Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Include AD (allelic depths) in format from somatic variants #233

Closed
juliawiggeshoff opened this issue Sep 21, 2023 · 1 comment
Closed

Comments

@juliawiggeshoff
Copy link

Is it possible to include the Allelic depths for the ref and alt alleles in the order listed (AD) in the format fields from the somatic SNV and INDEL files?

It seems like this feature is available for germline variant calling, but not for somatic.

The following has been mentioned by @ctsa under issue #3:

@IraDeveson - We will add a section to the user guide for the upcoming 2.8.0 release.
@student-t - "AF" is perhaps too easily confused with its population allele frequency usage, the likely trajectory is to move towards the more standard AD counts, which will make the corresponding allele frequency simpler to extract.

Originally posted by @ctsa in #3 (comment)

@juliawiggeshoff
Copy link
Author

Originally, I requested this to be able to easily calculate VAF using bcftools +fill-tags, as I can with other callers I use, but I have since "given up" on this request and had to write my own script to calculate the VAF for the variants, as mentioned in the comment from this issue: #234 (comment)

Here is the script, if anyone encounters the same problem...

@juliawiggeshoff juliawiggeshoff closed this as not planned Won't fix, can't repro, duplicate, stale Dec 18, 2023
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant