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index.html
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<html lang="en">
<head>
<meta charset="UTF-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>C.OMICS</title>
<!-- Latest compiled and minified CSS -->
<link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/css/bootstrap.min.css" integrity="sha384-BVYiiSIFeK1dGmJRAkycuHAHRg32OmUcww7on3RYdg4Va+PmSTsz/K68vbdEjh4u" crossorigin="anonymous">
<!-- Optional theme -->
<link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/css/bootstrap-theme.min.css" integrity="sha384-rHyoN1iRsVXV4nD0JutlnGaslCJuC7uwjduW9SVrLvRYooPp2bWYgmgJQIXwl/Sp" crossorigin="anonymous">
<!-- Latest compiled and minified JavaScript -->
<script src="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/js/bootstrap.min.js" integrity="sha384-Tc5IQib027qvyjSMfHjOMaLkfuWVxZxUPnCJA7l2mCWNIpG9mGCD8wGNIcPD7Txa" crossorigin="anonymous"></script>
<!-- Latest compiled and minified CSS -->
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/[email protected]/dist/css/bootstrap-select.min.css">
<!-- Latest compiled and minified JavaScript -->
<script src="https://cdn.jsdelivr.net/npm/[email protected]/dist/js/bootstrap-select.min.js"></script>
<script src="https://code.jquery.com/jquery-3.5.1.js"></script>
<script src="https://cdn.plot.ly/plotly-2.20.0.min.js"></script>
<link rel="stylesheet" href="https://software.broadinstitute.org/morpheus/css/morpheus-latest.min.css">
<script type="text/javascript"
src="https://software.broadinstitute.org/morpheus/js/morpheus-external-latest.min.js"></script>
<script src="https://software.broadinstitute.org/morpheus/js/morpheus-latest.min.js"></script>
<!--<script type="text/javascript" src="subpage/js/morpheus-external-latest.min.js"></script>
<script type="text/javascript" src="subpage/js/morpheus-latest.min.js"></script> -->
<link rel="stylesheet" href="//code.jquery.com/ui/1.12.1/themes/base/jquery-ui.css">
<script src="https://code.jquery.com/ui/1.12.1/jquery-ui.js"></script>
<!--<script src="https://cdnjs.cloudflare.com/ajax/libs/PapaParse/5.3.0/papaparse.min.js"></script>
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/selectize.js/0.15.2/css/selectize.default.min.css" integrity="sha512-pTaEn+6gF1IeWv3W1+7X7eM60TFu/agjgoHmYhAfLEU8Phuf6JKiiE8YmsNC0aCgQv4192s4Vai8YZ6VNM6vyQ==" crossorigin="anonymous" referrerpolicy="no-referrer"/>
<script src="https://cdnjs.cloudflare.com/ajax/libs/selectize.js/0.15.2/js/selectize.min.js" integrity="sha512-IOebNkvA/HZjMM7MxL0NYeLYEalloZ8ckak+NDtOViP7oiYzG5vn6WVXyrJDiJPhl4yRdmNAG49iuLmhkUdVsQ==" crossorigin="anonymous" referrerpolicy="no-referrer"></script>
-->
<script src="subpage/js/common_data.js"></script>
<script src="subpage/js/common_function.js"></script>
<link rel="stylesheet" href="subpage/css/common.css">
<link rel="stylesheet" href="subpage/css/selectize.css">
<script src="subpage/js/selectize.min.js"></script>
<link rel="stylesheet" href="subpage/css/component.css">
<script src="https://cdn.jsdelivr.net/npm/[email protected]/dist/jstat.min.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjs/10.1.0/math.min.js"></script>
<link rel="preconnect" href="https://fonts.googleapis.com">
<link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
<link href="https://fonts.googleapis.com/css2?family=Inter:[email protected]&display=swap" rel="stylesheet">
<link href="https://unpkg.com/gridjs/dist/theme/mermaid.min.css" rel="stylesheet" />
<script src="https://unpkg.com/gridjs/dist/gridjs.umd.js"></script>
<style type="text/css">
.btn:focus,
.btn:active:focus,
.btn.active:focus,
.btn.focus,
.btn:active.focus,
.btn.active.focus {
outline: none;
}
.m-5 {
margin: 3rem !important
}
.m-3 {
margin: 1rem !important
}
.th-text-align {
text-align: center
}
.progress-bar {
width:300px;
height:30px;
background-color:#f0f0f0;
border-radius:10px;
overflow:hidden;
position: relative;
top: 50%;
left: 45%;
}
.progress-bar-inner{
height:100%;
background-color: #5bb78c;
width:0;
transition:width 0.5s;
}
.main-content {
width: 90%;
margin: auto;
}
.content-box {
flex-direction: column;
border: 1px solid #ddd;
border-radius: 10px;
background: #fff;
padding: 13px;
display: flex;
}
.text-section {
order:1
}
.image-section {
order:2;
text-align: center;
}
.carousel-container {
position: relative;
width: 100%;
margin: auto;
overflow: hidden;
border-radius: 10px;
border: 1px solid #ddd;
}
.carousel-images {
display: flex;
transition: transform 0.5s ease-in-out;
}
.carousel-images img {
width: 100%; /* 화면 너비에 맞게 이미지 조정 */
height: auto; /* 이미지 비율 유지 */
object-fit: cover; /* 다른 비율의 이미지를 슬라이드에 맞게 조정 */
flex-shrink: 0; /* 이미지가 크기를 잃지 않도록 고정 */
}
.carousel-button {
position: absolute;
top: 50%;
transform: translateY(-50%);
background-color: rgba(0, 0, 0, 0.5);
color: white;
border: none;
padding: 10px;
cursor: pointer;
z-index: 10;
}
.carousel-button.left {
left: 10px;
}
.carousel-button.right {
right: 10px;
}
.reference-section {
order: 3;
}
.reference-section h3 {
margin-bottom: 10px;
}
.reference-section p {
margin: 5px 0;
}
.reference-section a {
color: #007BFF;
text-decoration: none;
}
.reference-section a:hover {
text-decoration: underline;
}
.close{
display: none;
}
.dropdown-menu li a[data-name="Pin tab"]{
display: none;
}
/* Responsive design for smaller screens */
@media (max-width: 768px) {
.content-box {
flex-direction: column;
}
.image-section img {
width: 100%;
height: auto;
}
}
</style>
</head>
<body>
<div class="components-page">
<div class="component-item">
<header class="custom-header">
<img src="/subpage/images/1-Photoroom.png" class="header-logo" id="logoImg">
<div class="custom-header-inner">
<ul class="custom-header-nav-grp" id="mymenu">
<li class="custom-header-nav" name="HOME">
<a href="#" class="link active">HOME</a>
</li>
<li class="custom-header-nav" name="NMF">
<a href="#" class="link">NMF Cluster</a>
</li>
<li class="custom-header-nav" name="IMMUNE">
<a href="#" class="link">Immune Cluster</a>
</li>
<li class="custom-header-nav" style="z-index: 999;">
<a href="#" class="link">Quantitation</a>
<div class="custom-header-sub-nav-grp">
<ul>
<li class="custom-header-sub-nav" name="PROTEIN">
<a href="#" class="sub-link">Protein</a>
</li>
<li class="custom-header-sub-nav" name="PHOSPHO">
<a href="#" class="sub-link">Phosphosite</a>
</li>
<li class="custom-header-sub-nav" name="ACETYL">
<a href="#" class="sub-link">Acetylsite</a>
</li>
<li class="custom-header-sub-nav" name="RNA">
<a href="#" class="sub-link">RNA</a>
</li>
</ul>
</div>
</li>
<li class="custom-header-nav" name="COMPARISON">
<a href="#" class="link">Group Comparison</a>
</li>
<li class="custom-header-nav" name="SURVIVAL">
<a href="#" class="link">Survival Analysis</a>
</li>
<li class="custom-header-nav" name="HELP">
<a href="/subpage/nmf_help.html" target="_blank" class="link">Help</a>
</li>
</ul>
</div>
</header>
</div>
</div>
<div id="homeContent">
<div id="homeMainContent" class="main-content">
<div id="mainContent">
<div style="text-align: center; margin-bottom: 10px;">
<span style="color:#790F09;font-size: 22px;font-weight: 500; margin-right: 20px;">Cancer</span><span style="font-size: 22px;font-weight: 500;">Omics</span>
</div>
<div class="content-box">
<div class="text-section">
<h4 style="margin-top: 0;">Introduction</h4>
<!--<h3>Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment</h3>-->
<p>Non-small cell lung cancer (NSCLC) is histologically classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LSCC).
However, some tumors are histologically ambiguous and other pathophysiological features or microenvironmental factors may be more prominent.
Here we report integrative multiomics analyses using data for 229 patients from a Korean NSCLC cohort and 462 patients from previous multiomics
studies. Histological examination reveals five molecular subtypes, one of which is a NSCLC subtype with PI3K-Akt pathway upregulation,
showing a high proportion of metastasis and poor survival outcomes regardless of any specific NSCLC histology. Proliferative subtypes
are present in LUAD and LSCC, which show strong associations with whole genome doubling (WGD) events. Comprehensive characterization of the
immune microenvironment reveals various immune cell compositions and neoantigen loads across molecular subtypes, which predicting different
prognoses. Immunological subtypes exhibit a hot tumor-enriched state and a higher efficacy of adjuvant therapy.</p>
</div>
<div class="image-section">
<img src="/subpage/images/all.png" style="height: 100%;width:44%">
</div>
<div class="reference-section">
<h4>Reference</h4>
<i><p style="font-size: 13px;">Song KJ, Choi S, Kim K, Hwang HS, Chang E, Park JS, Shim SB, Choi S, Heo YJ, An WJ, Yang DY, Cho KC, Ji W, Choi CM, Lee JC, Kim HR, Yoo J, Ahn HS,
Lee GH, Hwa C, Kim S, Kim K, Kim MS, Paek E, Na S, Jang SJ, An JY, Kim KP.</p></i>
<p style="font-weight:bold;">Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment. </p>
<p>Nat Commun. 2024 Nov 23;15(1):10164. <a href="https://pubmed.ncbi.nlm.nih.gov/39580524/" target="_blank">doi: 10.1038/s41467-024-54434-4.</a> PMID: 39580524; PMCID: PMC11585665.</p>
</div>
</div>
</div>
</div>
<div id="NMFmainContent" ></div>
<div id="IMMUNEmainContent" ></div>
<div id="PROTEINmainContent" ></div>
<div id="PHOSPHOmainContent"></div>
<div id="ACETYLmainContent"></div>
<div id="GENEmainContent"></div>
<div id="COMPARISONmainContent"></div>
<div id="SURVIVALmainContent"></div>
</div>
</div>
<!--<footer class="main-footer">
<table style="margin: auto; font-size: 13px;margin-top:20px">
<tbody>
<tr>
<td class="copy">Copyright © 2024
<a href="http://bislab.hanyang.ac.kr/" class="under" target="_blank">Bioinformatics & Intelligent Systems Lab</a>,
<a href="http://www.hanyang.ac.kr/english/" class="under" target="_blank">Hanyang University</a>,
Korea. All rights reserved.<br>
<a href="/inc/policy.jsp" class="under" target="_blank">Personal Information Policy</a>
</td>
</tr>
</tbody>
</table>
</footer>-->
</body>
<script type="text/javascript">
var homePage = false;
var nmfPage = true;
var immunPage = true;
var proteinPage = true;
var phosphoPage = true;
var acetylPage = true;
var genePage = true;
var survivalPage = true;
var comparisonPage = true;
$(function() {
dropdownOpen();
$.ajax({
type:"GET",
url: "../file/nmf_meta_sort.csv",
data:[],
dataType:"text",
cache:false,
success:function(data){
//debugger
metaArray = data.split('\n');
//$('#NMFmainContent').load('/subpage/nmf.html')
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if($(this).attr('name') != undefined){
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$('#NMFmainContent').load('/subpage/nmf_cluster.html')
}
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case 'IMMUNE':
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if(immunPage){
immunPage = false
$('#IMMUNEmainContent').load('/subpage/immune.html')
}
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case 'PROTEIN':
$('#PROTEINmainContent').show();
if(proteinPage){
proteinPage = false
$('#PROTEINmainContent').load('/subpage/quantitation_protein_all.html')
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break;
case 'PHOSPHO':
$('#PHOSPHOmainContent').show();
if(phosphoPage){
phosphoPage = false
$('#PHOSPHOmainContent').load('/subpage/quantitation_phosphosite_all.html')
}
break;
case 'ACETYL':
$('#ACETYLmainContent').show();
if(acetylPage){
acetylPage = false
$('#ACETYLmainContent').load('/subpage/quantitation_acetylsite_all.html')
}
break;
case 'RNA':
$('#GENEmainContent').show();
if(genePage){
genePage = false
$('#GENEmainContent').load('/subpage/quantitation_gene_all.html')
}
break;
case 'COMPARISON':
$('#COMPARISONmainContent').show();
if(comparisonPage){
comparisonPage = false
$('#COMPARISONmainContent').load('/subpage/comparison.html')
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break;
case 'SURVIVAL':
$('#SURVIVALmainContent').show();
if(survivalPage){
survivalPage = false
$('#SURVIVALmainContent').load('/subpage/survival_analysis.html')
}
break;
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});
});
//debugger
let currentIndex = 0;
const images = document.querySelectorAll('.carousel-images img');
const imageContainer = document.querySelector('.carousel-images');
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currentIndex += direction;
if (currentIndex < 0) {
currentIndex = imageCount - 1;
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if (currentIndex >= imageCount) {
currentIndex = 0;
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imageContainer.style.transform = `translateX(${offset}%)`;
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$(this).find(".dropdown-menu").addClass('show');
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$(this).find(".dropdown-menu").removeClass('show');
$(this).removeClass('show');
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}
</script>
</html>