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Influenza: highlight mutations of interest #478

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anna-parker opened this issue Jan 17, 2025 · 2 comments
Open

Influenza: highlight mutations of interest #478

anna-parker opened this issue Jan 17, 2025 · 2 comments
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@anna-parker
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anna-parker commented Jan 17, 2025

For influenza there are known NA and HA amino acid substitutions associated with reduced inhibition by antivirals, e.g. https://www.who.int/teams/global-influenza-programme/laboratory-network/quality-assurance/antiviral-susceptibility-influenza/neuraminidase-inhibitor

We should mark these mutations in our mutations over time heat map. We should also consider allowing the option to only show non-synonymous mutations.

Additionally, it would make sense to try to highlight mutations in known epitopes: example of known file: https://github.com/nextstrain/seasonal-flu/blob/master/config/distance_maps/h1n1pdm/ha/canton.json

@fengelniederhammer fengelniederhammer added the question Further information is requested label Feb 4, 2025
@fengelniederhammer
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We need more refinement.

@anna-parker
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Yesterday I asked Richard Neher which formats are typically used for marking epitope sites and mutations of interest and he said that they primarily just have lists (e.g. JSON, YAML) for this and don't use GFF3 etc.

As we have these lists it would be good to create a simple version of this that takes JSON or YAML as input with these lists.

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