - + - + - +

@@ -7986,10 +12693,10 @@ - + - + @@ -7997,19 +12704,19 @@ - + - + - + - + - +

@@ -8017,10 +12724,10 @@ - + - + @@ -8030,28 +12737,30 @@ - + - + - + -

+

Infantile sudden cardiac failure + +

- + - + @@ -8059,30 +12768,32 @@ - + - + - + - +
- + -

+

Acylglycerol kinase deficiency + +

- + - + @@ -8090,34 +12801,30 @@ - + - + - + - +
- + -

Spinocerebellar ataxia type 28 - -m-AAA protease AFG3L2 subunit deficiency - -

+

- + - + @@ -8125,19 +12832,19 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - +

@@ -8145,15 +12852,10 @@ m-AAA protease AFG3L2 subunit deficiency - - - - - - + - + @@ -8161,32 +12863,32 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - + -

encephalopathy due to defective mitochondrondrial and peroxisomal fission type 2 +

Mitochondrial myopathy and ataxia

- + - + @@ -8196,30 +12898,35 @@ m-AAA protease AFG3L2 subunit deficiency - + - +
- + -

Optic atrophy type 11 +

AKA P5C

- + - + + + + + + @@ -8227,19 +12934,19 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - +
- +

@@ -8247,10 +12954,10 @@ m-AAA protease AFG3L2 subunit deficiency - + - + @@ -8258,19 +12965,19 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - +

@@ -8278,30 +12985,25 @@ m-AAA protease AFG3L2 subunit deficiency - - - - - - + - + - + - + - + - +

@@ -8309,7 +13011,7 @@ m-AAA protease AFG3L2 subunit deficiency - + @@ -8317,35 +13019,28 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + -

Active in Cytosol - -

+

- - - - - - + - + @@ -8353,36 +13048,30 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - + -

3-METHYLGLUTACONIC ACIDURIA, TYPE IX - -Alternative name for Mitochondrial epileptic encephalopathy according to IEMBase - -Intellectual disability and seizure disorder due to TIMM50 variant - -

+

- + - + @@ -8390,19 +13079,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - + - +

@@ -8410,10 +13099,10 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + @@ -8421,32 +13110,30 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - + - + -

Nephronophthisis-like nephropathy type 1 - -

+

- + - + @@ -8454,19 +13141,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - + - +

@@ -8474,10 +13161,10 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + @@ -8487,28 +13174,30 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + -

+

Combined oxidative phosphorylation deficiency type 18 + +

- + - + @@ -8516,19 +13205,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - +
- +

@@ -8536,10 +13225,10 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + @@ -8547,37 +13236,34 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - + - + -

AKA P5C +

Dystonia Deafness Syndrome + +Mohr-Tranebjaerg syndrome

- - - - - - + - + @@ -8585,19 +13271,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - +
- +

@@ -8605,36 +13291,43 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + + + + + + - + - + - + - + - + -

+

Spastic paraplegia type7 + +

- + - + @@ -8642,19 +13335,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - +
- +

@@ -8662,10 +13355,10 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + @@ -8675,17 +13368,17 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - +

@@ -8693,46 +13386,45 @@ Intellectual disability and seizure disorder due to TIMM50 variant - - - - - - - - - - - + - + - + - + - + + + + + + - + -

+

Spinocerebellar ataxia type 28 + +m-AAA protease AFG3L2 subunit deficiency + +

- + - + @@ -8740,19 +13432,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - +
- +

@@ -8760,10 +13452,10 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + @@ -8773,50 +13465,43 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + -

Not in Figure, but added in Table 46.35 - -

+

- - - - - - + - + - + - + - + - +

@@ -8824,10 +13509,10 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + @@ -8835,19 +13520,19 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - + - +

@@ -8855,41 +13540,43 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + + + + + + - + - + - + - + - + -

+

X-linked mental retardation type 99 + +

- - - - - - + - + @@ -8897,34 +13584,34 @@ Intellectual disability and seizure disorder due to TIMM50 variant - + - + - + - +
- + -

Hereditary motor and sensory neuropathy type 6B +

Sideoblastic anemia type 4 -CHARCOT-MARIE-TOOTH DISEASE, TYPE 6B +Epiphyseal, vertebral, ear, nose, plus associated malformations (EVEN-plus) syndrome

- + - + @@ -8934,17 +13621,17 @@ CHARCOT-MARIE-TOOTH DISEASE, TYPE 6B - + - +
- +

@@ -8952,10 +13639,10 @@ CHARCOT-MARIE-TOOTH DISEASE, TYPE 6B - + - + @@ -8965,32 +13652,28 @@ CHARCOT-MARIE-TOOTH DISEASE, TYPE 6B - + - + - + -

inclusion body myopathy with early-onset Paget disease and frontotemporal dementia type 1 - -Valosin-containing protein superactivity - -

+

- + - + @@ -8998,34 +13681,27 @@ Valosin-containing protein superactivity - + - + - + - + - + -

Axonal Charcot-Marie-Tooth disease type 2A2B - -

+

- - - - - - + @@ -9033,32 +13709,37 @@ Valosin-containing protein superactivity - + - + - + -

Costeff Syndrome +

also known as optic atrophy-10 (OPA10); NADPH oxidoreductase, enriched in the mitochondrial matrix of muscle tissues. DOI: https://doi.org/10.1038/s41589-023-01452-w -Methylglutaconic aciduria type III +"COQ3 was the most strongly biotinylated protein by RTN4IP1-TurboID, suggesting a potential involvement of RTN4IP1 in the CoQ production pathway within the mitochondria" DOI: https://doi.org/10.1038/s41589-023-01452-w

- + - + + + + + + @@ -9066,30 +13747,34 @@ Methylglutaconic aciduria type III - + - + - + - +
- + -

+

autosomal recessive spastic ataxia type 5 + +m-AAA protease AFG3L2 subunit deficiency + +

- + - + @@ -9097,32 +13782,36 @@ Methylglutaconic aciduria type III - + - + - + - +
- + -

Mitochondrial myopathy and ataxia +

3-METHYLGLUTACONIC ACIDURIA, TYPE IX + +Alternative name for Mitochondrial epileptic encephalopathy according to IEMBase + +Intellectual disability and seizure disorder due to TIMM50 variant

- + - + @@ -9132,17 +13821,17 @@ Methylglutaconic aciduria type III - + - +
- +

@@ -9150,10 +13839,10 @@ Methylglutaconic aciduria type III - + - + @@ -9161,32 +13850,30 @@ Methylglutaconic aciduria type III - + - + - + - + - + -

Listed as XNPEP3 in the chapter. - -

+

- + - + @@ -9196,28 +13883,34 @@ Methylglutaconic aciduria type III - + - + - + -

+

Dilated cardiomyopathy with ataxia + +3-methylglutaconice aciduria type 5 + +DCMA syndrome + +

- + - + @@ -9225,30 +13918,32 @@ Methylglutaconic aciduria type III - + - + - + - +
- + -

+

AKA P5C + +

- + - + @@ -9256,62 +13951,63 @@ Methylglutaconic aciduria type III - + - + - + - +
- + -

https://www.iembase.com/disorder/1198 - -ID in OMIM for gene (https://omim.org/entry/619405) - -

+

- + + + + + + - + - + - + - + - + -

Cerebral, ocular, dental, auricular, and skeletal syndrome +

Nephronophthisis-like nephropathy type 1

- + - + @@ -9321,30 +14017,33 @@ ID in OMIM for gene (https://omim.org/entry/619405) - + - +
- + -

Early-onset Parkinson disease type 2 - -

+

- + - + + + + + + @@ -9352,70 +14051,61 @@ ID in OMIM for gene (https://omim.org/entry/619405) - + - + - + - + - + - -

3-methylglutaconic aciduria type 8 - -

+ +

- - - - - - + - + - + - + + + + + + - + - + -

Active in Cytosol - -

+

- - - - - - + - + @@ -9425,32 +14115,30 @@ ID in OMIM for gene (https://omim.org/entry/619405) - + - + - + -

Autosomal recessive spinocerebellar ataxia type 2 - -mitochondrial processing peptidase alpha deficiency +

Axonal Charcot-Marie-Tooth type 2K

- + - + @@ -9460,30 +14148,30 @@ mitochondrial processing peptidase alpha deficiency - + - +
- + -

Infantile sudden cardiac failure +

Cerebral, ocular, dental, auricular, and skeletal syndrome

- + - + @@ -9493,17 +14181,17 @@ mitochondrial processing peptidase alpha deficiency - + - +
- +

@@ -9511,10 +14199,10 @@ mitochondrial processing peptidase alpha deficiency - + - + @@ -9522,32 +14210,32 @@ mitochondrial processing peptidase alpha deficiency - + - + - + - + - + -

Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay +

Optic atrophy type 10

- + - + @@ -9557,28 +14245,30 @@ mitochondrial processing peptidase alpha deficiency - + - +
- + -

+

SPINOCEREBELLAR ATAXIA + +

- + - + @@ -9586,19 +14276,19 @@ mitochondrial processing peptidase alpha deficiency - + - + - + - +
- +

@@ -9606,10 +14296,10 @@ mitochondrial processing peptidase alpha deficiency - + - + @@ -9617,19 +14307,19 @@ mitochondrial processing peptidase alpha deficiency - + - + - + - + - +

@@ -9637,10 +14327,10 @@ mitochondrial processing peptidase alpha deficiency - + - + @@ -9648,30 +14338,32 @@ mitochondrial processing peptidase alpha deficiency - + - + - + - + - + -

+

Perrault syndrome type 3 + +

- + - + @@ -9679,30 +14371,32 @@ mitochondrial processing peptidase alpha deficiency - + - + - + - +
- + -

+

Optic atrophy type 7 + +

- + - + @@ -9712,54 +14406,65 @@ mitochondrial processing peptidase alpha deficiency - + - +
- + -

+

Combined oxidative phosphorylation deficiency type 33 + +C1q-binding protein deficiency + +

- + + + + + + - + - + - + - +
- + -

+

MITOL/March5 + +

- + - + @@ -9767,34 +14472,30 @@ mitochondrial processing peptidase alpha deficiency - + - + - + - +
- + -

Dystonia Deafness Syndrome - -Mohr-Tranebjaerg syndrome - -

+

- + - + @@ -9804,34 +14505,30 @@ Mohr-Tranebjaerg syndrome - + - + - + -

Dilated cardiomyopathy with ataxia - -3-methylglutaconice aciduria type 5 - -DCMA syndrome +

3-methylglutaconic aciduria type 7, with cataracts, neurologic involvement and neutropenia

- + - + @@ -9841,33 +14538,30 @@ DCMA syndrome - + - +
- + -

+

AKA NPL4 + +

- - - - - - + - + @@ -9875,30 +14569,34 @@ DCMA syndrome - + - + - + - +
- + -

+

X-linked Mitochondrial Myopathy + +Combined Oxidative Phosphorylation Defect 6 + +

- + - + @@ -9906,32 +14604,30 @@ DCMA syndrome - + - + - + - +
- + -

AKA P5C - -

+

- + - + @@ -9939,32 +14635,32 @@ DCMA syndrome - + - + - + - + - + -

Axonal Charcot-Marie-Tooth type 2K +

AKA NPL4

- + - + @@ -9972,32 +14668,32 @@ DCMA syndrome - + - + - + - +
- + -

Acylglycerol kinase deficiency +

"Given that we identified COQ5 as part of the interactome of RTN4IP1-TurboID, it will be intriguing to further investigate whether RTN4IP1 can assist this reaction of COQ5." DOI: https://doi.org/10.1038/s41589-023-01452-w

- + - + @@ -10005,32 +14701,32 @@ DCMA syndrome - + - + - + - +
- + -

Autosomal recessive spastic ataxia of Charlevoix-Saguenay +

Hypomyelinating leukodystrophy type 4 (recessive)

- + - + @@ -10040,17 +14736,17 @@ DCMA syndrome - + - +
- +

@@ -10058,10 +14754,10 @@ DCMA syndrome - + - + @@ -10069,32 +14765,32 @@ DCMA syndrome - + - + - + - + - + -

X-linked mental retardation type 99 +

Axonal Charcot-Marie-Tooth disease type 2A2A

- + - + @@ -10104,30 +14800,32 @@ DCMA syndrome - + - +
- + -

Optic Atrophy 1 and deafness +

Juvenile Optic Atrophy + +Childhood-onset optic atrophy type 1

- + - + @@ -10137,79 +14835,47 @@ DCMA syndrome - + - - - - -
- - - -

- - - - - - - - - - - - - - - - - - - - - - - + - + -

+

https://www.iembase.com/disorder/1198 + +ID in OMIM for gene (https://omim.org/entry/619405) + +

- - - - - - + - + - + - + - +
- +

@@ -10217,10 +14883,10 @@ DCMA syndrome - + - + @@ -10228,30 +14894,32 @@ DCMA syndrome - + - + - + - + - + -

+

3-methylglutaconic aciduria type 8 + +

- + - + @@ -10259,34 +14927,32 @@ DCMA syndrome - + - + - + - +
- + -

Ubiquitin-specific peptidase 9 X-linked - -"Collectively, these findings suggest that USP9x regulates the proline biosynthesis pathway and the proline cycle via PYCR3, which affects PPP and mitochondrial respiration." DOI: https://doi.org/10.1038/s41420-024-02111-2 +

Early-onset Parkinson disease type 6

- + - + @@ -10294,30 +14960,34 @@ DCMA syndrome - + - + - + - +
- + -

+

also known as optic atrophy-10 (OPA10); NADPH oxidoreductase, enriched in the mitochondrial matrix of muscle tissues. DOI: https://doi.org/10.1038/s41589-023-01452-w + +"COQ3 was the most strongly biotinylated protein by RTN4IP1-TurboID, suggesting a potential involvement of RTN4IP1 in the CoQ production pathway within the mitochondria" DOI: https://doi.org/10.1038/s41589-023-01452-w + +

- + - + @@ -10325,19 +14995,19 @@ DCMA syndrome - + - + - + - +
- +

@@ -10345,10 +15015,10 @@ DCMA syndrome - + - + @@ -10358,32 +15028,30 @@ DCMA syndrome - + - + - + -

autosomal recessive spastic ataxia type 5 - -m-AAA protease AFG3L2 subunit deficiency +

Demyelinating Charcot-Marie-Tooth disease type 4A

- + - + @@ -10393,28 +15061,30 @@ m-AAA protease AFG3L2 subunit deficiency - + - +
- + -

+

Autosomal dominant spastic paraplegia type 13 + +

- + - + @@ -10422,61 +15092,69 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - +
- + -

+

Multiple mitochondrial dysfunctions syndrome 6 + +Mitochondria processing peptidase beta deficiency + +

- + + + + + + - - - - - - + - + - + - +
- + -

+

Autosomal recessive spinocerebellar ataxia type 2 + +mitochondrial processing peptidase alpha deficiency + +

- + - + @@ -10484,32 +15162,30 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - +
- + -

Immunodeficiency type 44 - -

+

- + - + @@ -10517,19 +15193,19 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - +

@@ -10537,15 +15213,10 @@ m-AAA protease AFG3L2 subunit deficiency - - - - - - + - + @@ -10553,19 +15224,19 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - +

@@ -10573,10 +15244,10 @@ m-AAA protease AFG3L2 subunit deficiency - + - + @@ -10584,19 +15255,19 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + - + - +

@@ -10604,10 +15275,10 @@ m-AAA protease AFG3L2 subunit deficiency - + - + @@ -10617,30 +15288,30 @@ m-AAA protease AFG3L2 subunit deficiency - + - + - + -

Acylglycerol kinase deficiency +

Immunodeficiency type 44

- + - + @@ -10650,32 +15321,35 @@ m-AAA protease AFG3L2 subunit deficiency - + - +
- + -

MAGMAS deficiency - -Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type +

Active in Cytosol

- + - + + + + + + @@ -10683,58 +15357,70 @@ Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type - + - + - + - +
- + -

+

Active in Cytosol + +

- + + + + + + + + + + + - + - + - + - +
- + -

Demyelinating Charcot-Marie-Tooth disease type 4A +

Early-onset Parkinson disease type 2

- + - + @@ -10744,32 +15430,30 @@ Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type - + - +
- + -

Multiple mitochondrial dysfunctions syndrome 6 - -Mitochondria processing peptidase beta deficiency +

Harel-Yoon syndrome

- + - + @@ -10779,30 +15463,28 @@ Mitochondria processing peptidase beta deficiency - + - +
- + -

Axonal Charcot-Marie-Tooth disease type 2A2A - -

+

- + - + @@ -10810,52 +15492,48 @@ Mitochondria processing peptidase beta deficiency - + - + - + - + - + + + -

Combined oxidative phosphorylation deficiency type 18 +

Degradation

- + - + - - - - - - - - - - - - -
- + + + + + + + +

@@ -10863,96 +15541,79 @@ Mitochondria processing peptidase beta deficiency - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

Spastic paraplegia type7 - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + + + + +

+ + + + + + + + + + + + + + + + + -

Early-onset Parkinson disease type 6 - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + +

@@ -10960,251 +15621,144 @@ Mitochondria processing peptidase beta deficiency - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

Sideoblastic anemia type 4 - -Epiphyseal, vertebral, ear, nose, plus associated malformations (EVEN-plus) syndrome - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

Active in Cytosol - -

+

- - - - - - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

Juvenile Optic Atrophy - -Childhood-onset optic atrophy type 1 - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

aka 2-oxoglutaric acid - -

+

- - - - - - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

also known as optic atrophy-10 (OPA10); NADPH oxidoreductase, enriched in the mitochondrial matrix of muscle tissues. DOI: https://doi.org/10.1038/s41589-023-01452-w - -"COQ3 was the most strongly biotinylated protein by RTN4IP1-TurboID, suggesting a potential involvement of RTN4IP1 in the CoQ production pathway within the mitochondria" DOI: https://doi.org/10.1038/s41589-023-01452-w - -

+

- + - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

Dynamin-like protein 1 deficiency - -encephalopathy due to defective mitochondrondrial and peroxisomal fission - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + +

@@ -11212,89 +15766,69 @@ encephalopathy due to defective mitochondrondrial and peroxisomal fission - + - - - - - - - - - - - - - - + + + + + + + + -

Perrault syndrome type 3 - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

+

Found in transgenic mouse model + +

- + - + - - - - - - - - - - - - -
- + + + + + + + + + + +

@@ -11302,30 +15836,19 @@ encephalopathy due to defective mitochondrondrial and peroxisomal fission - - - - - - + - - - - - - - - - - - - - - + + + + + + + +

@@ -11333,176 +15856,99 @@ encephalopathy due to defective mitochondrondrial and peroxisomal fission - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

cofactor to PYCR3 - -

+

- - - - - - - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

Combined oxidative phosphorylation deficiency type 31 - -Mitochondrial intermediate peptidase deficiency - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

SPINOCEREBELLAR ATAXIA - -

+

- - - - - - + - - - - - - - - - - - - - - + + + + + + + + -

"Given that we identified COQ5 as part of the interactome of RTN4IP1-TurboID, it will be intriguing to further investigate whether RTN4IP1 can assist this reaction of COQ5." DOI: https://doi.org/10.1038/s41589-023-01452-w - -

+

- - - - - - - - - - - + - - - - - - - - - - - - - - - - + + + + + + + +

@@ -11510,24 +15956,19 @@ Mitochondrial intermediate peptidase deficiency - - - - - - + - + - + - +

@@ -11535,19 +15976,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11555,19 +15996,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11575,19 +16016,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11595,19 +16036,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11615,19 +16056,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11635,19 +16076,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11655,19 +16096,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11675,19 +16116,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11695,19 +16136,24 @@ Mitochondrial intermediate peptidase deficiency - + + + + + + - + - + - +

@@ -11715,19 +16161,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11735,19 +16181,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11755,39 +16201,49 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - + -

+

Degradation + +

- + + + + + + - + - + + + +
- +

@@ -11795,19 +16251,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11815,19 +16271,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11835,19 +16291,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11855,19 +16311,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11875,19 +16331,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11895,19 +16351,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11915,19 +16371,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11935,19 +16391,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11955,19 +16411,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11975,19 +16431,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -11995,19 +16451,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12015,19 +16471,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12035,19 +16491,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12055,19 +16511,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12075,10 +16531,10 @@ Mitochondrial intermediate peptidase deficiency - + - + @@ -12086,13 +16542,13 @@ Mitochondrial intermediate peptidase deficiency - + - + - +

@@ -12100,24 +16556,19 @@ Mitochondrial intermediate peptidase deficiency - - - - - - + - + - + - +

@@ -12125,19 +16576,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12145,19 +16596,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12165,19 +16616,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12185,19 +16636,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12205,27 +16656,19 @@ Mitochondrial intermediate peptidase deficiency - - - - - - + - + - + - - - - +

@@ -12233,19 +16676,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12253,19 +16696,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12273,19 +16716,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12293,19 +16736,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12313,19 +16756,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12333,19 +16776,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12353,19 +16796,24 @@ Mitochondrial intermediate peptidase deficiency - + + + + + + - + - + - +

@@ -12373,19 +16821,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12393,19 +16841,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12413,19 +16861,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12433,19 +16881,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12453,19 +16901,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12473,19 +16921,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12493,19 +16941,24 @@ Mitochondrial intermediate peptidase deficiency - + + + + + + - + - + - +

@@ -12513,19 +16966,29 @@ Mitochondrial intermediate peptidase deficiency - + + + + + + - + - + + + + + + - +

@@ -12533,19 +16996,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12553,29 +17016,19 @@ Mitochondrial intermediate peptidase deficiency - - - - - - + - + - + - - - - - - +

@@ -12583,19 +17036,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12603,19 +17056,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12623,19 +17076,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12643,19 +17096,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12663,19 +17116,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12683,39 +17136,46 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - + -

+

Detachment from mitochondrial outer membrane + +

- + + + + + + - + - +
- +

@@ -12723,24 +17183,19 @@ Mitochondrial intermediate peptidase deficiency - - - - - - + - + - + - +

@@ -12748,19 +17203,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12768,19 +17223,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12788,19 +17243,24 @@ Mitochondrial intermediate peptidase deficiency - + + + + + + - + - + - +

@@ -12808,19 +17268,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12828,19 +17288,19 @@ Mitochondrial intermediate peptidase deficiency - + - + - + - +

@@ -12848,17 +17308,25 @@ Mitochondrial intermediate peptidase deficiency - + + + + + + - + - + + + + diff --git a/sbml/WP5504.svg b/sbml/WP5504.svg index 4d4bb3a..37d2da7 100644 --- a/sbml/WP5504.svg +++ b/sbml/WP5504.svg @@ -1,1591 +1,1990 @@ -b7b26da100?d376e??d9562?? DegradationDLP1 deficiencyarginineOPA3?e425aUBXN1OXA1LAFG3L2PYCR3arginineNADPHpyrroline-5-carboxylateYME1L1Urea CyclePYCR3AFG3L2OPA3?COQ3pyrroline-5-carboxylateProlineUrea CycleDegradationUFD1inner membrane translocation insertionCOQ3CoQ BiosynthesisAIFM1AGKC1QBPCLPBCLPPDNAJC19GFERHSPA9HSPD1HTRA2LONP1MIPEPPAM16PITRM1PMPCAPMPCBSFXN4SPG7TIMM8ATIMM50TIMMDC1XPNPEP3 DNM1LGDAP1L1MFFSTAT2TRAK1 MFN2OPA1SLC25A46YME1L1MSTO1?MitochondrialdysfunctionMitophagyPINK1PRKNSACS?PPA2TXN2TXNRD2MICU1ATAD3AMICOS13RTN4IP1TMEM126AUSP9Xc3635VCPCOQ5COQ3biotinProlinepyrroline-5-carboxylate?ornithineglutamateTCA cycleα-KetoglutaratePYCR1PYCR2DNM1LMFFMFF deficiencyGDAP1L1CMT2KCMT4ASTAT2IMD44SLC25A46HMSN6BOPA1OPA1Behr syndromeOPA3MGA3MFN2CMT2A2ACMT2A2BMSTO1MMYATYME1L1OPA11DNAJC19MGCA5TIMM8AMTSTIMMDC1Mitochondrial complex I deficiencyTIMM50MGCA9GFERGFER deficiencyPAM16SMDMDMAGKSengers syndromeCataract 38 (AR)PMPCASCAR2PMPCBMMDS6MIPEPCOXPD31CLPBMEGCANNCLPPPRLTS3LONP1CODASHSPA9SIDBA4HSPD1HLD4SPG13SACS?Sacsin deficiencyAFG3L2SPAX5SCA28SPG7ParapleginDeficiencyHTRA2MGCA8PRKNPARK2PINK1PARK6USP9XMRX99VCPIBMPFD1PITRM1Pitrilysinmetallopeptidase 1deficiencySCAR30OPA11XPNPEP3 NPHPL1PPA2SCFISFXN4COXPD18Protein import, sorting and processingMitochondrial biogenesisMitochondrial biogenesisAIFM1COXPD6ATAD3AHAYOSTMEM126AOPA7C1QBPCOXPD33TRAK1Trafficking kinesin-binding protein 1deficiencyEIEE68MICU1RTN4IP1OPA10MPXPSMICOS13MIC13COXPD37TXN2TXNRD2COXPD29GCCD5NPLOC4UFD1NPLOC4VCPMitophagyregulationSASK1p47?UBXN1SASK1p47a33c3PINK1MFN2MFN1UBXD1/UBXN6MCL1VCP?MitochondrialMembranePotentialVCPMARCHF5Redox metabolismFission+FissionContact site and cristae organizationPhosphate metabolismMitochondrial degradationFragmented mitochondriaMotilityFusionMitochondrial biogenesisFilamentous mitochondriaMitochondrial functionMitochondrial degradationMitochondrial biogenesisMitochondrial degradationPhosphate metabolismContact site and cristae organizationCalcium uptakeFragmented mitochondriaProtein import, sorting and processing+FissionFusionCalcium uptakeMitochondrial biogenesisMitochondrial degradationMotilityFissionMitochondrial functionFusion - + @@ -119,7 +119,7 @@ - + @@ -136,37 +136,10 @@ - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - + @@ -183,10 +156,10 @@ - + - + @@ -203,10 +176,10 @@ - + - + @@ -223,10 +196,10 @@ - + - + @@ -243,7 +216,7 @@ - + @@ -254,15 +227,7 @@ - - - - - - - - - + @@ -279,30 +244,29 @@ - + - - + + - - - - - - + + + + + + - - - + + - + @@ -319,30 +283,26 @@ - + - - - - - - - - - - - - - - - + + + - - + + - + + + + + + + + + @@ -359,10 +319,18 @@ - + - + + + + + + + + + @@ -379,10 +347,10 @@ - + - + @@ -399,10 +367,10 @@ - + - + @@ -419,10 +387,10 @@ - + - + @@ -438,45 +406,9 @@ - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -496,7 +428,15 @@ - + + + + + + + + + @@ -513,10 +453,18 @@ - + - + + + + + + + + + @@ -533,56 +481,50 @@ - + - - + + - - - - - - + + + + + + + - - - - - - - - - - + + - - + + - - - - - - + + + + + + + - - + + - + @@ -599,18 +541,10 @@ - + - - - - - - - - - + @@ -627,18 +561,18 @@ - + - + - + - + @@ -655,10 +589,26 @@ - + - + + + + + + + + + + + + + + + + + @@ -675,10 +625,10 @@ - + - + @@ -695,10 +645,18 @@ - + - + + + + + + + + + @@ -715,26 +673,18 @@ - - - - - - - - - + - + - + - + @@ -751,10 +701,18 @@ - + - + + + + + + + + + @@ -771,34 +729,48 @@ - + - - - - - - - - - - - + + + + + + + + + + + + + + - - + + - - - + + + + + + + + + + + + + + - - + + - + @@ -815,18 +787,10 @@ - + - - - - - - - - - + @@ -843,10 +807,18 @@ - + - + + + + + + + + + @@ -863,10 +835,18 @@ - + - + + + + + + + + + @@ -882,9 +862,29 @@ - + + + + + + + + + + + + + + + + + + + + + @@ -894,14 +894,14 @@ - + - - - - + + + + @@ -936,14 +936,14 @@ - + - - - - + + + + @@ -957,14 +957,14 @@ - + - - - - + + + + @@ -978,20 +978,20 @@ - + - - - - + + + + - + @@ -999,14 +999,14 @@ - + - - - - + + + + @@ -1020,14 +1020,14 @@ - + - - - - + + + + @@ -1039,16 +1039,16 @@ - + - + - - - - + + + + @@ -1060,22 +1060,22 @@ - + - + - - - - + + + + - + @@ -1083,14 +1083,14 @@ - + - - - - + + + + @@ -1156,82 +1156,88 @@ - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + @@ -1240,242 +1246,236 @@ - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -1524,344 +1524,344 @@ - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + - + - - + + - + - - + + - + - - + + - + - - - - - - - - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -1930,82 +1930,88 @@ - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + @@ -2014,219 +2020,213 @@ - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - - - - - - - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + @@ -2234,289 +2234,258 @@ - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + @@ -2525,12 +2494,26 @@ - + - + + + + + + + + + + + + + + + @@ -2539,130 +2522,161 @@ - + - + - + + + - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + - + @@ -2671,65 +2685,51 @@ - + - + - + - - - - + + + + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - - + + @@ -2785,7 +2785,7 @@ - +

@@ -2796,7 +2796,7 @@ - + @@ -2804,19 +2804,19 @@ - + - + - + - + - +

@@ -2825,24 +2825,29 @@ + + + + + - + - + - + - + - +

@@ -2851,29 +2856,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -2884,7 +2889,7 @@ - + @@ -2892,22 +2897,24 @@ - + - + - + - + - + -

+

old name: PGAP5 + +

@@ -2915,7 +2922,7 @@ - + @@ -2923,19 +2930,19 @@ - + - + - + - +
- +

@@ -2944,29 +2951,24 @@ - - - - - - + - + - + - + - +

@@ -2977,7 +2979,7 @@ - + @@ -2985,19 +2987,19 @@ - + - + - + - + - +

@@ -3011,19 +3013,24 @@ - + - + - + + + + + + - + - +

@@ -3034,7 +3041,7 @@ - + @@ -3042,19 +3049,19 @@ - + - + - + - + - +

@@ -3063,29 +3070,24 @@ - - - - - - + - + - + - + - +

@@ -3096,7 +3098,7 @@ - + @@ -3104,19 +3106,19 @@ - + - + - + - + - +

@@ -3127,7 +3129,7 @@ - + @@ -3135,14 +3137,14 @@ - + - + - + - + @@ -3168,17 +3170,17 @@ - + - + - +

@@ -3189,7 +3191,7 @@ - + @@ -3197,52 +3199,50 @@ - + - + - + - + - + -

old name: PGAP5 - -

+

- - - - - - + - + - + + + + + + - + - +

@@ -3251,29 +3251,29 @@ - - - - - - + - + - + - + + + + + + - +

@@ -3282,29 +3282,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -3313,29 +3313,24 @@ - - - - - - + - + - + - + - +

@@ -3344,29 +3339,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -3377,7 +3372,7 @@ - + @@ -3385,19 +3380,19 @@ - + - + - + - + - +

@@ -3408,7 +3403,7 @@ - + @@ -3416,19 +3411,19 @@ - + - + - + - + - +

@@ -3437,29 +3432,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -3468,29 +3463,29 @@ + + + + + - - - - - - + - + - + - + - +

@@ -3501,7 +3496,7 @@ - + @@ -3509,19 +3504,19 @@ - + - + - + - + - +

@@ -3532,7 +3527,7 @@ - + @@ -3540,19 +3535,19 @@ - + - + - + - + - +

@@ -3563,7 +3558,7 @@ - + @@ -3571,19 +3566,19 @@ - + - + - + - + - +

@@ -3594,7 +3589,7 @@ - + @@ -3602,19 +3597,19 @@ - + - + - + - + - +

@@ -3625,7 +3620,7 @@ - + @@ -3633,19 +3628,19 @@ - + - + - + - + - +

@@ -3656,7 +3651,7 @@ - + @@ -3664,19 +3659,19 @@ - + - + - + - + - +

@@ -3690,19 +3685,24 @@ - + - + - + + + + + + - + - +

@@ -3711,29 +3711,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -3744,7 +3744,7 @@ - + @@ -3752,19 +3752,19 @@ - + - + - + - + - +

@@ -3775,7 +3775,7 @@ - + @@ -3783,19 +3783,19 @@ - + - + - + - + - +

@@ -3806,7 +3806,7 @@ - + @@ -3814,19 +3814,19 @@ - + - + - + - + - +

@@ -3835,29 +3835,29 @@ - - - - - - + - + - + + + + + + - + - +

@@ -3866,31 +3866,31 @@ + + + + + - - - - - - + - + - + - + - +

@@ -3898,19 +3898,19 @@ - + - + - + - + @@ -3927,16 +3927,16 @@ - + - + - + - +

@@ -3944,22 +3944,22 @@ - + - + - + - + - +

@@ -3967,22 +3967,22 @@ - + - + - + - + - +

@@ -3990,22 +3990,22 @@ - + - + - + - + - +

@@ -4013,22 +4013,22 @@ - + - + - + - + - +

@@ -4036,22 +4036,22 @@ - + - + - + - + - +

@@ -4059,22 +4059,22 @@ - + - + - + - + - +

@@ -4082,22 +4082,22 @@ - + - + - + - + - +

@@ -4105,19 +4105,19 @@ - + - + - + - + @@ -4134,13 +4134,13 @@ - + - + - + diff --git a/sbml/WP5505.svg b/sbml/WP5505.svg index 85c2c63..4d8f5e5 100644 --- a/sbml/WP5505.svg +++ b/sbml/WP5505.svg @@ -8,21 +8,50 @@ />b0fd8?d5eb9da077b0fd8c97bcd5eb9ea1bdda077d53f8?c97bcd53f8ea1bdMetaboliteGolgi then Cell SurfaceCytoplasmEndoplasmic Reticulum MembraneGolgi then Cell Surface - + @@ -8,13 +8,20 @@ -[CATALYSIS:id26150] Interaction is not connected +[CATALYSIS:id43adc656] Interaction is not connected [CATALYSIS:id681c2324] Interaction is not connected +[CATALYSIS:id7374853e] Interaction is not connected +[ARROW:id9efe3bda] Interaction is not connected +[ARROW:idb6b2dde8] Interaction is not connected [CONVERSION:idbe850b0b] Interaction is not connected [CATALYSIS:bd2f5] Interaction is not connected +[CATALYSIS:e19e8] Interaction is not connected +[CATALYSIS:f9be5] Interaction is not connected +[CATALYSIS:f2383] Interaction is not connected [Label:d7a82] Label cannot be part of reaction. Tranforming to Unknown [Label:cf0ea] Label cannot be part of reaction. Tranforming to Unknown -[Label:f7ea7] Label cannot be part of reaction. Tranforming to Unknown

+[Label:f7ea7] Label cannot be part of reaction. Tranforming to Unknown +[BiopaxReference:cdb] Publication is invalid.

@@ -29,10 +36,10 @@ + + - - @@ -72,46 +79,78 @@ - + + + + + + + + + - + - + - + - - - + + + - + + + + + + + + + - - - + + + - - + + - + - + + + + + + + + + + + + + + + + + @@ -120,45 +159,61 @@ - + - + - + + + + + + + + + + + + + + + + + - + - + - + - + - + - - - + + + - - + + @@ -174,50 +229,50 @@ - + - - - - + + + + - + - + - - + + - - - - + + + + - + - + - - + + - - - - + + + + @@ -228,32 +283,32 @@ - + - - - - + + + + - + - + - - + + - - - - + + + + @@ -264,14 +319,14 @@ - + - - - - + + + + @@ -282,7 +337,25 @@ - + + + + + + + + + + + + + + + + + + + @@ -294,13 +367,31 @@ - + + + + + + + + + + + + + + + + + + + - + - + @@ -312,56 +403,92 @@ - + - + - + - - - - + + + + - + + + + + + + + + + + + + + + + + + + - + - + - - - - + + + + - + - + - + - - - - + + + + + + + + + + + + + + + + + + + + + + @@ -372,283 +499,351 @@ - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + + + + + + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + @@ -658,7 +853,7 @@ - + @@ -668,7 +863,7 @@ - + @@ -680,103 +875,103 @@ - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + @@ -786,7 +981,7 @@ - + @@ -796,7 +991,7 @@ - + @@ -808,54 +1003,180 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + + + + + + + + + + + + + + + + + + + - + - + - + - + - - + + - + - - + + - + - + + + + + + + - + - + - + - - + + + + + + + + @@ -864,27 +1185,33 @@ - + - - + + - + - - + + + + + + + + - + - + @@ -892,44 +1219,44 @@ - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -959,10 +1286,18 @@ - + -

+

DISEASE + +ICIMD Nosology Number: 21.4.06.01 + +IEM Nosology Code: IEM1559 + +OMIM: # 618845 + +

@@ -970,7 +1305,43 @@ - + + + + + + + + + + + + + + + + + + + + + + + + +
+ + + +

+ + + + + + + + @@ -980,17 +1351,17 @@ - + - + - +

@@ -998,10 +1369,10 @@ - + - + @@ -1011,41 +1382,187 @@ - + - + - + -

DISEASE - -ICIMD Nosology Number: 21.4.06.01 - -IEM Nosology Code: IEM1559 +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

nicotinate mononucleotide -OMIM: # 618845 +

+ +
+ + + + + + + + + + + + + + + + + + + + + + + + +
+ + + +

nicotinate adenine dinucleotide

- - - - - - + + + + + + + + + + + + + + + + + + + + + + +
+ + + +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

+ + + + + - + @@ -1053,30 +1570,43 @@ OMIM: # 618845 - + - + - + - + - + -

+

DISEASE + +ICIMD Nosology Number: 21.4.03.01 + +IEM Nosology Code: IEM0243 + +OMIM: # 617186 + +

- + - + + + + + + @@ -1084,19 +1614,19 @@ OMIM: # 618845 - + - + - + - +
- +

@@ -1104,7 +1634,7 @@ OMIM: # 618845 - + @@ -1117,41 +1647,28 @@ OMIM: # 618845 - + - + - + -

DISEASE - -ICIMD Nosology Number: 21.4.03.01 - -IEM Nosology Code: IEM0243 - -OMIM: # 617186 - -

+

- - - - - - + - + @@ -1159,19 +1676,19 @@ OMIM: # 617186 - + - + - + - + - +

@@ -1179,10 +1696,10 @@ OMIM: # 617186 - + - + @@ -1190,32 +1707,32 @@ OMIM: # 617186 - + - + - + - + - + -

nicotinate adenine dinucleotide +

SMILES NC(=O)C1=CN2C(CC1)OC1C2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)[C@H]1O

- + - + @@ -1225,30 +1742,30 @@ OMIM: # 617186 - + - +
- + -

SMILES NC(=O)C1=CN2C(CC1)OC1C2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)[C@H]1O +

nicotinate adenine dinucleotide

- + - + @@ -1258,28 +1775,30 @@ OMIM: # 617186 - + - +
- + -

+

nicotinate adenine dinucleotide + +

- + - + @@ -1289,28 +1808,30 @@ OMIM: # 617186 - + - +
- + -

+

nicotinate adenine dinucleotide + +

- + - + @@ -1318,19 +1839,19 @@ OMIM: # 617186 - + - + - + - +
- +

DISEASE @@ -1346,10 +1867,10 @@ OMIM: # 618321 - + - + @@ -1364,19 +1885,19 @@ OMIM: # 618321 - + - + - +

@@ -1384,19 +1905,19 @@ OMIM: # 618321 - + - + - + - +

@@ -1404,19 +1925,19 @@ OMIM: # 618321 - + - + - + - +

@@ -1424,19 +1945,51 @@ OMIM: # 618321 - + + + + + + - + - + - + + + +

Reversible + +

+ +
+ + + + + + + + + + + + + + + + + + + +

@@ -1444,19 +1997,19 @@ OMIM: # 618321 - + - + - +

@@ -1464,7 +2017,12 @@ OMIM: # 618321 - + + + + + + @@ -1473,20 +2031,25 @@ OMIM: # 618321 - + - + -

Reversible +

Eukaryotic NAXD is ATP-dependent (Rhea:19017) while prokaryotic homolog is ADP-dependent (Rhea:32223)

- + + + + + + @@ -1495,7 +2058,7 @@ OMIM: # 618321 - +
@@ -1507,15 +2070,45 @@ OMIM: # 618321 + + + + + + + + + + - + - + + + + + + +

+ + + + + + + + + + + + + + @@ -1532,13 +2125,13 @@ OMIM: # 618321 - + - + - +

@@ -1546,19 +2139,39 @@ OMIM: # 618321 - + + + + + + + + + +

+ + + + + + + + + + + - + - +

@@ -1566,19 +2179,39 @@ OMIM: # 618321 - + + + + + + + + + +

+ + + + + + + + + + + - + - +

@@ -1586,16 +2219,21 @@ OMIM: # 618321 - + + + + + + - + - + diff --git a/sbml/WP5506.svg b/sbml/WP5506.svg index 5e240f6..4186c8b 100644 --- a/sbml/WP5506.svg +++ b/sbml/WP5506.svg @@ -1,45 +1,86 @@ -NAD(P)HX epimeraseNAD(+)deamido-NAD(+)NADSYNTHETASE 1NADH(S)-NADHX(R)-NADHXNAD(P)HX DEHYDRATASENAD(P)HX dehydratase deficiencyNAD synthetase 1 deficiencynicotamide ADP-D-ribose cyclic ADP-D-ribose NMN(+)CD38BSTSpontaneus - + @@ -35,10 +35,10 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - - + + @@ -88,22 +88,66 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + + + + + + + + + - + - - - + + + + + + + + + + + + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -112,28 +156,36 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + + + + + + + + + - + - + - + @@ -144,6 +196,22 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui + + + + + + + + + + + + + + + + @@ -160,21 +228,13 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - - - - - - - - - - - + + + - - + + @@ -193,111 +253,90 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - - - - - - - - - - - - - - - - - - - - + - + - - - - - - - + + - - - - + + - - + + - - + + - - - - - - + + + + - - - - - - - - - - - - - + + - - + + - - + + - + - + - + - + - - - - + + + + - + - + + + + + + + + + + + + + + + + + + + - + @@ -309,34 +348,43 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + + + + + + + - + + + + - + - - - - + + + + - + - + - + @@ -348,52 +396,37 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - - + + - - - - - - - - - - - + + - + - + - + - + - + - + - + - - - - - - - + @@ -405,36 +438,6 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -463,193 +466,275 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + - + - - + + - + + + + + + + + + + + + + - - + + + + + + + + - - + + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + + + + + - + - - + + - + @@ -659,7 +744,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -677,7 +762,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -689,139 +774,129 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - - + + - + - - - - - - + + - + - - + + + + + + + + - - + + - + - - + + + + + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - + - - - - - - + + - + - - + + - + - + - + - + @@ -831,170 +906,120 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - - + + - + - - + + - + - - + + - - + + - - + + - + - - - - - - - - - - - - - - - + - - + + - - - - - - - - + + - - - - - - - - + + - - - - - - - - + + - - - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - - - - - - - + + - + - - + + - + - - + + @@ -1015,112 +1040,112 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - - + + - + - - + + - + - + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + @@ -1137,12 +1162,12 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + @@ -1151,26 +1176,12 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - - - - - - - - - - - - - - - + - + - + @@ -1179,12 +1190,12 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + @@ -1193,17 +1204,31 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + + + + + + + + + + + + + + + @@ -1268,20 +1293,22 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + -

+

Mitochondrial membrane transporter + +

@@ -1289,7 +1316,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1297,24 +1324,22 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - +
- + -

Mitochondrial membrane transporter - -

+

@@ -1322,7 +1347,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1330,19 +1355,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - +

@@ -1353,7 +1378,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1361,57 +1386,53 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - + -

Mitochondrial membrane transporter - -

+

- - - - - - + - + - + + + + + + - + - + -

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 82 - -

+

@@ -1419,7 +1440,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1427,19 +1448,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - +

@@ -1450,7 +1471,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1458,22 +1479,22 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - + -

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 39 WITH LEUKODYSTROPHY +

Mitochondrial membrane transporter

@@ -1483,7 +1504,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1491,22 +1512,24 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui
- + - + - + - +
- + -

+

Mitochondrial membrane transporter + +

@@ -1514,7 +1537,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1522,22 +1545,24 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - +
- + -

+

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 3 + +

@@ -1545,7 +1570,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1553,24 +1578,22 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - +
- + -

Mitochondrial membrane transporter - -

+

@@ -1578,7 +1601,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1586,22 +1609,24 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - + -

+

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 39 WITH LEUKODYSTROPHY + +

@@ -1609,7 +1634,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1617,19 +1642,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - +
- +

@@ -1640,7 +1665,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1648,19 +1673,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - +

@@ -1669,29 +1694,29 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui + + + + + - - - - - - + - + - + - + - +

@@ -1702,7 +1727,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1712,22 +1737,20 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + -

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 3 - -

+

@@ -1735,7 +1758,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1743,22 +1766,24 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - + - + -

+

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 82 + +

@@ -1766,7 +1791,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1774,19 +1799,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - +
- +

@@ -1797,7 +1822,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1807,17 +1832,17 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - +

@@ -1828,7 +1853,7 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + @@ -1838,45 +1863,49 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + -

+

Maybe also reversed reaction possible through GLUD1, GLUD1 can use both NAD(H) and NADP(H) which are different RHEA entries + +

- + + + + + + - - - + - - + - + - +

@@ -1884,19 +1913,30 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + + + + + + - + + - + + + + + + - +

@@ -1904,22 +1944,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - - - - +

@@ -1927,19 +1964,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - + - + - +

@@ -1947,19 +1984,30 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + + + + + + - + + + - + + + + + - +

@@ -1967,28 +2015,19 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + - - - - + - - - + - - - - - +

@@ -1996,23 +2035,30 @@ Reflecting the pathway as shown in Figure 43.2 of Blau et al. "Physician’s gui - + + + + + + + + + + + - + - - - + + + - - - diff --git a/sbml/WP5507.svg b/sbml/WP5507.svg index 8978b4d..e97a25f 100644 --- a/sbml/WP5507.svg +++ b/sbml/WP5507.svg @@ -8,33 +8,36 @@ />H+SLC25A12SLC25A13NICCDCTLN2 - + @@ -48,9 +48,9 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme + - @@ -84,158 +84,117 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - + + + - - + + - + - + - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - - - - - - - - - - - - - - + + + - - + + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - + - + - + - + - - + + - + - - - + + + - - + + - + - + - - - + + + - - + + @@ -245,164 +204,178 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - - - - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - - + + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - - + + - + - + - + - - - - - - - - - - - + + + - - + + - + - + - + - + - - + + - + - + - + - + - + - + - + - + + + + + + + + + - + @@ -424,41 +397,68 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - + + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + - + - + - - - - + + + + + + + @@ -471,14 +471,14 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - - - + + + + @@ -514,66 +514,69 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + + + + - - - - - - - - + + + + + + + + - - - - + - + + + + - + - - - - + + + + - + - + - + - + - + @@ -585,9 +588,6 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - @@ -600,14 +600,14 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - - - + + + + @@ -627,14 +627,14 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - - - + + + + @@ -661,94 +661,88 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - + - + - - + + - + - - + + - + - - + + - + - - + + @@ -757,260 +751,262 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + - + - - + + - - - - - - - - - - - + - - - - - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + + + + + + + + + + - - + + - + - - + + @@ -1087,133 +1083,147 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - + - - + + - + - - + + + + + + - + - - + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - - + + - + - - + + - + @@ -1223,7 +1233,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1233,7 +1243,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1243,7 +1253,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1257,7 +1267,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1269,136 +1279,126 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - - - - - - - - - - - + - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - - + + - + - - + + @@ -1407,130 +1407,154 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -1539,22 +1563,16 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - - + - - + + - + - - + + @@ -1563,52 +1581,46 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + @@ -1617,27 +1629,15 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - - - - - - - - + - - + + - + @@ -1649,7 +1649,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1657,30 +1657,30 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - + - + - + - + - + - + @@ -1689,63 +1689,68 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - + - + - + - + + + + + + + + + + - + - - - - - + - + - + - + - + - + - + - + - + - + @@ -1754,17 +1759,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + @@ -1773,120 +1778,115 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + + + + + + - + + + + + - + - + - + - + - + - + - + - - + + @@ -1914,7 +1914,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - +

@@ -1925,7 +1925,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1933,19 +1933,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -1956,7 +1956,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -1966,17 +1966,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -1985,24 +1985,29 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme + + + + + - + - + - + - + - +

@@ -2011,29 +2016,29 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme + + + + + - - - - - - + - + - + - + - +

@@ -2042,29 +2047,29 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme + + + + + - - - - - - + - + - + - + - +

@@ -2075,7 +2080,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2083,19 +2088,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2106,7 +2111,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2114,19 +2119,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2137,7 +2142,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2147,17 +2152,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -2166,29 +2171,29 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme + + + + + - - - - - - + - + - + - + - +

@@ -2199,7 +2204,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2209,17 +2214,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -2230,7 +2235,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2238,19 +2243,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2261,7 +2266,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2269,19 +2274,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2292,7 +2297,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2300,19 +2305,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

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@@ -2507,11 +2512,6 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - @@ -2519,17 +2519,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -2540,7 +2540,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2548,19 +2548,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

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@@ -2633,7 +2633,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2643,17 +2643,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

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@@ -2695,7 +2695,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2703,19 +2703,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2726,7 +2726,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2736,17 +2736,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -2757,7 +2757,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2767,17 +2767,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -2788,7 +2788,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2796,19 +2796,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2819,7 +2819,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2827,19 +2827,19 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - + - + - +

@@ -2848,29 +2848,29 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - + - + - + + + + + + - + - +

@@ -2881,7 +2881,7 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + @@ -2891,17 +2891,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + - +

@@ -2910,29 +2910,29 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme + + + + + - - - - - - + - + - + - + - +

@@ -2941,31 +2941,31 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - - - - - + - + - + + + + + + - + - +

@@ -2973,24 +2973,23 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + - - + + - + - +

@@ -2998,20 +2997,21 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + + - + - + @@ -3028,18 +3028,18 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - - + + - - + + - + - +

@@ -3047,23 +3047,24 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - + + - - + + - + - +

@@ -3071,21 +3072,21 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - - + + - + @@ -3102,17 +3103,17 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - + - +

@@ -3120,24 +3121,23 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + - - + + - + - +

@@ -3145,21 +3145,21 @@ Source: Wikipedia http://en.wikipedia.org/wiki/Heme - + - - + + - - + + - + diff --git a/sbml/WP561.svg b/sbml/WP561.svg index 2dcdfa1..6830069 100644 --- a/sbml/WP561.svg +++ b/sbml/WP561.svg @@ -8,41 +8,14 @@ />d103aaab29d6a95b51edaab29protoporphyrinogen IXb51eddelta-aminolevulinateprotoporphyrinogen IXALAS1CO2PorphobilinogenALADH2OO2Fe2+H2O2CO2H+NH3PPOXCO2hydroxymethylbilaneGlycineURODCO2PorphobilinogenH2OUROShydroxymethylbilaneH2OGlycineprotoporphyrin IXFECHALADH+porphobilinogenprotohemeALAS2NH3coproporphyrinogen IIIUROSsuccinyl-CoAprotoporphyrin IXCO2H2Ocoproporphyrinogen IIIprotohemePPOXCPOXALAS1H2O2H2OURODCO2uroporphyrinogen IIICoAuroporphyrinogen IIIFECHFe2+O2Red - side productsBlack - reactantsrate limiting stepBlack - reactants - + @@ -71,8 +71,8 @@ Metabolic Process - + @@ -105,311 +105,319 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + + + @@ -420,271 +428,263 @@ Metabolic Process - - - - - - - - - - - - - - - - - - - - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - + + + + + + + + + + + + + + - - + + - + - + - + - + - + - + - - - + + + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - + - + - + - + - + - + - + + + + + + + + + - + @@ -762,423 +762,423 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - + - + - + - + - + - + - + @@ -1300,93 +1300,99 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + @@ -1396,129 +1402,129 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -1528,195 +1534,189 @@ Metabolic Process - + - - + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - + + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -1742,212 +1742,226 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + + + + + + + + + + + + + + + - + @@ -1956,124 +1970,124 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -2082,680 +2096,666 @@ Metabolic Process - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - + - + - - - - - + - + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -2783,7 +2783,7 @@ Metabolic Process - +

@@ -2794,7 +2794,7 @@ Metabolic Process - + @@ -2802,19 +2802,19 @@ Metabolic Process - + - + - + - + - +

@@ -2825,7 +2825,7 @@ Metabolic Process - + @@ -2833,19 +2833,19 @@ Metabolic Process - + - + - + - + - +

@@ -2856,7 +2856,7 @@ Metabolic Process - + @@ -2864,19 +2864,19 @@ Metabolic Process - + - + - + - + - +

@@ -2887,7 +2887,7 @@ Metabolic Process - + @@ -2895,19 +2895,19 @@ Metabolic Process - + - + - + - + - +

@@ -2918,7 +2918,7 @@ Metabolic Process - + @@ -2926,19 +2926,19 @@ Metabolic Process - + - + - + - + - +

@@ -2949,7 +2949,7 @@ Metabolic Process - + @@ -2957,19 +2957,19 @@ Metabolic Process - + - + - + - + - +

@@ -2980,7 +2980,7 @@ Metabolic Process - + @@ -2988,19 +2988,19 @@ Metabolic Process - + - + - + - + - +

@@ -3011,7 +3011,7 @@ Metabolic Process - + @@ -3019,19 +3019,19 @@ Metabolic Process - + - + - + - + - +

@@ -3042,7 +3042,7 @@ Metabolic Process - + @@ -3050,19 +3050,19 @@ Metabolic Process - + - + - + - + - +

@@ -3073,7 +3073,7 @@ Metabolic Process - + @@ -3081,19 +3081,19 @@ Metabolic Process - + - + - + - + - +

@@ -3104,7 +3104,7 @@ Metabolic Process - + @@ -3112,19 +3112,19 @@ Metabolic Process - + - + - + - + - +

@@ -3135,7 +3135,7 @@ Metabolic Process - + @@ -3143,19 +3143,19 @@ Metabolic Process - + - + - + - + - +

@@ -3166,7 +3166,7 @@ Metabolic Process - + @@ -3174,19 +3174,19 @@ Metabolic Process - + - + - + - + - +

@@ -3197,7 +3197,7 @@ Metabolic Process - + @@ -3205,19 +3205,19 @@ Metabolic Process - + - + - + - + - +

@@ -3228,7 +3228,7 @@ Metabolic Process - + @@ -3236,19 +3236,19 @@ Metabolic Process - + - + - + - + - +

@@ -3259,7 +3259,7 @@ Metabolic Process - + @@ -3267,19 +3267,19 @@ Metabolic Process - + - + - + - + - +

@@ -3290,7 +3290,7 @@ Metabolic Process - + @@ -3298,19 +3298,19 @@ Metabolic Process - + - + - + - + - +

@@ -3321,7 +3321,7 @@ Metabolic Process - + @@ -3329,19 +3329,19 @@ Metabolic Process - + - + - + - + - +

@@ -3352,12 +3352,7 @@ Metabolic Process - - - - - - + @@ -3365,19 +3360,19 @@ Metabolic Process - + - + - + - + - +

@@ -3388,7 +3383,7 @@ Metabolic Process - + @@ -3396,19 +3391,19 @@ Metabolic Process - + - + - + - + - +

@@ -3419,7 +3414,7 @@ Metabolic Process - + @@ -3427,19 +3422,19 @@ Metabolic Process - + - + - + - + - +

@@ -3450,7 +3445,7 @@ Metabolic Process - + @@ -3458,19 +3453,19 @@ Metabolic Process - + - + - + - + - +

@@ -3481,7 +3476,7 @@ Metabolic Process - + @@ -3489,19 +3484,19 @@ Metabolic Process - + - + - + - + - +

@@ -3512,7 +3507,7 @@ Metabolic Process - + @@ -3520,19 +3515,19 @@ Metabolic Process - + - + - + - + - +

@@ -3543,7 +3538,7 @@ Metabolic Process - + @@ -3551,19 +3546,19 @@ Metabolic Process - + - + - + - + - +

@@ -3572,29 +3567,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -3603,29 +3598,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -3636,7 +3631,7 @@ Metabolic Process - + @@ -3644,19 +3639,19 @@ Metabolic Process - + - + - + - + - +

@@ -3667,7 +3662,7 @@ Metabolic Process - + @@ -3675,19 +3670,19 @@ Metabolic Process - + - + - + - + - +

@@ -3698,7 +3693,7 @@ Metabolic Process - + @@ -3706,19 +3701,19 @@ Metabolic Process - + - + - + - + - +

@@ -3729,7 +3724,7 @@ Metabolic Process - + @@ -3737,19 +3732,19 @@ Metabolic Process - + - + - + - + - +

@@ -3760,7 +3755,7 @@ Metabolic Process - + @@ -3768,19 +3763,19 @@ Metabolic Process - + - + - + - + - +

@@ -3791,7 +3786,7 @@ Metabolic Process - + @@ -3799,19 +3794,19 @@ Metabolic Process - + - + - + - + - +

@@ -3822,7 +3817,7 @@ Metabolic Process - + @@ -3830,19 +3825,19 @@ Metabolic Process - + - + - + - + - +

@@ -3853,7 +3848,7 @@ Metabolic Process - + @@ -3861,19 +3856,19 @@ Metabolic Process - + - + - + - + - +

@@ -3884,7 +3879,7 @@ Metabolic Process - + @@ -3892,19 +3887,19 @@ Metabolic Process - + - + - + - + - +

@@ -3915,7 +3910,7 @@ Metabolic Process - + @@ -3923,19 +3918,19 @@ Metabolic Process - + - + - + - + - +

@@ -3946,12 +3941,7 @@ Metabolic Process - - - - - - + @@ -3959,19 +3949,19 @@ Metabolic Process - + - + - + - + - +

@@ -3980,29 +3970,34 @@ Metabolic Process + + + + + + + + + + - - - - - - + - + - + - + - +

@@ -4013,7 +4008,7 @@ Metabolic Process - + @@ -4021,19 +4016,19 @@ Metabolic Process - + - + - + - + - +

@@ -4044,7 +4039,7 @@ Metabolic Process - + @@ -4052,19 +4047,19 @@ Metabolic Process - + - + - + - + - +

@@ -4075,7 +4070,7 @@ Metabolic Process - + @@ -4083,19 +4078,19 @@ Metabolic Process - + - + - + - + - +

@@ -4106,7 +4101,7 @@ Metabolic Process - + @@ -4114,19 +4109,19 @@ Metabolic Process - + - + - + - + - +

@@ -4137,7 +4132,7 @@ Metabolic Process - + @@ -4145,19 +4140,19 @@ Metabolic Process - + - + - + - + - +

@@ -4168,7 +4163,7 @@ Metabolic Process - + @@ -4176,19 +4171,19 @@ Metabolic Process - + - + - + - + - +

@@ -4199,7 +4194,7 @@ Metabolic Process - + @@ -4207,19 +4202,19 @@ Metabolic Process - + - + - + - + - +

@@ -4230,7 +4225,7 @@ Metabolic Process - + @@ -4238,19 +4233,19 @@ Metabolic Process - + - + - + - + - +

@@ -4261,7 +4256,7 @@ Metabolic Process - + @@ -4269,19 +4264,19 @@ Metabolic Process - + - + - + - + - +

@@ -4292,7 +4287,7 @@ Metabolic Process - + @@ -4300,19 +4295,19 @@ Metabolic Process - + - + - + - + - +

@@ -4323,7 +4318,7 @@ Metabolic Process - + @@ -4331,19 +4326,19 @@ Metabolic Process - + - + - + - + - +

@@ -4354,7 +4349,7 @@ Metabolic Process - + @@ -4362,19 +4357,19 @@ Metabolic Process - + - + - + - + - +

@@ -4385,7 +4380,7 @@ Metabolic Process - + @@ -4393,19 +4388,19 @@ Metabolic Process - + - + - + - + - +

@@ -4416,7 +4411,7 @@ Metabolic Process - + @@ -4424,19 +4419,19 @@ Metabolic Process - + - + - + - + - +

@@ -4447,7 +4442,7 @@ Metabolic Process - + @@ -4455,19 +4450,19 @@ Metabolic Process - + - + - + - + - +

@@ -4476,29 +4471,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -4509,7 +4504,7 @@ Metabolic Process - + @@ -4517,19 +4512,19 @@ Metabolic Process - + - + - + - + - +

@@ -4540,7 +4535,7 @@ Metabolic Process - + @@ -4548,19 +4543,19 @@ Metabolic Process - + - + - + - + - +

@@ -4571,7 +4566,7 @@ Metabolic Process - + @@ -4579,19 +4574,19 @@ Metabolic Process - + - + - + - + - +

@@ -4602,7 +4597,7 @@ Metabolic Process - + @@ -4610,19 +4605,19 @@ Metabolic Process - + - + - + - + - +

@@ -4633,7 +4628,7 @@ Metabolic Process - + @@ -4641,19 +4636,19 @@ Metabolic Process - + - + - + - + - +

@@ -4664,7 +4659,7 @@ Metabolic Process - + @@ -4672,19 +4667,19 @@ Metabolic Process - + - + - + - + - +

@@ -4695,7 +4690,7 @@ Metabolic Process - + @@ -4703,19 +4698,19 @@ Metabolic Process - + - + - + - + - +

@@ -4726,7 +4721,7 @@ Metabolic Process - + @@ -4734,19 +4729,19 @@ Metabolic Process - + - + - + - + - +

@@ -4757,7 +4752,7 @@ Metabolic Process - + @@ -4765,19 +4760,19 @@ Metabolic Process - + - + - + - + - +

@@ -4788,7 +4783,7 @@ Metabolic Process - + @@ -4796,19 +4791,19 @@ Metabolic Process - + - + - + - + - +

@@ -4819,7 +4814,12 @@ Metabolic Process - + + + + + + @@ -4829,17 +4829,17 @@ Metabolic Process - + - + - +

@@ -4850,7 +4850,7 @@ Metabolic Process - + @@ -4858,19 +4858,19 @@ Metabolic Process - + - + - + - + - +

@@ -4881,7 +4881,7 @@ Metabolic Process - + @@ -4889,19 +4889,19 @@ Metabolic Process - + - + - + - + - +

@@ -4912,7 +4912,7 @@ Metabolic Process - + @@ -4920,19 +4920,19 @@ Metabolic Process - + - + - + - + - +

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@@ -8902,7 +8899,7 @@ Metabolic Process - + @@ -8910,19 +8907,19 @@ Metabolic Process - + - + - + - + - +

@@ -8933,7 +8930,7 @@ Metabolic Process - + @@ -8941,19 +8938,19 @@ Metabolic Process - + - + - + - + - +

@@ -8962,29 +8959,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -8995,7 +8987,7 @@ Metabolic Process - + @@ -9003,19 +8995,19 @@ Metabolic Process - + - + - + - + - +

@@ -9026,7 +9018,7 @@ Metabolic Process - + @@ -9034,19 +9026,19 @@ Metabolic Process - + - + - + - + - +

@@ -9057,7 +9049,7 @@ Metabolic Process - + @@ -9065,19 +9057,19 @@ Metabolic Process - + - + - + - + - +

@@ -9086,29 +9078,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -9117,29 +9109,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -9148,29 +9135,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -9179,29 +9161,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -9210,24 +9192,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -9238,7 +9225,7 @@ Metabolic Process - + @@ -9246,19 +9233,19 @@ Metabolic Process - + - + - + - + - +

@@ -9269,7 +9256,7 @@ Metabolic Process - + @@ -9277,19 +9264,19 @@ Metabolic Process - + - + - + - + - +

@@ -9300,7 +9287,7 @@ Metabolic Process - + @@ -9308,19 +9295,19 @@ Metabolic Process - + - + - + - + - +

@@ -9331,7 +9318,7 @@ Metabolic Process - + @@ -9339,19 +9326,19 @@ Metabolic Process - + - + - + - + - +

@@ -9362,7 +9349,7 @@ Metabolic Process - + @@ -9370,19 +9357,19 @@ Metabolic Process - + - + - + - + - +

@@ -9393,7 +9380,7 @@ Metabolic Process - + @@ -9401,19 +9388,19 @@ Metabolic Process - + - + - + - + - +

@@ -9422,29 +9409,29 @@ Metabolic Process - - - - - - + - + - + - + + + + + + - +

@@ -9455,7 +9442,7 @@ Metabolic Process - + @@ -9463,19 +9450,19 @@ Metabolic Process - + - + - + - + - +

@@ -9486,7 +9473,7 @@ Metabolic Process - + @@ -9494,19 +9481,19 @@ Metabolic Process - + - + - + - + - +

@@ -9517,7 +9504,7 @@ Metabolic Process - + @@ -9525,19 +9512,19 @@ Metabolic Process - + - + - + - + - +

@@ -9548,7 +9535,7 @@ Metabolic Process - + @@ -9556,19 +9543,19 @@ Metabolic Process - + - + - + - + - +

@@ -9579,7 +9566,7 @@ Metabolic Process - + @@ -9587,19 +9574,19 @@ Metabolic Process - + - + - + - + - +

@@ -9610,7 +9597,7 @@ Metabolic Process - + @@ -9618,19 +9605,19 @@ Metabolic Process - + - + - + - + - +

@@ -9639,29 +9626,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -9672,7 +9654,7 @@ Metabolic Process - + @@ -9680,19 +9662,19 @@ Metabolic Process - + - + - + - + - +

@@ -9703,7 +9685,7 @@ Metabolic Process - + @@ -9711,19 +9693,19 @@ Metabolic Process - + - + - + - + - +

@@ -9734,7 +9716,7 @@ Metabolic Process - + @@ -9742,19 +9724,19 @@ Metabolic Process - + - + - + - + - +

@@ -9765,7 +9747,7 @@ Metabolic Process - + @@ -9773,19 +9755,19 @@ Metabolic Process - + - + - + - + - +

@@ -9796,7 +9778,7 @@ Metabolic Process - + @@ -9804,19 +9786,19 @@ Metabolic Process - + - + - + - + - +

@@ -9827,7 +9809,7 @@ Metabolic Process - + @@ -9835,19 +9817,19 @@ Metabolic Process - + - + - + - + - +

@@ -9856,29 +9838,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -9889,7 +9871,7 @@ Metabolic Process - + @@ -9897,19 +9879,19 @@ Metabolic Process - + - + - + - + - +

@@ -9918,29 +9900,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -9951,7 +9928,7 @@ Metabolic Process - + @@ -9959,19 +9936,19 @@ Metabolic Process - + - + - + - + - +

@@ -9982,7 +9959,7 @@ Metabolic Process - + @@ -9990,19 +9967,19 @@ Metabolic Process - + - + - + - + - +

@@ -10013,7 +9990,7 @@ Metabolic Process - + @@ -10021,19 +9998,19 @@ Metabolic Process - + - + - + - + - +

@@ -10042,29 +10019,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -10075,7 +10047,7 @@ Metabolic Process - + @@ -10083,19 +10055,19 @@ Metabolic Process - + - + - + - + - +

@@ -10106,7 +10078,7 @@ Metabolic Process - + @@ -10114,19 +10086,19 @@ Metabolic Process - + - + - + - + - +

@@ -10137,7 +10109,7 @@ Metabolic Process - + @@ -10145,19 +10117,19 @@ Metabolic Process - + - + - + - + - +

@@ -10168,7 +10140,7 @@ Metabolic Process - + @@ -10176,19 +10148,19 @@ Metabolic Process - + - + - + - + - +

@@ -10199,7 +10171,7 @@ Metabolic Process - + @@ -10207,19 +10179,19 @@ Metabolic Process - + - + - + - + - +

@@ -10228,29 +10200,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -10259,29 +10231,29 @@ Metabolic Process - - - - - - + - + - + - + + + + + + - +

@@ -10292,7 +10264,7 @@ Metabolic Process - + @@ -10300,19 +10272,19 @@ Metabolic Process - + - + - + - + - +

@@ -10323,7 +10295,7 @@ Metabolic Process - + @@ -10331,19 +10303,19 @@ Metabolic Process - + - + - + - + - +

@@ -10354,7 +10326,7 @@ Metabolic Process - + @@ -10362,19 +10334,19 @@ Metabolic Process - + - + - + - + - +

@@ -10385,7 +10357,7 @@ Metabolic Process - + @@ -10393,19 +10365,19 @@ Metabolic Process - + - + - + - + - +

@@ -10416,7 +10388,7 @@ Metabolic Process - + @@ -10424,19 +10396,19 @@ Metabolic Process - + - + - + - + - +

@@ -10447,7 +10419,7 @@ Metabolic Process - + @@ -10455,19 +10427,19 @@ Metabolic Process - + - + - + - + - +

@@ -10476,29 +10448,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -10509,7 +10481,7 @@ Metabolic Process - + @@ -10517,19 +10489,19 @@ Metabolic Process - + - + - + - + - +

@@ -10540,7 +10512,7 @@ Metabolic Process - + @@ -10548,19 +10520,19 @@ Metabolic Process - + - + - + - + - +

@@ -10571,7 +10543,7 @@ Metabolic Process - + @@ -10579,19 +10551,19 @@ Metabolic Process - + - + - + - + - +

@@ -10602,7 +10574,7 @@ Metabolic Process - + @@ -10610,19 +10582,19 @@ Metabolic Process - + - + - + - + - +

@@ -10633,7 +10605,7 @@ Metabolic Process - + @@ -10641,19 +10613,19 @@ Metabolic Process - + - + - + - + - +

@@ -10664,7 +10636,7 @@ Metabolic Process - + @@ -10672,19 +10644,19 @@ Metabolic Process - + - + - + - + - +

@@ -10695,7 +10667,7 @@ Metabolic Process - + @@ -10703,19 +10675,19 @@ Metabolic Process - + - + - + - + - +

@@ -10729,19 +10701,24 @@ Metabolic Process - + - + - + + + + + + - + - +

@@ -10752,7 +10729,7 @@ Metabolic Process - + @@ -10760,19 +10737,19 @@ Metabolic Process - + - + - + - + - +

@@ -10783,7 +10760,7 @@ Metabolic Process - + @@ -10791,19 +10768,19 @@ Metabolic Process - + - + - + - + - +

@@ -10814,7 +10791,7 @@ Metabolic Process - + @@ -10822,19 +10799,19 @@ Metabolic Process - + - + - + - + - +

@@ -10845,7 +10822,7 @@ Metabolic Process - + @@ -10853,19 +10830,19 @@ Metabolic Process - + - + - + - + - +

@@ -10874,29 +10851,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -10907,7 +10884,7 @@ Metabolic Process - + @@ -10915,19 +10892,19 @@ Metabolic Process - + - + - + - + - +

@@ -10936,29 +10913,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -10967,29 +10939,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -11000,7 +10972,7 @@ Metabolic Process - + @@ -11008,19 +10980,19 @@ Metabolic Process - + - + - + - + - +

@@ -11031,7 +11003,7 @@ Metabolic Process - + @@ -11039,19 +11011,19 @@ Metabolic Process - + - + - + - + - +

@@ -11062,7 +11034,7 @@ Metabolic Process - + @@ -11070,19 +11042,19 @@ Metabolic Process - + - + - + - + - +

@@ -11093,7 +11065,7 @@ Metabolic Process - + @@ -11101,19 +11073,19 @@ Metabolic Process - + - + - + - + - +

@@ -11124,7 +11096,7 @@ Metabolic Process - + @@ -11132,19 +11104,19 @@ Metabolic Process - + - + - + - + - +

@@ -11153,24 +11125,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -11181,7 +11158,7 @@ Metabolic Process - + @@ -11189,19 +11166,19 @@ Metabolic Process - + - + - + - + - +

@@ -11210,29 +11187,29 @@ Metabolic Process + + + + + - - - - - - - + + - + - + - + - +

@@ -11241,29 +11218,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -11274,7 +11246,7 @@ Metabolic Process - + @@ -11282,19 +11254,19 @@ Metabolic Process - + - + - + - + - +

@@ -11303,24 +11275,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -11331,7 +11308,7 @@ Metabolic Process - + @@ -11339,19 +11316,19 @@ Metabolic Process - + - + - + - + - +

@@ -11360,29 +11337,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -11396,24 +11373,19 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -11424,7 +11396,7 @@ Metabolic Process - + @@ -11432,19 +11404,19 @@ Metabolic Process - + - + - + - + - +

@@ -11455,7 +11427,7 @@ Metabolic Process - + @@ -11463,19 +11435,19 @@ Metabolic Process - + - + - + - + - +

@@ -11484,24 +11456,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -11512,7 +11489,7 @@ Metabolic Process - + @@ -11520,19 +11497,19 @@ Metabolic Process - + - + - + - + - +

@@ -11543,7 +11520,7 @@ Metabolic Process - + @@ -11551,19 +11528,19 @@ Metabolic Process - + - + - + - + - +

@@ -11574,7 +11551,7 @@ Metabolic Process - + @@ -11582,19 +11559,19 @@ Metabolic Process - + - + - + - + - +

@@ -11608,19 +11585,19 @@ Metabolic Process - + - + - + - + - +

@@ -11631,7 +11608,7 @@ Metabolic Process - + @@ -11639,19 +11616,19 @@ Metabolic Process - + - + - + - + - +

@@ -11662,7 +11639,7 @@ Metabolic Process - + @@ -11670,19 +11647,19 @@ Metabolic Process - + - + - + - + - +

@@ -11691,24 +11668,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -11719,7 +11701,7 @@ Metabolic Process - + @@ -11727,19 +11709,19 @@ Metabolic Process - + - + - + - + - +

@@ -11750,7 +11732,7 @@ Metabolic Process - + @@ -11758,19 +11740,19 @@ Metabolic Process - + - + - + - + - +

@@ -11779,29 +11761,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -11812,7 +11794,7 @@ Metabolic Process - + @@ -11820,19 +11802,19 @@ Metabolic Process - + - + - + - + - +

@@ -11843,7 +11825,7 @@ Metabolic Process - + @@ -11851,19 +11833,19 @@ Metabolic Process - + - + - + - + - +

@@ -11874,7 +11856,7 @@ Metabolic Process - + @@ -11882,19 +11864,19 @@ Metabolic Process - + - + - + - + - +

@@ -11903,29 +11885,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -11936,7 +11913,7 @@ Metabolic Process - + @@ -11944,19 +11921,19 @@ Metabolic Process - + - + - + - + - +

@@ -11967,7 +11944,7 @@ Metabolic Process - + @@ -11975,19 +11952,19 @@ Metabolic Process - + - + - + - + - +

@@ -11998,7 +11975,7 @@ Metabolic Process - + @@ -12006,19 +11983,19 @@ Metabolic Process - + - + - + - + - +

@@ -12029,7 +12006,7 @@ Metabolic Process - + @@ -12037,19 +12014,19 @@ Metabolic Process - + - + - + - + - +

@@ -12060,7 +12037,7 @@ Metabolic Process - + @@ -12068,19 +12045,19 @@ Metabolic Process - + - + - + - + - +

@@ -12091,7 +12068,7 @@ Metabolic Process - + @@ -12099,19 +12076,19 @@ Metabolic Process - + - + - + - + - +

@@ -12122,7 +12099,7 @@ Metabolic Process - + @@ -12130,19 +12107,19 @@ Metabolic Process - + - + - + - + - +

@@ -12153,7 +12130,7 @@ Metabolic Process - + @@ -12161,19 +12138,19 @@ Metabolic Process - + - + - + - + - +

@@ -12184,7 +12161,7 @@ Metabolic Process - + @@ -12192,19 +12169,19 @@ Metabolic Process - + - + - + - + - +

@@ -12215,7 +12192,7 @@ Metabolic Process - + @@ -12223,19 +12200,19 @@ Metabolic Process - + - + - + - + - +

@@ -12244,24 +12221,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -12272,7 +12254,7 @@ Metabolic Process - + @@ -12280,19 +12262,19 @@ Metabolic Process - + - + - + - + - +

@@ -12303,7 +12285,7 @@ Metabolic Process - + @@ -12311,19 +12293,19 @@ Metabolic Process - + - + - + - + - +

@@ -12334,7 +12316,7 @@ Metabolic Process - + @@ -12342,19 +12324,19 @@ Metabolic Process - + - + - + - + - +

@@ -12365,7 +12347,7 @@ Metabolic Process - + @@ -12373,19 +12355,19 @@ Metabolic Process - + - + - + - + - +

@@ -12396,7 +12378,7 @@ Metabolic Process - + @@ -12404,19 +12386,19 @@ Metabolic Process - + - + - + - + - +

@@ -12427,7 +12409,7 @@ Metabolic Process - + @@ -12435,19 +12417,19 @@ Metabolic Process - + - + - + - + - +

@@ -12456,29 +12438,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -12489,7 +12466,7 @@ Metabolic Process - + @@ -12497,19 +12474,19 @@ Metabolic Process - + - + - + - + - +

@@ -12520,7 +12497,7 @@ Metabolic Process - + @@ -12528,19 +12505,19 @@ Metabolic Process - + - + - + - + - +

@@ -12551,7 +12528,7 @@ Metabolic Process - + @@ -12559,19 +12536,19 @@ Metabolic Process - + - + - + - + - +

@@ -12580,24 +12557,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -12606,29 +12588,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -12639,7 +12616,7 @@ Metabolic Process - + @@ -12647,19 +12624,19 @@ Metabolic Process - + - + - + - + - +

@@ -12668,24 +12645,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -12696,7 +12678,7 @@ Metabolic Process - + @@ -12704,19 +12686,19 @@ Metabolic Process - + - + - + - + - +

@@ -12727,7 +12709,7 @@ Metabolic Process - + @@ -12735,19 +12717,19 @@ Metabolic Process - + - + - + - + - +

@@ -12758,7 +12740,7 @@ Metabolic Process - + @@ -12766,19 +12748,19 @@ Metabolic Process - + - + - + - + - +

@@ -12789,7 +12771,7 @@ Metabolic Process - + @@ -12797,19 +12779,19 @@ Metabolic Process - + - + - + - + - +

@@ -12820,7 +12802,7 @@ Metabolic Process - + @@ -12828,14 +12810,14 @@ Metabolic Process - + - + - + - + @@ -12856,22 +12838,22 @@ Metabolic Process - + - + - + - +

@@ -12882,7 +12864,7 @@ Metabolic Process - + @@ -12890,19 +12872,19 @@ Metabolic Process - + - + - + - + - +

@@ -12913,7 +12895,7 @@ Metabolic Process - + @@ -12921,19 +12903,19 @@ Metabolic Process - + - + - + - + - +

@@ -12944,7 +12926,7 @@ Metabolic Process - + @@ -12952,19 +12934,19 @@ Metabolic Process - + - + - + - + - +

@@ -12975,7 +12957,7 @@ Metabolic Process - + @@ -12983,19 +12965,19 @@ Metabolic Process - + - + - + - + - +

@@ -13004,29 +12986,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -13035,29 +13017,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -13068,7 +13050,7 @@ Metabolic Process - + @@ -13076,19 +13058,19 @@ Metabolic Process - + - + - + - + - +

@@ -13099,7 +13081,7 @@ Metabolic Process - + @@ -13107,19 +13089,19 @@ Metabolic Process - + - + - + - + - +

@@ -13130,7 +13112,7 @@ Metabolic Process - + @@ -13138,19 +13120,19 @@ Metabolic Process - + - + - + - + - +

@@ -13161,7 +13143,7 @@ Metabolic Process - + @@ -13169,19 +13151,19 @@ Metabolic Process - + - + - + - + - +

@@ -13190,24 +13172,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -13218,7 +13205,7 @@ Metabolic Process - + @@ -13226,19 +13213,19 @@ Metabolic Process - + - + - + - + - +

@@ -13249,7 +13236,7 @@ Metabolic Process - + @@ -13257,19 +13244,19 @@ Metabolic Process - + - + - + - + - +

@@ -13280,7 +13267,7 @@ Metabolic Process - + @@ -13288,19 +13275,19 @@ Metabolic Process - + - + - + - + - +

@@ -13311,7 +13298,7 @@ Metabolic Process - + @@ -13319,19 +13306,19 @@ Metabolic Process - + - + - + - + - +

@@ -13340,29 +13327,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -13371,24 +13358,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -13399,7 +13391,7 @@ Metabolic Process - + @@ -13407,19 +13399,19 @@ Metabolic Process - + - + - + - + - +

@@ -13430,7 +13422,7 @@ Metabolic Process - + @@ -13438,19 +13430,19 @@ Metabolic Process - + - + - + - + - +

@@ -13461,7 +13453,7 @@ Metabolic Process - + @@ -13469,19 +13461,19 @@ Metabolic Process - + - + - + - + - +

@@ -13492,7 +13484,7 @@ Metabolic Process - + @@ -13500,19 +13492,19 @@ Metabolic Process - + - + - + - + - +

@@ -13521,29 +13513,29 @@ Metabolic Process - - - - - - + - + - + - + + + + + + - +

@@ -13554,7 +13546,7 @@ Metabolic Process - + @@ -13562,19 +13554,19 @@ Metabolic Process - + - + - + - + - +

@@ -13585,7 +13577,7 @@ Metabolic Process - + @@ -13593,19 +13585,19 @@ Metabolic Process - + - + - + - + - +

@@ -13616,7 +13608,7 @@ Metabolic Process - + @@ -13624,19 +13616,19 @@ Metabolic Process - + - + - + - + - +

@@ -13647,7 +13639,7 @@ Metabolic Process - + @@ -13655,19 +13647,19 @@ Metabolic Process - + - + - + - + - +

@@ -13676,24 +13668,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -13704,7 +13701,7 @@ Metabolic Process - + @@ -13712,19 +13709,19 @@ Metabolic Process - + - + - + - + - +

@@ -13735,7 +13732,7 @@ Metabolic Process - + @@ -13743,19 +13740,19 @@ Metabolic Process - + - + - + - + - +

@@ -13764,29 +13761,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -13795,29 +13787,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -13828,7 +13815,7 @@ Metabolic Process - + @@ -13836,19 +13823,19 @@ Metabolic Process - + - + - + - + - +

@@ -13859,7 +13846,7 @@ Metabolic Process - + @@ -13867,19 +13854,19 @@ Metabolic Process - + - + - + - + - +

@@ -13890,7 +13877,7 @@ Metabolic Process - + @@ -13898,19 +13885,19 @@ Metabolic Process - + - + - + - + - +

@@ -13921,7 +13908,7 @@ Metabolic Process - + @@ -13929,19 +13916,19 @@ Metabolic Process - + - + - + - + - +

@@ -13952,7 +13939,7 @@ Metabolic Process - + @@ -13960,19 +13947,19 @@ Metabolic Process - + - + - + - + - +

@@ -13981,29 +13968,24 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -14014,7 +13996,7 @@ Metabolic Process - + @@ -14022,19 +14004,19 @@ Metabolic Process - + - + - + - + - +

@@ -14045,7 +14027,7 @@ Metabolic Process - + @@ -14053,19 +14035,19 @@ Metabolic Process - + - + - + - + - +

@@ -14076,7 +14058,7 @@ Metabolic Process - + @@ -14084,19 +14066,19 @@ Metabolic Process - + - + - + - + - +

@@ -14107,7 +14089,7 @@ Metabolic Process - + @@ -14115,19 +14097,19 @@ Metabolic Process - + - + - + - + - +

@@ -14138,7 +14120,7 @@ Metabolic Process - + @@ -14146,19 +14128,19 @@ Metabolic Process - + - + - + - + - +

@@ -14169,7 +14151,7 @@ Metabolic Process - + @@ -14177,19 +14159,19 @@ Metabolic Process - + - + - + - + - +

@@ -14200,7 +14182,7 @@ Metabolic Process - + @@ -14208,19 +14190,19 @@ Metabolic Process - + - + - + - + - +

@@ -14231,7 +14213,7 @@ Metabolic Process - + @@ -14239,19 +14221,19 @@ Metabolic Process - + - + - + - + - +

@@ -14260,24 +14242,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -14286,29 +14273,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -14317,24 +14304,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -14345,7 +14337,7 @@ Metabolic Process - + @@ -14353,19 +14345,19 @@ Metabolic Process - + - + - + - + - +

@@ -14376,7 +14368,7 @@ Metabolic Process - + @@ -14384,19 +14376,19 @@ Metabolic Process - + - + - + - + - +

@@ -14407,7 +14399,7 @@ Metabolic Process - + @@ -14415,19 +14407,19 @@ Metabolic Process - + - + - + - + - +

@@ -14436,29 +14428,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -14469,7 +14461,7 @@ Metabolic Process - + @@ -14477,19 +14469,19 @@ Metabolic Process - + - + - + - + - +

@@ -14500,7 +14492,7 @@ Metabolic Process - + @@ -14508,19 +14500,19 @@ Metabolic Process - + - + - + - + - +

@@ -14531,7 +14523,7 @@ Metabolic Process - + @@ -14539,19 +14531,19 @@ Metabolic Process - + - + - + - + - +

@@ -14559,30 +14551,25 @@ Metabolic Process - - - - - - + - + - + - + - + - +

@@ -14593,7 +14580,7 @@ Metabolic Process - + @@ -14601,19 +14588,19 @@ Metabolic Process - + - + - + - + - +

@@ -14624,7 +14611,7 @@ Metabolic Process - + @@ -14632,19 +14619,19 @@ Metabolic Process - + - + - + - + - +

@@ -14655,7 +14642,7 @@ Metabolic Process - + @@ -14663,19 +14650,19 @@ Metabolic Process - + - + - + - + - +

@@ -14684,29 +14671,29 @@ Metabolic Process - - - - - - + - + - + - + + + + + + - +

@@ -14717,7 +14704,7 @@ Metabolic Process - + @@ -14725,19 +14712,19 @@ Metabolic Process - + - + - + - + - +

@@ -14748,7 +14735,7 @@ Metabolic Process - + @@ -14756,19 +14743,19 @@ Metabolic Process - + - + - + - + - +

@@ -14779,7 +14766,7 @@ Metabolic Process - + @@ -14787,19 +14774,19 @@ Metabolic Process - + - + - + - + - +

@@ -14810,7 +14797,7 @@ Metabolic Process - + @@ -14818,19 +14805,19 @@ Metabolic Process - + - + - + - + - +

@@ -14841,7 +14828,7 @@ Metabolic Process - + @@ -14849,19 +14836,19 @@ Metabolic Process - + - + - + - + - +

@@ -14872,7 +14859,7 @@ Metabolic Process - + @@ -14880,19 +14867,19 @@ Metabolic Process - + - + - + - + - +

@@ -14903,7 +14890,7 @@ Metabolic Process - + @@ -14911,19 +14898,19 @@ Metabolic Process - + - + - + - + - +

@@ -14937,24 +14924,19 @@ Metabolic Process - - - - - - + - + - + - + - +

@@ -14963,24 +14945,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -14991,7 +14978,7 @@ Metabolic Process - + @@ -14999,19 +14986,19 @@ Metabolic Process - + - + - + - + - +

@@ -15022,7 +15009,7 @@ Metabolic Process - + @@ -15030,19 +15017,19 @@ Metabolic Process - + - + - + - + - +

@@ -15053,7 +15040,7 @@ Metabolic Process - + @@ -15061,19 +15048,19 @@ Metabolic Process - + - + - + - + - +

@@ -15084,7 +15071,7 @@ Metabolic Process - + @@ -15092,19 +15079,19 @@ Metabolic Process - + - + - + - + - +

@@ -15115,7 +15102,7 @@ Metabolic Process - + @@ -15123,19 +15110,19 @@ Metabolic Process - + - + - + - + - +

@@ -15144,29 +15131,29 @@ Metabolic Process - - - - - - + - + - + + + + + + - + - +

@@ -15177,7 +15164,7 @@ Metabolic Process - + @@ -15185,19 +15172,19 @@ Metabolic Process - + - + - + - + - +

@@ -15206,24 +15193,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -15234,7 +15226,7 @@ Metabolic Process - + @@ -15242,19 +15234,19 @@ Metabolic Process - + - + - + - + - +

@@ -15263,29 +15255,29 @@ Metabolic Process + + + + + - - - - - - + - + - + - + - +

@@ -15296,7 +15288,7 @@ Metabolic Process - + @@ -15304,19 +15296,19 @@ Metabolic Process - + - + - + - + - +

@@ -15325,24 +15317,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -15353,7 +15350,7 @@ Metabolic Process - + @@ -15361,19 +15358,19 @@ Metabolic Process - + - + - + - + - +

@@ -15384,7 +15381,7 @@ Metabolic Process - + @@ -15392,19 +15389,19 @@ Metabolic Process - + - + - + - + - +

@@ -15413,24 +15410,29 @@ Metabolic Process + + + + + - + - + - + - + - +

@@ -15441,7 +15443,7 @@ Metabolic Process - + @@ -15449,24 +15451,22 @@ Metabolic Process - + - + - + - + - + -

Protein family - -

+

@@ -15474,7 +15474,7 @@ Metabolic Process - + @@ -15482,21 +15482,21 @@ Metabolic Process - + - + - + - + - +

@@ -15504,20 +15504,20 @@ Metabolic Process - + - - + + - + - +

@@ -15525,17 +15525,17 @@ Metabolic Process - + - - + + - + @@ -15552,14 +15552,14 @@ Metabolic Process - - + + - + - +

@@ -15567,20 +15567,20 @@ Metabolic Process - + - - + + - + - +

@@ -15588,20 +15588,21 @@ Metabolic Process - + - - + + + - + - +

@@ -15609,20 +15610,20 @@ Metabolic Process - + - - + + - + - +

@@ -15630,20 +15631,20 @@ Metabolic Process - + - - + + - + - +

@@ -15651,20 +15652,20 @@ Metabolic Process - + - - + + - + - +

@@ -15672,18 +15673,17 @@ Metabolic Process - + - - - + + - + diff --git a/sbml/WP702.svg b/sbml/WP702.svg index 0671987..ab5b584 100644 --- a/sbml/WP702.svg +++ b/sbml/WP702.svg @@ -8,58 +8,22 @@ />eef3bbb15db9d98fb077c826af8ad5f4986e36ffa2419c66bee444bd0731c826aa2419fa9a6f4986bb15db9d98f8ad5fb077e444bGSTM4CHST11SULT1B1Glutathione transferaseUGT1A3UGT1A5UGT1A10CYP3A5AKR1C2CHST12NAT5CYP2C9CYP2J2GAL3ST2CYP2C9GPX3SULT1E1GAL3ST3SULT1C1AKR7A2CYP450GLYATL2CYP27A1Substrate-SO3HCYP2A13CYP2W1GPX5UGT2B11CYP3A4GLYATL2CYP1A1CYP11B2CYP11B1CYP26A1GAL3ST1CHST10NAT11CYP11A1CYP1B1FMO1GAL3ST4Substrate-O-RAKR1C2GSTA3MGST2SULT2B1HNMTUGT2B7CHST2SULT1C3NAT1CYP3A5UGT2B28GSTT2BUGT1A4N-acetyltransferaseAKR1B1KCNAB2Substrate-AaCYP4F2SULT1A1FMO4CYP4Z1CYP4F22CYP19A1CHST14HNMTCHST1SULT1A2NNMTCYP20A1CYP46A1UGT1A8CYP2D6FMO2CYP46A1CYP26C1UGT1A6NAT5CHST9SULT1E1CYP1B1NDST1AKR1C3CYP4F3BAATSulfotransferaseCYP4Z1CYP1A2Aldo-keto reductaseUGT2B15Substrate=ONDST3CYP2E1NAT14EPHX1GPX1Substrate-SHUGT1A3CHST11Aldo-keto reductaseAmino acid acyltransferaseKCNAB3CYP4B1FMO5Substrate-CH3BAATCHST6CYP4X1GSTO1CYP2S1MGST1Substrate-OHCYP7B1CYP7A1AKR1B1HS3ST3B1Substrate-NH2UGT2B17CYP17A1CYP27C1GSSGSTA5HS6ST1CHST13HS3ST2N-acetyltransferaseNAT13CYP24A1NAT8LCHST8NAT6UGT2B4SULT1C2AKR1C4GSTT2GPX3GPX5CHST4CYP26B1GSTCDCYP4V2GAL3ST1CYP4F8GAL3ST2CYP27B1CHST12KCNAB2CHST7MethyltransferaseSULT1C2UGT1A9NAT8AKR1C3GSTA1NAT14GSTP1CHST1HS6ST2UGT1A7CYP2B6UGT2A3CYP2A6CYP1A2AKR1C1CYP2A7EPHX2CYP2A6GSTCDCHST3AKR7A3CYP2F1Substrate-SHSulfotransferaseSULT1C3GAL3ST4CYP39A1SULT6B1CHST7FMO2GSTT1CYP27B1CYP4F11HS6ST2GSTM3KCNAB3SULT1C1HS3ST3B1CYP450NAT9GSTM5CYP2C8CYP51A1UGT2B15UGT1A10GSTT2CYP2R1CYP3A43AKR1B10GSTP1SULT4A1CYP39A1UGT1A7GPX2CHST8SULT1A1INMTNDST4CHST9CYP2W1Substrate=OAKR7A2GPX4NDST3SULT6B1MethyltransferaseGSTM4AKR1C1CYP3A4GSTZ1CYP11A1MGST2CHST4GSTA2GlucuronosyltransferaseSubstrate-AaGSSSubstrate-SGSULT1A4CYP4F22SULT2A1GSTM1CYP4F8COMTCYP2U1CYP4F12CYP2S1GSTM2GSTM3HS3ST6CYP19A1SULT1B1SULT2A1GSTT1GSTA4HS6ST3Amino acid acyltransferaseCYP2C18NAT13NAT2Substrate-O-RNAT10GAL3ST3SULT1C4UGT2A1GSTT2BCYP4F3CYP26A1Substrate-GlUGT1A1GSTK1NAT12SULT1A3HS3ST5GLYATHS3ST2MGST3CYP21A2HS3ST6Substrate-CH3NAT10GSTO1GlucuronosyltransferaseCYP3A7CHST5NDST4KCNAB1AKR1A1CYP8B1CYP2F1GSTA5GSTZ1CYP4X1CHST6CHST10CYP51A1CYP4F2INMTUGT2A2NDST2CYP2C8CYP8B1SULT1C4SULT2B1UGT1A4CYP2A13HS2ST1HS6ST1CHST13GSTO2CYP24A1GSRCYP21A2NAT8LCYP2R1CYP20A1AKR1D1HS3ST1CYP27C1CYP2C18SULT4A1UGT2B4NAT11HS3ST4CYP11B1CYP7B1NAT1NAT8EPHX2AKR1C4NAT6GSTA1Substrate-SO3HCHST5CYP2D6CYP17A1NNMTSULT1A2GSTA4Substrate-NH2HS3ST1NDST2CYP26C1CHST3Glutathione transferaseFMO1UGT2A2HS2ST1CYP2C19CYP4F11GSTM1MGST3CYP1A1HS6ST3HS3ST3A1Xenobiotic substrateCHST2Flavin monooxygenaseGSRUGT2B7TPMTGSTA3CYP7A1CYP2E1NDST1GSTA2CYP2B6CYP4B1CYP26B1FMO4EPHX1GLYATL1CYP4V2UGT2A3Substrate-AcMGST1CYP3A7CYP2A7UGT1A1CYP2U1Flavin monooxygenaseHS3ST3A1GSTO2CYP3A43NAT2GSTM5HS3ST5UGT2A1HS3ST4GPX2Substrate-OHSubstrate-AcUGT1A9UGT1A6NAT12CYP27A1Xenobiotic substrateAKR1D1FMO5GSTK1AKR1A1UGT2B17GLYATL1UGT1A8AKR7A3SULT1A3UGT1A5CYP2J2FMO3SULT1A4COMTCYP11B2GSTM2FMO3UGT2B28GLYATUGT2B11Substrate-GlCYP4F12TPMTAKR1B10KCNAB1GPX4OxidationGlutathione synthetaseGlucuronidationGlutathione peroxidasesCytochrome P450Amino acid acyl transferasesGlutathione conjugationEpoxide hydrolasesGlutathione reductaseN-acetyltransferasesMethyltransferasesReduction HydrolysisAldo-keto reductasesMethyltransferasesOxidationAcetylationSulfationEpoxide hydrolasesNucleophilesAmino acid acyl transferasesFlavin monooxygenasesAcetylationSulfotransferasesElectrophilesCytochrome P450N-acetyltransferasesGlucuronidationGlucuronosyltransferasesGlutathione synthetaseMethylationSulfotransferasesAmino acid conjugationGlutathione transferasesElectrophilesGlutathione conjugationFlavin monooxygenases