diff --git a/src/app/features/genes/components/gene-resources/gene-resources.component.ts b/src/app/features/genes/components/gene-resources/gene-resources.component.ts index 0fa53683..b7b0905b 100644 --- a/src/app/features/genes/components/gene-resources/gene-resources.component.ts +++ b/src/app/features/genes/components/gene-resources/gene-resources.component.ts @@ -9,7 +9,7 @@ import { Gene, ResourceCard } from '../../../../models'; }) export class GeneResourcesComponent implements OnInit { @Input() gene: Gene | undefined; - + additionalResources: ResourceCard[] = []; drugDevelopmentResources: ResourceCard[] = []; @@ -34,43 +34,43 @@ export class GeneResourcesComponent implements OnInit { { title: 'Chemical Probes', description: - 'View expert reviews and evaluations of chemical probes.', + 'View expert reviews and evaluations of any chemical probes that are available for this target.', linkText: 'Visit Chemical Probes', link: `https://www.chemicalprobes.org/?q=${this.gene?.hgnc_symbol}`, }, { title: 'Open Targets', description: - 'View this gene on Open Targets, a resource that provides evidence on the validity of therapeutic targets based on genome-scale experiments and analysis.', + 'View evidence on the validity of this therapeutic target based on genome-scale experiments and analysis.', linkText: 'Visit Open Targets', link: `https://platform.opentargets.org/target/${this.gene?.ensembl_gene_id}`, }, { title: 'PharmGKB', description: - 'Search PharmGKB for information on gene-drug and gene-phenotype relationships.', + 'Search for information on gene-drug and gene-phenotype relationships.', linkText: 'Visit PharmGKB', link: 'https://www.pharmgkb.org', }, { title: 'Pharos', description: - 'View this gene on Pharos, a resource that provides access to the integrated knowledge-base from the Illuminating the Druggable Genome program.', + 'View information about this target in the Knowledge Management Center for the Illuminating the Druggable Genome program.', linkText: 'Visit Pharos', link: `https://pharos.nih.gov/targets?q=${this.gene?.ensembl_gene_id}`, }, { title: 'Probe Miner', description: - 'Search Probe Miner for information on chemical probes for this gene.', + 'Search for information on chemical probes based on large-scale, publicly available, medicinal chemistry data.', linkText: 'Visit Probe Miner', link: 'https://probeminer.icr.ac.uk/#/', }, { title: 'Protein Data Bank', description: - 'Search PDB for experimental and computed protin structure information.', - linkText: 'Search PDB', + 'Search for experimental and computed 3D protein structure information.', + linkText: 'Visit PDB', link: 'https://www.rcsb.org', }, ]; @@ -79,16 +79,9 @@ export class GeneResourcesComponent implements OnInit { { title: 'AD Atlas', description: - 'View this gene on the AD Atlas site, a network-based resource for investigating AD in a multi-omic context.', + 'Perform interactive network and enrichment analyses on this target using a heterogenous network of multiomic, association, and endophenotypic data.', linkText: 'Visit AD Atlas', - link: `https://adatlas.org/?geneID=${this.gene?.ensembl_gene_id}`, - }, - { - title: 'Allen Institute Transcriptomics', - description: - 'View single nucleus RNAseq data for this gene using the Allen Institute’s Transcriptomics Comparative Viewer.', - linkText: 'Visit AD Transcriptomics Viewer', - link: `https://knowledge.brain-map.org/data/5IU4U8BP711TR6KZ843/2CD0HDC5PS6A58T0P6E/compare?geneOption=${this.gene?.hgnc_symbol ?? this.gene?.ensembl_gene_id}`, + link: `https://adatlas.org/?type=geneEnsembl&ids=${this.gene?.ensembl_gene_id}`, }, { title: 'Alzforum', @@ -100,62 +93,69 @@ export class GeneResourcesComponent implements OnInit { { title: 'AlzPED', description: - 'Search AlzPED for information on preclinical efficacy studies of candidate AD therapeutics.', + 'Search for information on preclinical efficacy studies of candidate AD therapeutics.', linkText: 'Visit AlzPED', link: 'https://alzped.nia.nih.gov', }, { - title: 'AMP-PD Target Explorer', - description: 'View this gene in the AMP-PD Target Explorer, a resource that hosts evidence about whether genes are associated with Parkinson\'s Disease.', + title: 'AMP-PD Target Explorer', + description: 'View evidence about whether this target is associated with Parkinson\'s Disease.', linkText: 'Visit AMP-PD', link: `https://target-explorer.amp-pd.org/genes/target-search?gene=${this.gene?.ensembl_gene_id}` }, + { + title: 'Brain Knowledge Platform', + description: + 'View single nucleus RNAseq results for this target using the Allen Institute SEA-AD Comparative Viewer.', + linkText: 'Visit Brain Knowledge Platform', + link: `https://knowledge.brain-map.org/data/5IU4U8BP711TR6KZ843/2CD0HDC5PS6A58T0P6E/compare?geneOption=${this.gene?.hgnc_symbol ?? this.gene?.ensembl_gene_id}`, + }, { title: 'Gene Ontology', description: - 'View the gene ontology information for this gene on Ensembl.', - linkText: 'Visit Ensembl', - link: `https://www.ensembl.org/Homo_sapiens/Gene/Ontologies/molecular_function?g=${this.gene?.ensembl_gene_id}`, + 'View the GO terms associated with this target and explore ontology-related tools.', + linkText: 'Visit AmiGO 2', + link: `https://amigo.geneontology.org/amigo/search/annotation?q=${this.gene?.hgnc_symbol ?? this.gene?.ensembl_gene_id}`, }, { title: 'GeneCards', description: - 'Visit GeneCards to view integrated information about this gene.', + 'View integrated information about this target gathered from a comprehensive collection of public sources.', linkText: 'Visit GeneCards', - link: `https://www.genecards.org/Search/Keyword?queryString=${this.gene?.ensembl_gene_id}`, + link: `https://www.genecards.org/cgi-bin/carddisp.pl?gene=${this.gene?.hgnc_symbol ?? this.gene?.ensembl_gene_id}`, }, { title: 'Genomics DB', description: - 'View this gene on the National Institute on Aging Genetics of Alzheimer\'s Disease Data Storage Site (NIAGADS) Genomics Database.', + 'View information about this target on the National Institute on Aging Genetics of Alzheimer\'s Disease Data Storage Site (NIAGADS) Genomics Database.', linkText: 'Visit Genomics DB', link: `https://www.niagads.org/genomics/app/record/gene/${this.gene?.ensembl_gene_id}`, }, { title: 'Pub AD', description: - 'View dementia-related publication information for this gene on PubAD.', + 'View dementia-related publication information for this target.', linkText: 'Visit PubAD', link: `${ this.getPubADLink() }`, }, { title: 'Reactome Pathways', description: - 'View the reactome pathway information for this gene on Ensembl.', + 'View the reactome pathway information for this target on Ensembl.', linkText: 'Visit Ensembl', link: `https://www.ensembl.org/Homo_sapiens/Gene/Pathway?g=${this.gene?.ensembl_gene_id}`, }, { title: 'SEA-AD', description: - 'Explore the Seattle Alzheimer’s Disease Brain Cell Atlas resources.', + 'Explore the Seattle Alzheimer’s Disease Brain Cell Atlas resources from the Allen Institute.', linkText: 'Visit SEA-AD', link: 'https://portal.brain-map.org/explore/seattle-alzheimers-disease', }, { title: 'UniProtKB', description: - 'View sequence and functional information about the protein(s) encoded by this gene.', + 'View protein sequence and functional information about this target.', linkText: 'Visit UniProtKB', link: `https://www.uniprot.org/uniprotkb?query=${this.gene?.ensembl_gene_id}`, },