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GO-based terms following the XAO "develops from" path #79

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seger opened this issue Aug 28, 2019 · 0 comments
Open

GO-based terms following the XAO "develops from" path #79

seger opened this issue Aug 28, 2019 · 0 comments
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seger commented Aug 28, 2019

From Joshua, originally in #26:

The GO term "hindgut development" [GO:0061525] could be the basis for "abnormal hindgut development", and connected to the hindgut portion of the XPO.

In regards to how these development terms are used, it would be helpful to follow the "develops from" relationships in the XAO. For instance, hindgut develops from hindgut primordium. This means that any morphological or developmental terms for hindgut primordium "is_a" abnormal hindgut development. However this "develops_from" graph path can only go so far. For instance, the central endoderm develops into the foregut endoderm, hindgut primordium, and midgut primordium. So, saying that there was an abnormal central endoderm morphology does not guarantee that there is an abnormal hindgut development, as the morphological abnormality in the central endoderm could be isolated to a region that isn't fated to be hindgut.

GO also has morphogenesis terms, however I do not believe we would use them much. I believe we would use the higher level morphology term.

Notes:

Abnormal morphology and abnormal development are disjoint from each other. For instance, an abnormal development could include developmental delay, but the morphology is correct.

@seger seger self-assigned this Aug 28, 2019
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