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 PTN004187732 H3K9me/H3K9me2 demethylase activity to =/- reg of transcription. AND PTN000290238 #4822

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ValWood opened this issue Nov 14, 2023 · 2 comments
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@ValWood
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ValWood commented Nov 14, 2023

  • PTHR ID & PTN node:

  • Sequences with problematic annotation (ID + gene/protein name):

PomBase Lsd1
GO:0140683 | histone H3K9me/H3K9me2 demethylase activity
is annotated to

GO:0000122 negative regulation of transcription by RNA polymerase II IBA with PTN004187732 , MGI:1196256 , O60341 Gaudet P et al. (2011) 52
  • | GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA with MGI:1196256 , PTN004187732 , 1562975 , O60341 | Gaudet P et al. (2011) | 99

I'm not sure that either of these annotations are correct t (at least for yeast).
Mutation will affect transcription, but this seems to be more heterochromatin assembly and boundr formation?

@colinlog
@pgaudet
do you agree?

  • Type of Issue: Erroneous source or erroneous propagation, or other issue

  • Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).

@ValWood
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ValWood commented Nov 14, 2023

Similarly

GO:0006355 | regulation of DNA-templated transcription | IBA with PTN000290238 , locus:2005538 , Q8H991 , locus:2090694 , MGI:1921266

(these are both https://www.pombase.org/term/GO:0033193
probably the definition of this complex should change?)

@ValWood ValWood changed the title  PTN004187732 H3K9me/H3K9me2 demethylase activity to =/- reg of transcription  PTN004187732 H3K9me/H3K9me2 demethylase activity to =/- reg of transcription. AND PTN000290238 Nov 14, 2023
@marcfeuermann
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As we try to focus on the core functions of the families, I removed all downstream transcription regulation propagation.

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