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This website was created within the discipline of Bioinformatics Laboratory, Master's Course in Bioinformatics 2015/2016.

The objective of this work was to apply bioinformatic tools in the analysis of a bacteria. 

The chosen strain was Treponema pallidum subsp. Pallidum str.Nichols, a gram negative a spirochaete bacterium, with approximately 1000 genes enclosed in a circular genome. The NCBI RefSeq accession number used was NC_000919 (GI:15638995).
Furthermore, we only analysed a set of 100 genes comprised between TP_RS02955 TA TP_RS03535 (locus tag), genome area 639851 to 765100.


This bacterium causes treponemal diseases such as syphilis, bejel, pinta, and yaws. This is a cause of concern because of the probability of transmission of disease, especially because the drugs used will become obsolete. 

For more information about this Syphilis and Treponema pallidum please visit these websites and read the append bibliography:
http://www.insa.pt/sites/INSA/Portugues/ObsSaude/Paginas/TreponemapallidumAmostrasClinicas.aspx
https://microbewiki.kenyon.edu/index.php/Treponema_pallidum
http://www.ncbi.nlm.nih.gov/books/NBK7716/
http://www.britannica.com/science/Treponema-pallidum