The code files in this repository generate the results for the paper "miRNA-Gene Activity Interaction Networks (miGAIN): Integrated joint models of miRNA-gene targeting and disturbance in signaling pathways" by Henry Linder and Yuping Zhang.
This repository is hosted at the following locations:
In order to run the code, the following resources are necessary:
- TCGA data omics data, downloaded and formatted using
TCGA-Assembler
software, version 2. The data must include:
- Gene expression
- miRNA expression
- Gene methylation
- Gene copy number The results in the paper were obtained using data published via the NCI Genomic Data Commons Legacy Archive.
- The mirDIP: microRNA Data Integration Portal database of miRNA-gene target interactions.