From 998dc4585a9a7a1fdfae85d122dc227cb22fc7e9 Mon Sep 17 00:00:00 2001
From: pgaudet <pgaudet1@gmail.com>
Date: Thu, 30 Nov 2023 17:52:27 +0100
Subject: [PATCH] Update gorule-0000061.md

---
 metadata/rules/gorule-0000061.md | 16 ++++++++--------
 1 file changed, 8 insertions(+), 8 deletions(-)

diff --git a/metadata/rules/gorule-0000061.md b/metadata/rules/gorule-0000061.md
index 5b363445..af441c97 100644
--- a/metadata/rules/gorule-0000061.md
+++ b/metadata/rules/gorule-0000061.md
@@ -10,16 +10,16 @@ contact: "go-quality@lists.stanford.edu"
 ---
 
 GAF2.2 files require a gene product to term (gp2term) relation in Column 4. Allowed gp2term relations:  
-* For `GO:0003674 "molecular function"` and subclass descendants:
-    * If the annotation is to the root term `"molecular function"`, then the gp2term relation should `RO:0002327 "enables"`; else, it is repaired to `RO:0002327 "enables"`.
-    * If the annotation is to is a subclass descendant of `"molecular function"`, then the allowed gp2term relations are `RO:0002327 "enables"` and `RO_0002326 "contributes_to"`; else, it is updated to `RO:0002327 "enables"`.
+* For `GO:0003674 "molecular_function"` and subclass descendants:
+    * If the annotation is to the root term `"molecular_function"`, then the gp2term relation should `RO:0002327 "enables"`; else, it is repaired to `RO:0002327 "enables"`.
+    * If the annotation is to is a subclass descendant of `"molecular_function"`, then the allowed gp2term relations are `RO:0002327 "enables"` and `RO_0002326 "contributes_to"`; else, it is updated to `RO:0002327 "enables"`.
 * For `GO:0008150 "biological process"`: 
-    * If the annotation is to the root term `"biological process"`, then the gp2term relation should be `RO:0002331 "involved_in"`. If the gp2term relation is different, it is repaired to `RO:0002331 "involved_in"`.
-    * If the annotation is to is a subclass descendant of `"biological process"` then the allowed gp2term relations are `RO:0002331 "involved_in"`, `RO:0002264 "acts upstream or within"`, `RO:0004032 "acts upstream of or within, positive effect"`, `RO:0004033 "acts upstream of or within, negative effect"`, `RO:0002263 "acts upstream of"`, `RO:0004034 "acts upstream of, positive effect"`, `RO:0004035 "acts upstream of, negative effect"`; else, the relation is repaired to `RO:0002264 "acts upstream of or within"`.
+    * If the annotation is to the root term `"biological_process"`, then the gp2term relation should be `RO:0002331 "involved_in"`. If the gp2term relation is different, it is repaired to `RO:0002331 "involved_in"`.
+    * If the annotation is to is a subclass descendant of `"biological_process"` then the allowed gp2term relations are `RO:0002331 "involved_in"`, `RO:0002264 "acts_upstream_or_within"`, `RO:0004032 "acts_upstream_of_or_within_positive_effect"`, `RO:0004033 "acts upstream of or within_negative_effect"`, `RO:0002263 "acts_upstream_of"`, `RO:0004034 "acts_upstream_of_positive_effect"`, `RO:0004035 "acts upstream of, negative effect"`; else, the relation is repaired to `RO:0002264 "acts upstream of or within"`.
 * For `GO:0005575 "cellular component"`
     * If the annotation is to the root term `"cellular_component"`, then the gp2term relation should be `RO:0002432 "is_active_in"`; else, it is repaired to `RO:0002432 "is_active_in"`.
-    * If the annotation is to `"GO:0032991 "protein-containing complex"` or a subclass descendant of, then the gp2term relation should be `"BFO:0000050 "part of"`; else, it is repaired to `"BFO:0000050 "part of"`.
-    * If the annotation is to `GO:0110165 "cellular anatomical entity"` or to `GO:0044423 "virion component"` or a descendant of either of these terms, then the allowed gp2term relations are `RO:0001025 "located in"` and `RO:0002432 "is_active_in"`, and `RO_0002325 "colocalizes_with"`; else it is repaired to `RO:0001025 "located in"`.
+    * If the annotation is to `"GO:0032991 "protein-containing complex"` or a subclass descendant of, then the gp2term relation should be `"BFO:0000050 "part_of"`; else, it is repaired to `"BFO:0000050 "part of"`.
+    * If the annotation is to `GO:0110165 "cellular anatomical entity"` or to `GO:0044423 "virion component"` or a descendant of either of these terms, then the allowed gp2term relations are `RO:0001025 "located_in"` and `RO:0002432 "is_active_in"`, and `RO_0002325 "colocalizes_with"`; else it is repaired to `RO:0001025 "located_in"`.
     
 * If an annotation has a negation (`NOT`), is is kept as a pipe-separated value with the gp2term relation.
-
+* Note that RO does not have underscores in the term labels, but the userscores are used in the GP2Term relations in GAF 2.2.