diff --git a/requirements.txt b/requirements.txt
index 3c85e5e..7f73820 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,5 +1,5 @@
 Cython>=0.29.21
-fhirclient==3.2.0
+fhirclient==4.2.0
 pysam
 pandas
 pytz>=2019.3
diff --git a/setup.cfg b/setup.cfg
index de106a0..817cefb 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -24,7 +24,7 @@ packages =
 python_version = >=3.6
 install_requires =
     Cython>=0.29.21
-    fhirclient==3.2.0
+    fhirclient==4.2.0
     pysam
     pandas
     pytz>=2019.3