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These results indicate that Tim54 and AGK likely share a common ancestor; however, the diacylglycerol kinase (DAGK) domain is now virtually undetectable in fungal sequences.
Tim54 is likely a divergent fungal AGK which lost the DAGK domain after the divergence of holomycota from holozoa (Figure 4).
PTHR ID & PTN node:
Sequences with problematic annotation (ID + gene/protein name):
Type of Issue: Erroneous source or erroneous propagation, or other issue
FThe lipid kinase activities described for meatazoa seem to be unlikely to be conserved in yeast
GO:0017050 | D-erythro-sphingosine kinase activity | IBA with MGI:1316649 , Q9NRA0 , MGI:1861380 , S000004250 , S000005697 , FBgn0030300 , DDB_G0272522 , FBgn0052484 , 620048 , PTN000270645 , DDB_G0284545 , Q9NYA1
This is all I found:
Tim54
https://f1000research.s3.amazonaws.com/manuscripts/28588/b9cfdbd7-e8a7-4346-ba92-e08242bc16be_25904_-_jeremy_g_wideman.pdf?doi=10.12688/f1000research.25904.1&numberOfBrowsableCollections=92&numberOfBrowsableInstitutionalCollections=5&numberOfBrowsableGateways=54
These results indicate that Tim54 and AGK likely share a common ancestor; however, the diacylglycerol kinase (DAGK) domain is now virtually undetectable in fungal sequences.
Tim54 is likely a divergent fungal AGK which lost the DAGK domain after the divergence of holomycota from holozoa (Figure 4).
Also
https://www.yeastgenome.org/locus/S000003590/go
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