DESCRIPTION

Package: multicrispr
Title: Multi-locus multi-purpose Crispr/Cas design 
Version: 1.5.3
Encoding: UTF-8
Authors@R: c(person("Aditya",   "Bhagwat",    NULL, "aditya.bhagwat@mpi-bn.mpg.de",   c("aut", "cre")),
            person( "Rene",     "Wiegandt",   NULL, "rene.wiegandt@mpi-bn.mpg.de",      "ctb"),
            person( "Mette",    "Bentsen",    NULL, "mette.bentsen@mpi-bn.mpg.de",      "ctb"),
            person( "Jens",     "Preussner",  NULL, "jens.preussner@mpi-bn.mpg.de",     "ctb"),
            person( "Michael",  "Lawrence",   NULL, "lawrence.michael@gene.com",        "ctb"),
            person( "Hervé",    "Pagès",      NULL, "hpages.on.github@gmail.com",       "ctb"),
            person( "Johannes", "Graumann",   NULL, 'johannes.graumann@uni-marburg.de', "sad"),
            person( "Mario",    "Looso",      NULL, "mario.looso@mpi-bn.mpg.de",        c("sad","rth")))
Description: This package is for designing Crispr/Cas9 and Prime Editing experiments.
             It contains functions to (1) define and transform genomic targets, (2) find spacers
             (4) count offtarget (mis)matches, and (5) compute Doench2016/2014 targeting efficiency. 
             Care has been taken for multicrispr to scale well towards large target sets, 
             enabling the design of large Crispr/Cas9 libraries.
License: GPL-2
LazyData: true
RoxygenNote: 7.1.2
Depends:
    R (>= 4.0)
Imports:
    assertive,
    BiocGenerics,
    Biostrings,
    BSgenome,
    CRISPRseek,
    data.table,
    GenomeInfoDb,
    GenomicFeatures,
    GenomicRanges,
    ggplot2,
    grid,
    karyoploteR,
    magrittr,
    methods,
    parallel,
    plyranges,
    Rbowtie,
    reticulate,
    rtracklayer,
    stats,
    stringi, 
    tidyr,
    tidyselect,
    utils
Suggests: 
    AnnotationHub,
    BiocStyle,
    BSgenome.Hsapiens.UCSC.hg38,
    BSgenome.Mmusculus.UCSC.mm10,
    BSgenome.Scerevisiae.UCSC.sacCer1,
    ensembldb,
    IRanges,
    knitr,
    magick,
    rmarkdown,
    testthat,
    TxDb.Mmusculus.UCSC.mm10.knownGene
VignetteBuilder: knitr
biocViews: CRISPR, Software
BugReports: https://github.com/loosolab/multicrispr/issues
URL: https://github.com/loosolab/multicrispr