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Obsoletion request: GO:0090308 regulation of DNA methylation-dependent heterochromatin formation & GO:0090309 positive regulation of DNA methylation-dependent heterochromatin formation
#28927
Closed
pgaudet opened this issue
Sep 13, 2024
· 0 comments
· Fixed by #28949
GO:0090308 regulation of DNA methylation-dependent heterochromatin formation
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin formation
(we want to keep GO:0090310 negative regulation of DNA methylation-dependent heterochromatin formation)
The annotations have been reviewed and we find no evidence for positive regulation; the process itself contains some feedback enhancements (ie, methylation of some histone may lead to increased DNA methylation, which may increase histone methylations for example), but this is how the process takes place, it's not been possible to define genes strictly involved in positive regulation.
GO:0090308 regulation of DNA methylation-dependent heterochromatin formation
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin formation
(we want to keep GO:0090310 negative regulation of DNA methylation-dependent heterochromatin formation)
The annotations have been reviewed and we find no evidence for positive regulation; the process itself contains some feedback enhancements (ie, methylation of some histone may lead to increased DNA methylation, which may increase histone methylations for example), but this is how the process takes place, it's not been possible to define genes strictly involved in positive regulation.
See annotation review: geneontology/go-annotation#4893
Some FB annotations still need to be reviewed; all others have been changed.
Thanks, Pascale
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