diff --git a/msal/application.py b/msal/application.py
index 5cf7e32a..9ca07025 100644
--- a/msal/application.py
+++ b/msal/application.py
@@ -5,6 +5,7 @@
 import sys
 import warnings
 from threading import Lock
+from typing import Optional  # Needed in Python 3.7 & 3.8
 import os
 
 from .oauth2cli import Client, JwtAssertionCreator
@@ -448,11 +449,13 @@ def __init__(
             Instructs MSAL to use the Entra regional token service. This legacy feature is only available to
             first-party applications. Only ``acquire_token_for_client()`` is supported.
 
-            Supports 3 values:
+            Supports 4 values:
 
-              ``azure_region=None`` - meaning no region is used. This is the default value.
+              ``azure_region=None`` - This default value means no region is configured.
+              MSAL will use the region defined in env var ``MSAL_FORCE_REGION``.
               ``azure_region="some_region"`` - meaning the specified region is used.
               ``azure_region=True`` - meaning MSAL will try to auto-detect the region. This is not recommended.
+              ``azure_region=False`` - meaning MSAL will use no region.
 
             .. note::
                 Region auto-discovery has been tested on VMs and on Azure Functions. It is unreliable.
@@ -630,7 +633,10 @@ def __init__(
         except ValueError:  # Those are explicit authority validation errors
             raise
         except Exception:  # The rest are typically connection errors
-            if validate_authority and azure_region and not oidc_authority:
+            if validate_authority and not oidc_authority and (
+                azure_region  # Opted in to use region
+                or (azure_region is None and os.getenv("MSAL_FORCE_REGION"))  # Will use region
+            ):
                 # Since caller opts in to use region, here we tolerate connection
                 # errors happened during authority validation at non-region endpoint
                 self.authority = Authority(
@@ -724,9 +730,11 @@ def _build_telemetry_context(
             self._telemetry_buffer, self._telemetry_lock, api_id,
             correlation_id=correlation_id, refresh_reason=refresh_reason)
 
-    def _get_regional_authority(self, central_authority):
-        if not self._region_configured:  # User did not opt-in to ESTS-R
+    def _get_regional_authority(self, central_authority) -> Optional[Authority]:
+        if self._region_configured is False:  # User opts out of ESTS-R
             return None  # Short circuit to completely bypass region detection
+        if self._region_configured is None:  # User did not make an ESTS-R choice
+            self._region_configured = os.getenv("MSAL_FORCE_REGION") or None
         self._region_detected = self._region_detected or _detect_region(
             self.http_client if self._region_configured is not None else None)
         if (self._region_configured != self.ATTEMPT_REGION_DISCOVERY
diff --git a/tests/test_e2e.py b/tests/test_e2e.py
index ff35a73e..a0796547 100644
--- a/tests/test_e2e.py
+++ b/tests/test_e2e.py
@@ -1130,11 +1130,23 @@ def _test_acquire_token_for_client(self, configured_region, expected_region):
     def test_acquire_token_for_client_should_hit_global_endpoint_by_default(self):
         self._test_acquire_token_for_client(None, None)
 
-    def test_acquire_token_for_client_should_ignore_env_var_by_default(self):
+    def test_acquire_token_for_client_should_ignore_env_var_region_name_by_default(self):
         os.environ["REGION_NAME"] = "eastus"
         self._test_acquire_token_for_client(None, None)
         del os.environ["REGION_NAME"]
 
+    @patch.dict(os.environ, {"MSAL_FORCE_REGION": "eastus"})
+    def test_acquire_token_for_client_should_use_env_var_msal_force_region_by_default(self):
+        self._test_acquire_token_for_client(None, "eastus")
+
+    @patch.dict(os.environ, {"MSAL_FORCE_REGION": "eastus"})
+    def test_acquire_token_for_client_should_prefer_the_explicit_region(self):
+        self._test_acquire_token_for_client("westus", "westus")
+
+    @patch.dict(os.environ, {"MSAL_FORCE_REGION": "eastus"})
+    def test_acquire_token_for_client_should_allow_opt_out_env_var_msal_force_region(self):
+        self._test_acquire_token_for_client(False, None)
+
     def test_acquire_token_for_client_should_use_a_specified_region(self):
         self._test_acquire_token_for_client("westus", "westus")