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Multisample VCF #105

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kkarbasi opened this issue Oct 14, 2020 · 1 comment
Open

Multisample VCF #105

kkarbasi opened this issue Oct 14, 2020 · 1 comment

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@kkarbasi
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kkarbasi commented Oct 14, 2020

Merging snps from different samples and saving them as a multi-sample VCF.
Hi, would that be possible?

Thanks!

@apriha
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apriha commented Oct 16, 2020

Thanks for the issue! Yes, I think a multi-sample VCF could be constructed from merged files. To do this, I'm envisioning the SNPs object maintaining the results of each merge (e.g., RSIDs in common, discrepant SNPs) and building the VCF from that summary information.

Related, the fix for this issue should also operate in reverse to read a multi-sample VCF, identifying discrepant SNPs in the process.

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