diff --git a/config.layout b/config.layout
index da63e895a9d..4846fe3b6e9 100644
--- a/config.layout
+++ b/config.layout
@@ -277,3 +277,23 @@
     logdir:        /var/log+
     cachedir:      /var/lib+
 </Layout>
+
+<Layout NixOS>
+    prefix:        /opt/trafficserver
+    exec_prefix:   ${prefix}
+    bindir:        ${exec_prefix}/bin
+    sbindir:       ${exec_prefix}/sbin
+    libdir:        ${exec_prefix}/lib
+    libexecdir:    ${exec_prefix}/libexec
+    infodir:       ${prefix}/share/info
+    mandir:        ${prefix}/share/man
+    sysconfdir:    /etc+
+    datadir:       ${prefix}/share+
+    docdir:        ${prefix}/share/doc+
+    installbuilddir: ${datadir}/build
+    includedir:    ${prefix}/include
+    localstatedir: /var/lib+
+    runtimedir:    /run+
+    logdir:        /var/log+
+    cachedir:      /var/cache+
+</Layout>
diff --git a/rc/trafficserver.in b/rc/trafficserver.in
index b0512ada4ee..03952d16ea2 100644
--- a/rc/trafficserver.in
+++ b/rc/trafficserver.in
@@ -66,6 +66,8 @@ elif [ "$UNAME_S" = "Darwin" ]; then
     DISTRIB_ID="Darwin"
 elif [ "$UNAME_S" = "FreeBSD" ]; then
     DISTRIB_ID="FreeBSD"
+elif nixos-version > /dev/null; then
+    DISTRIB_ID="nixos"
 fi
 
 # We might want to move over to use /etc/system-release for more distros?
@@ -90,7 +92,7 @@ test -x $ESED || ESED=sed
 # Ubuntu: Do NOT "set -e"
 
 #Ubuntu:PATH should only include /usr/* if it runs after the mountnfs.sh script
-PATH=/usr/sbin:/usr/bin:/sbin:/bin
+test "$DISTRIB_ID" != nixos && PATH=/usr/sbin:/usr/bin:/sbin:/bin
 DESC="start/stop Traffic Server"
 NAME=trafficserver
 SLEEP_TIME=5
@@ -135,6 +137,10 @@ elif [ "$DISTRIB_ID" = "Darwin" ]; then
     SCRIPTNAME=$0 # Darwin
 elif [ "$DISTRIB_ID" = "FreeBSD" ]; then
     SCRIPTNAME=$0 # FreeBSD
+elif [ "$DISTRIB_ID" = "nixos" ]; then
+    SCRIPTNAME=$0 # NixOS
+    echo "Warn: Use of this script is not recommended on NixOS. Instead, enable the module"
+    echo "      'services.trafficserver' and use systemctl to control Traffic Server."
 else
     echo "This script needs to be ported to this OS"
     exit 1
@@ -183,7 +189,7 @@ if [ ! -d $TS_BASE@exp_runtimedir@ ]; then
 fi
 
 #
-# Fedora:
+# Fedora/NixOS:
 #  launches $* in the background
 #  and checks if program creates its own pid lock file
 #  redirects stdout and stderr to files
@@ -201,7 +207,7 @@ forkdaemon()
     do
         # check for regular file and size greater than 0
         if [[ -f $TM_PIDFILE ]] && [[ -s $TM_PIDFILE ]]; then
-            success
+            success || true
             return 0
         fi
 
@@ -210,7 +216,7 @@ forkdaemon()
 
     done
 
-    failure
+    failure || true
     return 1
 }
 
@@ -321,6 +327,9 @@ case "$1" in
             echo -n "Starting ${TS_PACKAGE_NAME}"
             startproc -p $TM_PIDFILE $TM_DAEMON $TM_DAEMON_ARGS
             rc_status -v
+        elif [ "$DISTRIB_ID" = "nixos" ]; then
+            echo "Starting ${TS_PACKAGE_NAME}"
+            forkdaemon $TM_DAEMON $TM_DAEMON_ARGS
         elif [ "$DISTRIB_ID" = "Darwin" ]; then
             echo "Starting ${TS_PACKAGE_NAME}"
             launchctl bsexec / launchctl list $TM_NAME > /dev/null 2>&1 && exit 0
@@ -359,6 +368,16 @@ case "$1" in
             echo -n "Stopping ${TS_NAME}"
             killproc -p $TS_PIDFILE $TS_DAEMON
             rc_status -v
+        elif [ "$DISTRIB_ID" = "nixos" ]; then
+            echo "Stopping ${TS_PACKAGE_NAME}"
+            if [ -e "$TM_PIDFILE" ]; then
+                kill $(cat $TM_PIDFILE)
+                rm -f ${TM_PIDFILE}
+            fi
+            if [ -e "$TS_PIDFILE" ]; then
+                kill $(cat $TS_PIDFILE)
+                rm -f ${TS_PIDFILE}
+            fi
         elif [ "$DISTRIB_ID" = "Darwin" ]; then
             echo "Stopping ${TS_PACKAGE_NAME}"
             launchctl bsexec / launchctl list $TM_NAME > /dev/null 2>&1 || exit 0
@@ -404,6 +423,9 @@ case "$1" in
             echo -n "Reloading ${NAME}"
             $TL_BINARY config reload
             rc_status -v
+        elif [ "$DISTRIB_ID" = "nixos" ]; then
+            echo "Reloading ${NAME}"
+            $TL_BINARY config reload
         elif [ "$DISTRIB_ID" = "Darwin" ]; then
             echo "Reloading ${NAME}"
             $TL_BINARY config reload
@@ -460,7 +482,7 @@ case "$1" in
             status=$?
             [ $status -eq 0 ] || /bin/echo -n "not "
             echo "running."
-        elif [ "$DISTRIB_ID" = "FreeBSD" -o "$DISTRIB_ID" = "gentoo" ]; then
+        elif [ "$DISTRIB_ID" = "FreeBSD" -o "$DISTRIB_ID" = "gentoo" -o "$DISTRIB_ID" = "nixos" ]; then
             if pgrep $TM_NAME > /dev/null ; then
                 echo "$TM_NAME running as pid `cat $TM_PIDFILE`" ; else
                 echo "$TM_NAME not running"
@@ -496,6 +518,8 @@ case "$1" in
             echo "Usage: $0 {start|stop|reload|restart|status}"
         elif [ "$DISTRIB_ID" = "suse" ]; then
             echo "Usage: $0 {start|stop|restart|status}"
+        elif [ "$DISTRIB_ID" = "nixos" ]; then
+            echo "Usage: $0 {start|stop|reload|restart|status}"
         elif [ "$DISTRIB_ID" = "Darwin" ]; then
             echo "Usage: $0 {start|stop|restart|status}"
         elif [ "$DISTRIB_ID" = "FreeBSD" ]; then
diff --git a/rc/trafficserver.service.in b/rc/trafficserver.service.in
index 7aab8488dbd..a503a49d8cf 100644
--- a/rc/trafficserver.service.in
+++ b/rc/trafficserver.service.in
@@ -17,7 +17,7 @@
 #
 [Unit]
 Description=Apache Traffic Server is a fast, scalable and extensible caching proxy server.
-After=syslog.target network.target
+After=network.target
 
 [Service]
 Type=simple
@@ -26,10 +26,7 @@ ExecStart=@exp_bindir@/traffic_manager $TM_DAEMON_ARGS
 Restart=on-failure
 RestartSec=5s
 LimitNOFILE=1000000
-ExecStopPost=/bin/sh -c ' \
-        export TM_PIDFILE=$(@exp_bindir@/traffic_layout 2>/dev/null | grep RUNTIMEDIR | cut -d: -f2)/manager.lock ; \
-        /bin/rm $TM_PIDFILE ; \
-        if [[ $? -ne 0 ]]; then echo "ERROR: Unable to delete PID"; exit 1; fi'
+PIDFile=@exp_runtimedir@/manager.lock
 TimeoutStopSec=5s
 ExecReload=@exp_bindir@/traffic_ctl config reload
 KillMode=process
diff --git a/tools/tsxs.in b/tools/tsxs.in
index b480a36bfc9..c3cc8d44d85 100755
--- a/tools/tsxs.in
+++ b/tools/tsxs.in
@@ -204,6 +204,9 @@ do
 		OBJ=$OPTARG
 		;;
 	i)
+		if [[ "$INSTALLDIR" = /nix/store* ]]; then
+			bail "unsupported option: -i is disabled on Nix"
+		fi
 		INSTALL=1
 		;;
 	c)