diff --git a/NEWS.md b/NEWS.md
index 06b653d90a..3aaeb007bb 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -6,6 +6,7 @@
 * Scripting: Added `Tileset.transformationFlags` (#3753)
 * Scripting: Added `Dialog.addRadioButtonGroup` for selecting one of a list of mutually exclusive options (#4107)
 * Scripting: Made `currentWangSet` and `currentWangColorIndex` properties writeable (#4105)
+* AutoMapping: Ignore rules with empty input or output regions (#3834)
 * Fixed saving/loading of custom properties set on worlds (#4025)
 * Fixed issue with placing tile objects after switching maps (#3497)
 * Fixed crash when accessing a world through a symlink (#4042)
diff --git a/src/tiled/automapper.cpp b/src/tiled/automapper.cpp
index f6dd498e86..cbf8d1ea59 100644
--- a/src/tiled/automapper.cpp
+++ b/src/tiled/automapper.cpp
@@ -639,9 +639,16 @@ void AutoMapper::setupRules()
     mRules.reserve(combinedRegions.size());
 
     for (const QRegion &combinedRegion : combinedRegions) {
+        QRegion inputRegion = combinedRegion & regionInput;
+        QRegion outputRegion = combinedRegion & regionOutput;
+
+        // Skip rules where either input or output region is empty
+        if (inputRegion.isEmpty() || outputRegion.isEmpty())
+            continue;
+
         Rule &rule = mRules.emplace_back();
-        rule.inputRegion = combinedRegion & regionInput;
-        rule.outputRegion = combinedRegion & regionOutput;
+        rule.inputRegion = std::move(inputRegion);
+        rule.outputRegion = std::move(outputRegion);
         rule.options = mRuleOptions;
 
         for (const auto &optionsArea : setup.mRuleOptionsAreas)
@@ -1474,5 +1481,3 @@ void AutoMapper::addWarning(const QString &message, std::function<void ()> callb
 }
 
 } // namespace Tiled
-
-#include "moc_automapper.cpp"
diff --git a/src/tiled/automapper.h b/src/tiled/automapper.h
index 52a43ad098..a8ca7da548 100644
--- a/src/tiled/automapper.h
+++ b/src/tiled/automapper.h
@@ -27,6 +27,7 @@
 #include "tilelayer.h"
 #include "tileset.h"
 
+#include <QCoreApplication>
 #include <QList>
 #include <QMap>
 #include <QRegion>
@@ -275,9 +276,9 @@ struct TILED_EDITOR_EXPORT AutoMappingContext
  * - copy regions of Maps (multiple Layers, the layerlist is a
  *                         lookup-table for matching the Layers)
  */
-class TILED_EDITOR_EXPORT AutoMapper : public QObject
+class TILED_EDITOR_EXPORT AutoMapper
 {
-    Q_OBJECT
+    Q_DECLARE_TR_FUNCTIONS(Tiled::AutoMapper)
 
 public:
     struct Options
@@ -333,7 +334,7 @@ class TILED_EDITOR_EXPORT AutoMapper : public QObject
      *                 AutoMapper takes ownership of this map.
      */
     AutoMapper(std::unique_ptr<Map> rulesMap, const QRegularExpression &mapNameFilter = {});
-    ~AutoMapper() override;
+    ~AutoMapper();
 
     QString rulesMapFileName() const;
     const QRegularExpression &mapNameFilter() const;
diff --git a/tests/automapping/ignore-empty-region/map-result.tmx b/tests/automapping/ignore-empty-region/map-result.tmx
new file mode 100644
index 0000000000..4c6d81183d
--- /dev/null
+++ b/tests/automapping/ignore-empty-region/map-result.tmx
@@ -0,0 +1,10 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<map version="1.11" tiledversion="1.11.0" orientation="orthogonal" renderorder="right-down" width="2" height="2" tilewidth="16" tileheight="16" infinite="0" nextlayerid="6" nextobjectid="1">
+ <tileset firstgid="1" source="../spr_test_tileset.tsx"/>
+ <layer id="1" name="set" width="2" height="2">
+  <data encoding="csv">
+2,2,
+2,2
+</data>
+ </layer>
+</map>
diff --git a/tests/automapping/ignore-empty-region/map.tmx b/tests/automapping/ignore-empty-region/map.tmx
new file mode 100644
index 0000000000..4c6d81183d
--- /dev/null
+++ b/tests/automapping/ignore-empty-region/map.tmx
@@ -0,0 +1,10 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<map version="1.11" tiledversion="1.11.0" orientation="orthogonal" renderorder="right-down" width="2" height="2" tilewidth="16" tileheight="16" infinite="0" nextlayerid="6" nextobjectid="1">
+ <tileset firstgid="1" source="../spr_test_tileset.tsx"/>
+ <layer id="1" name="set" width="2" height="2">
+  <data encoding="csv">
+2,2,
+2,2
+</data>
+ </layer>
+</map>
diff --git a/tests/automapping/ignore-empty-region/rules.tmx b/tests/automapping/ignore-empty-region/rules.tmx
new file mode 100644
index 0000000000..9515a709a6
--- /dev/null
+++ b/tests/automapping/ignore-empty-region/rules.tmx
@@ -0,0 +1,18 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<map version="1.11" tiledversion="1.11.0" orientation="orthogonal" renderorder="right-down" width="5" height="3" tilewidth="16" tileheight="16" infinite="0" nextlayerid="12" nextobjectid="2">
+ <tileset firstgid="1" source="../spr_test_tileset.tsx"/>
+ <layer id="6" name="input_set" width="5" height="3">
+  <data encoding="csv">
+0,0,0,0,0,
+0,3,0,0,0,
+0,0,0,0,0
+</data>
+ </layer>
+ <layer id="2" name="output_set" width="5" height="3">
+  <data encoding="csv">
+0,0,0,0,0,
+0,0,0,4,0,
+0,0,0,0,0
+</data>
+ </layer>
+</map>
diff --git a/tests/automapping/ignore-empty-region/rules.txt b/tests/automapping/ignore-empty-region/rules.txt
new file mode 100644
index 0000000000..262b188fa9
--- /dev/null
+++ b/tests/automapping/ignore-empty-region/rules.txt
@@ -0,0 +1 @@
+./rules.tmx
diff --git a/tests/automapping/test_automapping.cpp b/tests/automapping/test_automapping.cpp
index bc09b8ff3b..e7d23f7c07 100644
--- a/tests/automapping/test_automapping.cpp
+++ b/tests/automapping/test_automapping.cpp
@@ -22,6 +22,7 @@ void test_AutoMapping::autoMap_data()
 {
     QTest::addColumn<QString>("directory");
 
+    QTest::newRow("ignore-empty-region") << QStringLiteral("ignore-empty-region");
     QTest::newRow("ignore-flip") << QStringLiteral("ignore-flip");
     QTest::newRow("infinite-target-map") << QStringLiteral("infinite-target-map");
     QTest::newRow("inputnot") << QStringLiteral("inputnot");