diff --git a/src/ontology/catalog-v001.xml b/src/ontology/catalog-v001.xml
index 9eae1c78d..ccba390f9 100644
--- a/src/ontology/catalog-v001.xml
+++ b/src/ontology/catalog-v001.xml
@@ -43,7 +43,6 @@
       <uri name="http://purl.obolibrary.org/obo/uberon/bridge/uberon-bridge-to-wbbt.owl" uri="bridge/uberon-bridge-to-wbbt.owl"/>
       <uri name="http://purl.obolibrary.org/obo/uberon/bridge/uberon-bridge-to-wbls.owl" uri="bridge/uberon-bridge-to-wbls.owl"/>
       <uri name="http://purl.obolibrary.org/obo/uberon/bridge/uberon-bridge-to-xao.owl" uri="bridge/uberon-bridge-to-xao.owl"/>
-      <uri name="http://purl.obolibrary.org/obo/uberon/components/develops-from-chains.owl" uri="components/develops-from-chains.owl"/>
       <uri name="http://purl.obolibrary.org/obo/uberon/components/disjoint_union_over.owl" uri="components/disjoint_union_over.owl"/>
       <uri name="http://purl.obolibrary.org/obo/uberon/components/hra_depiction_3d_images.owl" uri="components/hra_depiction_3d_images.owl"/>
       <uri name="http://purl.obolibrary.org/obo/uberon/components/hra_subset.owl" uri="components/hra_subset.owl"/>
diff --git a/src/ontology/components/develops-from-chains.owl b/src/ontology/components/develops-from-chains.owl
deleted file mode 100644
index 872b459c7..000000000
--- a/src/ontology/components/develops-from-chains.owl
+++ /dev/null
@@ -1,13 +0,0 @@
-Prefix(:=<http://purl.obolibrary.org/obo/uberon/core.owl#>)
-Prefix(owl:=<http://www.w3.org/2002/07/owl#>)
-Prefix(rdf:=<http://www.w3.org/1999/02/22-rdf-syntax-ns#>)
-Prefix(xml:=<http://www.w3.org/XML/1998/namespace>)
-Prefix(xsd:=<http://www.w3.org/2001/XMLSchema#>)
-Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
-
-
-Ontology(<http://purl.obolibrary.org/obo/uberon/components/develops-from-chains.owl>
-
-SubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/RO_0002202>) <http://purl.obolibrary.org/obo/RO_0002202>)
-SubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002202> <http://purl.obolibrary.org/obo/BFO_0000050>) <http://purl.obolibrary.org/obo/RO_0002202>)
-)
\ No newline at end of file
diff --git a/src/ontology/uberon-edit.obo b/src/ontology/uberon-edit.obo
index e9503de8d..422a6c834 100644
--- a/src/ontology/uberon-edit.obo
+++ b/src/ontology/uberon-edit.obo
@@ -55,7 +55,6 @@ treat-xrefs-as-equivalent: VSAO
 treat-xrefs-as-is_a: BFO
 treat-xrefs-as-is_a: VHOG
 remark: Aurelie Comte, Bill Bug, Catherine Leroy, Duncan Davidson and Trish Whetzel are also contributors. However their ORCIDs were not found.
-import: http://purl.obolibrary.org/obo/uberon/components/develops-from-chains.owl
 import: http://purl.obolibrary.org/obo/uberon/components/disjoint_union_over.owl
 import: http://purl.obolibrary.org/obo/uberon/components/hra_depiction_3d_images.owl
 import: http://purl.obolibrary.org/obo/uberon/components/hra_subset.owl
diff --git a/src/ontology/uberon.Makefile b/src/ontology/uberon.Makefile
index 3b3dd4c14..86bd0a49e 100644
--- a/src/ontology/uberon.Makefile
+++ b/src/ontology/uberon.Makefile
@@ -117,9 +117,6 @@ $(OWLSRC): $(SRC) $(REPORTDIR)/$(SRC)-gocheck $(REPORTDIR)/$(SRC)-iconv
 			-o $@
 
 # Step 2: Reasoning.
-# For the temporary injection of property chains, see
-# <https://github.com/obophenotype/uberon/issues/2381>
-DEVELOPS_FROM_CHAIN=$(COMPONENTSDIR)/develops-from-chains.owl
 # The 'materialize' step is too resource-intensive for the GitHub
 # Action runners, so we leave it out when running online QC checks, see
 # <https://github.com/obophenotype/uberon/pull/3087#issuecomment-1755553647>
@@ -128,13 +125,11 @@ MATERIALIZE=
 else
 MATERIALIZE = materialize -T $(CONFIGDIR)/basic_properties.txt -r elk
 endif
-$(POSTPROCESS_SRC): $(OWLSRC) $(BRIDGEDIR)/uberon-bridge-to-bfo.owl $(DEVELOPS_FROM_CHAIN)
+$(POSTPROCESS_SRC): $(OWLSRC) $(BRIDGEDIR)/uberon-bridge-to-bfo.owl
 	$(ROBOT) merge -i $(OWLSRC) -i $(BRIDGEDIR)/uberon-bridge-to-bfo.owl \
-	               -i $(DEVELOPS_FROM_CHAIN) \
 	         relax $(MATERIALIZE) \
 	         reason -r elk --exclude-duplicate-axioms true \
 	                       --equivalent-classes-allowed asserted-only \
-	         unmerge -i $(DEVELOPS_FROM_CHAIN) \
 	         annotate -O $(URIBASE)/uberon.owl -V $(RELEASE)/uberon.owl -o $@
 
 # Step 3: Postprocessing. We merge some files that are derived from the