diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index c0f202de9e..15f6c81d14 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -53,6 +53,20 @@ jobs:
               -DEXTRA_CXXFLAGS=-flto=full
             with_pgo: true
 
+          - job_name: Alpine musl x86_64
+            os: ubuntu-latest
+            container_image: alpine:3.20
+            arch: x86_64
+            bootstrap_cmake_flags: -DBUILD_LTO_LIBS=ON
+            extra_cmake_flags: >-
+              -DBUILD_LTO_LIBS=ON
+              -DBUILD_SHARED_LIBS=OFF
+              -DTEST_COMPILER_RT_LIBRARIES="profile;lsan;asan;msan;fuzzer"
+              -DCMAKE_EXE_LINKER_FLAGS=-static-libstdc++
+              -DJITRT_EXTRA_LDFLAGS=-static-libstdc++
+              -DD_COMPILER_FLAGS="-O -flto=full -defaultlib=phobos2-ldc-lto,druntime-ldc-lto -link-defaultlib-shared=false"
+            with_pgo: false
+
           - job_name: macOS x86_64
             os: macos-13
             arch: x86_64
@@ -110,16 +124,27 @@ jobs:
     steps:
       - name: 'Container: Install git and sudo'
         if: matrix.container_image
-        shell: bash
         run: |
           set -eux
-          apt-get -q update
-          DEBIAN_FRONTEND=noninteractive apt-get -yq install git-core sudo
+          if type -P apt-get &>/dev/null; then
+            apt-get -q update
+            DEBIAN_FRONTEND=noninteractive apt-get -yq install git-core sudo
+          else # set up Alpine container
+            apk add \
+              git cmake ninja g++ ldc llvm-dev llvm-static compiler-rt \
+              libxml2-static zstd-static zlib-static \
+              bash grep diffutils make curl
+            # create ../llvm symlink to distro LLVM (no prebuilt LDC-LLVM for musl)
+            ln -s /usr/lib/llvm17 $(dirname $(pwd))/llvm
+            ../llvm/bin/llvm-config --version
+          fi
       - uses: actions/checkout@v4
         with:
           submodules: true
           fetch-depth: 50
       - name: Install prerequisites
+        if: |
+          !startsWith(matrix.container_image, 'alpine')
         uses: ./.github/actions/1-setup
         with:
           llvm_version: ${{ matrix.llvm_version || env.LLVM_VERSION }}