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mitochondrial carriers and substrates #11

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ValWood opened this issue Nov 9, 2024 · 12 comments
Open

mitochondrial carriers and substrates #11

ValWood opened this issue Nov 9, 2024 · 12 comments

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@ValWood
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ValWood commented Nov 9, 2024 •
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As far as I know them....will be useful for linking metabolic pathways that cross mitochondrion/cytosol:
I will weed out the non transporters. Can confirm the ortholgies with fly.

Systematic ID Gene name Product description Budding yeast orthologs Human orthologs
SPCC1020.03 mmt1 mitochondrial (zinc or iron) ion transmembrane transporter Mmt1 MMT1,MMT2 SLC30A9
SPAC3H1.08c   mitochondrial calcium uniporter regulator FMP32 CCDC90B,MCUR1
SPAC2C4.09   mitochondrial calcium uniporter regulator FMP32 CCDC90B,MCUR1
SPAC328.09 odc1 mitochondrial carrier, 2-oxoadipate/2-oxoglutarate ODC1,ODC2 SLC25A21
SPAPB17E12.12c mrx21 mitochondrial carrier, 3'-phosphoadenosine 5'-phosphosulfate/ 5'-adenylyl sulfate Mrx21 MRX21 SLC25A42
SPBC12D12.05c   mitochondrial carrier, ATP:ADP antiporter SAL1 SLC25A23,​SLC25A24,​SLC25A25,​SLC25A41
SPBC530.10c anc1 mitochondrial carrier, ATP:ADP antiporter Anc1 AAC1,AAC3,PET9 SLC25A31,​SLC25A4,​SLC25A5,​SLC25A6
SPAC19G12.05 mce1 mitochondrial carrier, citrate CTP1 SLC25A1
SPAC17H9.08 leu5 mitochondrial carrier, coenzyme A, Leu5 LEU5 SLC25A16
SPBC27B12.09c flx1 mitochondrial carrier, FAD Flx1 FLX1 SLC25A32
SPAC4G9.20c ymc1 mitochondrial carrier, glutamate/glycine YMC1,YMC2 SLC25A29,​SLC25A45,​SLC25A47
SPBP23A10.06 mtm1 mitochondrial carrier, glutathione Mtm1 MTM1 SLC25A39,SLC25A40
SPAC823.10c hem25 mitochondrial carrier, glycine Hem25 HEM25 SLC25A38
SPCC1682.09c ggc1 mitochondrial carrier, guanine nucleotide Ggc1 GGC1 SLC25A18,SLC25A22
SPBC1703.13c   mitochondrial carrier, inorganic phosphate/copper MIR1,PIC2 SLC25A3
SPAC4G8.08   mitochondrial carrier, iron ion MRS3,MRS4 SLC25A28,SLC25A37
SPAC8C9.12c mrs3 mitochondrial carrier, iron ion Mrs3 MRS3,MRS4 SLC25A28,SLC25A37
SPCC1442.03 mme1 mitochondrial carrier, magnesium ion Mme1 MME1  
SPAC227.03c yea6 mitochondrial carrier, NAD Yea6 YEA6,YIA6  
SPAC139.02c oac1 mitochondrial carrier, ocaloacetate family anion OAC1 SLC25A34,SLC25A35
SPBC29A3.11c ort1 mitochondrial carrier, ornithine Ort1 CRC1,ORT1 SLC25A29,​SLC25A45,​SLC25A47
SPAC688.09 rim2 mitochondrial carrier, pyrimidine nucleotide Rim2 RIM2 SLC25A33,SLC25A36
SPCC1235.11 mpc1 mitochondrial carrier, pyruvate Mpc1 MPC1 MPC1
SPAC24B11.09 mpc2 mitochondrial carrier, pyruvate Mpc2 MPC2,MPC3 MPC2
SPAC12B10.09 pet801 mitochondrial carrier, S-adenosylmethionine PET8 SLC25A26
SPBC1271.11 pet802 mitochondrial carrier, S-adenosylmethionine Pet802 PET8 SLC25A26
SPAC17G6.15c fsf1 mitochondrial carrier, serine Fsf1 FSF1 SFXN1,​SFXN2,​SFXN3,​SFXN4,​SFXN5
SPBC1604.04   mitochondrial carrier, thiamine pyrophosphate TPC1 SLC25A19
SPBC83.13 yhm2 mitochondrial carrier, tricarboxylic acid Yhm2 YHM2  
SPCC550.06c hsp10 mitochondrial heat shock protein Hsp10 HSP10 HSPE1
SPAC12G12.04 mcp60 mitochondrial heat shock protein Hsp60/Mcp60 HSP60 HSPD1
SPAC23H3.12c   mitochondrial hydrogen/potassium transport system protein MRX19  
SPBC25H2.08c mrs2 mitochondrial inner membrane magnesium ion transmembrane transporter Mrs2 MFM1,MRS2 MRS2
SPAC15A10.01 atm1 mitochondrial iron-sulfur cluster exporter Atm1 ATM1 ABCB7
SPAC3G6.05   mitochondrial Mpv17/PMP22 family protein 1 YOR292C MPV17
SPAC1635.01 por1 mitochondrial outer membrane voltage-dependent anion-selective channel Por1 POR1,POR2 VDAC1,VDAC2,VDAC3
SPBC9B6.09c mdl1 mitochondrial peptide-transporting ATPase MDL1,MDL2 ABCB10
SPAP14E8.05c   mitochondrial protoporphyrinogen IX import factor, TMEM14 family TMH11 TMEM14A,TMEM14B,TMEM14C
SPBC21.07c ppk24 serine/threonine protein kinase Ppk24 PTK1,PTK2

Systematic ID Gene name Product descriptionSorted by: Product description Budding yeast orthologs Human orthologs
SPCC1020.03 mmt1 mitochondrial (zinc or iron) ion transmembrane transporter Mmt1 MMT1,MMT2 SLC30A9
SPAC3H1.08c mitochondrial calcium uniporter regulator FMP32 CCDC90B,MCUR1
SPAC2C4.09 mitochondrial calcium uniporter regulator FMP32 CCDC90B,MCUR1
SPAC328.09 odc1 mitochondrial carrier, 2-oxoadipate/2-oxoglutarate ODC1,ODC2 SLC25A21
SPAPB17E12.12c mrx21 mitochondrial carrier, 3'-phosphoadenosine 5'-phosphosulfate/ 5'-adenylyl sulfate Mrx21 MRX21 SLC25A42
SPBC12D12.05c mitochondrial carrier, ATP:ADP antiporter SAL1 SLC25A23,​SLC25A24,​SLC25A25,​SLC25A41
SPBC530.10c anc1 mitochondrial carrier, ATP:ADP antiporter Anc1 AAC1,AAC3,PET9 SLC25A31,​SLC25A4,​SLC25A5,​SLC25A6
SPAC19G12.05 mce1 mitochondrial carrier, citrate CTP1 SLC25A1
SPAC17H9.08 leu5 mitochondrial carrier, coenzyme A, Leu5 LEU5 SLC25A16
SPBC27B12.09c flx1 mitochondrial carrier, FAD Flx1 FLX1 SLC25A32
SPAC4G9.20c ymc1 mitochondrial carrier, glutamate/glycine YMC1,YMC2 SLC25A29,​SLC25A45,​SLC25A47
SPBP23A10.06 mtm1 mitochondrial carrier, glutathione Mtm1 MTM1 SLC25A39,SLC25A40
SPAC823.10c hem25 mitochondrial carrier, glycine Hem25 HEM25 SLC25A38
SPCC1682.09c ggc1 mitochondrial carrier, guanine nucleotide Ggc1 GGC1 SLC25A18,SLC25A22
SPBC1703.13c mitochondrial carrier, inorganic phosphate/copper MIR1,PIC2 SLC25A3
SPAC4G8.08 mitochondrial carrier, iron ion MRS3,MRS4 SLC25A28,SLC25A37
SPAC8C9.12c mrs3 mitochondrial carrier, iron ion Mrs3 MRS3,MRS4 SLC25A28,SLC25A37
SPCC1442.03 mme1 mitochondrial carrier, magnesium ion Mme1 MME1
SPAC227.03c yea6 mitochondrial carrier, NAD Yea6 YEA6,YIA6
SPAC139.02c oac1 mitochondrial carrier, ocaloacetate family anion OAC1 SLC25A34,SLC25A35
SPBC29A3.11c ort1 mitochondrial carrier, ornithine Ort1 CRC1,ORT1 SLC25A29,​SLC25A45,​SLC25A47
SPAC688.09 rim2 mitochondrial carrier, pyrimidine nucleotide Rim2 RIM2 SLC25A33,SLC25A36
SPCC1235.11 mpc1 mitochondrial carrier, pyruvate Mpc1 MPC1 MPC1
SPAC24B11.09 mpc2 mitochondrial carrier, pyruvate Mpc2 MPC2,MPC3 MPC2
SPAC12B10.09 pet801 mitochondrial carrier, S-adenosylmethionine PET8 SLC25A26
SPBC1271.11 pet802 mitochondrial carrier, S-adenosylmethionine Pet802 PET8 SLC25A26
SPAC17G6.15c fsf1 mitochondrial carrier, serine Fsf1 FSF1 SFXN1,​SFXN2,​SFXN3,​SFXN4,​SFXN5
SPBC1604.04 mitochondrial carrier, thiamine pyrophosphate TPC1 SLC25A19
SPBC83.13 yhm2 mitochondrial carrier, tricarboxylic acid Yhm2 YHM2
SPCC550.06c hsp10 mitochondrial heat shock protein Hsp10 HSP10 HSPE1
SPAC12G12.04 mcp60 mitochondrial heat shock protein Hsp60/Mcp60 HSP60 HSPD1
SPAC23H3.12c mitochondrial hydrogen/potassium transport system protein MRX19
SPBC25H2.08c mrs2 mitochondrial inner membrane magnesium ion transmembrane transporter Mrs2 MFM1,MRS2 MRS2
SPAC15A10.01 atm1 mitochondrial iron-sulfur cluster exporter Atm1 ATM1 ABCB7
SPAC3G6.05 mitochondrial Mpv17/PMP22 family protein 1 YOR292C MPV17
SPAC1635.01 por1 mitochondrial outer membrane voltage-dependent anion-selective channel Por1 POR1,POR2 VDAC1,VDAC2,VDAC3
SPBC9B6.09c mdl1 mitochondrial peptide-transporting ATPase MDL1,MDL2 ABCB10
SPAP14E8.05c mitochondrial protoporphyrinogen IX import factor, TMEM14 family TMH11 TMEM14A,TMEM14B,TMEM14C
SPBC21.07c ppk24 serine/threonine protein kinase Ppk24 PTK1,PTK2
@ValWood
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ValWood commented Nov 9, 2024

Nice review, table and figures in

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mitochondrial-carrier

Screenshot 2024-11-09 at 08 52 03

@hattrill
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Nice review. All SLC transporters have been done in gene groups, so looking fairly good. Might be able to deepen MFs with the help of this review. Will do the orthology later.
These are the carriers cross-ref with mitochondrial GO annotation:

Group_member_FB_gene_id Group_member_FB_gene_symbol FB_group_name
FBgn0033762 ZnT49B SLC30 FAMILY OF ZINC TRANSPORTERS
FBgn0036756 Cln3 ATYPICAL SOLUTE CARRIERS
FBgn0284252 Letm1 SLC55 FAMILY OF MITOCHONDRIAL CATION/PROTON EXCHANGERS
FBgn0017429 CG5989 SLC55 FAMILY OF MITOCHONDRIAL CATION/PROTON EXCHANGERS
FBgn0033324 CG14744 SLC8 FAMILY OF SODIUM/CALCIUM EXCHANGERS
FBgn0019830 colt SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0033905 CG18324 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0030872 Ucp4A SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0040383 CG5254 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0033904 CG18327 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0260743 GC1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0030218 CG1628 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0039223 CG5805 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0037970 GC2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0038797 Dic2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0032090 CG9582 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0031881 MME1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0031039 Shawn SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0031359 Rim2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0039674 CG1907 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0033903 CG8323 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0033391 CG8026 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0027786 Mtch SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0037512 CG2616 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0003360 sesB SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0039741 CG7943 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0033248 Dic3 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0067783 DPCoAC SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0026409 Mpcp2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0029963 CG10920 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0039357 CG4743 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0032664 Slc25A46b SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0037912 sea SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0025111 Ant2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0031038 Tyler SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0052103 SCaMC SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0028646 Aralar SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0034497 Mpcp1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0035078 Tpc2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0030717 Slc25A46a SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0037852 Tpc1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0027610 Dic1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0036808 Dic4 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0039525 CG5646 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0039561 mfrn SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0032219 CG4995 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS
FBgn0037239 Sfxn1-3 SLC56 FAMILY OF SIDEROFLEXINS
FBgn0036843 Sfxn2 SLC56 FAMILY OF SIDEROFLEXINS
FBgn0037715 CG9399 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS
FBgn0038662 Mpc1 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS
FBgn0037714 CG9396 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS
FBgn0052832 CG32832 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS

@hattrill
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hattrill commented Nov 14, 2024 •
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Attempted to align the fly carriers with yeast via the human ortholog and append your table columns to the fly ones.

FBgn ID Symbol Gene Group Human Ortholog Systematic ID Gene name Product description Budding yeast orthologs Human orthologs NOTES
FBgn0036756 Cln3 ATYPICAL SOLUTE CARRIERS CLN3 SPAC607.09c btn1 battenin CLN3 family protein YHC3 CLN3 Only one study in flies showed mitochondrial localization, also has exp loc inm many other membranes
FBgn0284252 Letm1 SLC55 FAMILY OF MITOCHONDRIAL CATION/PROTON EXCHANGERS LETM1,LETM2 SPAC23C11.17 Mdm38 mitochondrial inner membrane protein involved in translation Mdm38 MDM38,YLH47 LETM2,LETM1 PMID:17541427, Mdm38 might be a carrier
FBgn0017429 CG5989 SLC55 FAMILY OF MITOCHONDRIAL CATION/PROTON EXCHANGERS LETMD1 SPAC23C11.17 Mdm38 mitochondrial inner membrane protein involved in translation Mdm38 MDM38,YLH47 LETM2,LETM1 PMID: 17541427, Mdm38 might be a carrier
FBgn0038662 Mpc1 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS MPC1 SPCC1235.11 mpc1 mitochondrial carrier, pyruvate Mpc1 MPC1 MPC1  
FBgn0037715 CG9399 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS MPC2 SPAC24B11.09 mpc2 mitochondrial carrier, pyruvate Mpc2 MPC2,MPC3 MPC2  
FBgn0037714 CG9396 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS MPC2 SPAC24B11.09 mpc2 mitochondrial carrier, pyruvate Mpc2 MPC2,MPC3 MPC2  
FBgn0052832 CG32832 SLC54 FAMILY OF MITOCHONDRIAL PYRUVATE CARRIERS MPC2 SPAC24B11.09 mpc2 mitochondrial carrier, pyruvate Mpc2 MPC2,MPC3 MPC2  
FBgn0027786 Mtch SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS MTCH2,MTCH1 none          
FBgn0029963 CG10920 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS MTCH2,MTCH1 none          
FBgn0037239 Sfxn1-3 SLC56 FAMILY OF SIDEROFLEXINS SFXN1,SFXN3 SPAC17G6.15c fsf1 mitochondrial carrier, serine Fsf1 FSF1 SFXN1,​SFXN2,​SFXN3,​SFXN4,​SFXN5
FBgn0036843 Sfxn2 SLC56 FAMILY OF SIDEROFLEXINS SFXN2 SPAC17G6.15c fsf1 mitochondrial carrier, serine Fsf1 FSF1 SFXN1,​SFXN2,​SFXN3,​SFXN4,​SFXN5
FBgn0037912 sea SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A1 SPAC19G12.05 mce1 mitochondrial carrier, citrate CTP1 SLC25A1  
FBgn0038797 Dic2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A10 none          
FBgn0033248 Dic3 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A10 none          
FBgn0027610 Dic1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A10 none          
FBgn0036808 Dic4 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A10,SLC25A11,UCP1,UCP3 none          
FBgn0039674 CG1907 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A11 none          
FBgn0028646 Aralar SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A12,SLC25A13 none          
FBgn0030218 CG1628 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A15,SLC25A2 SPAC4G9.20c ymc1,ort1 mitochondrial carrier, glutamate/glycine YMC2,YMC1 SLC25A29,​SLC25A45,​SLC25A47
FBgn0035078 Tpc2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A19 SPBC1604.04 - mitochondrial carrier, thiamine pyrophosphate TPC1 SLC25A19  
FBgn0037852 Tpc1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A19 SPBC1604.04 - mitochondrial carrier, thiamine pyrophosphate TPC1 SLC25A19  
FBgn0019830 colt SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A20 SPAC4G9.20c,SPBC29A3.11c ymc1,ort1 mitochondrial carrier, glutamate/glycine,mitochondrial carrier, ornithine Ort1 YMC1,YMC2,CRC1,ORT1 SLC25A29,​SLC25A45,​SLC25A47
FBgn0031881 MME1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A20 SPAC4G9.20c,SPBC29A3.11c ymc1,ort1 mitochondrial carrier, glutamate/glycine,mitochondrial carrier, ornithine Ort1 YMC1,YMC2,CRC1,ORT1 SLC25A29,​SLC25A45,​SLC25A47
FBgn0040383 CG5254 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A21 SPAC328.09 odc1 mitochondrial carrier, 2-oxoadipate/2-oxoglutarate ODC1,ODC2 SLC25A21  
FBgn0032090 CG9582 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A21 SPAC328.09 odc1 mitochondrial carrier, 2-oxoadipate/2-oxoglutarate ODC1,ODC2 SLC25A21  
FBgn0260743 GC1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A22,SLC25A18 SPCC1682.09c ggc1 mitochondrial carrier, guanine nucleotide Ggc1 GGC1 SLC25A18,SLC25A22
FBgn0037970 GC2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A22,SLC25A18 SPCC1682.09c ggc1 mitochondrial carrier, guanine nucleotide Ggc1 GGC1 SLC25A18,SLC25A22
FBgn0052103 SCaMC SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A25,SLC25A23,SLC25A24 SPBC12D12.05c - mitochondrial carrier, ATP:ADP antiporter SAL1 SLC25A23,​SLC25A24,​SLC25A25,​SLC25A41
FBgn0039357 CG4743 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A26 SPAC12B10.09,SPBC1271.11 pet801pet802 mitochondrial carrier, S-adenosylmethionine PET8 SLC25A26  
FBgn0030872 Ucp4A SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A27SLC25A14,SLC25A30 none          
FBgn0039561 mfrn SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A28,SLC25A37 SPAC4G8.08,SPAC8C9.12c ,mrs3 mitochondrial carrier, iron ion,mitochondrial carrier, iron ion Mrs3 MRS3,MRS4 SLC25A28,SLC25A37
FBgn0032219 CG4995 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A29 SPAC4G9.20c,SPBC29A3.11c ymc1,ort1 mitochondrial carrier, glutamate/glycine,mitochondrial carrier, ornithine Ort1 YMC1,YMC2,CRC1,ORT1 SLC25A29,​SLC25A45,​SLC25A47
FBgn0026409 Mpcp2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A3 SPBC1703.13c - mitochondrial carrier, inorganic phosphate/copper MIR1,PIC2 SLC25A3  
FBgn0034497 Mpcp1 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A3 SPBC1703.13c - mitochondrial carrier, inorganic phosphate/copper MIR1,PIC2 SLC25A3  
FBgn0033391 CG8026 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A32 SPBC27B12.09c flx1 mitochondrial carrier, FAD Flx1 FLX1 SLC25A32  
FBgn0033905 CG18324 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A34,SLC25A35 SPAC139.02c oac1 mitochondrial carrier, ocaloacetate family anion OAC1 SLC25A34,SLC25A35
FBgn0033904 CG18327 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A34,SLC25A35 SPAC139.02c oac1 mitochondrial carrier, ocaloacetate family anion SPBC12D12.05c SLC25A34,SLC25A35
FBgn0033903 CG8323 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A34,SLC25A35 SPAC139.02c oac1 mitochondrial carrier, ocaloacetate family anion OAC1 SLC25A34,SLC25A35
FBgn0031359 Rim2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A36,SLC25A33 SPAC688.09 rim2 mitochondrial carrier, pyrimidine nucleotide Rim2 RIM2 SLC25A33,SLC25A36
FBgn0003360 sesB SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A4,SLC25A6, SLC25A5,SLC25A31 SPBC530.10c anc1 mitochondrial carrier, ATP:ADP antiporter Anc1 AAC1,AAC3,PET9 SLC25A31,​SLC25A4,​SLC25A5,​SLC25A6
FBgn0031039 Shawn SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A40,SLC25A39 SPBP23A10.06 mtm1 mitochondrial carrier, glutathione Mtm1 MTM1 SLC25A39,SLC25A40
FBgn0037512 CG2616 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A40,SLC25A39 SPBP23A10.06 mtm1 mitochondrial carrier, glutathione Mtm1 MTM1 SLC25A39,SLC25A40
FBgn0031038 Tyler SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A40,SLC25A39 SPBP23A10.06 mtm1 mitochondrial carrier, glutathione Mtm1 MTM1 SLC25A39,SLC25A40
FBgn0067783 DPCoAC SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A42 SPAPB17E12.12c,SPAC17H9.08 mrx21,leu5 mitochondrial carrier, 3'-phosphoadenosine 5'-phosphosulfate/ 5'-adenylyl sulfate Mrx21,mitochondrial carrier, coenzyme A, Leu5 MRX21,LEU5 SLC25A42,SLC25A16
FBgn0039223 CG5805 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A44 SPAC4G8.08 - mitochondrial carrier, iron ion MRS3,MRS4 SLC25A28,SLC25A37
FBgn0039525 CG5646 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A45 SPAC4G9.20c ymc1 mitochondrial carrier, glutamate/glycine YMC1,YMC2 SLC25A29,SLC25A45,SLC25A47
FBgn0032664 Slc25A46b SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A46 none          
FBgn0030717 Slc25A46a SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A46 none          
FBgn0039741 CG7943 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A51,SLC25A52 none          
FBgn0025111 Ant2 SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS SLC25A6,SLC25A4,SLC25A5,SLC25A31 SPBC530.10c anc1 mitochondrial carrier, ATP:ADP antiporter Anc1 AAC1,AAC3,PET9 SLC25A31,​SLC25A4,​SLC25A5,​SLC25A6
FBgn0033762 ZnT49B SLC30 FAMILY OF ZINC TRANSPORTERS SLC30A9 SPCC1020.03 mmt1 mitochondrial (zinc or iron) ion transmembrane transporter Mmt1 MMT1,MMT2 SLC30A9  
FBgn0033324 CG14744 SLC8 FAMILY OF SODIUM/CALCIUM EXCHANGERS SLC8B1 SPAC3A12.06c   sodium/calcium exchanger YCX1,ECM27 SLC8B1 ER in yeast and mito in multicellular

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hattrill commented Nov 14, 2024 •
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One exciting thing that might be worth following up for yeast @ValWood is Mdm38 (PMID:17541427)

FBgn ID Symbol Gene Group Human Ortholog Systematic ID Gene name Product description Budding yeast orthologs Human orthologs NOTES
FBgn0284252 Letm1 SLC55 FAMILY OF MITOCHONDRIAL CATION/PROTON EXCHANGERS LETM1,LETM2 SPAC23C11.17 Mdm38 mitochondrial inner membrane protein involved in translation Mdm38 MDM38,YLH47 LETM2,LETM1 PMID:17541427, Mdm38 might be a carrier
FBgn0017429 CG5989 SLC55 FAMILY OF MITOCHONDRIAL CATION/PROTON EXCHANGERS LETMD1 SPAC23C11.17 Mdm38 mitochondrial inner membrane protein involved in translation Mdm38 MDM38,YLH47 LETM2,LETM1 PMID: 17541427, Mdm38 might be a carrier

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These Pombe ones map to non-carrier transport classes in FlyBase, so might be added to future transporter lists:

Systematic ID Gene name Product description Budding yeast orthologs Human orthologs Fly ortholog Fly Gene Group
SPAC15A10.01 atm1 mitochondrial iron-sulfur cluster exporter Atm1 ATM1 ABCB7 ABCB7 ABCB ATP-BINDING CASSETTE TRANSPORTER ATM SUBFAMILY - HALF TRANSPORTERS
SPAC3G6.05   mitochondrial Mpv17/PMP22 family protein 1 YOR292C MPV17 Mpv17 MPV17/PMP22 PUTATIVE MITOCHONDRIAL CHANNEL FAMILY
SPAC1635.01 por1 mitochondrial outer membrane voltage-dependent anion-selective channel Por1 POR1,POR2 VDAC1,VDAC2,VDAC3 porin MITOCHONDRIAL PORINS
SPBC9B6.09c mdl1 mitochondrial peptide-transporting ATPase MDL1,MDL2 ABCB10 CG3156 ABCB ATP-BINDING CASSETTE TRANSPORTER ATM SUBFAMILY - HALF TRANSPORTERS

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ValWood commented Nov 14, 2024

I don't think LetM1/2 are really cation transporters though
Check out the caution on
https://www.uniprot.org/uniprotkb/O95202/entry
It doesn't really look like a carrier...

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ValWood commented Nov 14, 2024

These Pombe ones map to non-carrier transport classes in FlyBase, so might be added to future transporter lists:

agreed, I included all TM transporters that weren't FTP synthase or protein transporters, so it was more than carriers

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For flies, looks like there is reasonable evidence for H+/cation exchange for Letm1, although there seems to be a bit of a disagreement on what it being exchanged:
PMID:19797662 Ca2+/H+
PMID:20026556 K+/H+

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ValWood commented Nov 15, 2024

https://flybase.org/reports/FBrf0210163.htm
says
We also show that DmLETM1 complements growth and mitochondrial K(+)/H(+) exchange (KHE) activity in yeast deficient for LETM1

but yeast LETM1 says
https://www.yeastgenome.org/locus/S000005387
Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome

so i think there is something more subtle here?

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ValWood commented Nov 15, 2024 •
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Actually, the evidence for a role in translation seems weaker. I'll dig some more next week...
Although the ribosome receptor stuff is a decade after the ion transporter https://www.ebi.ac.uk/interpro/entry/InterPro/IPR033122/

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Exciting stuff!

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ValWood commented Feb 27, 2025

ANother review https://pmc.ncbi.nlm.nih.gov/articles/PMC8395155/

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