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---------------Text extracted from ontology: DO NOT EDIT---------------
- OWL ID: GOREL_0001006
- label: acts_on_population_of
- synonyms []
The relationship that links an entity with a process in which the process has more than one participant that is of the same entity type.
Use this relation to relate a process to a population of cells that it acts on. The main usage of this relations is to relate GO: cell proliferation to the proliferating cells type. (Individual cells divide, populations of cells proliferate.)
Example of use: an annotation of gene X to cell proliferation with acts_on_population_of CL:0000057 means that gene X is involved in the proliferation of fibroblasts.
[valid_for_annotation_extension, AE_cell_or_anatomical, display_for_curators]
##local domain {u'GO:0008283': ''}
{u'CL:0000000': u'cell', u'WBbt:0004017': u'Cell'}
---------------END AUTO GENERATED SECTION---------------
1. SEMA3A signals through NRP1 and PLXNA4 to guide the axons of facial visceromotor neurons:
Statement from paper:
Whilst axons formed normal projections in 5/5 Nrp2-null and 3/3 Sema3F-null mutants, we observed striking axon guidance errors in 5/5 Nrp1-null and 5/5 Sema3a-null mutants. Specifically, there was defasciculation and midline crossing of ectopic axons near Rathke's pouch, consistent with the idea that Sema3a normally provides repulsive cues for GSPN axons. Moreover, there was no arborisation in the area where the sphenopalatine ganglion forms; rather, some axons appeared to extend beyond the target area.
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
|---|---|---|---|---|
| O08665 Sema3a | GO:0008045 motor neuron axon guidance | PMID:18804103 | IMP | acts_on_population of(CL:0005025 visceromotor neuron) |
Using examples to demonstrate Folding_and_Unfolding using the relationship acts_on_population_of
1. SEMA3A signals through NRP1 and PLXNA4 to guide the axons of facial visceromotor neurons:
| Folded/unfolded | Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) | Parent terms of new folded GO term |
|---|---|---|---|---|---|---|
| Unfolded | O08665 Sema3a | GO:0008045 motor neuron axon guidance | PMID:18804103 | IMP | acts_on_population of(CL:0005025 visceromotor neuron) | |
| Folded | O08665 Sema3a | New GO ID visceromotor neuron motor neuron axon guidance | PMID:18804103 | IMP | is_a GO:0008045 motor neuron axon guidance |
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