ALANYL-TRNA SYNTHETASE (PTHR11777)-FBgn0027094

[hattrill]

• PTHR ID & PTN node:
  ALANYL-TRNA SYNTHETASE (PTHR11777)
  PTN000206953

• Sequences with problematic annotation (ID + gene/protein name):
  FBgn0027094 AlaRS

• Type of Issue: Erroneous source or erroneous propagation, or other issue

• Block propagation of mitochondrion GO:0005739 to FBgn0027094 as this is the cytoplasmic version of this enzyme

• Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).

[ValWood]

These will be tricky to propagate correctly. The localizations don't always align well with the ortholog. For example, the family member is the only alanyl-tRNA synthase in pombe, and is both mitochondrial and cytosolic

[pgaudet]

This is when 'cytoplasmic' may be useful ;)

[hattrill]

I think that in these cases, not propagating a CC is the correct choice. As Ronan Keating once said, "you say it best when you say nothing at all"

[marcfeuermann]

This is a case in which the cytosolic and mitochondrial members are completely mixed within the tree. And yes, some have both CCs... I've cleaned up the annotation. I have kept the annotations for small and safe nodes (i.e. vertebrates AARS1 vs AARS2).