diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/.gitignore b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/.gitignore
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/.gitignore
rename to dev-packages/e2e-tests/test-applications/node-profiling-cjs/.gitignore
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/.npmrc b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/.npmrc
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/.npmrc
rename to dev-packages/e2e-tests/test-applications/node-profiling-cjs/.npmrc
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/build-cjs.mjs b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/build-cjs.mjs
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/build-cjs.mjs
rename to dev-packages/e2e-tests/test-applications/node-profiling-cjs/build-cjs.mjs
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/index.ts b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/index.ts
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/index.ts
rename to dev-packages/e2e-tests/test-applications/node-profiling-cjs/index.ts
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-cjs/package.json b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/package.json
new file mode 100644
index 000000000000..aa729a030a5d
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/package.json
@@ -0,0 +1,22 @@
+{
+  "name": "node-profiling-cjs",
+  "version": "1.0.0",
+  "private": true,
+  "scripts": {
+    "typecheck": "tsc --noEmit",
+    "test": "node dist/cjs/index.js",
+    "clean": "npx rimraf node_modules dist",
+    "test:build": "pnpm install && node build-cjs.mjs",
+    "test:assert": "pnpm run typecheck && pnpm run test"
+  },
+  "dependencies": {
+    "@playwright/test": "~1.50.0",
+    "@sentry/node": "latest || *",
+    "@sentry/profiling-node": "latest || *",
+    "esbuild": "0.20.0",
+    "typescript": "^5.7.3"
+  },
+  "volta": {
+    "extends": "../../package.json"
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/tsconfig.json b/dev-packages/e2e-tests/test-applications/node-profiling-cjs/tsconfig.json
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/tsconfig.json
rename to dev-packages/e2e-tests/test-applications/node-profiling-cjs/tsconfig.json
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-electron/.gitignore b/dev-packages/e2e-tests/test-applications/node-profiling-electron/.gitignore
new file mode 100644
index 000000000000..1521c8b7652b
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-electron/.gitignore
@@ -0,0 +1 @@
+dist
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-electron/.npmrc b/dev-packages/e2e-tests/test-applications/node-profiling-electron/.npmrc
new file mode 100644
index 000000000000..949fbddc2343
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-electron/.npmrc
@@ -0,0 +1,2 @@
+# @sentry:registry=http://127.0.0.1:4873
+# @sentry-internal:registry=http://127.0.0.1:4873
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/__tests__/electron.spec.js b/dev-packages/e2e-tests/test-applications/node-profiling-electron/__tests__/electron.spec.js
similarity index 95%
rename from dev-packages/e2e-tests/test-applications/node-profiling/__tests__/electron.spec.js
rename to dev-packages/e2e-tests/test-applications/node-profiling-electron/__tests__/electron.spec.js
index 4519220008d1..49c0666fc1f7 100644
--- a/dev-packages/e2e-tests/test-applications/node-profiling/__tests__/electron.spec.js
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-electron/__tests__/electron.spec.js
@@ -7,6 +7,7 @@ test('an h1 contains hello world"', async () => {
     process: {
       env: {
         ...process.env,
+        NODE_ENV: 'development',
       },
     },
   });
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/index.electron.js b/dev-packages/e2e-tests/test-applications/node-profiling-electron/index.electron.js
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/index.electron.js
rename to dev-packages/e2e-tests/test-applications/node-profiling-electron/index.electron.js
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/index.html b/dev-packages/e2e-tests/test-applications/node-profiling-electron/index.html
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/index.html
rename to dev-packages/e2e-tests/test-applications/node-profiling-electron/index.html
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-electron/package.json b/dev-packages/e2e-tests/test-applications/node-profiling-electron/package.json
new file mode 100644
index 000000000000..dc176c847538
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-electron/package.json
@@ -0,0 +1,24 @@
+{
+  "name": "node-profiling-electron",
+  "version": "1.0.0",
+  "private": true,
+  "scripts": {
+    "clean": "npx rimraf node_modules dist",
+    "test:build": "pnpm install",
+    "test:assert": "$(pnpm bin)/electron-rebuild && pnpm playwright test"
+  },
+  "dependencies": {
+    "@electron/rebuild": "^3.7.0",
+    "@playwright/test": "~1.50.0",
+    "@sentry/electron": "latest || *",
+    "@sentry/node": "latest || *",
+    "@sentry/profiling-node": "latest || *",
+    "electron": "^33.2.0"
+  },
+  "volta": {
+    "extends": "../../package.json"
+  },
+  "sentryTest": {
+    "skip": true
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-esm/.gitignore b/dev-packages/e2e-tests/test-applications/node-profiling-esm/.gitignore
new file mode 100644
index 000000000000..1521c8b7652b
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-esm/.gitignore
@@ -0,0 +1 @@
+dist
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-esm/.npmrc b/dev-packages/e2e-tests/test-applications/node-profiling-esm/.npmrc
new file mode 100644
index 000000000000..949fbddc2343
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-esm/.npmrc
@@ -0,0 +1,2 @@
+# @sentry:registry=http://127.0.0.1:4873
+# @sentry-internal:registry=http://127.0.0.1:4873
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/build-esm.mjs b/dev-packages/e2e-tests/test-applications/node-profiling-esm/build-esm.mjs
similarity index 100%
rename from dev-packages/e2e-tests/test-applications/node-profiling/build-esm.mjs
rename to dev-packages/e2e-tests/test-applications/node-profiling-esm/build-esm.mjs
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-esm/index.ts b/dev-packages/e2e-tests/test-applications/node-profiling-esm/index.ts
new file mode 100644
index 000000000000..e956a1d9de33
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-esm/index.ts
@@ -0,0 +1,15 @@
+import * as Sentry from '@sentry/node';
+import { nodeProfilingIntegration } from '@sentry/profiling-node';
+
+const wait = (ms: number) => new Promise(resolve => setTimeout(resolve, ms));
+
+Sentry.init({
+  dsn: 'https://7fa19397baaf433f919fbe02228d5470@o1137848.ingest.sentry.io/6625302',
+  integrations: [nodeProfilingIntegration()],
+  tracesSampleRate: 1.0,
+  profilesSampleRate: 1.0,
+});
+
+Sentry.startSpan({ name: 'Precompile test' }, async () => {
+  await wait(500);
+});
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-esm/package.json b/dev-packages/e2e-tests/test-applications/node-profiling-esm/package.json
new file mode 100644
index 000000000000..b633df2df172
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-esm/package.json
@@ -0,0 +1,22 @@
+{
+  "name": "node-profiling-esm",
+  "version": "1.0.0",
+  "private": true,
+  "scripts": {
+    "typecheck": "tsc --noEmit",
+    "test": "node dist/esm/index.mjs",
+    "clean": "npx rimraf node_modules dist",
+    "test:build": "pnpm install && node build-esm.mjs",
+    "test:assert": "pnpm run typecheck && pnpm run test"
+  },
+  "dependencies": {
+    "@playwright/test": "~1.50.0",
+    "@sentry/node": "latest || *",
+    "@sentry/profiling-node": "latest || *",
+    "esbuild": "0.20.0",
+    "typescript": "^5.7.3"
+  },
+  "volta": {
+    "extends": "../../package.json"
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling-esm/tsconfig.json b/dev-packages/e2e-tests/test-applications/node-profiling-esm/tsconfig.json
new file mode 100644
index 000000000000..1308ed76609c
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling-esm/tsconfig.json
@@ -0,0 +1,13 @@
+{
+  "compilerOptions": {
+    "types": ["node"],
+    "esModuleInterop": true,
+    "lib": ["es2018"],
+    "strict": true,
+    "outDir": "dist",
+    "target": "ESNext",
+    "moduleResolution": "node",
+    "skipLibCheck": true
+  },
+  "include": ["index.ts"]
+}
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/package.json b/dev-packages/e2e-tests/test-applications/node-profiling/package.json
deleted file mode 100644
index c48ab9c3d42d..000000000000
--- a/dev-packages/e2e-tests/test-applications/node-profiling/package.json
+++ /dev/null
@@ -1,29 +0,0 @@
-{
-  "name": "node-profiling",
-  "version": "1.0.0",
-  "private": true,
-  "scripts": {
-    "typecheck": "tsc --noEmit",
-    "build": "node build-cjs.mjs && node build-esm.mjs",
-    "test": "node dist/cjs/index.js && node --experimental-require-module dist/cjs/index.js && node dist/esm/index.mjs",
-    "clean": "npx rimraf node_modules dist",
-    "test:electron": "$(pnpm bin)/electron-rebuild && playwright test",
-    "test:build": "pnpm run typecheck && pnpm run build",
-    "test:assert": "pnpm run test && pnpm run test:electron"
-  },
-  "dependencies": {
-    "@electron/rebuild": "^3.7.0",
-    "@playwright/test": "~1.50.0",
-    "@sentry/electron": "latest || *",
-    "@sentry/node": "latest || *",
-    "@sentry/profiling-node": "latest || *",
-    "electron": "^33.2.0",
-    "esbuild": "0.20.0"
-  },
-  "volta": {
-    "extends": "../../package.json"
-  },
-  "sentryTest": {
-    "skip": true
-  }
-}