Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

PTN000542090 () #5597

Closed
sjm41 opened this issue Jan 7, 2025 · 1 comment
Closed

PTN000542090 () #5597

sjm41 opened this issue Jan 7, 2025 · 1 comment

Comments

@sjm41
Copy link

sjm41 commented Jan 7, 2025

  • PTHR ID & PTN node:
    PTN000542090

  • Sequences with problematic annotation (ID + gene/protein name):
    D. melanogaster Prm (FBgn0003149, P35415 / P35416)

  • Type of Issue: Erroneous source or erroneous propagation, or other issue
    erroneous propagation

D. melanogaster Prm (Paramyosin) is getting 'Rho-dependent protein serine/threonine kinase activity' via PTN000542090, for which the sources are O75116 (human Rho-associated protein kinase 2, ROCK2) and Q13464 (human Rho-associated protein kinase 1, ROCK1).
But Prm has no kinase domains and just has a 'myosin tail' (it's characterized as a structural component of invertebrate muscle thick filaments. (e.g. PMID:16020538))

Can you check, and if you agree, block the kinase annotation to Prm?

This previously came up in #2888

@marcfeuermann
Copy link

In fact "protein serine/threonine kinase activity" was blocked, but it was not the case for the child term "Rho-dependent protein serine/threonine kinase activity", which made the first block silent. I've corrected this.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
Development

No branches or pull requests

3 participants