diff --git a/CMakeLists.txt b/CMakeLists.txt
index fc1fa967af715..b1ffc021ba977 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -330,58 +330,57 @@ include(cmake/leveldb.cmake)
 include(cmake/minisketch.cmake)
 include(cmake/secp256k1.cmake)
 
+add_library(warn_interface INTERFACE)
+target_link_libraries(core_interface INTERFACE warn_interface)
 include(ProcessConfigurations)
 are_flags_overridden(CMAKE_CXX_FLAGS cxx_flags_overridden)
 # TODO: Rework after https://github.com/bitcoin/bitcoin/pull/25972.
-if(NOT cxx_flags_overridden AND NOT CMAKE_CROSSCOMPILING)
-  add_library(warn_interface INTERFACE)
-  target_link_libraries(core_interface INTERFACE warn_interface)
-  if(MSVC)
-    try_append_cxx_flags("/W3" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("/wd4018" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("/wd4244" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("/wd4267" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("/wd4715" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("/wd4805" TARGET warn_interface SKIP_LINK)
-    target_compile_definitions(warn_interface INTERFACE
-      _CRT_SECURE_NO_WARNINGS
-      _SILENCE_CXX17_CODECVT_HEADER_DEPRECATION_WARNING
-    )
-  else()
-    try_append_cxx_flags("-Wall" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wextra" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wgnu" TARGET warn_interface SKIP_LINK)
-    # Some compilers will ignore -Wformat-security without -Wformat, so just combine the two here.
-    try_append_cxx_flags("-Wformat;-Wformat-security" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wvla" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wshadow-field" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wthread-safety" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wloop-analysis" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wredundant-decls" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wunused-member-function" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wdate-time" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wconditional-uninitialized" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wduplicated-branches" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wduplicated-cond" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wlogical-op" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Woverloaded-virtual" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wsuggest-override" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wimplicit-fallthrough" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wunreachable-code" TARGET warn_interface SKIP_LINK)
-    try_append_cxx_flags("-Wdocumentation" TARGET warn_interface SKIP_LINK)
-
-    # Some compilers (gcc) ignore unknown -Wno-* options, but warn about all
-    # unknown options if any other warning is produced. Test the -Wfoo case, and
-    # set the -Wno-foo case if it works.
-    try_append_cxx_flags("-Wunused-parameter" TARGET warn_interface SKIP_LINK
-      IF_CHECK_PASSED "-Wno-unused-parameter"
-    )
-    try_append_cxx_flags("-Wself-assign" TARGET warn_interface SKIP_LINK
-      IF_CHECK_PASSED "-Wno-self-assign"
-    )
-  endif()
+if(NOT cxx_flags_overridden AND NOT CMAKE_TOOLCHAIN_FILE)
+  try_append_cxx_flags("-Wall" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wextra" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wgnu" TARGET warn_interface SKIP_LINK)
+  # Some compilers will ignore -Wformat-security without -Wformat, so just combine the two here.
+  try_append_cxx_flags("-Wformat;-Wformat-security" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wvla" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wshadow-field" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wthread-safety" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wloop-analysis" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wredundant-decls" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wunused-member-function" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wdate-time" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wconditional-uninitialized" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wduplicated-branches" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wduplicated-cond" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wlogical-op" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Woverloaded-virtual" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wsuggest-override" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wimplicit-fallthrough" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wunreachable-code" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("-Wdocumentation" TARGET warn_interface SKIP_LINK)
+
+  # Some compilers (gcc) ignore unknown -Wno-* options, but warn about all
+  # unknown options if any other warning is produced. Test the -Wfoo case, and
+  # set the -Wno-foo case if it works.
+  try_append_cxx_flags("-Wunused-parameter" TARGET warn_interface SKIP_LINK
+    IF_CHECK_PASSED "-Wno-unused-parameter"
+  )
+  try_append_cxx_flags("-Wself-assign" TARGET warn_interface SKIP_LINK
+    IF_CHECK_PASSED "-Wno-self-assign"
+  )
 endif()
 unset(cxx_flags_overridden)
+if(MSVC)
+  try_append_cxx_flags("/W3" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("/wd4018" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("/wd4244" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("/wd4267" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("/wd4715" TARGET warn_interface SKIP_LINK)
+  try_append_cxx_flags("/wd4805" TARGET warn_interface SKIP_LINK)
+  target_compile_definitions(warn_interface INTERFACE
+    _CRT_SECURE_NO_WARNINGS
+    _SILENCE_CXX17_CODECVT_HEADER_DEPRECATION_WARNING
+  )
+endif()
 
 set_default_config(RelWithDebInfo)
 
@@ -530,22 +529,20 @@ else()
   )
 endif()
 
-if(CMAKE_CROSSCOMPILING)
-  target_compile_definitions(core_base_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS})
-  target_compile_definitions(core_depends_release_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS_RELWITHDEBINFO})
-  target_compile_definitions(core_depends_debug_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS_DEBUG})
-
-  # If {C,CXX}FLAGS variables are defined during building depends and
-  # configuring this build system, their content might be duplicated.
-  if(DEFINED ENV{CFLAGS})
-    deduplicate_flags(CMAKE_C_FLAGS)
-  endif()
-  if(DEFINED ENV{CXXFLAGS})
-    deduplicate_flags(CMAKE_CXX_FLAGS)
-  endif()
-  if(DEFINED ENV{LDFLAGS})
-    deduplicate_flags(CMAKE_EXE_LINKER_FLAGS)
-  endif()
+target_compile_definitions(core_base_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS})
+target_compile_definitions(core_depends_release_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS_RELWITHDEBINFO})
+target_compile_definitions(core_depends_debug_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS_DEBUG})
+
+# If {C,CXX,LD}FLAGS variables are defined during building depends and
+# configuring this build system, their content might be duplicated.
+if(DEFINED ENV{CFLAGS})
+  deduplicate_flags(CMAKE_C_FLAGS)
+endif()
+if(DEFINED ENV{CXXFLAGS})
+  deduplicate_flags(CMAKE_CXX_FLAGS)
+endif()
+if(DEFINED ENV{LDFLAGS})
+  deduplicate_flags(CMAKE_EXE_LINKER_FLAGS)
 endif()
 
 add_subdirectory(src)
diff --git a/cmake/module/Maintenance.cmake b/cmake/module/Maintenance.cmake
index 1d4d61a4b38a2..84f4c71614db3 100644
--- a/cmake/module/Maintenance.cmake
+++ b/cmake/module/Maintenance.cmake
@@ -30,11 +30,9 @@ function(add_maintenance_targets)
   else()
     set(exe_format ELF)
   endif()
-  if(CMAKE_CROSSCOMPILING)
-    list(JOIN DEPENDS_C_COMPILER_WITH_LAUNCHER " " c_compiler_command)
-  else()
-    set(c_compiler_command ${CMAKE_C_COMPILER})
-  endif()
+  list(JOIN CMAKE_C_COMPILER_LAUNCHER " " c_compiler_command)
+  string(STRIP "${c_compiler_command} ${CMAKE_C_COMPILER}" c_compiler_command)
+  string(STRIP "${c_compiler_command} ${CMAKE_C_COMPILER_ARG1}" c_compiler_command)
   add_custom_target(test-security-check
     COMMAND ${CMAKE_COMMAND} -E env CC=${c_compiler_command} CFLAGS=${CMAKE_C_FLAGS} LDFLAGS=${CMAKE_EXE_LINKER_FLAGS} ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/devtools/test-security-check.py TestSecurityChecks.test_${exe_format}
     COMMAND ${CMAKE_COMMAND} -E env CC=${c_compiler_command} CFLAGS=${CMAKE_C_FLAGS} LDFLAGS=${CMAKE_EXE_LINKER_FLAGS} ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/devtools/test-symbol-check.py TestSymbolChecks.test_${exe_format}
@@ -111,7 +109,20 @@ function(add_macos_deploy_target)
     )
 
     string(REPLACE " " "-" osx_volname ${PACKAGE_NAME})
-    if(CMAKE_CROSSCOMPILING)
+    if(CMAKE_HOST_APPLE)
+      add_custom_command(
+        OUTPUT ${CMAKE_BINARY_DIR}/${osx_volname}.zip
+        COMMAND ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR} -zip
+        DEPENDS ${CMAKE_BINARY_DIR}/${macos_app}/Contents/MacOS/Bitcoin-Qt
+        VERBATIM
+      )
+      add_custom_target(deploydir
+        DEPENDS ${CMAKE_BINARY_DIR}/${osx_volname}.zip
+      )
+      add_custom_target(deploy
+        DEPENDS ${CMAKE_BINARY_DIR}/${osx_volname}.zip
+      )
+    else()
       add_custom_command(
         OUTPUT ${CMAKE_BINARY_DIR}/dist/${macos_app}/Contents/MacOS/Bitcoin-Qt
         COMMAND OTOOL=${OTOOL} ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR}
@@ -133,19 +144,6 @@ function(add_macos_deploy_target)
         DEPENDS ${CMAKE_BINARY_DIR}/dist/${osx_volname}.zip
       )
       add_dependencies(deploy deploydir)
-    else()
-      add_custom_command(
-        OUTPUT ${CMAKE_BINARY_DIR}/${osx_volname}.zip
-        COMMAND ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR} -zip
-        DEPENDS ${CMAKE_BINARY_DIR}/${macos_app}/Contents/MacOS/Bitcoin-Qt
-        VERBATIM
-      )
-      add_custom_target(deploydir
-        DEPENDS ${CMAKE_BINARY_DIR}/${osx_volname}.zip
-      )
-      add_custom_target(deploy
-        DEPENDS ${CMAKE_BINARY_DIR}/${osx_volname}.zip
-      )
     endif()
   endif()
 endfunction()
diff --git a/depends/Makefile b/depends/Makefile
index fac703966a03f..57aebcc4d14d7 100644
--- a/depends/Makefile
+++ b/depends/Makefile
@@ -258,9 +258,16 @@ $(host_prefix)/share/config.site : config.site.in $(host_prefix)/.stamp_$(final_
             $< > $@
 	touch $@
 
+ifeq ($(host),$(build))
+  crosscompiling=FALSE
+else
+  crosscompiling=TRUE
+endif
+
 $(host_prefix)/toolchain.cmake : toolchain.cmake.in $(host_prefix)/.stamp_$(final_build_id)
 	@mkdir -p $(@D)
-	sed -e 's|@host_system@|$($(host_os)_cmake_system)|' \
+	sed -e 's|@depends_crosscompiling@|$(crosscompiling)|' \
+            -e 's|@host_system@|$($(host_os)_cmake_system)|' \
             -e 's|@host_arch@|$(host_arch)|' \
             -e 's|@CC@|$(host_CC)|' \
             -e 's|@CXX@|$(host_CXX)|' \
diff --git a/depends/toolchain.cmake.in b/depends/toolchain.cmake.in
index 8676b65f68a60..4c7b36e0d11d9 100644
--- a/depends/toolchain.cmake.in
+++ b/depends/toolchain.cmake.in
@@ -4,8 +4,10 @@
 
 # This file is expected to be highly volatile and may still change substantially.
 
-set(CMAKE_SYSTEM_NAME @host_system@)
-set(CMAKE_SYSTEM_PROCESSOR @host_arch@)
+if(@depends_crosscompiling@)
+  set(CMAKE_SYSTEM_NAME @host_system@)
+  set(CMAKE_SYSTEM_PROCESSOR @host_arch@)
+endif()
 
 function(split_compiler_launcher env_compiler launcher compiler)
   set(${launcher})
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
index b528b4d68acfc..84a6716579768 100644
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -35,7 +35,7 @@ if(BUILD_GUI_TESTS)
   list(APPEND qt_components Test)
 endif()
 
-if(CMAKE_CROSSCOMPILING)
+if(CMAKE_TOOLCHAIN_FILE AND NOT VCPKG_TARGET_TRIPLET)
   # The find_package(Qt ...) function internally uses find_library()
   # calls for all dependencies to ensure their availability.
   # In turn, the find_library() inspects the well-known locations